EKS-BOT-00276

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-BOT-00276

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	456.4	4.0E-137	207	494	288

Status

Unreviewed

Ensembl Protein

ENSBTAP00000043941

UniProt Accession

F1MSQ2;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR1B

Gene Synonyms/Alias

ACVR1B;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000013555	ENSBTAP00000043941	ENSBTAT00000046665

Organism

Bos taurus

Functional Description

Protein Length

505

Protein Sequence
(FASTA)

MAESAGASSF FPLVVLLLAG SGGSGPRGIQ ALLCACTSCL QANYTCETDG ACMVSIFNLD 60

GMEHHVRTCI PKVELVPAGK PFYCLSSEDL RNTHCCYTDF CNKIDLRVPS GHLKEPEHPS 120

MWGPVELVGI IAGPVFLLFL IIIIVFLVIN YHQRVYHNRQ RLDMEDPSCE MCLSKDKTLQ 180

DLVYDLSTSG SGSGLPLFVQ RTVARTIVLQ EIIGKGRFGE VWRGRWRGGD VAVKIFSSRE 240

ERSWFREAEI YQTVMLRHEN ILGFIAADNK DNGTWTQLWL VSDYHEHGSL FDYLNRYTVT 300

IEGMIKLALS AASGLAHLHM EIVGTQGKPG IAHRDLKSKN ILVKKNGMCA IADLGLAVRH 360

DAVTDTIDIA PNQRVGTKRY MAPEVLDETI NMKHFDSFKC ADIYALGLVY WEIARRCNSG 420

GVHEEYQLPY YDLVPSDPSI EEMRKVVCDQ KLRPNIPNWW QSYEALRVMG KMMRECWYAN 480

GAARLTALRI KKTLSQLSVQ EDVKI 505

Nucleotide Sequence
(FASTA)

ATGGCGGAGT CGGCCGGAGC CTCCTCCTTC TTCCCCCTTG TTGTCCTCCT GCTTGCCGGC 60

AGCGGCGGGT CCGGGCCCCG GGGGATCCAG GCTCTGTTGT GTGCGTGCAC CAGCTGCCTC 120

CAAGCCAACT ACACGTGTGA GACGGATGGG GCCTGCATGG TCTCCATTTT CAACCTGGAC 180

GGGATGGAGC ACCACGTGCG CACCTGCATC CCCAAAGTGG AGCTGGTCCC GGCCGGGAAG 240

CCCTTCTACT GCCTGAGCTC CGAGGACTTG CGCAACACAC ACTGCTGCTA CACTGACTTC 300

TGCAACAAGA TCGACCTGAG GGTGCCCAGC GGTCACCTCA AGGAGCCTGA GCACCCCTCC 360

ATGTGGGGGC CTGTGGAGCT GGTGGGCATT ATTGCCGGCC CAGTGTTCCT CCTCTTTCTC 420

ATCATCATCA TTGTTTTCCT CGTCATTAAC TATCATCAGC GTGTCTATCA CAACCGCCAG 480

AGGCTGGACA TGGAGGACCC CTCGTGTGAG ATGTGTCTCT CCAAGGACAA GACGCTCCAG 540

GACCTGGTCT ATGACCTCTC CACGTCAGGG TCTGGCTCAG GGTTACCCCT TTTTGTCCAG 600

CGCACAGTGG CCCGGACCAT CGTTCTACAG GAAATTATTG GCAAGGGCCG GTTTGGAGAA 660

GTGTGGCGCG GCCGCTGGCG GGGCGGTGAT GTGGCTGTGA AAATATTCTC TTCTCGGGAG 720

GAACGGTCTT GGTTCCGGGA AGCAGAGATA TACCAGACAG TCATGCTTCG CCATGAGAAC 780

ATCCTCGGGT TCATCGCCGC TGACAATAAA GATAACGGCA CCTGGACACA GCTGTGGCTC 840

GTGTCGGACT ATCACGAGCA CGGCTCCCTG TTTGACTATC TGAACCGGTA CACGGTGACC 900

ATCGAGGGGA TGATCAAGCT GGCCTTGTCT GCCGCCAGCG GGCTAGCACA CCTGCACATG 960

GAGATCGTGG GCACCCAAGG GAAACCTGGA ATTGCTCATC GAGACTTAAA GTCAAAGAAC 1020

ATCCTGGTGA AGAAAAATGG CATGTGCGCC ATCGCAGACC TGGGTTTGGC TGTCCGTCAC 1080

GATGCGGTCA CAGACACCAT TGACATTGCC CCTAACCAGA GGGTGGGAAC TAAACGATAC 1140

ATGGCCCCCG AAGTGCTCGA TGAAACCATC AACATGAAGC ACTTCGACTC CTTTAAATGT 1200

GCTGATATCT ATGCCCTCGG TCTTGTGTAC TGGGAGATTG CTCGAAGATG CAACTCTGGA 1260

GGGGTCCATG AAGAATATCA GCTGCCATAT TATGACCTAG TGCCCTCTGA CCCTTCCATC 1320

GAGGAGATGC GGAAGGTTGT ATGTGACCAG AAGCTCCGTC CCAACATCCC CAACTGGTGG 1380

CAGAGTTACG AGGCGCTGCG GGTGATGGGG AAGATGATGC GGGAGTGCTG GTACGCCAAC 1440

GGCGCAGCCC GCCTGACTGC GCTGCGCATC AAGAAGACCC TCTCCCAGCT CAGTGTGCAG 1500

GAGGACGTGA AGATCTAG 1518

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         + l+e+igkGr+geVw++++rg +vAvKifs+++e+sw+rE+eiyqtv+lrhenil+fia

Q: 207   IVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIA  266

         5789********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k+++++t+l+lv++yhe+gsL+dyL+r+t+++e +++lals+asGlahLH+eivgt+

Q: 267   ADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEIVGTQ  326

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  Kp iaHRDlkskNilvkk+++c+iaDlGLa+++++ ++++d+a n++vGtkRYmaPE

Q: 327   G--KPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQRVGTKRYMAPE  384

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl+e++n+k+f++fk+aD+Y+lgLv+WE+a+Rc++ ++++eey+lp+++ v+sdPs+eem

Q: 385   VLDETINMKHFDSFKCADIYALGLVYWEIARRCNS-GGVHEEYQLPYYDLVPSDPSIEEM  443

         ***********************************.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         ++vv+++klrP+ip+ w++ eal+++ k+++ecW+a+++aRltalr+kk+l

Q: 444   RKVVCDQKLRPNIPNWWQSYEALRVMGKMMRECWYANGAARLTALRIKKTL  494

         *************************************************97

Domain Sequence
(FASTA)

IVLQEIIGKG RFGEVWRGRW RGGDVAVKIF SSREERSWFR EAEIYQTVML RHENILGFIA 60

ADNKDNGTWT QLWLVSDYHE HGSLFDYLNR YTVTIEGMIK LALSAASGLA HLHMEIVGTQ 120

GKPGIAHRDL KSKNILVKKN GMCAIADLGL AVRHDAVTDT IDIAPNQRVG TKRYMAPEVL 180

DETINMKHFD SFKCADIYAL GLVYWEIARR CNSGGVHEEY QLPYYDLVPS DPSIEEMRKV 240

VCDQKLRPNI PNWWQSYEAL RVMGKMMREC WYANGAARLT ALRIKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0009986	; C:cell surface
GO:0005887	; C:integral to plasma membrane
GO:0017002	; F:activin-activated receptor activity
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0000082	; P:G1/S transition of mitotic cell cycle
GO:0001942	; P:hair follicle development
GO:0001701	; P:in utero embryonic development
GO:0006917	; P:induction of apoptosis
GO:0030308	; P:negative regulation of cell growth
GO:0038092	; P:nodal signaling pathway
GO:0018107	; P:peptidyl-threonine phosphorylation
GO:0032927	; P:positive regulation of activin receptor signaling pathway
GO:0045648	; P:positive regulation of erythrocyte differentiation
GO:0046777	; P:protein autophosphorylation
GO:0006355	; P:regulation of transcription, DNA-dependent

KEGG

bta:539315

;

InterPros

IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013