EKS-BOT-00370
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-BOT-00370
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Src437.02.1E-131245494250
StatusUnreviewed
Ensembl ProteinENSBTAP00000037887
UniProt AccessionQ3ZCM0;
Protein Name
Protein Synonyms/Alias Lymphocyte-specific protein tyrosine kinase;
Gene NameLCK
Gene Synonyms/Alias LCK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSBTAG00000012695ENSBTAP00000037887ENSBTAT00000038070
OrganismBos taurus
Functional Description
Protein Length509
Protein Sequence
(FASTA)
MGCSCSSNPE DDWMENIDVC ENCHYPIVPL DGKTTLPMRN GSEVRDPLVT YEGSNPPASP 60
LQDNLVIALH SYEPSHDGDL GFEKGEQLRI LEQNGEWWKA QSLTTGQEGF IPFNFVAKAN 120
SLEPEPWFFK TLSRKDAERQ LLAPGNTHGS FLIRESESTA GSFSLSVRDF DQTQGEVVKH 180
YKIRNLDKGG FYISPRVTFP GLHELVRHYM NTSDGLCTRL SRPCQTQKPQ KPWWEDEWEV 240
PRETLKLVER LGAGQFGEVW MGYYNGHTKV AVKSLKQGSM SPDAFLAEAN LMKQLQHQRL 300
VRLYAVVTQE PIYIITEYME NGSLVDFLKT SEGIKLTINK LLDMAAQIAE GMAFIEEQNY 360
IHRDLRAANI LVSHSLSCKI ADFGLARLIE DNEYTAREGA KFPIKWTAPE AINYGTFTIK 420
SDVWSFGILL TEIVTHGRIP YPGMTNPEVI QNLERGYRMV RPDNCPEELY QLMMLCWKER 480
PEERPTFDYL RSVLEDFFTA TEGQYQPQP 509
Nucleotide Sequence
(FASTA)
ATGGGCTGTA GCTGCAGCTC AAACCCAGAA GATGACTGGA TGGAAAACAT CGATGTATGT 60
GAAAACTGCC ACTACCCCAT AGTCCCACTG GATGGCAAGA CCACGCTGCC CATGCGGAAT 120
GGCTCTGAAG TGCGTGATCC ACTGGTCACC TACGAGGGAT CCAACCCCCC AGCTTCTCCA 180
CTGCAAGACA ACCTGGTTAT CGCCCTGCAC AGCTATGAGC CTTCTCACGA CGGAGACCTG 240
GGCTTCGAGA AGGGTGAACA GCTCCGTATC CTGGAGCAGA ACGGCGAGTG GTGGAAGGCG 300
CAGTCCCTGA CCACGGGCCA GGAAGGTTTC ATCCCCTTCA ACTTTGTGGC CAAAGCGAAC 360
AGCCTGGAGC CCGAACCCTG GTTCTTCAAG ACTCTGAGCC GCAAGGACGC GGAGAGGCAG 420
CTCCTGGCGC CGGGGAACAC GCACGGCTCC TTCCTGATCC GGGAGAGCGA GAGCACGGCG 480
GGATCGTTTT CACTGTCGGT CCGGGACTTC GACCAGACCC AGGGAGAAGT GGTGAAACAT 540
TACAAGATCC GTAACCTGGA CAAAGGCGGC TTCTACATCT CGCCCCGCGT CACTTTTCCC 600
GGCTTGCACG AGCTGGTCCG CCATTACATG AATACTTCGG ACGGGCTGTG CACACGGTTG 660
AGCCGCCCCT GCCAGACCCA GAAGCCCCAG AAGCCTTGGT GGGAGGATGA GTGGGAGGTT 720
CCCAGGGAGA CTCTGAAGCT GGTGGAGCGG CTGGGGGCTG GCCAGTTCGG AGAGGTGTGG 780
ATGGGGTACT ACAACGGGCA CACGAAGGTG GCAGTCAAGA GCCTGAAGCA GGGCAGCATG 840
TCCCCCGATG CCTTCCTGGC CGAGGCCAAC CTCATGAAGC AGCTGCAACA CCAGAGGCTG 900
GTCCGGCTCT ACGCGGTGGT CACCCAGGAG CCCATCTACA TCATCACGGA ATATATGGAG 960
AACGGAAGCC TGGTGGATTT TCTCAAGACC TCCGAAGGCA TCAAGCTGAC TATCAACAAA 1020
CTCTTGGACA TGGCAGCCCA AATTGCAGAG GGCATGGCAT TCATTGAAGA GCAGAATTAT 1080
ATCCACCGTG ACTTGAGGGC TGCCAACATC CTGGTGTCCC ATAGCCTGAG CTGCAAGATT 1140
GCGGACTTTG GTCTAGCACG CCTCATTGAG GACAACGAGT ACACAGCCAG GGAGGGTGCC 1200
AAGTTTCCCA TTAAGTGGAC AGCACCAGAA GCCATTAACT ATGGGACATT CACCATCAAG 1260
TCGGACGTGT GGTCTTTTGG GATCCTGCTG ACGGAGATTG TCACTCATGG TCGCATCCCT 1320
TACCCAGGGA TGACCAATCC TGAGGTGATT CAGAACCTGG AGCGAGGCTA CCGCATGGTA 1380
CGACCTGACA ACTGCCCGGA GGAGTTGTAC CAGCTTATGA TGCTGTGCTG GAAGGAGCGC 1440
CCGGAAGAAC GGCCCACCTT TGACTACCTG CGCAGCGTGT TGGAGGACTT CTTCACAGCC 1500
ACGGAGGGCC AGTACCAGCC CCAGCCCTGA 1530
Domain Profile
S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60
         lklv++lG+GqfGevw+g+++g++kvavk+lk+g++sp+afl+ea+++k+l+h++lv+ly
Q: 245   LKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLY  304
         6899********************************************************
S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120
         avv++ ePiyi+te+m++Gsl+dflk++eg kl+++kl+d+aaq+aeGma++ee+n+ihr
Q: 305   AVVTQ-EPIYIITEYMENGSLVDFLKTSEGIKLTINKLLDMAAQIAEGMAFIEEQNYIHR  363
         ****9.******************************************************
S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180
         dl+a+n+lv++sl +k+adfGlarlied+eyta+egak+PikWtaPeai++g+ftiksdv
Q: 364   DLRAANILVSHSLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDV  423
         ************************************************************
S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240
         WsfGillteivt+G++PypGmtn ev++++ergyr+ rp++cpeely+l++ cwk++pee
Q: 424   WSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMMLCWKERPEE  483
         ************************************************************
S: 241   rPtfetlqevl  251
         rPtf++l++vl
Q: 484   RPTFDYLRSVL  494
         *******9876
Domain Sequence
(FASTA)
LKLVERLGAG QFGEVWMGYY NGHTKVAVKS LKQGSMSPDA FLAEANLMKQ LQHQRLVRLY 60
AVVTQEPIYI ITEYMENGSL VDFLKTSEGI KLTINKLLDM AAQIAEGMAF IEEQNYIHRD 120
LRAANILVSH SLSCKIADFG LARLIEDNEY TAREGAKFPI KWTAPEAINY GTFTIKSDVW 180
SFGILLTEIV THGRIPYPGM TNPEVIQNLE RGYRMVRPDN CPEELYQLMM LCWKERPEER 240
PTFDYLRSVL 250
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00347
EKS-CAF-00371
EKS-CAP-00402
EKS-DAR-00750
EKS-DIO-00065
EKS-EQC-00361
EKS-ERE-00004
EKS-FEC-00358
EKS-GAM-00223
EKS-GAA-00453
EKS-GOG-00391
EKS-HOS-00376
EKS-ICT-00351
EKS-LAC-00385
EKS-LOA-00383
EKS-MEG-00303
EKS-MIM-00060
EKS-MOD-00357
EKS-MUM-00403
EKS-MUP-00365
EKS-MYL-00368
EKS-OCP-00080
EKS-ORN-00480
EKS-ORC-00349
EKS-ORL-00441
EKS-OTG-00374
EKS-PAT-00349
EKS-PES-00333
EKS-POA-00359
EKS-RAN-00384
EKS-SAH-00340
EKS-SOA-00006
EKS-SUS-00324
EKS-TAR-00475
EKS-TUT-00115
EKS-XET-00485
EKS-XIM-00468
Gene Ontology
GO:0005794; C:Golgi apparatus
GO:0045121; C:membrane raft
GO:0000242; C:pericentriolar material
GO:0005524; F:ATP binding
GO:0004722; F:protein serine/threonine phosphatase activity
GO:0004713; F:protein tyrosine kinase activity
GO:0042169; F:SH2 domain binding
GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0050853; P:B cell receptor signaling pathway
GO:0006882; P:cellular zinc ion homeostasis
GO:0006917; P:induction of apoptosis
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0045588; P:positive regulation of gamma-delta T cell differentiation
GO:0010628; P:positive regulation of gene expression
GO:0050870; P:positive regulation of T cell activation
GO:0042523; P:positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0046777; P:protein autophosphorylation
GO:0050856; P:regulation of T cell receptor signaling pathway
GO:0051209; P:release of sequestered calcium ion into cytosol
GO:0042493; P:response to drug
GO:0030217; P:T cell differentiation
KEGG
bta:508890;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013