EKS-BOT-00062

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-BOT-00062

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	379.8	7.9E-114	141	422	282

Status

Unreviewed

Ensembl Protein

ENSBTAP00000016835

UniProt Accession

A3KMY7; F1MVE7;

Protein Name

Protein Synonyms/Alias

PCTK3 protein;

Gene Name

PCTK3

Gene Synonyms/Alias

PCTK3; CDK18;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000012673	ENSBTAP00000016835	ENSBTAT00000016835

Organism

Bos taurus

Functional Description

Protein Length

471

Protein Sequence
(FASTA)

MSKMKNFKRR FSLSVPRTET IEESLAEFTE QFNQLHNRRN EDLQLGPLGG DPQPESSTFS 60

PTDSGKDLGQ LSPGVQYRRQ NQRRFSMEDI SKRLSLPMDI RLPQEFLQKL QLESPDLPKP 120

LTRMSRRASL SDIGFGKLET YVKLDKLGEG TYATVFKGRS KLTENLVALK EIRLEHEEGA 180

PCTAIREVSL LRNLKHANIV TLHDLVHTER SLTLVFEYLD RDLKQYLDHC GNLMSMHNVK 240

IFMFQLLRGL AYCHRRKILH RDLKPQNLLI NERGELKLAD FGLARAKSVP TKTYSNEVVT 300

LWYRPPDVLL GSTEYSTPLD MWGVGCIQYE MATGRPLFPG STVKEELHLI FRLLGTPTEE 360

TWPGVMALTE FRAYNFPRYL PQPLLSHVPR LDPDGINLLS SLLLYESKSR VSAEAALRHP 420

YFRSLGERVH QLEDTASLFS LKEIQLQKDP GYRGLAFQQP GRGKNRRQSI F 471

Nucleotide Sequence
(FASTA)

ATGAGCAAGA TGAAGAACTT TAAGCGCCGC TTCTCCCTAT CCGTGCCCCG CACTGAGACC 60

ATTGAGGAGT CCTTGGCGGA GTTCACAGAG CAGTTCAACC AGCTCCACAA CAGGCGCAAC 120

GAGGACCTGC AGCTCGGTCC TCTTGGTGGA GACCCCCAGC CAGAGTCCAG CACCTTCTCC 180

CCCACAGACA GTGGGAAGGA CCTCGGGCAG CTGTCCCCAG GCGTGCAGTA CCGGCGGCAG 240

AACCAACGCC GCTTCTCCAT GGAGGACATC AGTAAGAGGC TCTCTCTGCC CATGGACATC 300

CGCTTGCCCC AGGAATTCCT ACAGAAGCTG CAGCTGGAGA GCCCAGACCT ACCCAAACCG 360

CTCACCCGAA TGTCCCGCCG CGCCTCTCTG TCAGATATCG GCTTTGGGAA ACTGGAAACA 420

TACGTGAAAC TGGACAAACT GGGGGAGGGA ACCTATGCCA CAGTCTTCAA GGGGCGCAGC 480

AAACTGACAG AGAACCTCGT GGCCCTGAAG GAGATCCGGC TGGAGCACGA GGAGGGGGCG 540

CCCTGCACTG CCATCCGCGA GGTGTCTCTC CTGCGGAACC TGAAACACGC CAACATCGTG 600

ACCCTGCATG ACCTCGTGCA CACGGAGCGC TCCCTCACCC TGGTGTTTGA GTACCTGGAC 660

CGTGACCTGA AGCAGTATCT GGACCACTGT GGAAACCTCA TGAGCATGCA CAACGTCAAG 720

ATTTTCATGT TCCAGCTGCT CCGGGGCCTC GCCTACTGCC ACCGCCGCAA GATCCTGCAC 780

CGGGACCTGA AGCCCCAGAA CCTGCTCATC AACGAGAGAG GGGAGCTGAA GCTGGCCGAT 840

TTTGGACTGG CCCGGGCCAA GTCAGTGCCC ACGAAGACCT ACTCCAATGA GGTGGTGACC 900

CTGTGGTACA GGCCCCCCGA CGTGCTGCTG GGGTCCACGG AGTACTCCAC CCCCCTTGAC 960

ATGTGGGGTG TGGGCTGCAT CCAGTACGAG ATGGCCACAG GGAGGCCGCT CTTCCCAGGC 1020

TCCACGGTCA AGGAGGAGCT GCACCTCATC TTCCGACTCC TCGGGACCCC CACGGAAGAG 1080

ACGTGGCCCG GTGTGATGGC CCTGACCGAG TTCCGAGCCT ACAACTTCCC CCGGTACCTC 1140

CCCCAGCCGC TCCTCAGCCA CGTTCCCAGG TTGGACCCTG ACGGCATCAA CCTCTTGAGC 1200

AGCCTCCTCC TGTATGAATC CAAGAGCCGC GTGTCAGCAG AGGCGGCCCT GAGGCACCCC 1260

TACTTCCGGT CTCTGGGGGA GCGCGTGCAC CAGCTGGAAG ACACTGCCTC CCTCTTCTCC 1320

CTGAAGGAGA TCCAGCTCCA GAAGGACCCC GGCTACCGGG GCCTGGCCTT CCAGCAGCCA 1380

GGGCGAGGGA AGAACCGGCG GCAGAGCATC TTCTGA 1416

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         y kl+k+geGty++v+k+++k t+++vAlK+irle+e eg p+ta+rE+sll++lkh+ni

Q: 141   YVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLRNLKHANI  199

         7899********************************9.9*********************

S: 61    vkLlevvakdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlleglaylHsnk  120

         v+L+++v+ ++++l+Lvfe+l++dLk++l+++ +  +s+++vk +++qll+glay+H++k

Q: 200   VTLHDLVH-TERSLTLVFEYLDRDLKQYLDHCGN-LMSMHNVKIFMFQLLRGLAYCHRRK  257

         ********.99***********************.*************************

S: 121   ilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLlgakeYst  180

         ilHRDlKpqNlLi+++g+lklaDfGlara s+p+kty++evvTlwYr+P++Llg++eYst

Q: 258   ILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYST  317

         ************************************************************

S: 181   avDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklpeyk.ksfp  239

          +D+W+vgci  e++t +plf+g++ +++l+ if+llgtp+e++wp+v  l e++ ++fp

Q: 318   PLDMWGVGCIQYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVMALTEFRaYNFP  377

         *******************************************************99***

S: 240   kkkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf  284

         ++ ++ l ++v++l+ ++++ll++ll ++ k+R+sa++al+h+yf

Q: 378   RYLPQPLLSHVPRLDPDGINLLSSLLLYESKSRVSAEAALRHPYF  422

         ********************************************9

Domain Sequence
(FASTA)

YVKLDKLGEG TYATVFKGRS KLTENLVALK EIRLEHEEGA PCTAIREVSL LRNLKHANIV 60

TLHDLVHTER SLTLVFEYLD RDLKQYLDHC GNLMSMHNVK IFMFQLLRGL AYCHRRKILH 120

RDLKPQNLLI NERGELKLAD FGLARAKSVP TKTYSNEVVT LWYRPPDVLL GSTEYSTPLD 180

MWGVGCIQYE MATGRPLFPG STVKEELHLI FRLLGTPTEE TWPGVMALTE FRAYNFPRYL 240

PQPLLSHVPR LDPDGINLLS SLLLYESKSR VSAEAALRHP YF 282

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

bta:534048

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013