EKS-BOT-00393

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-BOT-00393

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	318.2	5.4E-95	1238	1504	267

Status

Unreviewed

Ensembl Protein

ENSBTAP00000018325

UniProt Accession

E1B847;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K1

Gene Synonyms/Alias

MAP3K1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000013790	ENSBTAP00000018325	ENSBTAT00000018325

Organism

Bos taurus

Functional Description

Protein Length

1509

Protein Sequence
(FASTA)

MAAAAGNRAS SSGFPGAGAA SPEAGGGRGA LKASSAPAAA AGLLREAGSG GRERADWRRR 60

QLRKVRSVEL DQLPEPPLFL AASPPSSSTS PSPEPPDAAA GGSGFQPVAV PPPHGAASRG 120

GAHPAEPAAA PDSGAQSPAG AEPGEKRTPA AEPTAAAPAG REMENKETLK GLHKMDDRPE 180

ERMIREKLKA TCMPAWKHEW LERRNRRGPV VVKPIPIKGD GSEINNLAAE SQGEGPTSAA 240

SSTPKGRRSP SPGSSPSGRT VKSESPGVRR KRVSPVPFQS GRITPPRRAP SPDGFSPYSP 300

EETNRRVNKV MRARLYLLQQ IGPNSFLIGG DSPDNKYRVF IGPQNCSCGR GTFCIHLLFV 360

MLRVFQLEPS DPMLWRKTLK NFEVESLFQK YHSRRSSRIK APSRNTIQKF VSRMSNSHTL 420

SSSSTSTSSS ENSIKDEEEQ MCPICLLGML DEESLTVCED GCRNKLHHHC MSIWAEECRR 480

NREPLICPLC RSKWRSHDFY SHELSSPVDS PSPLRAPQQQ TTQQHALAGS QRRNQEGSLT 540

LTHYGTQQIP PSYKDLAEPW IQVFGMELVG CLFSRNWNVR EMALRRLSHD VSGALLLANG 600

ESTGNSGSSS GSGPGAGATS GSSQTSISGD VVEACCNVLS MVCADPVYKV YVAALKTLRA 660

MLVYTPCHSL AERIKLQRLL RPVVDTILVK CADVNSRTSQ LSISTLLELC KGQAGELAVG 720

REILKAGSIG IGGVDYVLNC ILGNQTESNN WQELLGRLCL IDRLLLEFPA EFYPHIVSTD 780

ISQAEPVEVR YKKLLSLLTF ALQSIDNSHS MVGKLSRRIY LSSARMVTAV PHVFSKLLEM 840

LNVSSSTHFT RMRRRLMAIA DEVEIAEAIQ LGVEDTLDGR HDCFLQASAP NSYPEAMDNS 900

SFERMDHLEK PGKGLCATKL SASSEDISDR LASISVGLPN STTMEQPKPM VQTKGRPHSQ 960

CLNASPASPH SQLMFPALST PSSSTPSVPS GTGTDLSKQR PQGFVPCKMP SASPQTQRKF 1020

SLQFQRNCSE NKDSDKLSPI FTQSRPLPSS NIHRPKPSRP TPSNTSKQGD ASKNSMTLDL 1080

NSRSKCDDSF GSSSNSSNAV IPSDETVFTP VEEKCRLDVS TELNSSIEDL LEASMPSSDT 1140

TVTFKSEVAV LSPEKDENDD TYKDDVNHNQ KCKEKMEAEE EEALAIAMAM SASQDALPVV 1200

PQLQVENGED IIIIQQDTPE TLPGHTKAKQ PYREDSEWLK GQQIGLGAFS SCYQAQDVGT 1260

GTLMAVKQVT YVRNTSSEQE EVVEALREEI RMMSHLNHPN IIRMLGATCE KSNYNLFIEW 1320

MAGLGGSVAH LLSKYGAFKE SVVINYTEQL LRGLSYLHEN QIIHRDVKGA NLLIDSTGQR 1380

LRIADFGAAA RLASKGTGAG EFQGQLLGTI AFMAPEVLRG QQYGRSCDVW SVGCAIIEMA 1440

CAKPPWNAEK HSNHLALIFK IASATTAPSI PSHLSPGLRD VALRCLELQP QDRPPSRELL 1500

KHPVFRTTW 1509

Nucleotide Sequence
(FASTA)

ATGGCGGCGG CGGCGGGGAA TCGCGCCTCG TCCTCGGGAT TCCCGGGCGC CGGGGCGGCG 60

AGCCCCGAAG CGGGCGGCGG CAGAGGGGCC CTCAAGGCGA GCAGCGCGCC CGCGGCAGCC 120

GCGGGGCTGC TGCGGGAGGC GGGCAGTGGG GGCCGTGAGC GGGCGGACTG GAGGCGGCGG 180

CAGCTGCGCA AAGTGCGGAG TGTGGAGCTG GACCAGCTGC CCGAGCCGCC GCTTTTCCTC 240

GCCGCCTCGC CGCCGTCCTC CTCCACTTCC CCGTCGCCGG AGCCCCCGGA CGCGGCGGCG 300

GGCGGGAGCG GTTTCCAGCC TGTGGCGGTG CCGCCGCCCC ACGGAGCCGC GAGCCGCGGT 360

GGCGCCCACC CTGCCGAGCC GGCGGCCGCA CCGGACAGCG GCGCCCAGAG CCCCGCGGGG 420

GCCGAGCCGG GGGAGAAGCG GACGCCCGCC GCCGAGCCGA CTGCGGCGGC CCCGGCTGGT 480

CGTGAGATGG AGAATAAAGA AACTCTCAAG GGACTGCACA AGATGGACGA TCGCCCAGAA 540

GAACGAATGA TCAGGGAGAA ACTGAAGGCC ACCTGTATGC CAGCCTGGAA GCACGAATGG 600

CTGGAACGGA GAAACAGGAG AGGCCCTGTG GTGGTAAAAC CAATCCCTAT TAAAGGAGAT 660

GGATCTGAAA TTAATAACTT GGCAGCCGAG TCTCAAGGAG AGGGCCCAAC GAGCGCTGCT 720

TCCTCCACTC CCAAAGGCCG ACGCAGCCCT TCCCCTGGCA GCTCCCCCTC AGGTCGCACA 780

GTGAAATCTG AATCTCCAGG AGTAAGGAGG AAAAGAGTTT CTCCGGTGCC CTTTCAGAGT 840

GGGAGAATCA CACCACCTCG AAGAGCCCCT TCACCAGATG GCTTCTCACC ATACAGCCCG 900

GAGGAGACAA ACCGCCGAGT GAACAAAGTG ATGCGGGCCA GGCTGTACTT ACTGCAGCAG 960

ATAGGACCCA ACTCCTTCCT GATTGGAGGA GACAGCCCAG ACAACAAATA CCGGGTGTTT 1020

ATCGGGCCTC AGAACTGCAG CTGTGGGCGT GGAACATTTT GTATTCATCT GCTATTTGTT 1080

ATGCTCCGGG TATTTCAGCT AGAACCTTCA GACCCAATGT TATGGAGAAA AACTTTAAAG 1140

AATTTTGAGG TTGAGAGTTT GTTCCAGAAA TACCACAGTA GGCGTAGCTC AAGGATCAAA 1200

GCCCCGTCTC GTAACACCAT CCAGAAATTT GTTTCACGCA TGTCAAATTC TCATACATTG 1260

TCGTCATCTA GCACGTCTAC ATCCAGTTCA GAAAACAGTA TAAAAGATGA AGAGGAACAG 1320

ATGTGTCCTA TTTGCTTGTT GGGCATGCTT GATGAAGAAA GTCTTACAGT GTGTGAAGAC 1380

GGCTGCAGGA ACAAGCTGCA CCACCACTGC ATGTCCATTT GGGCAGAAGA ATGTAGAAGA 1440

AATAGAGAAC CTTTAATATG TCCCCTTTGT AGGTCGAAGT GGAGATCCCA CGATTTCTAC 1500

AGCCACGAGT TGTCCAGCCC TGTGGATTCC CCTTCTCCCC TGCGAGCTCC ACAGCAGCAG 1560

ACCACCCAGC AGCATGCCTT GGCTGGGTCC CAGCGGAGGA ATCAGGAGGG CAGTCTTACC 1620

CTTACTCATT ACGGGACTCA GCAGATCCCT CCTTCTTACA AAGATTTAGC TGAGCCTTGG 1680

ATTCAGGTAT TTGGAATGGA ACTCGTTGGC TGCTTATTTT CTAGAAACTG GAATGTAAGA 1740

GAGATGGCTC TCAGACGTCT TTCCCACGAC GTTAGTGGGG CTCTGCTGTT GGCAAATGGG 1800

GAGAGCACTG GAAATTCTGG GAGCAGTAGC GGAAGCGGTC CAGGTGCTGG AGCCACCAGT 1860

GGGTCTTCCC AGACCAGTAT CTCAGGAGAT GTGGTGGAGG CATGCTGCAA CGTTTTGTCA 1920

ATGGTCTGTG CTGACCCTGT CTACAAAGTG TACGTTGCTG CTTTAAAAAC GTTGAGAGCC 1980

ATGCTAGTAT ATACTCCTTG CCATAGTCTG GCAGAAAGAA TCAAACTGCA GAGACTTCTC 2040

CGGCCAGTTG TAGACACCAT CCTAGTCAAG TGTGCAGACG TCAATAGTCG CACAAGTCAG 2100

CTGTCTATAT CAACGCTATT GGAATTGTGC AAAGGCCAAG CAGGAGAGTT GGCAGTTGGC 2160

AGAGAAATAC TTAAAGCTGG ATCCATTGGT ATTGGTGGTG TTGATTATGT CTTAAATTGT 2220

ATTCTTGGAA ACCAAACTGA ATCAAACAAC TGGCAAGAAC TCCTGGGCCG GCTCTGTCTC 2280

ATAGATAGAC TGCTGTTGGA ATTTCCTGCT GAATTTTACC CTCATATTGT CAGTACTGAT 2340

ATTTCACAAG CTGAGCCTGT TGAAGTCAGG TATAAGAAGC TGCTGTCCCT CCTGACCTTT 2400

GCTTTGCAGT CCATTGATAA TTCCCACTCA ATGGTTGGTA AACTCTCCCG AAGGATATAT 2460

TTGAGTTCTG CAAGAATGGT TACTGCAGTA CCCCATGTAT TTTCAAAACT GTTAGAAATG 2520

CTGAACGTTT CTAGTTCCAC TCATTTTACC AGGATGCGGC GTCGTTTGAT GGCTATTGCA 2580

GATGAGGTGG AAATTGCTGA GGCCATTCAG CTGGGCGTAG AAGACACTTT GGATGGTCGA 2640

CATGACTGCT TTTTGCAGGC ATCTGCCCCT AACAGCTATC CAGAAGCCAT GGACAATAGT 2700

TCCTTTGAAC GCATGGACCA TTTAGAGAAA CCTGGAAAAG GACTGTGTGC TACAAAATTG 2760

AGTGCCAGTT CAGAGGACAT TTCTGACCGA CTGGCCAGCA TTTCAGTAGG ACTTCCTAAT 2820

TCAACAACAA TGGAGCAACC AAAGCCAATG GTTCAAACAA AGGGCAGACC CCACAGTCAG 2880

TGTCTGAACG CGTCTCCTGC ATCTCCTCAT TCCCAGTTAA TGTTCCCAGC CTTGTCAACC 2940

CCTTCTTCAT CAACCCCATC TGTACCATCT GGCACTGGGA CAGATCTCTC TAAGCAGAGA 3000

CCTCAGGGGT TTGTTCCCTG CAAAATGCCT TCTGCATCTC CTCAAACACA GCGTAAGTTT 3060

TCTCTACAGT TCCAAAGAAA CTGTTCTGAA AACAAAGACT CAGATAAACT TTCCCCAATC 3120

TTCACTCAGT CAAGACCCCT ACCCTCTAGT AATATACACA GGCCAAAGCC ATCTCGACCT 3180

ACCCCAAGTA ATACCAGTAA ACAGGGAGAT GCCTCAAAAA ACAGCATGAC ACTTGATTTG 3240

AACAGTAGGT CCAAATGTGA TGACAGCTTT GGCAGTAGCA GCAATAGCAG TAATGCTGTT 3300

ATACCCAGTG ACGAGACAGT GTTCACCCCA GTAGAAGAGA AATGCAGATT AGATGTCAGT 3360

ACAGAGCTCA ACTCCAGTAT TGAGGACCTT CTTGAAGCGT CTATGCCTTC AAGTGACACA 3420

ACAGTAACTT TTAAGTCAGA AGTTGCTGTG CTCTCTCCTG AAAAAGATGA AAATGATGAT 3480

ACCTACAAAG ATGATGTGAA TCATAATCAA AAGTGCAAAG AAAAGATGGA AGCTGAAGAA 3540

GAAGAAGCTT TAGCGATTGC CATGGCAATG TCAGCATCTC AGGATGCCCT CCCCGTAGTT 3600

CCTCAACTTC AGGTTGAAAA TGGAGAAGAT ATCATCATTA TTCAACAAGA TACACCAGAG 3660

ACTCTACCAG GACATACCAA AGCAAAACAG CCTTATAGAG AAGACAGTGA ATGGCTGAAA 3720

GGTCAGCAGA TAGGCCTTGG CGCCTTCTCT TCTTGTTATC AGGCTCAAGA TGTGGGAACT 3780

GGAACTTTAA TGGCTGTTAA ACAGGTGACA TATGTCAGAA ATACATCTTC TGAGCAAGAA 3840

GAAGTAGTAG AAGCATTAAG AGAAGAGATA AGAATGATGA GCCATCTGAA TCATCCAAAC 3900

ATCATTAGGA TGTTGGGAGC CACATGCGAG AAGAGCAATT ATAATCTCTT CATTGAATGG 3960

ATGGCAGGTT TAGGGGGATC TGTGGCTCAT TTGCTCAGTA AATATGGAGC CTTCAAGGAG 4020

TCGGTAGTTA TTAACTATAC TGAGCAATTA CTTCGTGGCC TTTCATATCT CCATGAAAAC 4080

CAGATCATTC ACAGAGATGT CAAAGGTGCC AATTTGCTCA TTGACAGCAC AGGTCAGAGA 4140

CTGAGAATTG CTGACTTTGG AGCTGCAGCC AGGCTGGCAT CAAAAGGAAC CGGTGCAGGA 4200

GAGTTTCAGG GACAGTTACT GGGGACAATT GCATTTATGG CACCTGAGGT CCTAAGAGGT 4260

CAGCAGTATG GTAGGAGCTG TGATGTATGG AGCGTTGGCT GTGCTATTAT AGAAATGGCT 4320

TGTGCTAAAC CACCTTGGAA TGCAGAAAAA CACTCCAATC ATCTTGCTTT GATATTTAAG 4380

ATTGCCAGTG CAACTACTGC TCCATCAATT CCTTCACATT TGTCTCCTGG TTTACGAGAT 4440

GTGGCTCTTC GTTGTTTAGA ACTTCAACCT CAGGACAGAC CTCCATCGAG AGAGCTACTG 4500

AAGCATCCAG TCTTCCGTAC TACGTGGTAG 4530

Domain Profile

S: 1     wqkrevigkGsfgsvyaaldvdtgellavKeveikpekksekk.evkalkeEikllkelk  59

         w k+++ig G+f+s+y+a+dv tg+l+avK+v++ ++++se++ +v+al+eEi+++++l+

Q: 1238  WLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEeVVEALREEIRMMSHLN  1297

         899*******************************999998887699**************

S: 60    HenivkyyGveveeeelkiflEyve..gGslssllekygkleesvikkytkqileglayL  117

         H+ni++++G+++e++++++f+E+++  gGs+++ll+kyg+++esv+ +yt+q+l+gl+yL

Q: 1298  HPNIIRMLGATCEKSNYNLFIEWMAglGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYL  1357

         ************************9446********************************

S: 118   HekkivHRDiKgaNillds.sgvvklsDFGaskrlaelntkaae.lesltGtlaymaPEv  175

         He++i+HRD+KgaN+l+ds  + ++++DFGa++rla++ t a+e + +l Gt+a+maPEv

Q: 1358  HENQIIHRDVKGANLLIDStGQRLRIADFGAAARLASKGTGAGEfQGQLLGTIAFMAPEV  1417

         *******************7789******************9996779************

S: 176   ikkkekgygrkaDiWslgcvviemltgkrPfa..eldeelaimfkvgakktkPeipekls  233

         ++++  +ygr++D+Ws+gc++iem+++k+P++  +++++la++fk+++++t+P+ip++ls

Q: 1418  LRGQ--QYGRSCDVWSVGCAIIEMACAKPPWNaeKHSNHLALIFKIASATTAPSIPSHLS  1475

         *998..8************************87678899*********************

S: 234   eegkdflekcleldpkkrpsaeeLLkhef  262

         +  +d+  +clel+p++rp ++eLLkh++

Q: 1476  PGLRDVALRCLELQPQDRPPSRELLKHPV  1504

         ***************************86

Domain Sequence
(FASTA)

WLKGQQIGLG AFSSCYQAQD VGTGTLMAVK QVTYVRNTSS EQEEVVEALR EEIRMMSHLN 60

HPNIIRMLGA TCEKSNYNLF IEWMAGLGGS VAHLLSKYGA FKESVVINYT EQLLRGLSYL 120

HENQIIHRDV KGANLLIDST GQRLRIADFG AAARLASKGT GAGEFQGQLL GTIAFMAPEV 180

LRGQQYGRSC DVWSVGCAII EMACAKPPWN AEKHSNHLAL IFKIASATTA PSIPSHLSPG 240

LRDVALRCLE LQPQDRPPSR ELLKHPV 267

Keyword

ATP-binding; Complete proteome; Metal-binding; Nucleotide-binding; Reference proteome; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Vicugna pacos"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0008545	; F:JUN kinase kinase activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0008270	; F:zinc ion binding
GO:0008637	; P:apoptotic mitochondrial changes
GO:0043010	; P:camera-type eye development
GO:0071260	; P:cellular response to mechanical stimulus
GO:0030838	; P:positive regulation of actin filament polymerization
GO:0030334	; P:regulation of cell migration
GO:0007179	; P:transforming growth factor beta receptor signaling pathway
GO:0042060	; P:wound healing

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR001841	; Znf_RING.
IPR013083	; Znf_RING/FYVE/PHD.
IPR007527	; Znf_SWIM.

Pfam

PF00069	; Pkinase; 1.
PF04434	; SWIM; 1.

SMARTs

SM00184	; RING; 1.
SM00220	; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50089	; ZF_RING_2; 1.
PS50966	; ZF_SWIM; 1.

Prints

Created Date

20-Feb-2013