EKS-BOT-00281
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-BOT-00281
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/STKR433.05.6E-130203489287
StatusUnreviewed
Ensembl ProteinENSBTAP00000018383
UniProt AccessionF1MIW7;
Protein Name
Protein Synonyms/Alias
Gene NameACVRL1
Gene Synonyms/Alias ACVRL1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSBTAG00000013843ENSBTAP00000018383ENSBTAT00000018383
OrganismBos taurus
Functional Description
Protein Length503
Protein Sequence
(FASTA)
MTLNLPRRRL LMLLIALGLT QGDPLKPSRG PLVTCTCENP HCKGPTCQGS WCTVVLVWED 60
GHLREYRGCG NMHPEVCRAR PTEFVNHYCC YSPLCNHNVS LTLEATQTAP EQPQGDGQLP 120
LILGPVLAFL VLVALGALGL WHVRRRKEKQ RGANSELGES SLILKPSEQG DSMLGDLLDS 180
DCTTGSGSGL PFLVQRTVAR QVALVECVGK GRYGEVWRGL WHGESVAVKI FSSRDEQSWF 240
RETEIYNTVL LRHDNILGFI ASDMTSRNSS TQLWLITHYH EHGSLYDFLQ RQTLEPQLAL 300
KLAVSAACGL AHLHVEIFGT QGKPAIAHRD LKSRNVLVKS NLQCCIADLG LAVMHSQSSD 360
YLDIGNNPRV GTKRYMAPEV LEEQIRTDCF ESYKWTDIWA FGLVLWEITR RTIVNGIVED 420
YRPPFYDVVP NDPSFEDMKK VVCVDQQTPT IPNRLAADPV LSGLAQMMRE CWYPNPSARL 480
TALRIKKTLQ KLSNGLQKPK VIP 503
Nucleotide Sequence
(FASTA)
ATGACCTTGA ACCTTCCCAG GAGAAGGCTT CTGATGCTAC TGATAGCCTT GGGCCTGACC 60
CAGGGTGACC CCTTGAAACC CTCTCGGGGC CCGCTGGTGA CCTGCACGTG TGAGAACCCA 120
CACTGCAAGG GGCCTACCTG CCAGGGGTCC TGGTGTACAG TCGTGCTGGT GTGGGAGGAT 180
GGACACCTCC GGGAATACCG GGGCTGCGGG AACATGCACC CAGAGGTCTG TAGGGCGCGC 240
CCCACGGAGT TCGTCAACCA CTACTGCTGC TACAGCCCCC TATGCAACCA CAACGTGTCC 300
CTGACGCTAG AAGCCACCCA GACTGCTCCG GAGCAGCCTC AAGGAGATGG CCAGCTGCCT 360
TTGATCCTGG GCCCCGTGCT GGCCTTTCTA GTGCTTGTGG CCCTGGGTGC CCTGGGCCTG 420
TGGCATGTCC GGCGGAGGAA GGAGAAGCAG CGGGGCGCGA ACAGTGAGCT GGGCGAGTCC 480
AGCCTCATCC TGAAGCCATC TGAGCAGGGG GACAGCATGT TGGGGGACCT CCTGGACAGT 540
GACTGTACCA CGGGCAGTGG CTCAGGGCTC CCGTTCCTGG TGCAGAGGAC AGTGGCTCGA 600
CAGGTCGCCC TGGTGGAGTG TGTGGGAAAG GGCCGCTATG GTGAGGTGTG GCGGGGCCTG 660
TGGCATGGTG AGAGCGTAGC CGTCAAGATC TTCTCCTCCA GAGATGAACA GTCCTGGTTC 720
CGGGAGACTG AGATCTACAA CACAGTGCTG CTCAGACACG ACAACATCCT AGGCTTTATC 780
GCCTCGGACA TGACTTCCCG CAACTCGAGC ACGCAGCTGT GGCTCATCAC GCACTACCAC 840
GAGCACGGCT CGCTCTACGA CTTTCTGCAG AGGCAGACGC TGGAGCCTCA GCTGGCCCTG 900
AAGCTAGCCG TGTCCGCGGC CTGCGGCCTG GCGCACCTGC ACGTGGAGAT CTTCGGCACG 960
CAGGGCAAAC CGGCCATCGC CCACCGCGAC CTCAAGAGCC GCAACGTGCT GGTCAAGAGC 1020
AACCTGCAGT GCTGCATCGC CGACCTGGGC CTGGCTGTGA TGCACTCTCA GAGTAGCGAT 1080
TACCTGGACA TTGGCAACAA CCCGCGAGTG GGCACCAAGC GGTACATGGC CCCTGAGGTG 1140
CTGGAAGAGC AGATCCGAAC CGACTGCTTC GAATCCTACA AGTGGACGGA CATCTGGGCC 1200
TTTGGCCTGG TGCTGTGGGA GATCACCCGC CGGACCATTG TCAATGGCAT TGTGGAGGAC 1260
TACCGGCCAC CCTTCTATGA TGTGGTGCCC AATGACCCCA GCTTTGAGGA CATGAAGAAG 1320
GTGGTGTGTG TTGACCAGCA GACCCCCACC ATCCCCAACC GGCTGGCTGC AGACCCGGTC 1380
CTCTCAGGCC TGGCTCAGAT GATGCGGGAG TGCTGGTACC CCAACCCCTC TGCCCGCCTC 1440
ACTGCGCTGC GGATCAAGAA GACACTACAG AAACTCAGCA ATGGTCTCCA GAAGCCCAAA 1500
GTTATTCCCT AG 1512
Domain Profile
S: 2     klleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfiaa  61
          l+e++gkGrygeVw++ ++ge+vAvKifs++de+sw+rE+eiy+tvllrh+nil+fia+
Q: 203   ALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIAS  262
         689*********************************************************
S: 62    dkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtkg  121
         d+++++s+t+l+l+t+yhe+gsL+d+L+r+tl+ + +l+la s+a+GlahLH ei+gt+g
Q: 263   DMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPQLALKLAVSAACGLAHLHVEIFGTQG  322
         ************************************************************
S: 122   kkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPEv  181
           KpaiaHRDlks+N+lvk++l+cciaDlGLa++++++++ ld+ +n +vGtkRYmaPEv
Q: 323   --KPAIAHRDLKSRNVLVKSNLQCCIADLGLAVMHSQSSDYLDIGNNPRVGTKRYMAPEV  380
         ..**********************************************************
S: 182   leealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleemk  241
         lee++ +++fe++k++D++++gLvlWE+++R+   +++ve+y++pf++vv++dPs+e+mk
Q: 381   LEEQIRTDCFESYKWTDIWAFGLVLWEITRRTIV-NGIVEDYRPPFYDVVPNDPSFEDMK  439
         ********************************99.*************************
S: 242   evvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291
         +vv+++++ P+ip+++ ++++l+ l+++++ecW+ +p+aRltalr+kk+l
Q: 440   KVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKKTL  489
         ************************************************97
Domain Sequence
(FASTA)
ALVECVGKGR YGEVWRGLWH GESVAVKIFS SRDEQSWFRE TEIYNTVLLR HDNILGFIAS 60
DMTSRNSSTQ LWLITHYHEH GSLYDFLQRQ TLEPQLALKL AVSAACGLAH LHVEIFGTQG 120
KPAIAHRDLK SRNVLVKSNL QCCIADLGLA VMHSQSSDYL DIGNNPRVGT KRYMAPEVLE 180
EQIRTDCFES YKWTDIWAFG LVLWEITRRT IVNGIVEDYR PPFYDVVPND PSFEDMKKVV 240
CVDQQTPTIP NRLAADPVLS GLAQMMRECW YPNPSARLTA LRIKKTL 287
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>
EKS-AIM-00263
EKS-CAJ-00287
EKS-CAF-00287
EKS-CAP-00316
EKS-ECT-00031
EKS-EQC-00273
EKS-FEC-00267
EKS-GOG-00280
EKS-HOS-00287
EKS-ICT-00265
EKS-LOA-00291
EKS-MAM-00283
EKS-MAE-00018
EKS-MUM-00312
EKS-MUP-00276
EKS-MYL-00284
EKS-NOL-00259
EKS-OCP-00028
EKS-OTG-00286
EKS-PAT-00265
EKS-PES-00250
EKS-POA-00271
EKS-PRC-00026
EKS-RAN-00296
EKS-SAH-00263
EKS-SOA-00026
EKS-SUS-00247
EKS-TUT-00043
EKS-VIP-00020
Gene Ontology
GO:0009986; C:cell surface
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005024; F:transforming growth factor beta-activated receptor activity
GO:0001525; P:angiogenesis
GO:0060840; P:artery development
GO:0001974; P:blood vessel remodeling
GO:0030509; P:BMP signaling pathway
GO:0071773; P:cellular response to BMP stimulus
GO:0071560; P:cellular response to transforming growth factor beta stimulus
GO:0061154; P:endothelial tube morphogenesis
GO:0001701; P:in utero embryonic development
GO:0001946; P:lymphangiogenesis
GO:0060836; P:lymphatic endothelial cell differentiation
GO:0043537; P:negative regulation of blood vessel endothelial cell migration
GO:0030308; P:negative regulation of cell growth
GO:2000279; P:negative regulation of DNA biosynthetic process
GO:0045602; P:negative regulation of endothelial cell differentiation
GO:0001937; P:negative regulation of endothelial cell proliferation
GO:0051895; P:negative regulation of focal adhesion assembly
GO:0045603; P:positive regulation of endothelial cell differentiation
GO:0001938; P:positive regulation of endothelial cell proliferation
GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter
GO:0008217; P:regulation of blood pressure
GO:0061298; P:retina vasculature development in camera-type eye
GO:0007179; P:transforming growth factor beta receptor signaling pathway
GO:0060841; P:venous blood vessel development
GO:0035313; P:wound healing, spreading of epidermal cells
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR008271; Ser/Thr_kinase_AS.
IPR003605; TGF_beta_rcpt_GS.
Pfam
PF00069; Pkinase; 1.
PF08515; TGF_beta_GS; 1.
SMARTs
SM00467; GS; 1.
Prosites
PS51256; GS; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013