EKS-BOT-00405
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-BOT-00405
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR573.32.2E-172579908330
StatusUnreviewed
Ensembl ProteinENSBTAP00000016977
UniProt AccessionA7Z067; F1MWJ7;
Protein Name
Protein Synonyms/Alias CSF1R protein;
Gene NameCSF1R
Gene Synonyms/Alias CSF1R;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSBTAG00000012771ENSBTAP00000016977ENSBTAT00000016977
ENSBTAG00000012771ENSBTAP00000040510ENSBTAT00000042906
OrganismBos taurus
Functional Description
Protein Length964
Protein Sequence
(FASTA)
MGPRTLLILL VVTAWHGQGV PVIEPSGPEL VVEPGTAVTL RCTSNGSVKW DGPVSPYWTL 60
DSDAPRSILT TNNATFLHTG TYRCTEPGDP LAGTATIHLY VKDPARPWRV LAEEVTVLEG 120
QDALLPCLLT DPALEAGVSL VRVRGRSVLR QTSYSFSPWY GFTIHKAKFI ESQDYECSVR 180
VAGRVVKSLS IRLKVQKVIP GPPTLTLEPE ELVRIQGETA KIVCSASDVD VNFDVFLQRG 240
DTKLAISQQS DFRDNRYQKV LTLELDHVGF QDAGNYTCVA TNARGVHTTS MVFRVVDSAY 300
LNLTSEQNLL QEVAVGEKLE LRVKVEAYPS LQSFNWTYEG PFFGSQPKLN FETTNNTYRY 360
TSKLTLPRLK PSEAGLYSFQ ARNARGEDTL TFELTLLYPP EVEVMWTLSS GSKALLCEAS 420
GYPQPNVTWV QCSSHTNRCD KTHVLVLEEP NPDVLRQEPF HKVTVQSLLT PGTLEHNRTY 480
ECRAQNSMGN TSGALGPISV GASMQPRDEP LFTPVLVACM SIMALLLLLL LLLFYKYKQK 540
PKYEVRWKII ESYEGNSYTF IDPTQLPYNE KWEFPRNNLQ FGKTLGAGAF GKVVEATAFG 600
LGKEDAVLKV AVKMLKSTAH ADEKEALMSE LKIMSHLGQH ENIVNLLGAC THGGPVLVIT 660
EYCCYGDLLN FLRRKAEAML GPSLSPGQDP EAGTGYKNIH LEKKYIRRDS GFSSQGVDTY 720
VEMRPVSTSS SNDSFSEQDL DKEDGRPLEL RDLLHFSSQV AQGMAFLASK NCIHRDVAAR 780
NVLLTSGHVA KIGDFGLARD IMNDSNYIVK GNARLPVKWM APESIFDCVY TVQSDVWSYG 840
ILLWEIFSLG LNPYPGILVN SKFYKLVKDG YQMAQPAFAP ENIYSIMQAC WALEPTRRPT 900
FQQICSLLQE QVQVDRREQD YSNLPSSGSS SSEPEEESSS EHLTCCEQGD IAQPLLQPNN 960
YQFC 964
Nucleotide Sequence
(FASTA)
ATGGGCCCAC GGACCCTGCT GATCCTGCTG GTGGTCACAG CTTGGCATGG TCAGGGGGTC 60
CCAGTGATAG AGCCCAGTGG CCCTGAGCTG GTGGTGGAGC CAGGCACAGC GGTGACCTTG 120
CGATGTACGA GCAATGGCAG CGTGAAGTGG GATGGCCCCG TTTCCCCCTA CTGGACTCTG 180
GACTCTGACG CCCCCAGAAG CATCCTCACC ACGAACAATG CCACCTTCCT ACACACGGGA 240
ACGTACCGCT GCACTGAGCC TGGAGACCCC CTGGCGGGCA CTGCTACTAT CCACCTCTAT 300
GTCAAAGACC CTGCTCGGCC CTGGAGGGTC CTGGCCGAGG AAGTGACGGT GTTGGAGGGT 360
CAGGACGCGC TGCTGCCCTG TCTGCTCACT GACCCAGCAC TGGAGGCGGG CGTCTCGCTG 420
GTGCGGGTGC GCGGCCGGTC TGTCTTGCGC CAAACCAGCT ATTCCTTCTC GCCCTGGTAC 480
GGCTTCACCA TCCACAAGGC CAAGTTCATT GAGAGCCAGG ACTACGAGTG CAGCGTTCGG 540
GTGGCTGGCA GGGTGGTGAA GTCCCTCAGC ATCCGGCTTA AAGTTCAGAA AGTCATCCCA 600
GGACCGCCGA CCTTGACATT GGAGCCTGAA GAGCTGGTGC GGATTCAAGG GGAGACTGCC 660
AAGATCGTGT GCTCAGCCAG TGACGTTGAT GTCAACTTTG ACGTCTTCCT TCAACGTGGA 720
GACACAAAAC TCGCAATCTC TCAACAATCC GACTTCCGTG ACAACCGTTA TCAAAAAGTC 780
CTGACTCTCG AACTCGATCA CGTAGGCTTC CAAGATGCTG GCAACTACAC CTGTGTGGCC 840
ACCAATGCCC GGGGCGTCCA CACTACCTCC ATGGTCTTCC GGGTGGTAGA CAGTGCCTAC 900
TTGAACTTAA CCTCTGAGCA GAACCTCCTC CAAGAGGTGG CCGTGGGTGA AAAGCTTGAA 960
CTCAGAGTCA AGGTGGAGGC CTACCCAAGC CTGCAAAGTT TCAACTGGAC CTATGAGGGT 1020
CCCTTCTTTG GTTCCCAGCC CAAGCTCAAC TTTGAAACCA CGAACAACAC ATACAGATAC 1080
ACCTCCAAGC TCACCCTGCC TCGCCTGAAG CCCTCCGAGG CCGGCCTCTA CTCCTTCCAG 1140
GCTAGAAATG CCAGAGGCGA GGACACCCTG ACCTTTGAAC TCACCCTCCT ATACCCCCCG 1200
GAAGTAGAAG TCATGTGGAC CCTCTCCAGT GGCTCTAAAG CCCTGCTCTG TGAAGCCTCC 1260
GGGTACCCCC AGCCCAATGT GACGTGGGTG CAGTGCAGCA GCCACACCAA CAGATGTGAT 1320
AAGACCCACG TGCTGGTCCT GGAGGAGCCG AACCCTGATG TCCTGCGCCA GGAGCCCTTC 1380
CACAAAGTGA CCGTCCAGAG CCTGCTGACC CCTGGGACCT TGGAACACAA CAGGACGTAC 1440
GAGTGCAGGG CCCAGAACAG CATGGGGAAC ACCTCCGGGG CGTTGGGGCC CATCTCCGTA 1500
GGAGCCTCCA TGCAGCCCCG CGATGAGCCC CTCTTCACAC CGGTGCTGGT GGCCTGCATG 1560
TCCATCATGG CCTTGCTGCT GCTGCTGCTG CTGCTGCTCT TCTACAAGTA CAAGCAGAAG 1620
CCCAAGTACG AGGTGCGCTG GAAGATCATC GAGAGCTATG AAGGCAACAG CTACACCTTC 1680
ATCGACCCCA CCCAGCTGCC CTACAATGAG AAGTGGGAGT TCCCCCGGAA CAACCTGCAG 1740
TTTGGTAAGA CCCTTGGAGC CGGCGCCTTC GGGAAGGTGG TAGAGGCCAC GGCTTTTGGT 1800
CTGGGCAAGG AAGATGCTGT CCTGAAGGTG GCTGTGAAGA TGCTGAAGTC CACGGCGCAT 1860
GCTGACGAGA AGGAAGCCCT CATGTCAGAG CTGAAGATCA TGAGCCACCT GGGCCAGCAC 1920
GAGAACATAG TCAACCTCTT GGGAGCCTGT ACCCACGGAG GCCCTGTCCT GGTCATCACG 1980
GAGTACTGTT GCTATGGTGA CCTGCTCAAC TTTCTGCGAA GGAAGGCTGA GGCCATGCTG 2040
GGACCCAGCC TGAGTCCAGG CCAGGATCCC GAGGCAGGCA CCGGCTACAA GAACATCCAC 2100
TTGGAAAAGA AATACATCCG CAGGGACAGC GGCTTCTCCA GCCAGGGTGT GGACACCTAT 2160
GTGGAGATGA GACCTGTGTC CACTTCGTCG TCAAATGACT CATTCTCTGA ACAAGACCTG 2220
GACAAGGAGG ACGGGCGGCC GCTGGAGCTG CGTGACCTGC TCCACTTCTC GAGCCAGGTG 2280
GCCCAGGGCA TGGCCTTTCT TGCTTCCAAG AATTGCATCC ATCGGGACGT GGCGGCCAGA 2340
AACGTGCTGC TGACCAGCGG CCACGTGGCC AAGATTGGGG ACTTTGGTCT GGCTCGGGAC 2400
ATCATGAATG ACTCCAACTA CATCGTTAAG GGCAACGCTC GCCTGCCCGT GAAGTGGATG 2460
GCGCCAGAGA GCATCTTCGA CTGCGTCTAC ACCGTTCAGA GCGACGTGTG GTCCTACGGC 2520
ATCCTGCTCT GGGAGATCTT CTCACTCGGG CTCAACCCCT ACCCTGGTAT CCTGGTGAAC 2580
AGCAAGTTCT ATAAGCTGGT GAAGGATGGA TACCAAATGG CTCAGCCCGC GTTTGCCCCA 2640
GAGAACATAT ACAGCATCAT GCAGGCCTGC TGGGCCCTGG AGCCGACGCG CAGACCCACC 2700
TTCCAGCAGA TCTGCTCCCT CCTCCAGGAG CAGGTTCAGG TGGACAGGAG AGAGCAGGAC 2760
TACAGCAATC TGCCGAGCAG TGGCAGCAGC AGCAGCGAGC CAGAGGAGGA GAGCTCCAGC 2820
GAACACCTGA CCTGCTGTGA GCAGGGCGAC ATCGCCCAGC CCCTGCTGCA ACCCAACAAC 2880
TACCAGTTCT GCTGA 2895
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         l++Gk+lG+GafGkvveata+Gl+k+davlkvavkmlksta+++ekealmselki+shlG
Q: 579   LQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLG  638
         79**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +henivnllGact+gGp++viteyccyGdlln+lrrk+e++l  sl+  +++e+ + +k+
Q: 639   QHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEAGTGYKN  698
         ************************************************************
S: 121   l.ladkslrsksslssesseeyvdlkkdvsdvssskadklasekkksalerevkaaleee  179
         + l++k++r++s +ss++ ++yv++++    vs+s+++   se+            l++e
Q: 699   IhLEKKYIRRDSGFSSQGVDTYVEMRP----VSTSSSNDSFSEQ-----------DLDKE  743
         *999***********************....6666555544444...........37899
S: 180   dsevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGkvvkicdfGlardimk  239
         d ++lel+dll+fs+qva+Gm+flasknc+hrd+aarnvllt+G+v+ki+dfGlardim+
Q: 744   DGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTSGHVAKIGDFGLARDIMN  803
         9***********************************************************
S: 240   dsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifslGstpypgllvdskf  299
         dsny+vkGnarlpvkwmapesifd++ytv+sdvwsyGillweifslG +pypg+lv+skf
Q: 804   DSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKF  863
         ************************************************************
S: 300   yklikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvell  344
         ykl+k+Gy+maqpa+a+e+iy+imq+cw+ ep++rp+f+q+++ll
Q: 864   YKLVKDGYQMAQPAFAPENIYSIMQACWALEPTRRPTFQQICSLL  908
         ******************************************996
Domain Sequence
(FASTA)
LQFGKTLGAG AFGKVVEATA FGLGKEDAVL KVAVKMLKST AHADEKEALM SELKIMSHLG 60
QHENIVNLLG ACTHGGPVLV ITEYCCYGDL LNFLRRKAEA MLGPSLSPGQ DPEAGTGYKN 120
IHLEKKYIRR DSGFSSQGVD TYVEMRPVST SSSNDSFSEQ DLDKEDGRPL ELRDLLHFSS 180
QVAQGMAFLA SKNCIHRDVA ARNVLLTSGH VAKIGDFGLA RDIMNDSNYI VKGNARLPVK 240
WMAPESIFDC VYTVQSDVWS YGILLWEIFS LGLNPYPGIL VNSKFYKLVK DGYQMAQPAF 300
APENIYSIMQ ACWALEPTRR PTFQQICSLL 330
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00376
EKS-ANC-00391
EKS-CAJ-00409
EKS-CAF-00405
EKS-CAP-00434
EKS-DAR-00788
EKS-EQC-00397
EKS-FEC-00389
EKS-GAG-00342
EKS-GAA-00492
EKS-GOG-00397
EKS-HOS-00411
EKS-ICT-00384
EKS-LAC-00420
EKS-LOA-00414
EKS-MAM-00404
EKS-MEG-00336
EKS-MOD-00393
EKS-MUM-00437
EKS-MUP-00398
EKS-MYL-00400
EKS-ORN-00515
EKS-ORC-00380
EKS-ORL-00473
EKS-OTG-00407
EKS-PAT-00383
EKS-PES-00359
EKS-POA-00396
EKS-PTV-00115
EKS-RAN-00419
EKS-SAH-00375
EKS-SUS-00355
EKS-TAG-00474
EKS-TAR-00511
EKS-TEN-00512
EKS-TUT-00118
EKS-XET-00514
EKS-XIM-00507
Gene Ontology
GO:0009986; C:cell surface
GO:0016021; C:integral to membrane
GO:0005886; C:plasma membrane
GO:0043235; C:receptor complex
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0008283; P:cell proliferation
GO:0045217; P:cell-cell junction maintenance
GO:0038145; P:macrophage colony-stimulating factor signaling pathway
GO:0030316; P:osteoclast differentiation
GO:0046488; P:phosphatidylinositol metabolic process
GO:0048015; P:phosphatidylinositol-mediated signaling
GO:0030335; P:positive regulation of cell migration
GO:0090197; P:positive regulation of chemokine secretion
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade
GO:0071902; P:positive regulation of protein serine/threonine kinase activity
GO:0061098; P:positive regulation of protein tyrosine kinase activity
GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein
GO:2000249; P:regulation of actin cytoskeleton reorganization
GO:0031529; P:ruffle organization
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
bta:509418;
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR013151; Immunoglobulin.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
Pfam
PF07679; I-set; 1.
PF00047; ig; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 3.
SM00408; IGc2; 1.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 4.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
Created Date20-Feb-2013