EKS-BOT-00236

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-BOT-00236

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	388.1	1.7E-116	56	307	252

Status

Unreviewed

Ensembl Protein

ENSBTAP00000017848

UniProt Accession

F1MAZ8;

Protein Name

Protein Synonyms/Alias

Gene Name

MARK3

Gene Synonyms/Alias

MARK3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000013410	ENSBTAP00000017848	ENSBTAT00000017848

Organism

Bos taurus

Functional Description

Protein Length

798

Protein Sequence
(FASTA)

MKVLDSVPRG EEAVSAQHTS HGDGRQEVTS RSGRSGARCR NSIASCADEQ PHIGNYRLLK 60

TIGKGNFAKV KLARHILTGR EVAIKIIDKT QLNPTSLQKL FREVRIMKIL NHPNIVKLFE 120

VIETDKTLYL IMEYASGGEV FDYLVAHGRM KEKEARAKFR QIVSAVQYCH QKRIVHRDLK 180

AENLLLDADM NIKIADFGFS NEFTVGSKLD TFCGSPPYAA PELFQGKKYD GPEVDVWSLG 240

VILYTLVSGS LPFDGQNLKE LRERVLRGKY RIPFYMSTDC ENLLKRFLVL NPIKRGTLEQ 300

IMKDRWINAG HEDDELKPFV EPELDISDQK RIDIMVGMGY TQEEIQESLS KMKYDEITAT 360

YLLLGRKSSE LDASDSSSSS NLSLAKVRPS SDLNNSTGQS PHHKVQRSVS SSQKQRRYSD 420

HAGPAIPSVV AYPKRSQTST ADSDLKEDGV PSRKPGASAV GGKGIAPASP MLGNASNPNK 480

ADIPERKKSS TVPSSNTASG GMTRRNTYVC SERTTADRHS VIQNGKENSL TEMFAYAASP 540

ASVCKTSSTC RLRHQKSMSM SASGHPKMML PPIDSEGDNF KAITIPDQRA PVASTHSISS 600

STTPDRTRFP RGTASRSTFH GQPRERRTAT YNGPPASPSL SHEATPLSQT RSRGSTNLFS 660

KLTSKLTRRL PTEYERNGRY EGSSRNVSAE QKEENKDAKP RSLRFTWSMK TTSCMDPKDM 720

MREIRKVLDA NSCDYEQRER FLLFCVHGDG HAENLVQWEM EVCKLPRLSL NGVRFKRISG 780

TSIAFKNIAS KIANELKL 798

Nucleotide Sequence
(FASTA)

ATGAAGGTGC TTGACAGTGT CCCGAGAGGA GAGGAAGCAG TTAGCGCTCA GCACACGTCA 60

CATGGAGATG GGCGGCAAGA AGTTACCTCT CGCTCTGGGC GCTCTGGAGC ACGGTGTAGA 120

AACTCTATAG CTTCCTGTGC AGATGAACAG CCTCACATTG GAAACTACAG GCTGTTAAAA 180

ACTATCGGCA AGGGGAATTT TGCAAAAGTG AAGTTGGCAA GACACATCCT TACAGGCAGA 240

GAGGTTGCAA TAAAAATAAT TGACAAAACT CAGTTGAATC CAACAAGTCT ACAAAAGCTC 300

TTCAGAGAAG TGAGAATAAT GAAGATTTTA AATCATCCAA ACATAGTGAA GTTATTCGAA 360

GTCATTGAAA CTGACAAAAC ACTCTACCTA ATCATGGAGT ATGCAAGTGG AGGTGAAGTG 420

TTTGACTATT TGGTTGCACA TGGAAGAATG AAGGAAAAAG AAGCAAGAGC TAAATTTAGA 480

CAGATTGTGT CTGCAGTGCA GTACTGCCAC CAGAAGCGCA TCGTTCACAG AGACCTCAAG 540

GCTGAAAATC TATTGTTAGA TGCTGATATG AACATTAAAA TAGCTGACTT TGGTTTTAGC 600

AATGAATTTA CTGTTGGCAG TAAACTGGAT ACGTTTTGTG GCAGTCCTCC GTATGCGGCC 660

CCAGAGCTCT TCCAGGGCAA GAAATACGAT GGGCCGGAAG TGGACGTGTG GAGCCTCGGC 720

GTCATTCTTT ACACTCTAGT CAGCGGGTCG CTCCCCTTTG ATGGGCAGAA CCTAAAGGAA 780

CTGAGAGAGC GAGTATTAAG AGGGAAATAC AGAATCCCTT TCTACATGTC CACAGACTGT 840

GAAAACCTTC TCAAACGTTT CCTGGTGCTA AATCCAATAA AACGAGGCAC TCTAGAGCAA 900

ATCATGAAGG ACAGGTGGAT CAACGCAGGG CATGAGGATG ATGAGCTGAA ACCGTTCGTT 960

GAACCAGAAC TGGACATCTC AGACCAGAAA AGAATAGATA TTATGGTGGG AATGGGATAT 1020

ACACAAGAAG AAATTCAAGA ATCTCTTAGT AAGATGAAAT ATGATGAAAT CACAGCTACA 1080

TATTTATTGT TGGGGAGAAA ATCTTCAGAG CTGGATGCTA GTGATTCCAG TTCTAGCAGC 1140

AATCTTTCAC TTGCTAAGGT TAGGCCAAGC AGTGACCTCA ACAACAGTAC TGGCCAGTCT 1200

CCTCACCACA AAGTGCAGAG AAGCGTCTCT TCAAGCCAGA AGCAGAGGCG TTACAGTGAC 1260

CACGCTGGAC CAGCTATTCC TTCAGTTGTG GCATATCCAA AAAGGAGTCA GACCAGCACT 1320

GCAGACAGTG ACCTCAAAGA AGACGGAGTT CCCTCCCGGA AACCAGGTGC CAGTGCTGTT 1380

GGAGGAAAGG GGATTGCTCC AGCCAGTCCC ATGCTTGGGA ACGCAAGTAA TCCTAACAAG 1440

GCGGATATCC CTGAACGGAA GAAGAGCTCC ACTGTCCCTA GTAGTAATAC GGCATCTGGT 1500

GGAATGACGC GACGGAATAC TTACGTTTGC AGTGAAAGAA CTACAGCTGA TAGACATTCA 1560

GTAATCCAGA ATGGCAAAGA AAACAGCCTG ACAGAAATGT TCGCTTACGC AGCTAGCCCT 1620

GCCTCTGTTT GTAAGACATC TTCCACCTGT CGGCTGAGAC ATCAGAAGTC GATGTCCATG 1680

TCAGCCTCTG GGCACCCCAA GATGATGTTA CCTCCAATAG ACAGTGAAGG AGATAACTTC 1740

AAGGCTATCA CTATTCCTGA CCAGAGAGCT CCAGTCGCTT CAACACACAG TATTAGCAGC 1800

AGCACCACCC CAGATCGAAC CCGGTTCCCA AGAGGCACTG CCAGTCGTAG CACTTTCCAC 1860

GGTCAGCCCC GGGAGCGGCG CACAGCCACG TACAATGGCC CACCTGCCTC GCCCAGCCTG 1920

TCCCATGAAG CCACACCGTT GTCGCAGACT CGAAGCCGAG GCTCCACTAA TCTTTTTAGT 1980

AAATTAACTT CCAAACTCAC AAGGAGGCTT CCAACTGAAT ATGAGAGGAA CGGGAGATAT 2040

GAGGGCTCCA GTCGCAACGT GTCTGCCGAG CAAAAGGAGG AAAACAAAGA CGCGAAGCCT 2100

CGTTCCCTGC GCTTCACCTG GAGCATGAAA ACCACTAGCT GCATGGACCC CAAGGACATG 2160

ATGCGGGAGA TCCGCAAGGT GCTGGACGCC AACAGCTGCG ACTACGAGCA GAGAGAGCGC 2220

TTCTTGCTCT TCTGTGTCCA CGGCGATGGG CACGCGGAGA ACCTCGTGCA GTGGGAGATG 2280

GAGGTGTGCA AGCTGCCAAG ACTGTCTCTG AACGGGGTCC GGTTTAAGCG GATATCAGGG 2340

ACGTCCATAG CTTTCAAAAA TATCGCTTCC AAAATTGCCA ATGAGCTAAA GCTGTAA 2397

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpni  60

         y+llkt+G+g+f+kVkla+h +t+++va+Kii+k++l+ +sl+k++rE++i+k+l+hpni

Q: 56    YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNI  115

         99**********************************************************

S: 61    ikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgiv  120

         +kl+eviet+k+lyl++eyasgge+fdy++++gr+kekear+ f+q+vsav+Y+h+k+iv

Q: 116   VKLFEVIETDKTLYLIMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKRIV  175

         ************************************************************

S: 121   HrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkvD  180

         HrDlK+eNllld+++nikiaDFG++n+f+ g++l+tfcGsppYaaPel++gkkY+gp+vD

Q: 176   HRDLKAENLLLDADMNIKIADFGFSNEFTVGSKLDTFCGSPPYAAPELFQGKKYDGPEVD  235

         ************************************************************

S: 181   vWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpekR  240

         vWslGv+Ly+lv+g+lPfd++nlkel+e++l+gk++ip+++s+++e+Ll+++Lv +p kR

Q: 236   VWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKR  295

         ************************************************************

S: 241   atieeilkhewl  252

          t+e+i+k++w+

Q: 296   GTLEQIMKDRWI  307

         ***********7

Domain Sequence
(FASTA)

YRLLKTIGKG NFAKVKLARH ILTGREVAIK IIDKTQLNPT SLQKLFREVR IMKILNHPNI 60

VKLFEVIETD KTLYLIMEYA SGGEVFDYLV AHGRMKEKEA RAKFRQIVSA VQYCHQKRIV 120

HRDLKAENLL LDADMNIKIA DFGFSNEFTV GSKLDTFCGS PPYAAPELFQ GKKYDGPEVD 180

VWSLGVILYT LVSGSLPFDG QNLKELRERV LRGKYRIPFY MSTDCENLLK RFLVLNPIKR 240

GTLEQIMKDR WI 252

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR001772	; Kinase-assoc_KA1.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR015940	; UBA/transl_elong_EF1B_N_euk.

Pfam

PF02149	; KA1; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220	; S_TKc; 1.
SM00165	; UBA; 1.

Prosites

PS50032	; KA1; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50030	; UBA; 1.

Prints

Created Date

20-Feb-2013