EKS-BOT-00152
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-BOT-00152
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/NDR506.22.9E-152665970306
StatusUnreviewed
Ensembl ProteinENSBTAP00000019161
UniProt AccessionE1B9F9;
Protein Name
Protein Synonyms/Alias
Gene NameLATS2
Gene Synonyms/Alias
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSBTAG00000014406ENSBTAP00000019161ENSBTAT00000019161
OrganismBos taurus
Functional Description
Protein Length1086
Protein Sequence
(FASTA)
MRPKTFPATT YSGNSRQRLQ EIREGLKQPP VGPGSDAALD AKVLGGKVLG GKDTARQQQM 60
RSAPKFGPYQ KALREIRYSL LPFANESGTS AATEVNRQML QELVDAGCDQ EMAGRALKQT 120
GSRSIEAALE FISKMGYLEP GKEQIVRVVK QTSPDLWGSL KGRLISLILK HTCFPLCGLG 180
EPAARWQVAP EYGASGTGVG KPPPPYPRGG REPSPTSTAP HAPGEGQSPQ HPCLLVSGCF 240
SSWVEQMEPF GGPEAPGGAI STSRPLGSRG LCGSSSPSPS PAGSPGAGAS SSTGGLCRGS 300
CGAGRRVPDW RRGAFCPRPS NAASVSARRE GPGAGPRATE AELRSTGRAF PALHAGGRAG 360
FRGPRRPGGS ASPLPGLPLR RRRASLSSAP AQGLRGRRGA APARTGLGAE RFEPGAPAWP 420
GAGLARRDSL PKPGPSRTGS FSGAAAPPNA VTAVTAARIL HPVRSVRVLR PEPQTAVGPS 480
HPAWAPAPPP DGPEPAEELA GGAEARGRPP PYPRHLLRPQ ARAEPLDVDG LCAGLQQGLR 540
GGRAAESPDG SPTSPGATKA DRAGRDRKQI QTSPVPVRRG GRDEDRRESR IKSYSPSAFK 600
FFMEQHVENV LKTHQQKVAR RLQLEQEMAK AGLCEAEQEQ MRKILYQKES NYNRLKRAKM 660
DKSMFVKVKT LGVGAFGEVC LACKVDTHAL YAMKTLRKKD VLNRNQVAHV KAERDILAEA 720
DNEWVVKLYY SFQDKDSLYF VMDYIPGGDM MSLLIRMEVF PEHLARFYIA ELTLAVESVH 780
RMGFIHRDIK PDNILIDLDG HIKLTDFGLC TGFRWTHNSK YYQKGSHSRQ DSMEPSDLWD 840
DVSNCRCGDR LKTLEQRARR QHQRCLAHSL VGTPNYIAPE VLLRKGYTQL CDWWSVGVIL 900
FEMLVGQPPF LAPTPTETQL KVINWESTLH IPAQVELSPE ARDLIAKLCC AAEHRLGRNG 960
ADDLKAHPFL GAIDFSSDIR RQPAPYVPTI SHPMDTSNFD PVDEEGPWQD GSEDSSKAWD 1020
ALGPAGSRHP EHAFYEFTFR RFFDDNGHPF RCPKPAVAEA VTEAEQPASV GPALGAQAGG 1080
CQPVYV 1086
Nucleotide Sequence
(FASTA)
ATGCGGCCGA AGACCTTCCC CGCCACCACA TACTCGGGGA ACAGCCGGCA GCGGCTGCAG 60
GAGATCCGGG AGGGGCTGAA GCAGCCGCCT GTGGGGCCGG GCAGTGACGC CGCCCTGGAC 120
GCCAAGGTCC TAGGTGGCAA GGTCTTGGGG GGCAAGGACA CTGCCCGGCA GCAGCAGATG 180
AGGAGTGCCC CGAAGTTCGG GCCATACCAG AAAGCCCTGC GGGAGATCAG ATACTCCTTG 240
CTCCCCTTTG CTAACGAGTC AGGCACCTCG GCCGCCACAG AAGTGAACCG ACAGATGCTG 300
CAGGAGCTGG TGGATGCGGG CTGTGACCAG GAGATGGCGG GCAGGGCCCT CAAGCAGACT 360
GGCAGTCGCA GCATCGAGGC CGCCCTGGAG TTCATCAGTA AGATGGGCTA CCTGGAGCCA 420
GGCAAGGAGC AGATCGTGCG GGTCGTCAAG CAGACCTCCC CAGACTTGTG GGGGAGTCTT 480
AAGGGGAGGC TTATTTCATT GATTCTAAAA CACACTTGTT TCCCACTCTG TGGGCTCGGA 540
GAGCCAGCTG CACGGTGGCA GGTGGCTCCA GAGTACGGTG CCTCAGGCAC AGGTGTGGGA 600
AAGCCACCCC CACCATACCC CAGGGGAGGG AGGGAACCTT CCCCCACCTC CACCGCACCC 660
CATGCCCCTG GGGAGGGCCA GTCGCCTCAG CACCCCTGCC TGCTAGTCAG TGGGTGTTTC 720
TCTTCCTGGG TAGAGCAGAT GGAGCCATTT GGGGGACCTG AGGCCCCTGG GGGGGCAATA 780
AGCACGTCCA GGCCCTTGGG ATCTCGGGGT CTGTGTGGCA GCTCATCCCC CAGCCCCAGC 840
CCTGCGGGCA GCCCTGGCGC TGGTGCTTCA TCTTCCACTG GGGGGCTCTG CCGGGGCTCC 900
TGCGGCGCGG GGAGGAGGGT ACCCGACTGG CGACGCGGGG CCTTCTGCCC ACGGCCCTCT 960
AACGCCGCCT CCGTCTCTGC CCGCAGGGAA GGGCCTGGCG CCGGCCCCCG GGCCACGGAG 1020
GCCGAGCTTC GAAGCACCGG GCGAGCCTTT CCCGCCCTTC ACGCAGGTGG CCGGGCCGGC 1080
TTTCGAGGGC CCCGCCGCCC TGGAGGAAGC GCCTCGCCCT TACCCGGACT TCCTCTTCGC 1140
CGGCGTCGGG CCTCCTTGTC GTCCGCACCC GCCCAAGGGC TACGCGGCCG CCGGGGAGCC 1200
GCCCCCGCGC GCACCGGCCT GGGCGCCGAG CGTTTCGAGC CGGGTGCGCC GGCCTGGCCG 1260
GGCGCCGGCC TGGCCCGGCG TGACTCGCTG CCCAAGCCGG GCCCCAGCCG CACCGGTTCG 1320
TTCAGCGGCG CCGCGGCCCC GCCCAATGCC GTGACGGCCG TCACGGCCGC GCGCATCCTG 1380
CACCCGGTGC GGAGCGTGCG CGTGTTGCGG CCTGAACCCC AGACGGCCGT GGGGCCCTCG 1440
CACCCCGCTT GGGCGCCGGC GCCCCCACCC GACGGCCCTG AGCCCGCGGA GGAGCTCGCA 1500
GGGGGCGCCG AGGCGCGGGG CCGGCCCCCG CCTTATCCGC GGCACCTGCT GCGGCCACAG 1560
GCCCGCGCCG AGCCGCTCGA CGTGGACGGG CTGTGCGCCG GGCTGCAACA GGGCCTCCGG 1620
GGCGGCCGTG CCGCCGAGTC CCCCGACGGC AGCCCCACGA GCCCCGGGGC CACCAAAGCC 1680
GACAGGGCGG GCCGGGACAG AAAGCAGATC CAGACATCCC CGGTGCCCGT GCGCAGGGGC 1740
GGCCGCGACG AGGACAGGCG CGAGTCGCGC ATCAAGAGCT ACTCGCCGTC AGCCTTCAAG 1800
TTCTTCATGG AGCAGCACGT GGAGAACGTG CTCAAGACCC ACCAGCAGAA GGTGGCGCGC 1860
CGGCTGCAGC TGGAGCAGGA GATGGCGAAG GCCGGGCTCT GTGAGGCCGA GCAGGAGCAG 1920
ATGAGGAAGA TTCTTTACCA GAAGGAGTCC AATTACAATA GGCTCAAGCG GGCCAAGATG 1980
GACAAGTCCA TGTTTGTGAA GGTGAAGACC CTGGGCGTTG GCGCCTTTGG GGAGGTGTGC 2040
CTGGCCTGCA AGGTGGACAC GCACGCGCTG TATGCCATGA AGACCCTTAG AAAGAAGGAC 2100
GTCCTGAACC GCAACCAGGT GGCCCACGTC AAGGCAGAGC GGGACATCCT GGCGGAGGCG 2160
GACAATGAAT GGGTAGTCAA GCTCTACTAC TCCTTCCAGG ACAAGGACAG CCTGTACTTT 2220
GTGATGGACT ACATCCCGGG CGGGGACATG ATGAGCCTGC TCATCCGCAT GGAGGTGTTC 2280
CCCGAGCACC TGGCGCGCTT CTACATTGCT GAGCTGACGC TGGCCGTCGA GAGCGTTCAC 2340
AGGATGGGCT TCATCCACCG GGACATCAAG CCCGACAACA TCCTCATAGA CCTTGACGGC 2400
CACATCAAGC TGACAGACTT TGGCCTCTGC ACTGGGTTCA GGTGGACCCA CAACTCCAAA 2460
TACTACCAGA AAGGGAGTCA CTCCCGGCAG GACAGCATGG AGCCCAGCGA CCTCTGGGAC 2520
GATGTGTCTA ATTGCCGGTG TGGAGACCGG CTCAAGACCC TGGAGCAGAG GGCGCGGAGG 2580
CAGCACCAGC GGTGTCTGGC TCACTCCCTG GTTGGGACCC CAAACTACAT CGCCCCGGAA 2640
GTGCTCCTCC GGAAAGGTTA CACCCAGCTC TGCGACTGGT GGAGTGTCGG CGTGATTCTC 2700
TTTGAGATGC TAGTGGGGCA GCCGCCGTTC CTGGCGCCGA CGCCCACGGA GACCCAGCTG 2760
AAGGTGATTA ACTGGGAGAG CACGCTGCAC ATCCCCGCGC AGGTGGAGCT GAGCCCCGAG 2820
GCCCGGGACC TCATCGCCAA GCTGTGCTGT GCAGCTGAGC ACCGGTTAGG CCGAAACGGG 2880
GCCGATGATC TGAAGGCCCA CCCATTCCTG GGCGCCATCG ACTTCTCCAG CGACATCCGG 2940
AGGCAACCGG CCCCCTACGT ACCCACCATC AGCCACCCCA TGGATACATC CAACTTTGAC 3000
CCAGTGGATG AGGAGGGCCC CTGGCAGGAC GGCAGTGAGG ACAGCTCTAA AGCCTGGGAC 3060
GCACTGGGCC CTGCGGGCAG CCGGCACCCT GAGCACGCCT TTTACGAGTT CACCTTCCGG 3120
AGGTTCTTCG ATGACAATGG TCACCCGTTC CGATGCCCCA AGCCTGCAGT GGCTGAAGCC 3180
GTGACTGAGG CTGAGCAGCC AGCTTCGGTG GGTCCAGCCC TGGGGGCGCA GGCCGGGGGC 3240
TGCCAGCCCG TGTACGTGTA G 3261
Domain Profile
S: 1     feklkvigkGafGevrlvrkkdtkevyalkilrkkdllkknqvahvkaerdilaeadsew  60
         f k+k++g+GafGev+l++k dt+++ya+k+lrkkd+l++nqvahvkaerdilaead+ew
Q: 665   FVKVKTLGVGAFGEVCLACKVDTHALYAMKTLRKKDVLNRNQVAHVKAERDILAEADNEW  724
         789*********************************************************
S: 61    vvklyysfqdkenlylvmeylPGGdlmtllikkeilkeelarfyiaelvlavesvhklGf  120
         vvklyysfqdk++ly+vm+y+PGGd+m+lli++e+++e+larfyiael+lavesvh++Gf
Q: 725   VVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPEHLARFYIAELTLAVESVHRMGF  784
         ************************************************************
S: 121   ihrdlkPdnllidakGhikltdfGlctGlkkthrseyykelekakeddlease.......  173
         ihrd+kPdn+lid +GhikltdfGlctG+++th+s+yy++ +++++d++e s+       
Q: 785   IHRDIKPDNILIDLDGHIKLTDFGLCTGFRWTHNSKYYQKGSHSRQDSMEPSDlwddvsn  844
         **************************************************9999******
S: 174   .....elkvlerrkkkknrrllayslvGtpdyiapevlekkgynklcdwWslGvilyeml  228
              +lk+le+r++++++r+la+slvGtp+yiapevl++kgy++lcdwWs+Gvil+eml
Q: 845   crcgdRLKTLEQRARRQHQRCLAHSLVGTPNYIAPEVLLRKGYTQLCDWWSVGVILFEML  904
         ************************************************************
S: 229   vGypPflaetpqetykkvinwketlkfpeevelseeakdlierliadaekrlgkkGvdei  288
         vG+pPfla tp+et+ kvinw++tl++p++vels+ea+dli +l++ ae+rlg++G+d++
Q: 905   VGQPPFLAPTPTETQLKVINWESTLHIPAQVELSPEARDLIAKLCCAAEHRLGRNGADDL  964
         ************************************************************
S: 289   kkhpff  294
         k+hpf+
Q: 965   KAHPFL  970
         ****95
Domain Sequence
(FASTA)
FVKVKTLGVG AFGEVCLACK VDTHALYAMK TLRKKDVLNR NQVAHVKAER DILAEADNEW 60
VVKLYYSFQD KDSLYFVMDY IPGGDMMSLL IRMEVFPEHL ARFYIAELTL AVESVHRMGF 120
IHRDIKPDNI LIDLDGHIKL TDFGLCTGFR WTHNSKYYQK GSHSRQDSME PSDLWDDVSN 180
CRCGDRLKTL EQRARRQHQR CLAHSLVGTP NYIAPEVLLR KGYTQLCDWW SVGVILFEML 240
VGQPPFLAPT PTETQLKVIN WESTLHIPAQ VELSPEARDL IAKLCCAAEH RLGRNGADDL 300
KAHPFL 306
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00145
EKS-ANC-00145
EKS-CAJ-00156
EKS-CAF-00160
EKS-CAP-00152
EKS-DAR-00440
EKS-DIO-00082
EKS-EQC-00150
EKS-GAG-00130
EKS-GAA-00181
EKS-HOS-00158
EKS-ICT-00146
EKS-LAC-00163
EKS-LOA-00152
EKS-MEG-00120
EKS-MOD-00152
EKS-MUM-00157
EKS-MUP-00157
EKS-MYL-00162
EKS-NOL-00145
EKS-ORN-00189
EKS-ORC-00143
EKS-ORL-00177
EKS-OTG-00158
EKS-PAT-00143
EKS-POA-00149
EKS-SAH-00147
EKS-SOA-00027
EKS-TAG-00180
EKS-TAR-00198
EKS-TEN-00191
EKS-XET-00141
EKS-XIM-00183
Gene Ontology
GO:0005634; C:nucleus
GO:0000922; C:spindle pole
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0034613; P:cellular protein localization
GO:0000082; P:G1/S transition of mitotic cell cycle
GO:0035329; P:hippo signaling cascade
GO:0009755; P:hormone-mediated signaling pathway
GO:0007243; P:intracellular protein kinase cascade
GO:0030216; P:keratinocyte differentiation
GO:0090090; P:negative regulation of canonical Wnt receptor signaling pathway
GO:0045736; P:negative regulation of cyclin-dependent protein kinase activity
GO:0046620; P:regulation of organ growth
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
IPR009060; UBA-like.
IPR015940; UBA/transl_elong_EF1B_N_euk.
Pfam
PF00069; Pkinase; 2.
PF00433; Pkinase_C; 1.
SMARTs
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS50030; UBA; 1.
Prints
Created Date20-Feb-2013