EKS-BOT-00208

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-BOT-00208

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDKL	514.2	7.1E-155	4	287	284

Status

Unreviewed

Ensembl Protein

ENSBTAP00000031525

UniProt Accession

A5D7F0;

Protein Name

Protein Synonyms/Alias

CDKL2 protein;

Gene Name

CDKL2

Gene Synonyms/Alias

CDKL2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000014038	ENSBTAP00000031525	ENSBTAT00000031574

Organism

Bos taurus

Functional Description

Protein Length

569

Protein Sequence
(FASTA)

MEKYENLGLV GEGSYGMVMK CRNKDSGRIV AIKKFLESDD DKMVKKIAMR EIKLLKQLRH 60

ENLVNLLEVC KKKKRWYLVF EFVDHTVLDD LELSPNGLDY QLVQKYLFQV ISGIGFCHSH 120

NIIHRDIKPE NILVSQSGVV KLCDFGFART LAAPGEVYTD YVATRWYRAP ELLVGDVKYG 180

KAVDVWAIGC LVTEMLMGEP LFPGDSDIDQ LYHIMVCLGN LIPRHQELFY KNPVFAGVRL 240

PEIKETVPLE RRYPKLSEVV IDLAKKCLHI DPDKRPFCAE LLHHDFFHMD GFAERFPQEL 300

QLKVQKDVRN ISLSKKSQIR KKEKEKDESL GEERKTLVVQ DTNADPQTKD SKVFKIKGSK 360

TDGEKVEKAS RASNASCLND NGMSPVKIVP STSLRDCSNG SVDQTRNPGM AIPPLTHNLS 420

ATAPTITSGM GTISGIQSYR VDEKTKKYCI PFVKPNKHSP PGAYNINVTT LVASEKSLLQ 480

ANKKRREYSK TDVRLPELNY NHLPELKALE GIARNSRLIK KENKNLSESR IPSLATIDLH 540

TPSIALQQVS KSPLSDDSEA DLPPVEHQH 569

Nucleotide Sequence
(FASTA)

ATGGAAAAAT ATGAGAACCT AGGATTGGTT GGAGAAGGGA GCTATGGAAT GGTGATGAAG 60

TGTAGGAATA AAGATAGTGG AAGAATTGTG GCCATCAAGA AGTTCTTAGA AAGTGATGAT 120

GATAAAATGG TTAAAAAAAT TGCCATGCGA GAAATCAAGT TACTAAAGCA ACTAAGGCAT 180

GAAAATCTGG TGAATTTGTT GGAAGTATGT AAGAAAAAAA AGCGATGGTA CCTAGTCTTT 240

GAATTTGTTG ACCATACGGT TCTTGATGAC CTGGAGCTCT CTCCAAATGG ACTAGACTAC 300

CAACTAGTTC AAAAGTATTT GTTTCAGGTT ATCAGTGGGA TTGGATTTTG TCACAGTCAC 360

AATATTATTC ACAGAGATAT TAAGCCAGAG AACATATTAG TCTCCCAGTC CGGCGTTGTC 420

AAGCTATGTG ATTTTGGATT TGCACGGACA CTGGCAGCTC CTGGGGAGGT GTATACTGAT 480

TATGTGGCAA CACGATGGTA TAGAGCTCCA GAGCTGTTGG TTGGTGATGT CAAGTATGGC 540

AAGGCTGTTG ATGTGTGGGC CATCGGCTGT CTGGTAACTG AAATGCTCAT GGGGGAGCCC 600

CTCTTTCCTG GAGATTCTGA TATTGATCAG TTATATCATA TTATGGTGTG TTTAGGGAAT 660

CTAATTCCAA GACATCAGGA GCTGTTTTAT AAAAATCCTG TGTTTGCTGG AGTAAGGTTG 720

CCTGAAATCA AAGAAACTGT ACCTCTGGAA AGACGCTATC CCAAACTCTC TGAAGTTGTG 780

ATTGATTTAG CAAAGAAATG CTTACATATT GACCCAGACA AAAGGCCCTT CTGTGCTGAG 840

CTCCTGCACC ATGATTTCTT CCATATGGAT GGATTTGCTG AGAGGTTTCC TCAGGAACTG 900

CAGTTAAAAG TACAGAAAGA TGTCAGAAAC ATTTCTTTAT CTAAAAAATC TCAAATCAGA 960

AAGAAGGAAA AGGAAAAGGA TGAGTCCTTG GGTGAAGAGA GAAAAACACT TGTGGTACAG 1020

GATACCAATG CTGATCCCCA AACTAAGGAT TCTAAAGTAT TTAAAATAAA AGGATCAAAA 1080

ACAGATGGAG AAAAAGTGGA AAAAGCGAGT CGAGCTTCAA ATGCCAGCTG TCTCAATGAC 1140

AATGGGATGA GCCCTGTCAA AATAGTGCCT TCAACAAGCC TCCGAGATTG CAGCAATGGC 1200

AGCGTGGACC AAACAAGAAA TCCAGGCATG GCAATTCCCC CACTCACACA CAATCTTTCT 1260

GCAACAGCTC CCACTATTAC TTCTGGAATG GGAACTATCT CAGGAATTCA GAGTTACAGA 1320

GTGGATGAGA AAACCAAGAA GTATTGTATT CCATTTGTTA AACCAAATAA ACATTCTCCA 1380

CCAGGAGCTT ATAATATTAA TGTGACCACA TTGGTTGCTA GTGAAAAGAG CCTACTTCAG 1440

GCAAATAAGA AAAGAAGGGA ATACTCAAAG ACAGATGTCC GTTTGCCTGA ACTAAATTAT 1500

AATCATCTCC CTGAACTAAA AGCCCTGGAA GGCATCGCTC GGAATTCCAG GCTAATAAAG 1560

AAAGAGAACA AAAATCTTTC AGAATCTCGA ATTCCGTCTC TGGCCACAAT TGACTTGCAC 1620

ACTCCCAGTA TCGCATTACA GCAGGTATCA AAATCTCCCC TGTCAGATGA TTCAGAGGCT 1680

GATTTGCCTC CCGTGGAACA CCAGCACTGA 1710

Domain Profile

S: 1     yeklgkvGeGsyGvvlkcrnkdtgqivaikkfleseddkevkkialreikllkqlkhenl  60

         ye+lg vGeGsyG+v+kcrnkd+g+ivaikkfles+ddk+vkkia+reikllkql+henl

Q: 4     YENLGLVGEGSYGMVMKCRNKDSGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRHENL  63

         9***********************************************************

S: 61    vnllevfrrkkklylvfeyvdktvldelerypnGveeelvkkilyqilkaiefchknnii  120

         vnllev+++kk++ylvfe+vd+tvld+le  pnG++++lv+k+l+q++ +i fch++nii

Q: 64    VNLLEVCKKKKRWYLVFEFVDHTVLDDLELSPNGLDYQLVQKYLFQVISGIGFCHSHNII  123

         ************************************************************

S: 121   hrdikpenilisksgvvklcdfGfarllaapgdvytdyvatrwyrapellvgdtkyGksv  180

         hrdikpenil+s+sgvvklcdfGfar+laapg+vytdyvatrwyrapellvgd+kyGk+v

Q: 124   HRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELLVGDVKYGKAV  183

         ************************************************************

S: 181   dvwaiGcllaelltGeplfpgksdvdqlykirktlGeliprhqkifsknevfaGvklpev  240

         dvwaiGcl++e+l+Geplfpg+sd+dqly+i+ +lG+liprhq++f+kn+vfaGv+lpe+

Q: 184   DVWAIGCLVTEMLMGEPLFPGDSDIDQLYHIMVCLGNLIPRHQELFYKNPVFAGVRLPEI  243

         ************************************************************

S: 241   edleslekkypklnevlldllkkclkldpaerlsceellkheyf  284

         +++ +le++ypkl+ev++dl+kkcl++dp++r +c+ell+h++f

Q: 244   KETVPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFF  287

         ******************************************98

Domain Sequence
(FASTA)

YENLGLVGEG SYGMVMKCRN KDSGRIVAIK KFLESDDDKM VKKIAMREIK LLKQLRHENL 60

VNLLEVCKKK KRWYLVFEFV DHTVLDDLEL SPNGLDYQLV QKYLFQVISG IGFCHSHNII 120

HRDIKPENIL VSQSGVVKLC DFGFARTLAA PGEVYTDYVA TRWYRAPELL VGDVKYGKAV 180

DVWAIGCLVT EMLMGEPLFP GDSDIDQLYH IMVCLGNLIP RHQELFYKNP VFAGVRLPEI 240

KETVPLERRY PKLSEVVIDL AKKCLHIDPD KRPFCAELLH HDFF 284

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005813	; C:centrosome
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

bta:533114

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013