EKS-BOT-00339

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-BOT-00339

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PEK	369.1	1.7E-110	590	1001	412

Status

Unreviewed

Ensembl Protein

ENSBTAP00000019083

UniProt Accession

E1BAL6;

Protein Name

Protein Synonyms/Alias

Gene Name

EIF2AK4

Gene Synonyms/Alias

EIF2AK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000014351	ENSBTAP00000019083	ENSBTAT00000019083

Organism

Bos taurus

Functional Description

Protein Length

1649

Protein Sequence
(FASTA)

MAGGRGAPGR GRDEPPESYP QRQDHELQAL EAIYGADFQD LRPDARGRVK EPPEINLVLY 60

PQGLTGEEVY VKVDLRVKCP PTYPDVVPEI ELKNAKGLSN ESVNLLKSRL EEVAKKHCGE 120

VMIFELAYYV QSFLCEHNKP PPKSFHEEML ERRAQEEQRR QLEAKRKEEE EQREILHEIQ 180

KRKEEIKEEK KRKEMAKQER LEIAILSNQD HTSRKDPGGH RTAAILHGGS PDFVGNGKHR 240

TNSSGRSKRE RQYSMCNSED SPGSCEILYF SVGSPDQLMV HKGKCIGSDE QLGKLVYNAL 300

ETATGSFVLL HEWVLQWHKK MGPFLTSQEK EKIDKCKKQI QGAETEFSSL VKLSHPNIVR 360

YFAMNLKEQD DSIVVDILVE HTNGISLAAH LGHSGPIPVH QLRKYAAQLL SGLDYLHSNS 420

VVHKVLSALN VLVDAEGTIK ITDYSISKRL ADICKEDVFE QTRVRFSDSA LPYKTGKKGD 480

IWRLGLLLLS LSQGQECEEY PVTIPSDLPA DFQDFLKKCV CLDDKERWSP QQLLKHSFIN 540

PQSKIPLLEQ SPEDSGGQDY VETVIPSNQL PSAAFFSETQ RQFSRYFIEF EELQLLGKGA 600

FGAVIKVQNK LDGCCYAVKR IPINPASRHF RRIKGEVTLL SRLHHENIVR YYNAWIERHE 660

RPACPATPPP NSGPQAQDGQ ALAQPAGDSD PDGPGSVEAA APPPILSSSV EWSTSGERSA 720

STRFPAAGPD SSSDEDDDEE QGVFSQSFLP ASDSDSDIIF DNEDENSKSQ NQDEDCNGKN 780

SCHESEPPAT TEAVHYLYIQ MEYCEKSTLR DTIDQGLYRD TVRLWRLFRE ILDGLAYIHE 840

KGMIHRDLKP VNIFLDSDDH VKIGDFGLAT DHLAFAADGK QDDTSGDHLI KSDPSGHLTG 900

MVGTALYVSP EVQGSTKSAY NQKVDLFSLG IIFFEMSYHP MVTASERIFV LNQLRDPTSP 960

KFPEDFDDGE HTKQKSVISW LLNHDPAKRP TATELLKSEL LPPPQMEESE LHEVLHHTLA 1020

NVDGKAYRTM MGQIFAQRIS PAIDYTYDSD ILKGSFSIRT AKIQQHVCET IIRIFKRHGA 1080

VQLCTPLLLP RNRQIYEHNE AALFMDHSGM LVMLPFDLRV PFARYVARNN ILNLKRYCIE 1140

RVFRPRKLDR FHPKELLECA FDIVTSTTNS SLPTAEIIYT IYEIIQEFPA LQERNYSIYL 1200

NHTMLLKAIL LHCGIPEDKL SQVYVILYDA VTEKLTRREV EAKFCNLSLS SSSLCRLYKF 1260

IEQKGELQDL TPTINSLIKQ KTGVAQLVKY GLKDLEEVVG LLKKFGIKLQ VLINLGLVYK 1320

VQQHSGIIFQ FVAFIRRRQR AISEILAAGG RYDLLIPQFR GPQALGPVPT AIGVSIAIDK 1380

ITTAVLNMEE PVTVSSCDLL VVSVGQMSMS RAINLTQKLW SAGITAEIMY DWSQSQEELQ 1440

EYCRHHEITY VALVSDKEGS HVKVKSFEKD RQTEKRVPES DLVDHVVQKL RTKVSDERTT 1500

REASDNLTVQ NLKGSFSNAS GLFEIHGATV VPIVSVVAPE KLSASTRRRY ETQVQTRLQT 1560

SLANLHQKSS EIEILAVDLP KETILQFLSL EWDADEQAFN TTVKQLLSRL PKQRYLKLVC 1620

DEIYNIKVEK KVSVLFLYSY RDDYYRILF 1649

Nucleotide Sequence
(FASTA)

ATGGCCGGGG GCCGCGGGGC CCCCGGACGT GGCCGGGACG AGCCACCGGA GAGCTACCCG 60

CAACGACAAG ACCACGAGCT GCAGGCCCTG GAGGCCATCT ATGGCGCCGA CTTCCAGGAC 120

CTGCGGCCGG ACGCGCGCGG ACGGGTCAAA GAGCCTCCTG AAATCAATTT AGTTCTGTAC 180

CCTCAAGGCC TGACTGGTGA AGAAGTGTAC GTGAAAGTGG ATTTGAGAGT GAAATGCCCA 240

CCCACCTATC CAGATGTAGT CCCTGAAATA GAATTAAAGA ATGCCAAAGG TCTGTCAAAT 300

GAAAGTGTTA ATTTGTTAAA GTCCCGCCTA GAAGAAGTGG CCAAAAAACA CTGTGGTGAG 360

GTGATGATAT TTGAACTGGC TTACTATGTG CAGTCATTTC TCTGCGAGCA CAACAAGCCC 420

CCTCCCAAGT CTTTTCATGA AGAAATGCTG GAAAGGCGAG CTCAGGAGGA GCAGCGGAGG 480

CAGTTAGAGG CCAAGCGGAA AGAGGAAGAG GAGCAACGTG AAATCCTTCA TGAGATTCAG 540

AAAAGGAAAG AAGAGATAAA AGAGGAGAAA AAAAGGAAAG AAATGGCTAA GCAGGAACGT 600

TTAGAAATAG CTATTTTGTC AAATCAAGAT CATACCTCTA GAAAAGACCC AGGAGGACAC 660

AGAACAGCTG CCATTCTACA TGGAGGCTCT CCTGACTTCG TAGGAAATGG TAAACATCGG 720

ACCAACTCCT CTGGAAGGTC TAAGCGAGAA CGTCAGTATT CTATGTGTAA TAGCGAAGAT 780

TCTCCTGGCT CTTGTGAAAT CCTGTATTTC TCTGTGGGTA GTCCTGATCA GCTCATGGTG 840

CACAAAGGGA AATGTATTGG CAGTGATGAG CAGCTTGGAA AATTAGTTTA CAATGCTTTG 900

GAAACAGCTA CTGGCAGCTT TGTCTTGTTG CATGAGTGGG TCCTTCAATG GCACAAAAAA 960

ATGGGTCCAT TCCTTACCAG TCAAGAAAAA GAGAAGATTG ATAAGTGCAA AAAGCAGATT 1020

CAAGGGGCAG AAACAGAATT CAGCTCACTG GTGAAACTGA GCCATCCAAA CATAGTACGC 1080

TACTTTGCGA TGAACCTCAA AGAGCAAGAC GACTCCATCG TGGTGGATAT TTTAGTGGAG 1140

CACACTAATG GGATCTCCCT CGCAGCCCAC CTGGGCCACT CAGGCCCCAT CCCGGTACAT 1200

CAGCTTCGCA AGTATGCAGC TCAGCTCTTG TCAGGCCTTG ATTACTTGCA CAGCAATTCC 1260

GTGGTGCACA AGGTTCTGAG CGCATTGAAT GTCCTGGTGG ATGCAGAGGG CACCATCAAG 1320

ATTACGGACT ACAGCATTTC TAAGCGCCTG GCAGACATTT GCAAGGAGGA CGTGTTTGAG 1380

CAGACCCGGG TTCGTTTCAG TGACAGCGCC CTACCTTATA AAACCGGGAA GAAAGGGGAT 1440

ATTTGGCGTC TCGGCCTTCT GCTGCTCTCC CTCAGCCAAG GACAAGAGTG TGAAGAGTAT 1500

CCCGTGACCA TCCCTAGTGA CTTACCAGCT GATTTTCAAG ATTTTCTAAA GAAGTGTGTC 1560

TGCTTAGATG ACAAGGAAAG ATGGAGTCCT CAGCAGTTGT TAAAACACAG CTTTATAAAT 1620

CCTCAGTCTA AAATACCTTT ACTGGAACAA AGTCCCGAAG ATTCTGGAGG ACAAGATTAT 1680

GTGGAGACTG TCATTCCTAG CAACCAGCTA CCCAGTGCTG CATTCTTCAG TGAGACCCAG 1740

AGACAGTTTT CCCGCTATTT CATTGAGTTT GAAGAATTAC AGCTTCTCGG CAAAGGAGCT 1800

TTTGGAGCCG TCATCAAGGT GCAGAACAAG CTGGACGGCT GCTGCTATGC GGTGAAGCGC 1860

ATCCCCATCA ACCCGGCCAG CAGGCACTTC CGCAGGATCA AGGGCGAGGT GACGCTGCTG 1920

TCGCGCCTCC ACCATGAGAA CATCGTGCGT TACTACAATG CCTGGATCGA GAGACATGAG 1980

CGGCCGGCGT GCCCGGCGAC TCCACCCCCG AACTCGGGGC CCCAGGCCCA GGACGGGCAA 2040

GCCTTAGCCC AGCCAGCGGG CGACAGCGAC CCGGACGGCC CGGGCAGTGT GGAGGCGGCC 2100

GCGCCGCCGC CCATCCTCAG CAGCTCGGTG GAATGGAGCA CGTCAGGCGA GCGCTCGGCC 2160

AGCACCCGCT TCCCCGCCGC CGGCCCAGAC TCCAGCAGCG ACGAGGACGA CGACGAGGAG 2220

CAGGGCGTCT TCTCACAGTC CTTCCTACCT GCTTCAGATT CTGACAGTGA TATCATCTTT 2280

GACAATGAAG ATGAGAACAG TAAAAGCCAG AATCAGGATG AAGATTGCAA TGGAAAGAAC 2340

AGTTGTCATG AAAGTGAGCC ACCAGCAACC ACCGAGGCTG TGCACTACCT CTACATCCAG 2400

ATGGAGTACT GTGAGAAGAG CACTTTACGA GACACCATTG ACCAGGGACT GTATCGAGAC 2460

ACCGTCAGGC TCTGGAGGCT TTTCCGAGAG ATTCTGGATG GATTGGCTTA TATCCATGAG 2520

AAAGGAATGA TTCACCGAGA TTTGAAGCCT GTCAACATTT TTTTGGATTC TGATGACCAT 2580

GTCAAAATAG GTGATTTTGG TTTGGCCACC GACCATCTAG CCTTTGCTGC TGACGGCAAA 2640

CAAGATGACA CATCAGGAGA TCACTTGATT AAATCAGACC CTTCAGGTCA TTTGACTGGG 2700

ATGGTTGGCA CTGCTTTATA TGTAAGCCCT GAGGTCCAAG GAAGCACCAA ATCTGCATAC 2760

AACCAGAAAG TGGATCTCTT CAGCCTGGGG ATTATCTTCT TTGAGATGTC CTATCATCCC 2820

ATGGTCACAG CCTCAGAAAG AATCTTTGTT CTCAACCAGC TCAGAGATCC CACTTCGCCT 2880

AAGTTTCCAG AAGACTTCGA TGATGGGGAG CATACAAAGC AGAAATCTGT CATCTCCTGG 2940

CTGTTGAACC ACGATCCGGC AAAGCGGCCC ACGGCCACAG AACTGCTCAA GAGCGAGCTG 3000

CTGCCCCCGC CCCAGATGGA GGAATCGGAG CTGCACGAGG TGCTGCACCA CACCCTGGCC 3060

AACGTGGACG GGAAGGCCTA CCGCACCATG ATGGGCCAGA TCTTCGCCCA GCGCATCTCC 3120

CCTGCCATCG ACTACACCTA CGACAGTGAC ATACTGAAGG GCAGCTTCTC CATCCGCACA 3180

GCCAAGATAC AGCAGCACGT GTGTGAAACC ATCATCCGCA TCTTCAAAAG ACACGGAGCT 3240

GTCCAGTTGT GTACCCCACT GCTGCTTCCC CGAAACAGAC AAATATATGA GCACAACGAA 3300

GCTGCCTTAT TCATGGACCA CAGCGGGATG CTGGTGATGC TGCCTTTCGA CCTGCGGGTT 3360

CCTTTTGCAA GATATGTGGC GAGAAATAAT ATATTGAATT TAAAGCGATA TTGCATAGAA 3420

CGTGTGTTCA GACCTCGAAA ATTAGACCGA TTTCATCCCA AAGAACTTCT GGAGTGTGCA 3480

TTTGATATTG TTACCTCTAC TACCAACAGC TCGCTGCCCA CCGCTGAAAT CATCTACACC 3540

ATCTACGAAA TCATCCAGGA GTTTCCAGCA CTTCAGGAAA GAAATTACAG TATTTACTTG 3600

AACCATACCA TGTTACTGAA AGCAATACTC TTACACTGTG GGATCCCAGA AGATAAACTC 3660

AGCCAAGTCT ATGTTATTCT GTATGATGCT GTGACAGAAA AGCTGACGAG GAGAGAAGTG 3720

GAAGCTAAAT TTTGTAATCT ATCCTTGTCG TCAAGTAGTC TGTGTCGACT CTACAAATTT 3780

ATTGAGCAGA AGGGAGAGCT GCAAGATCTA ACCCCAACCA TAAATTCATT AATAAAACAG 3840

AAAACAGGTG TTGCCCAGTT GGTGAAGTAC GGCTTAAAAG ATCTGGAGGA GGTCGTTGGA 3900

CTGTTGAAGA AATTTGGCAT AAAGTTACAG GTCCTGATCA ATCTGGGCTT GGTTTACAAG 3960

GTGCAGCAGC ACAGCGGAAT CATCTTCCAG TTTGTGGCAT TCATCAGACG GAGGCAAAGG 4020

GCTATATCTG AAATCCTCGC AGCTGGTGGT AGATACGACC TGCTGATTCC CCAGTTTAGA 4080

GGACCACAGG CTCTGGGGCC AGTTCCTACT GCCATCGGGG TCAGCATAGC CATAGACAAG 4140

ATAACCACTG CTGTCCTCAA CATGGAAGAG CCTGTTACAG TAAGCTCTTG TGACCTCCTG 4200

GTTGTAAGTG TTGGTCAGAT GTCCATGTCC AGGGCCATCA ACCTAACCCA GAAACTCTGG 4260

TCAGCTGGAA TCACAGCAGA AATCATGTAT GACTGGTCAC AGTCCCAAGA GGAATTACAA 4320

GAGTACTGCA GACATCATGA AATCACCTAT GTGGCCCTTG TCTCGGATAA AGAAGGAAGC 4380

CACGTCAAGG TAAAGTCTTT TGAGAAGGAC AGGCAAACAG AGAAACGTGT GCCGGAGTCT 4440

GATCTCGTGG ACCACGTTGT ACAGAAACTG AGGACTAAAG TCAGTGATGA GAGGACTACC 4500

AGAGAAGCTT CCGATAATCT TACAGTACAA AATCTGAAGG GATCATTTTC TAATGCTTCA 4560

GGTTTGTTTG AAATCCATGG AGCAACGGTT GTTCCCATTG TGAGTGTGGT CGCCCCAGAA 4620

AAGCTGTCAG CCAGCACCCG ACGGCGGTAT GAGACTCAGG TACAAACCCG ACTTCAGACC 4680

TCCCTTGCCA ACTTACATCA GAAAAGCAGT GAAATTGAAA TTTTGGCTGT GGATCTACCC 4740

AAAGAAACAA TCTTACAGTT CCTGTCATTA GAGTGGGATG CTGATGAACA GGCATTTAAC 4800

ACAACTGTGA AGCAGCTGCT GTCACGCCTG CCAAAGCAAA GATACCTCAA ATTAGTCTGT 4860

GATGAGATTT ATAACATCAA AGTAGAAAAA AAGGTGTCTG TGCTCTTCCT GTACAGCTAC 4920

AGAGATGACT ACTACAGAAT CTTATTTTAA 4950

Domain Profile

S: 1     feeikvlGkGgfgvVlkaknkldkkeyaikriklnkakkelekverevkaLaklehpniv  60

         fee+++lGkG+fg+V+k++nkld+++ya+kri++n a++++++++ ev++L++l+h+niv

Q: 590   FEELQLLGKGAFGAVIKVQNKLDGCCYAVKRIPINPASRHFRRIKGEVTLLSRLHHENIV  649

         89**********************************************************

S: 61    rYfaawleekeesl..............................................  74

         rY++aw+e++e+++

Q: 650   RYYNAWIERHERPAcpatpppnsgpqaqdgqalaqpagdsdpdgpgsveaaapppilsss  709

         ****************************************98777777777777777777

S: 75    ...........................................tdsseveaeaeleeses  91

Q: 710   vewstsgersastrfpaagpdsssdedddeeqgvfsqsflpasD----------------  753

         77777777777777777777666666666666666666666642................

S: 92    seesdtk.........................................llyiqmelceke  110

               +                                         +lyiqme+cek+

Q: 754   ------SdsdiifdnedensksqnqdedcngknscheseppatteavhYLYIQMEYCEKS  807

         ......034444444444444444444456889999999999999999************

S: 111   tLkdwiderkllesrselvmrlfkqllegleylHskgliHrdLkpsniFldsddqvKigD  170

         tL+d+id+  l++++ +l+ rlf+++l+gl+y+H+kg+iHrdLkp+niFldsdd+vKigD

Q: 808   TLRDTIDQG-LYRDTVRLW-RLFREILDGLAYIHEKGMIHRDLKPVNIFLDSDDHVKIGD  865

         *********.9********.****************************************

S: 171   FgLatalaealkedvkqdaqske........akhtgqvgtklymsPeql..eksqYnkkv  220

         FgLat+ + a+ +d kqd++s++        ++ tg+vgt+ly+sPe++  +ks+Yn+kv

Q: 866   FGLATD-HLAFAADGKQDDTSGDhliksdpsGHLTGMVGTALYVSPEVQgsTKSAYNQKV  924

         *****9.88889999**999999788777777*****************999********

S: 221   DifsLGlilfeLly.pfstemervetltelrd...gkipedfdd.kvpkekkllqkllsr  275

         D+fsLG+i+fe++y p+ t++er+ +l++lrd    k+pedfdd +++k+k+++++ll++

Q: 925   DLFSLGIIFFEMSYhPMVTASERIFVLNQLRDptsPKFPEDFDDgEHTKQKSVISWLLNH  984

         ********************************9999************************

S: 276   dpkeRpsasellksell  292

         dp++Rp+a+ellksell

Q: 985   DPAKRPTATELLKSELL  1001

         **************986

Domain Sequence
(FASTA)

FEELQLLGKG AFGAVIKVQN KLDGCCYAVK RIPINPASRH FRRIKGEVTL LSRLHHENIV 60

RYYNAWIERH ERPACPATPP PNSGPQAQDG QALAQPAGDS DPDGPGSVEA AAPPPILSSS 120

VEWSTSGERS ASTRFPAAGP DSSSDEDDDE EQGVFSQSFL PASDSDSDII FDNEDENSKS 180

QNQDEDCNGK NSCHESEPPA TTEAVHYLYI QMEYCEKSTL RDTIDQGLYR DTVRLWRLFR 240

EILDGLAYIH EKGMIHRDLK PVNIFLDSDD HVKIGDFGLA TDHLAFAADG KQDDTSGDHL 300

IKSDPSGHLT GMVGTALYVS PEVQGSTKSA YNQKVDLFSL GIIFFEMSYH PMVTASERIF 360

VLNQLRDPTS PKFPEDFDDG EHTKQKSVIS WLLNHDPAKR PTATELLKSE LL 412

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004694	; F:eukaryotic translation initiation factor 2alpha kinase activity
GO:0000049	; F:tRNA binding
GO:0009267	; P:cellular response to starvation
GO:0030968	; P:endoplasmic reticulum unfolded protein response
GO:0017148	; P:negative regulation of translation
GO:0043558	; P:regulation of translational initiation in response to stress

KEGG

bta:513829

;

InterPros

IPR004154	; Anticodon-bd.
IPR026920	; EIF2AK4.
IPR024435	; GCN2_anticodon-bd_dom.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR006575	; RWD-domain.
IPR008271	; Ser/Thr_kinase_AS.
IPR016255	; Ser/Thr_kinase_GCN2.
IPR016135	; UBQ-conjugating_enzyme/RWD.

Pfam

PF12745	; HGTP_anticodon2; 1.
PF00069	; Pkinase; 3.
PF05773	; RWD; 1.

SMARTs

SM00591

; RWD; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50908	; RWD; 1.

Prints

Created Date

20-Feb-2013