EKS-BOT-00148

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-BOT-00148

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/FGFR	549.8	9.4E-166	498	776	279

Status

Unreviewed

Ensembl Protein

ENSBTAP00000018708

UniProt Accession

F1MNW2;

Protein Name

Fibroblast growth factor receptor

Protein Synonyms/Alias

Gene Name

FGFR2

Gene Synonyms/Alias

FGFR2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000014064	ENSBTAP00000018708	ENSBTAT00000018708

Organism

Bos taurus

Functional Description

Protein Length

840

Protein Sequence
(FASTA)

MGLTSTWRYG RGQGIGTVTM VSWGRFLCLV VVTMATLSLA RPSFNLVDDT TVEPEEPPTK 60

YQISQPEVYV AAPRESLELR CLLRDAAMIS WTKDGVHLGP NNRTVLIGEY LQIKGATPRD 120

SGLYACTAAR NVDSETVYFM VNVTDAISSG DDEDDADGSE DFVSENSNSK RAPYWTNTEK 180

MEKRLHAVPA ANTVKFRCPA GGNPTPTMRW LKNGKEFKQE HRIGGYKVRN QHWSLIMESV 240

VPSDKGNYTC VVENDYGSIN HTYHLDVVER SPHRPILQAG LPANASTVVG GDVEFVCKVY 300

SDAQPHIQWI KHVEKNGSKY GPDGLPYLKV LKAAGVNTTD KEIEVLYIRN VTFEDAGEYT 360

CLAGNSIGIS FHSAWLTVLP APVREKEIPA SPDYLEIAIY CIGVFFIACM VVTVILCRMR 420

NTTKKPDFSS QPAVHKLTKR IPLRRQVSAE SSSSMNSNTP LVRITTRLSS TADTPMLAGV 480

SEYELPEDPK WEFPRDKLTL GKPLGEGCFG QVVMAEAVGI DKEKPKEAVT VAVKMLKDDA 540

TEKDLSDLVS EMEMMKMIGK HKNIINLLGA CTQDATGPLY VIVEYASKGN LREYLRARRP 600

PGMEYSYDIN RVPEEQMAFK DLVSCTYQLA RGMEYLASQK CIHRDLAARN VLVTENNVMK 660

IADFGLARDI NNIDYYKKTT NGRLPVKWMA PEALFDRVYT HQSDVWSFGV LMWEIFTLGG 720

SPYPGIPVEE LFKLLKEGHR MDKPANCTNE LYMMMRDCWH AVPSQRPTFK QLVEDLDRIL 780

TLTTNEEYLD LSQLLEQYSP SYPDTRSSCS SGDDSVFSPD PMPYEPCLPQ YPHRNGSVKT 840

Nucleotide Sequence
(FASTA)

ATGGGATTAA CGTCCACATG GAGATATGGA AGAGGACAGG GGATCGGCAC TGTAACCATG 60

GTCAGCTGGG GTCGCTTCCT CTGCCTGGTT GTGGTCACCA TGGCAACCTT GTCCCTGGCC 120

CGGCCCTCCT TCAATTTAGT TGACGATACC ACGGTTGAGC CGGAAGAGCC ACCAACCAAA 180

TACCAAATCT CCCAACCAGA AGTTTACGTG GCTGCGCCCC GGGAGTCGCT AGAGTTGCGC 240

TGCCTGTTGC GAGATGCCGC CATGATCAGT TGGACTAAGG ATGGGGTACA CTTGGGGCCC 300

AACAATAGGA CAGTGCTTAT TGGGGAGTAT TTGCAGATAA AAGGTGCCAC GCCTAGAGAC 360

TCCGGCCTCT ATGCTTGTAC TGCTGCTAGG AACGTAGACA GTGAGACTGT CTACTTCATG 420

GTCAATGTCA CAGATGCCAT CTCATCCGGA GATGATGAGG ACGACGCAGA TGGCTCGGAG 480

GATTTTGTCA GTGAGAACAG TAACAGCAAG AGAGCACCAT ACTGGACCAA CACAGAAAAG 540

ATGGAAAAAC GGCTGCACGC GGTCCCAGCA GCCAACACTG TCAAGTTCCG CTGTCCAGCT 600

GGGGGGAATC CAACACCAAC CATGAGGTGG CTGAAAAACG GGAAGGAATT TAAGCAGGAG 660

CATCGCATTG GAGGCTATAA GGTACGAAAC CAGCATTGGA GCCTTATTAT GGAAAGTGTG 720

GTCCCGTCTG ACAAAGGAAA TTATACCTGC GTGGTGGAGA ACGATTACGG GTCCATCAAT 780

CATACGTACC ACCTTGACGT TGTTGAGCGA TCACCACACC GGCCCATCCT CCAAGCCGGG 840

CTGCCGGCAA ATGCCTCCAC TGTGGTTGGA GGCGATGTGG AGTTTGTCTG CAAAGTGTAC 900

AGCGATGCCC AGCCCCATAT CCAGTGGATC AAACACGTGG AAAAGAACGG CAGTAAATAT 960

GGGCCCGACG GGCTGCCCTA TCTCAAGGTT CTGAAGGCCG CCGGTGTTAA TACCACGGAC 1020

AAAGAAATTG AGGTTCTCTA TATTCGGAAT GTAACTTTTG AGGATGCTGG GGAATATACG 1080

TGCTTGGCGG GTAATTCTAT TGGGATATCC TTTCACTCTG CATGGTTGAC AGTTCTGCCA 1140

GCTCCTGTAA GAGAAAAGGA GATCCCAGCT TCCCCAGACT ACCTGGAAAT AGCCATTTAC 1200

TGCATAGGGG TGTTCTTCAT CGCCTGCATG GTGGTGACGG TCATCTTGTG CCGGATGAGG 1260

AACACGACCA AGAAGCCGGA CTTCAGCAGC CAGCCGGCTG TGCACAAGCT GACCAAGCGC 1320

ATCCCCCTGC GGAGACAGGT TTCTGCTGAG TCCAGCTCCT CCATGAACTC CAATACCCCG 1380

TTGGTGAGGA TTACAACTCG CCTCTCTTCA ACTGCAGACA CCCCCATGCT GGCGGGGGTC 1440

TCCGAGTACG AGCTGCCAGA AGATCCCAAA TGGGAGTTTC CAAGAGATAA GCTGACGCTG 1500

GGCAAACCCC TGGGAGAAGG TTGCTTTGGG CAAGTGGTCA TGGCTGAAGC AGTGGGAATT 1560

GACAAGGAGA AGCCCAAGGA AGCAGTCACT GTGGCCGTGA AGATGTTGAA AGATGATGCC 1620

ACTGAGAAAG ACCTTTCTGA TCTGGTGTCC GAGATGGAGA TGATGAAGAT GATTGGGAAA 1680

CACAAAAATA TCATAAATCT CCTTGGAGCC TGTACTCAGG ATGCCACAGG GCCGCTCTAT 1740

GTCATCGTTG AATACGCCTC TAAAGGCAAC CTTCGGGAAT ACCTGCGCGC CCGGAGGCCA 1800

CCCGGGATGG AGTATTCCTA CGACATCAAC CGCGTTCCCG AGGAGCAGAT GGCCTTCAAG 1860

GACCTGGTGT CGTGTACCTA CCAGCTGGCC CGGGGCATGG AGTACTTGGC TTCCCAGAAA 1920

TGCATTCATC GAGATTTAGC TGCCAGAAAT GTTTTGGTAA CAGAAAACAA CGTGATGAAA 1980

ATAGCTGACT TTGGACTGGC CAGAGATATC AACAATATAG ACTATTACAA AAAGACCACA 2040

AATGGCCGAC TTCCGGTCAA GTGGATGGCT CCCGAAGCCC TTTTCGACAG AGTGTACACC 2100

CATCAGAGCG ATGTCTGGTC CTTCGGGGTG TTAATGTGGG AGATCTTCAC GTTAGGGGGT 2160

TCGCCCTACC CAGGGATTCC CGTGGAGGAA CTTTTTAAGC TGCTTAAGGA AGGACATAGG 2220

ATGGACAAGC CAGCAAACTG CACCAACGAA CTGTATATGA TGATGAGAGA CTGCTGGCAT 2280

GCGGTACCCT CACAGAGACC CACCTTCAAG CAGTTGGTAG AAGACTTGGA TCGAATTCTC 2340

ACACTCACAA CCAATGAGGA ATACTTGGAC CTCAGTCAGC TTCTTGAACA ATATTCACCT 2400

AGTTACCCTG ACACAAGGAG TTCTTGCTCT TCGGGAGATG ATTCTGTTTT CTCTCCGGAC 2460

CCCATGCCTT ACGAACCCTG CCTTCCTCAG TATCCACATA GAAACGGCAG TGTTAAAACA 2520

TGA 2523

Domain Profile

S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60

         l+lgk+lGeG+fGqvv+aea+g+dk+k+k++vtvavkmlk+dat+kdl+dlvseme++k+

Q: 498   LTLGKPLGEGCFGQVVMAEAVGIDKEKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKM  557

         79**********************************************************

S: 61    iGkhkniinllGactqe..GplyviveyaakGnlreflrarrpkgeeaskdkskaseeql  118

         iGkhkniinllGactq+  Gplyviveya+kGnlre+lrarrp+g+e+s+d ++++eeq+

Q: 558   IGKHKNIINLLGACTQDatGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQM  617

         ***************97669****************************************

S: 119   tekdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyyk  178

         ++kdlvs++yq+arGmeylas+kcihrdlaarnvlvte+nv+kiadfGlard+++idyyk

Q: 618   AFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYK  677

         ************************************************************

S: 179   kttnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllke  238

         kttnGrlpvkwmapealfdrvyt+qsdvwsfGvl+wei+tlGgspypgi+veelfkllke

Q: 678   KTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKE  737

         ************************************************************

S: 239   Ghrmekpakctkelyvlmrecwhakaserptfkqlvedl  277

         Ghrm+kpa+ct+ely++mr+cwha++s+rptfkqlvedl

Q: 738   GHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDL  776

         *************************************97

Domain Sequence
(FASTA)

LTLGKPLGEG CFGQVVMAEA VGIDKEKPKE AVTVAVKMLK DDATEKDLSD LVSEMEMMKM 60

IGKHKNIINL LGACTQDATG PLYVIVEYAS KGNLREYLRA RRPPGMEYSY DINRVPEEQM 120

AFKDLVSCTY QLARGMEYLA SQKCIHRDLA ARNVLVTENN VMKIADFGLA RDINNIDYYK 180

KTTNGRLPVK WMAPEALFDR VYTHQSDVWS FGVLMWEIFT LGGSPYPGIP VEELFKLLKE 240

GHRMDKPANC TNELYMMMRD CWHAVPSQRP TFKQLVEDL 279

Keyword

ATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005938	; C:cell cortex
GO:0009986	; C:cell surface
GO:0031012	; C:extracellular matrix
GO:0005887	; C:integral to plasma membrane
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0005007	; F:fibroblast growth factor-activated receptor activity
GO:0001525	; P:angiogenesis
GO:0007409	; P:axonogenesis
GO:0030282	; P:bone mineralization
GO:0060349	; P:bone morphogenesis
GO:0060667	; P:branch elongation involved in salivary gland morphogenesis
GO:0060670	; P:branching involved in labyrinthine layer morphogenesis
GO:0048755	; P:branching morphogenesis of a nerve
GO:0060449	; P:bud elongation involved in lung branching
GO:0045165	; P:cell fate commitment
GO:0048557	; P:embryonic digestive tract morphogenesis
GO:0009880	; P:embryonic pattern specification
GO:0061031	; P:endodermal digestive tract morphogenesis
GO:0060664	; P:epithelial cell proliferation involved in salivary gland morphogenesis
GO:0060595	; P:fibroblast growth factor receptor signaling pathway involved in mammary gland specification
GO:0031069	; P:hair follicle morphogenesis
GO:0032808	; P:lacrimal gland development
GO:0060601	; P:lateral sprouting from an epithelium
GO:0070307	; P:lens fiber cell development
GO:0060174	; P:limb bud formation
GO:0048286	; P:lung alveolus development
GO:0060463	; P:lung lobe morphogenesis
GO:0060484	; P:lung-associated mesenchyme development
GO:0060615	; P:mammary gland bud formation
GO:0003149	; P:membranous septum morphogenesis
GO:0060915	; P:mesenchymal cell differentiation involved in lung development
GO:0060916	; P:mesenchymal cell proliferation involved in lung development
GO:0030901	; P:midbrain development
GO:0035264	; P:multicellular organism growth
GO:0008285	; P:negative regulation of cell proliferation
GO:0045839	; P:negative regulation of mitosis
GO:0000122	; P:negative regulation of transcription from RNA polymerase II promoter
GO:0007528	; P:neuromuscular junction development
GO:0042476	; P:odontogenesis
GO:0035265	; P:organ growth
GO:0030916	; P:otic vesicle formation
GO:0003148	; P:outflow tract septum morphogenesis
GO:0018108	; P:peptidyl-tyrosine phosphorylation
GO:0090263	; P:positive regulation of canonical Wnt receptor signaling pathway
GO:0060045	; P:positive regulation of cardiac muscle cell proliferation
GO:0051781	; P:positive regulation of cell division
GO:0060501	; P:positive regulation of epithelial cell proliferation involved in lung morphogenesis
GO:0070374	; P:positive regulation of ERK1 and ERK2 cascade
GO:0002053	; P:positive regulation of mesenchymal cell proliferation
GO:0010518	; P:positive regulation of phospholipase activity
GO:0045944	; P:positive regulation of transcription from RNA polymerase II promoter
GO:0009791	; P:post-embryonic development
GO:0060527	; P:prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0060523	; P:prostate epithelial cord elongation
GO:0046777	; P:protein autophosphorylation
GO:0060687	; P:regulation of branching involved in prostate gland morphogenesis
GO:0010453	; P:regulation of cell fate commitment
GO:0040036	; P:regulation of fibroblast growth factor receptor signaling pathway
GO:0040014	; P:regulation of multicellular organism growth
GO:0051150	; P:regulation of smooth muscle cell differentiation
GO:0008589	; P:regulation of smoothened signaling pathway
GO:0060529	; P:squamous basal epithelial stem cell differentiation involved in prostate gland acinus development
GO:0048489	; P:synaptic vesicle transport
GO:0001657	; P:ureteric bud development
GO:0055010	; P:ventricular cardiac muscle tissue morphogenesis

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016248	; Tyr_kinase_fibroblast_GF_rcpt.

Pfam

PF07679	; I-set; 2.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00408	; IGc2; 3.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013