EKS-BOT-00174
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-BOT-00174
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/PKC438.69.2E-132254520267
StatusUnreviewed
Ensembl ProteinENSBTAP00000018768
UniProt AccessionA0JNH7;
Protein Name
Protein Synonyms/Alias Protein kinase C, zeta;
Gene NamePRKCZ
Gene Synonyms/Alias PRKCZ;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSBTAG00000014119ENSBTAP00000018768ENSBTAT00000018768
OrganismBos taurus
Functional Description
Protein Length594
Protein Sequence
(FASTA)
MPSRTGPKMD GSGGRGRVRL KAHYSGDLLI TSLDSATTFD ELCAEVREMC WLHPGHPLTL 60
KWVDNEGDPC TVSSQMELEE AFRLSCQHKD EGLTLHVFPS IPKEPGMPCP GEDKSIYRRG 120
ARRWRKLYRA NGHLFQAKRF NRRAYCGQCS ERIWGLARQG YRCIHCKLLV HKRCYVLVPL 180
TCSRHMDSVM PSQEPAVDDK SDDVDLPSEE SDGIAYISST RKHDNIKDDA EDLKPVIDGM 240
DGIKISQGLG LQDFDLIRVI GRGSYAKVLL VRLKKNDQVY AMKVVKKELV HDDEDIDWVQ 300
TEKHVFEQAS SNPFLVGLHS CFQTTSRLFL VIEYVNGGDL MFHMQRQRKL PEEHARFYAA 360
EICIALNFLH ERGIIYRDLK LDNVLLDADG HIKLTDYGMC KEGLGPGDTT STFCGTPNYI 420
APEILRGEEY GFSVDWWALG VLMFEMMAGR SPFDIITDNP DMNTEDYLFQ VILEKPIRIP 480
RFLSVKASHV LKGFLNKDPK ERLGCRPQTG FSDIKSHAFF RSIDWDLLGK KQALPPFQPQ 540
ITDDYGLDNF DTQFTSEPVQ LTPDDEDVIK RIDQSEFEGF EYINPLLLST EESV 594
Nucleotide Sequence
(FASTA)
ATGCCCAGCA GGACGGGCCC CAAGATGGAC GGGAGCGGCG GCCGCGGCCG CGTCCGCCTA 60
AAGGCGCACT ATAGCGGGGA CCTCCTCATC ACCAGCCTGG ACTCCGCCAC CACCTTCGAC 120
GAGCTCTGCG CAGAGGTGCG GGAGATGTGC TGGCTGCACC CGGGCCACCC GCTCACCCTT 180
AAGTGGGTGG ACAATGAAGG TGACCCCTGC ACTGTGTCCT CCCAGATGGA GCTGGAGGAG 240
GCCTTCCGCC TGTCCTGTCA GCACAAGGAT GAAGGGCTCA CCCTTCACGT TTTCCCCAGC 300
ATCCCCAAGG AACCAGGCAT GCCCTGTCCG GGAGAAGACA AATCCATCTA CCGCCGTGGA 360
GCCAGAAGAT GGCGGAAGCT GTACCGCGCC AACGGCCACC TCTTCCAGGC CAAGCGCTTT 420
AACAGGAGAG CGTACTGCGG CCAGTGCAGC GAGAGGATAT GGGGCCTCGC GAGGCAGGGC 480
TACAGGTGCA TCCACTGCAA ACTGCTGGTT CATAAGCGCT GCTACGTGCT CGTCCCACTG 540
ACCTGCAGCA GGCATATGGA TTCCGTCATG CCTTCCCAGG AGCCTGCAGT GGACGACAAG 600
AGCGACGACG TGGACCTTCC CTCCGAGGAG AGTGATGGAA TTGCTTATAT TTCTTCAACC 660
CGGAAACATG ACAACATTAA AGATGATGCT GAGGACCTCA AGCCAGTCAT CGACGGGATG 720
GACGGGATCA AGATATCTCA GGGGCTCGGG CTGCAGGACT TCGACCTGAT CAGGGTCATC 780
GGGCGCGGGA GCTACGCCAA GGTCCTGCTG GTGCGGCTGA AGAAGAACGA CCAGGTCTAC 840
GCCATGAAGG TGGTAAAGAA GGAGCTGGTC CATGACGATG AGGATATTGA CTGGGTACAG 900
ACAGAGAAGC ACGTGTTTGA GCAGGCATCC AGCAACCCTT TCTTGGTCGG CTTACACTCC 960
TGCTTCCAGA CAACAAGTCG GTTGTTCCTG GTCATCGAGT ACGTCAACGG GGGCGACCTC 1020
ATGTTCCACA TGCAGAGGCA GAGGAAGCTG CCCGAGGAGC ACGCCAGGTT CTATGCTGCT 1080
GAAATTTGTA TCGCACTCAA CTTCCTACAC GAGAGAGGGA TTATCTACCG GGACCTGAAG 1140
CTGGACAATG TCCTCCTTGA CGCCGATGGC CACATCAAGC TGACGGACTA TGGCATGTGC 1200
AAGGAAGGCC TGGGCCCTGG TGATACAACA AGCACTTTCT GCGGAACCCC GAACTACATC 1260
GCCCCTGAAA TCCTGCGCGG AGAAGAGTAT GGGTTCAGCG TGGACTGGTG GGCGCTGGGC 1320
GTGCTGATGT TCGAGATGAT GGCAGGCCGC TCCCCCTTCG ACATCATCAC TGACAACCCC 1380
GACATGAACA CTGAAGACTA CCTTTTCCAA GTCATCCTGG AGAAGCCCAT CCGGATCCCC 1440
CGGTTCCTGT CCGTCAAGGC CTCCCACGTG TTGAAAGGAT TTTTAAACAA GGACCCCAAG 1500
GAGAGGCTTG GCTGCCGGCC GCAGACTGGA TTTTCTGATA TCAAGTCTCA CGCCTTCTTC 1560
CGCAGTATAG ACTGGGACCT GCTGGGGAAG AAGCAGGCCC TCCCGCCCTT CCAGCCGCAG 1620
ATCACAGACG ACTATGGCCT GGACAACTTC GATACGCAGT TCACCAGCGA GCCGGTGCAG 1680
CTGACCCCTG ACGACGAGGA CGTAATCAAG AGGATCGACC AGTCGGAGTT TGAAGGGTTC 1740
GAGTACATCA ACCCACTGCT GCTGTCCACT GAGGAGTCCG TATGA 1785
Domain Profile
S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60
         f+l++v+G+Gs++kvll++lkk+d++ya+kv+kk++v++d+d++++++ek+v+++as++p
Q: 254   FDLIRVIGRGSYAKVLLVRLKKNDQVYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNP  313
         89**********************************************************
S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120
         flv l+scfqt++rlf+v+eyvnGGdlmfh+q++rkl+ee+arfyaaei++al+flhe+g
Q: 314   FLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHERG  373
         ************************************************************
S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180
         iiyrdlkldnvllda+Ghikl+d+G+cke++  g+ttstfcGtP+yiaPeil++eeyg+s
Q: 374   IIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGFS  433
         ************************************************************
S: 181   vdwwalGvllyemlagqsPfe.......gededelfesilekevlyPkslskeaveilkg  233
         vdwwalGvl++em+ag+sPf+       +++ed+lf++ilek +++P+ ls++a+++lkg
Q: 434   VDWWALGVLMFEMMAGRSPFDiitdnpdMNTEDYLFQVILEKPIRIPRFLSVKASHVLKG  493
         **************************999*******************************
S: 234   lltkdpekrlGvk.eegeedikehaff  259
         +l+kdp++rlG++ ++g +dik+haff
Q: 494   FLNKDPKERLGCRpQTGFSDIKSHAFF  520
         ************889***********9
Domain Sequence
(FASTA)
FDLIRVIGRG SYAKVLLVRL KKNDQVYAMK VVKKELVHDD EDIDWVQTEK HVFEQASSNP 60
FLVGLHSCFQ TTSRLFLVIE YVNGGDLMFH MQRQRKLPEE HARFYAAEIC IALNFLHERG 120
IIYRDLKLDN VLLDADGHIK LTDYGMCKEG LGPGDTTSTF CGTPNYIAPE ILRGEEYGFS 180
VDWWALGVLM FEMMAGRSPF DIITDNPDMN TEDYLFQVIL EKPIRIPRFL SVKASHVLKG 240
FLNKDPKERL GCRPQTGFSD IKSHAFF 267
KeywordATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Canis familiaris"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Ochotona princeps"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00165
EKS-CAF-00181
EKS-DAR-00466
EKS-DIO-00088
EKS-EQC-00172
EKS-FEC-00166
EKS-GAG-00149
EKS-GAA-00210
EKS-GOG-00173
EKS-ICT-00168
EKS-LAC-00182
EKS-LOA-00172
EKS-MAM-00174
EKS-MEG-00138
EKS-MOD-00171
EKS-MUP-00178
EKS-OCP-00108
EKS-ORL-00205
EKS-OTG-00179
EKS-PES-00153
EKS-POA-00172
EKS-RAN-00170
EKS-SAH-00165
EKS-TEN-00219
EKS-XET-00161
EKS-XIM-00213
Gene Ontology
GO:0045179; C:apical cortex
GO:0016324; C:apical plasma membrane
GO:0035748; C:myelin sheath abaxonal region
GO:0005635; C:nuclear envelope
GO:0016363; C:nuclear matrix
GO:0043234; C:protein complex
GO:0005923; C:tight junction
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0008270; F:zinc ion binding
GO:0035556; P:intracellular signal transduction
GO:0000226; P:microtubule cytoskeleton organization
GO:0046627; P:negative regulation of insulin receptor signaling pathway
GO:0050732; P:negative regulation of peptidyl-tyrosine phosphorylation
GO:0031333; P:negative regulation of protein complex assembly
GO:0018105; P:peptidyl-serine phosphorylation
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade
GO:2001181; P:positive regulation of interleukin-10 secretion
GO:2000667; P:positive regulation of interleukin-13 secretion
GO:0032753; P:positive regulation of interleukin-4 production
GO:2000664; P:positive regulation of interleukin-5 secretion
GO:2000553; P:positive regulation of T-helper 2 cell cytokine production
GO:0045630; P:positive regulation of T-helper 2 cell differentiation
GO:0072659; P:protein localization to plasma membrane
KEGG
bta:286877;
InterPros
IPR000961; AGC-kinase_C.
IPR020454; DAG/PE-bd.
IPR011009; Kinase-like_dom.
IPR000270; OPR_PB1.
IPR012233; PKC_zeta.
IPR017892; Pkinase_C.
IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00130; C1_1; 1.
PF00564; PB1; 1.
PF00069; Pkinase; 1.
PF00433; Pkinase_C; 1.
SMARTs
SM00109; C1; 1.
SM00666; PB1; 1.
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS00479; ZF_DAG_PE_1; 1.
PS50081; ZF_DAG_PE_2; 1.
Prints
PR00008; DAGPEDOMAIN.
Created Date20-Feb-2013