EKS-BOT-00266

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-BOT-00266

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/DYRK	464.8	1.7E-139	209	522	314

Status

Unreviewed

Ensembl Protein

ENSBTAP00000017680

UniProt Accession

F6PR52;

Protein Name

Protein Synonyms/Alias

Gene Name

DYRK3

Gene Synonyms/Alias

DYRK3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000013294	ENSBTAP00000017680	ENSBTAT00000017680

Organism

Bos taurus

Functional Description

Protein Length

587

Protein Sequence
(FASTA)

MGGTARGPGR KDEGPPGAAL PPQQRRLGDG VYDTFMMIDE TKCPPCSNVP CNPSEPPLPR 60

RLNITTEHLT RDPTQRFLNG GEMKVEQLFQ DFSNRRADNL QSDGVNDSEK CSPTASQGKS 120

SDSLNTVKSS SSSKASKAVP LTPEQALKQY KHHLTAYEKL EIVNYPEIYF VGPNAKKRHG 180

VIGGPNNGGY DDADGSYIHV PRDHLAYRYE VLKIIGKGSF GQVARVYDHK LRQYVALKMV 240

RNEKRFHRQA AEEIRILEHL KKQDKTGSMN VIHMLESFTF RNHVCMAFEL LSIDLYELIK 300

KNKFQGFSIQ LVRKFAQSIL QSLDALHKNK IIHCDLKPEN ILLKQHGRSA TKVIDFGSSC 360

FEYQKLYTYI QSRFYRAPEI ILGSRYSTPI DIWSFGCILA ELLTGQPLFP GEDEGDQLAC 420

MMELLGMPPA KLLEQSKRAK YFINSKGLPR YCSVTTQADG RAVLVGGRSR RGKKRGPPGS 480

KDWVTALKGC EDYLFIEFLK RCLHWDPSAR LTPAQALRHP WISKSVPRPL TIEKVSGKRV 540

VNPANAFQGL GSKLPPVVGI ANKLKANLMS ETSGGMPLCS VLPKLIN 587

Nucleotide Sequence
(FASTA)

ATGGGAGGCA CGGCTCGCGG GCCCGGGCGG AAGGATGAGG GGCCGCCGGG GGCCGCACTC 60

CCGCCGCAGC AGCGGAGATT GGGGGATGGT GTCTATGATA CCTTCATGAT GATAGATGAA 120

ACCAAATGCC CACCCTGTTC AAATGTACCC TGCAATCCTT CTGAACCACC TCTACCCAGA 180

AGACTAAATA TCACCACTGA GCATTTAACA AGAGATCCTA CTCAACGCTT CCTGAATGGA 240

GGCGAGATGA AGGTAGAACA GCTATTTCAA GACTTCAGCA ACAGAAGAGC TGACAACCTT 300

CAGTCGGATG GTGTCAACGA CTCTGAAAAA TGCTCTCCCA CCGCTTCTCA GGGTAAAAGT 360

TCGGATAGTT TGAATACAGT GAAATCCAGC AGCTCATCCA AAGCATCCAA AGCGGTGCCT 420

CTGACTCCAG AACAGGCCCT GAAGCAATAT AAGCATCACC TCACTGCTTA TGAGAAGCTG 480

GAAATTGTCA ATTATCCAGA AATTTACTTT GTGGGTCCAA ATGCCAAAAA AAGACATGGA 540

GTTATTGGTG GTCCTAATAA CGGCGGGTAT GACGATGCAG ATGGGTCCTA TATTCACGTG 600

CCTCGAGACC ATCTAGCTTA TCGATATGAG GTGCTGAAAA TTATTGGCAA GGGCAGTTTT 660

GGGCAGGTAG CCCGGGTCTA TGATCACAAA CTTCGACAGT ACGTGGCCCT GAAGATGGTG 720

CGCAATGAAA AGCGCTTCCA TCGCCAAGCG GCAGAGGAGA TCCGGATTTT GGAGCATCTT 780

AAAAAGCAGG ATAAAACCGG TAGCATGAAC GTGATTCACA TGCTAGAAAG TTTCACATTC 840

CGGAACCATG TTTGCATGGC CTTTGAATTG CTGAGCATAG ACCTTTATGA GCTCATTAAA 900

AAAAACAAGT TCCAGGGCTT TAGCATCCAG TTAGTTCGCA AGTTCGCTCA ATCCATCTTG 960

CAATCCTTGG ATGCGCTCCA CAAAAACAAG ATCATTCACT GTGACCTAAA GCCAGAAAAC 1020

ATTCTCCTGA AACAGCATGG GCGCAGCGCA ACCAAGGTCA TTGACTTTGG CTCCAGCTGT 1080

TTCGAGTACC AGAAGCTGTA CACTTACATC CAGTCTCGGT TTTACAGAGC TCCGGAGATC 1140

ATCCTGGGAA GCCGCTACAG CACACCCATC GACATATGGA GTTTTGGCTG CATCCTTGCA 1200

GAACTTTTAA CAGGACAGCC GCTCTTCCCT GGAGAGGATG AAGGAGACCA GCTGGCCTGT 1260

ATGATGGAAC TTCTGGGGAT GCCACCAGCA AAACTTCTGG AACAATCCAA ACGTGCCAAG 1320

TACTTTATTA ACTCCAAGGG CCTGCCTCGC TACTGTTCTG TGACCACGCA GGCCGATGGG 1380

AGGGCTGTGC TTGTGGGAGG TCGTTCGCGG AGGGGTAAGA AGCGGGGTCC CCCAGGCAGC 1440

AAAGATTGGG TGACGGCACT GAAAGGGTGT GAGGACTACT TATTTATAGA GTTTCTGAAA 1500

AGATGCCTCC ACTGGGACCC CTCTGCCCGC TTGACCCCGG CTCAAGCATT AAGACACCCT 1560

TGGATTAGCA AATCTGTTCC TAGACCTCTC ACCATTGAAA AGGTGTCAGG CAAACGGGTA 1620

GTAAATCCTG CAAATGCTTT CCAGGGCCTG GGTTCCAAGT TGCCTCCAGT TGTAGGAATA 1680

GCCAATAAGC TCAAAGCTAA TTTAATGTCA GAGACGAGTG GTGGTATGCC TCTGTGCAGT 1740

GTATTGCCAA AGCTGATTAA CTGA 1764

Domain Profile

S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60

         yevl++igkGsfgqV++++d+k +++va+k+++n+krf+rqa+eE++iLe+l+k+dk+ +

Q: 209   YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS  268

         9***********************************************************

S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLke  120

         +nv+++le+f+frnh+c+ fells++Lyel+kknkf+g+s++lvrk+aq+il++L++L++

Q: 269   MNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSIQLVRKFAQSILQSLDALHK  328

         ************************************************************

S: 121   lkiiHaDlKPeNillvekkrsevkviDFGsssavsqkeiytyiqsrfYraPEiilglkyd  180

         +kiiH+DlKPeNill++++rs+ kviDFGss+++ qk +ytyiqsrfYraPEiilg +y+

Q: 329   NKIIHCDLKPENILLKQHGRSATKVIDFGSSCFEYQK-LYTYIQSRFYRAPEIILGSRYS  387

         *************************************.**********************

S: 181   eaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkfftkke  240

         + iD+WS+Gc+laEl+tG+pLfpGe+e dqla+++e+lg+pp+klle++k+ak+f+++k+

Q: 388   TPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPAKLLEQSKRAKYFINSKG  447

         ************************************************************

S: 241   apkyilktkksdrkkklvlnvkkaakkrkaplskelgealkekedklfkdllkrmleldp  300

          p+y+ +t+++d + +lv ++++++kkr +p+sk++++alk +ed+lf+++lkr+l++dp

Q: 448   LPRYCSVTTQADGRAVLVGGRSRRGKKRGPPGSKDWVTALKGCEDYLFIEFLKRCLHWDP  507

         ************************************************************

S: 301   akRitpkealkhpfv  315

         ++R+tp++al+hp++

Q: 508   SARLTPAQALRHPWI  522

         **************7

Domain Sequence
(FASTA)

YEVLKIIGKG SFGQVARVYD HKLRQYVALK MVRNEKRFHR QAAEEIRILE HLKKQDKTGS 60

MNVIHMLESF TFRNHVCMAF ELLSIDLYEL IKKNKFQGFS IQLVRKFAQS ILQSLDALHK 120

NKIIHCDLKP ENILLKQHGR SATKVIDFGS SCFEYQKLYT YIQSRFYRAP EIILGSRYST 180

PIDIWSFGCI LAELLTGQPL FPGEDEGDQL ACMMELLGMP PAKLLEQSKR AKYFINSKGL 240

PRYCSVTTQA DGRAVLVGGR SRRGKKRGPP GSKDWVTALK GCEDYLFIEF LKRCLHWDPS 300

ARLTPAQALR HPWI 314

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Dasypus novemcinctus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Taeniopygia guttata"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0030218	; P:erythrocyte differentiation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013