EKS-BOT-00392

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-BOT-00392

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	337.8	5.9E-101	1060	1323	264

Status

Unreviewed

Ensembl Protein

ENSBTAP00000042949

UniProt Accession

E1BGV8;

Protein Name

Protein Synonyms/Alias

Gene Name

YSK4

Gene Synonyms/Alias

YSK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000014409	ENSBTAP00000019164	ENSBTAT00000019164
ENSBTAG00000014409	ENSBTAP00000042949	ENSBTAT00000045570

Organism

Bos taurus

Functional Description

Protein Length

1327

Protein Sequence
(FASTA)

MNSMPKPAER HAESLLDICH DTNSSPTDMM TVTKNQNIIL QSIGSSEESD QDDDCSHSIL 60

ISEEGDPSGD GQDWQPRTEG VEIIVTFPRD VIHPQEMGQE ELPENNQITS EHQEWTPAHS 120

VSLPKNIEMV GFRTKMVTTE PLLAKKEERS QELFNMNLGF LLPRPHLETI ISKSVARDVP 180

HFLKGQPRKS EEFSISDMKY SSRRIEFSLP PLSCLPMRSG LLTIPLSHKD QKARERNMPR 240

LVSFIPKFSE PISQSDEFRP SNKQKEAPIK MLADQTLRSF DGSIWSRNMC SFWKAHRHRQ 300

HLEKEASRKS KEREGCVNIE VFHFEKGQSL VSLENFKEGS FPTGREEDTD CHGNELRRAE 360

ENAPSLSSGK KGDSGARNYE QDSEVGYTKP IKFQEALPSD IGLSQDEGTK SDKADSKSAS 420

ALKGEAIELD HISEDYTLRK SLSDAVTDGP IEKLSEDHSS METSTKISVA ETTKPGMNGT 480

VPLIHITFPG DETPKEPAIT KPSLQKRKGI LRSNSSLNIL AHQENDRHKV KTQRNKLDSK 540

TKTSNRTPQN FMISTEVSVK PTTHKTSIKT QVFPALGLVD PRPWQPPKFQ RRMPQTERKQ 600

SAYQALKPKK PSFPCLYKNP GIEKSSVPLS AQPAEPRLNY LDLKYSDMFK EINSTANGPG 660

IYEMFGTPVY CHMREAERHE NKYHREICSA SSGRCITNKC RSSHSERSSN SRNRLSQKRP 720

HSKPPKSSLG IKQKHRSLIS KEKDFQAVGS TLQDAENGDG ISETGWQIKS SGNDFLSLKD 780

EVQPMNLVQA HEQFTEQNDF FPVSDLSIVE EVSMEESADE EDISNNQILA TRLRDLHQLE 840

ELRHQTPFVL SENSWAVPSE KSSNMHVLQE EQKVASPGET NANQILTNNV DFDSFSDKSK 900

TLRSFSSQEK QESVTSQAYQ HWALFLDHDS LTNESIPYQT LGKTLNEADS ISQEILDSVK 960

NEELTDELLG CLAAELLALD EKDDNSCQIM ADETDPESRD FVLSKRGNTM QELGRETTNV 1020

KIQRYSNGFR RYDKEERFFN PHEKKTFSEN SLKYEESILW TKGEILGKGA YGTVYCGLTS 1080

QGQLIAVKQV ALDTSDKLAT VKEYQKLQEE VDLLKALKHV NIVAYLGTCL EENILSIFME 1140

FVPGGSISSI INRFGPLPEM VFCKYTEQIL QGVAYLHENC VVHRDIKGNN VMLMPTGIIK 1200

LIDFGCAKRL AWAGLNGTHS DMLKSMHGTP YWMAPEVINE SGYGRKSDIW SIGCTVFEMA 1260

TGKPPLASMD RMAAMFYIGA HRGLMPPLPD CFSENAADFV RACLTRDQHE RPSAVQLLKH 1320

SFLKRNH 1327

Nucleotide Sequence
(FASTA)

ATGAATTCTA TGCCAAAACC AGCAGAAAGA CATGCTGAAT CATTGCTTGA CATTTGTCAT 60

GATACAAACT CTTCTCCAAC TGATATGATG ACAGTTACTA AAAACCAAAA TATAATCTTG 120

CAGAGCATTG GCAGCAGTGA GGAGTCTGAC CAAGATGATG ACTGCTCTCA TTCCATATTG 180

ATTAGTGAAG AAGGAGATCC AAGTGGTGAT GGACAAGACT GGCAACCTAG GACAGAAGGT 240

GTTGAGATTA TTGTTACTTT TCCGAGAGAT GTCATCCATC CCCAAGAAAT GGGCCAAGAA 300

GAATTACCAG AAAACAATCA GATAACCTCA GAGCATCAGG AATGGACACC AGCACATTCT 360

GTTTCACTTC CAAAAAACAT TGAGATGGTG GGCTTCAGGA CAAAAATGGT AACCACGGAG 420

CCTTTACTTG CAAAGAAAGA GGAACGTTCC CAGGAACTCT TCAATATGAA CTTGGGCTTT 480

TTGTTGCCAA GACCTCACTT AGAAACGATA ATCTCCAAGT CTGTAGCCAG AGATGTTCCT 540

CACTTTCTGA AGGGGCAGCC AAGGAAATCT GAAGAGTTTT CTATCTCTGA CATGAAGTAT 600

AGTAGCCGAA GAATTGAGTT CTCTCTGCCA CCACTATCAT GTCTGCCCAT GAGATCTGGT 660

CTCCTTACTA TACCCCTAAG TCACAAGGAT CAAAAAGCGA GAGAAAGAAA TATGCCACGC 720

CTTGTATCTT TCATACCTAA GTTCTCAGAG CCTATTAGCC AATCTGATGA ATTTAGACCA 780

TCAAATAAGC AGAAGGAAGC ACCGATCAAG ATGTTAGCAG ATCAGACTCT CAGATCCTTT 840

GACGGTTCTA TTTGGTCCAG AAACATGTGC TCTTTTTGGA AGGCTCACCG TCACAGACAA 900

CACCTGGAAA AGGAAGCGAG TAGGAAATCC AAGGAAAGAG AAGGATGTGT CAACATTGAA 960

GTCTTTCACT TTGAAAAAGG ACAATCTTTA GTGTCCCTGG AGAATTTCAA GGAAGGCAGC 1020

TTTCCTACAG GTAGGGAAGA GGATACTGAC TGCCATGGTA ATGAACTGAG AAGAGCAGAA 1080

GAGAACGCTC CATCTCTTTC ATCGGGAAAG AAAGGGGATT CAGGAGCCAG AAACTATGAA 1140

CAAGATTCAG AAGTTGGATA TACCAAGCCA ATCAAGTTCC AAGAAGCCCT GCCATCAGAT 1200

ATAGGTCTAA GCCAGGATGA AGGGACTAAA AGTGATAAAG CTGATTCAAA AAGTGCTTCA 1260

GCACTTAAAG GCGAAGCAAT TGAACTAGAC CATATTTCAG AAGATTACAC TCTTCGCAAA 1320

AGTTTGTCTG ATGCAGTCAC TGATGGCCCC ATTGAAAAGC TCTCAGAAGA TCATAGCAGC 1380

ATGGAGACAA GCACAAAAAT ATCAGTAGCA GAAACAACCA AACCAGGAAT GAATGGGACG 1440

GTGCCTCTTA TCCACATCAC TTTCCCTGGA GATGAAACTC CCAAAGAACC AGCAATAACC 1500

AAACCAAGCC TCCAAAAACG AAAGGGCATC CTTCGTAGCA ATAGTAGCTT GAACATACTT 1560

GCACACCAAG AAAATGACAG GCATAAGGTG AAAACCCAGA GAAATAAGTT AGATTCAAAG 1620

ACCAAGACCA GTAACAGGAC ACCTCAAAAT TTCATGATTT CCACTGAAGT TTCTGTGAAG 1680

CCTACCACGC ATAAAACCAG TATAAAAACT CAAGTTTTTC CTGCTTTGGG GCTTGTGGAT 1740

CCCAGACCTT GGCAACCACC CAAGTTTCAA AGGAGAATGC CACAGACAGA AAGGAAGCAA 1800

TCTGCTTACC AGGCTTTGAA ACCTAAAAAG CCGTCATTCC CTTGCCTCTA TAAAAATCCA 1860

GGAATAGAAA AGTCTTCTGT TCCTCTCTCT GCTCAACCAG CAGAGCCAAG ACTGAATTAC 1920

TTAGATCTGA AGTATAGTGA CATGTTCAAA GAGATCAATT CAACTGCGAA TGGGCCTGGA 1980

ATCTATGAAA TGTTTGGAAC TCCTGTTTAT TGTCACATGC GAGAGGCTGA ACGGCATGAA 2040

AACAAGTATC ACCGAGAGAT ATGCTCAGCT TCATCAGGCA GATGTATCAC CAATAAATGT 2100

CGATCTTCAC ACAGTGAGAG GAGCAGCAAT AGCCGAAACA GACTTTCTCA GAAAAGACCG 2160

CATAGTAAAC CCCCCAAATC TTCTCTTGGC ATTAAACAAA AGCACAGAAG TTTAATTTCT 2220

AAAGAAAAGG ATTTCCAGGC TGTAGGTAGT ACCCTACAAG ATGCTGAAAA TGGTGATGGC 2280

ATTTCAGAAA CAGGGTGGCA GATTAAGTCT TCAGGAAATG ACTTTCTATC TTTGAAAGAT 2340

GAAGTTCAGC CCATGAACTT GGTTCAGGCT CATGAGCAGT TCACTGAACA GAATGATTTC 2400

TTTCCTGTCT CAGATTTGTC CATTGTTGAA GAAGTCTCTA TGGAAGAGTC GGCTGATGAA 2460

GAAGACATTT CTAACAATCA GATACTTGCC ACGCGCCTCA GAGATCTGCA TCAGCTTGAA 2520

GAGCTACGCC ACCAGACCCC ATTTGTCCTT TCAGAAAACA GCTGGGCAGT ACCCAGTGAG 2580

AAGAGTTCCA ACATGCATGT ACTGCAAGAA GAGCAGAAGG TAGCATCTCC CGGTGAAACA 2640

AATGCCAACC AAATTTTAAC TAACAATGTA GACTTTGATA GTTTTTCAGA TAAGTCAAAA 2700

ACTCTTAGGA GTTTCTCTTC CCAAGAGAAA CAAGAAAGTG TAACTTCTCA AGCATATCAA 2760

CACTGGGCAC TGTTTTTGGA TCATGATAGT TTAACTAATG AGTCAATTCC ATATCAAACA 2820

CTTGGAAAAA CTTTAAATGA GGCAGATTCA ATTTCCCAAG AAATTCTAGA CTCTGTAAAG 2880

AATGAAGAAT TGACAGATGA ACTCTTAGGT TGTCTAGCTG CAGAACTATT AGCTCTTGAT 2940

GAGAAAGATG ACAACTCTTG CCAAATAATG GCAGATGAAA CAGATCCTGA AAGCCGAGAT 3000

TTTGTCCTCA GCAAGAGAGG AAATACCATG CAAGAATTAG GTAGAGAGAC AACAAATGTC 3060

AAAATACAGA GATACAGTAA TGGCTTCAGG AGATATGACA AAGAGGAGAG ATTTTTCAAC 3120

CCACATGAAA AAAAGACATT TTCTGAAAAT AGTTTAAAGT ACGAAGAATC TATCCTGTGG 3180

ACCAAGGGTG AGATCCTCGG GAAGGGAGCA TATGGCACAG TATATTGTGG TCTTACTAGC 3240

CAAGGACAGC TAATAGCTGT AAAACAGGTG GCTTTGGATA CCTCTGATAA ATTAGCTACT 3300

GTAAAAGAAT ATCAGAAACT GCAGGAAGAA GTCGATTTGC TCAAAGCCTT GAAACATGTC 3360

AACATTGTGG CCTATTTGGG GACATGCTTG GAGGAAAACA TCTTAAGCAT TTTCATGGAG 3420

TTTGTTCCTG GTGGCTCCAT CTCTAGTATT ATAAACCGTT TTGGGCCATT GCCTGAGATG 3480

GTGTTCTGCA AATATACAGA ACAAATTCTG CAAGGTGTTG CTTATCTCCA TGAGAACTGT 3540

GTGGTGCATA GAGATATCAA AGGAAATAAT GTTATGCTTA TGCCAACTGG AATCATAAAG 3600

CTGATTGACT TTGGCTGTGC CAAGCGTTTG GCCTGGGCTG GCCTAAATGG CACCCACAGT 3660

GACATGCTCA AGTCCATGCA TGGGACTCCA TATTGGATGG CCCCAGAAGT CATCAATGAG 3720

TCTGGCTATG GACGGAAGTC AGACATCTGG AGCATTGGCT GCACTGTGTT TGAGATGGCC 3780

ACTGGGAAGC CTCCACTGGC TTCCATGGAC AGGATGGCAG CCATGTTTTA CATTGGCGCA 3840

CACCGAGGGC TGATGCCTCC TTTACCAGAT TGCTTCTCAG AAAACGCAGC AGACTTTGTG 3900

CGTGCATGCC TCACCAGGGA CCAGCATGAG CGACCCTCTG CTGTTCAGCT TCTGAAGCAC 3960

TCCTTCTTGA AGAGAAATCA CTGA 3984

Domain Profile

S: 1     wqkrevigkGsfgsvyaaldvdtgellavKeveikp.ekksekkevkalkeEikllkelk  59

         w+k+e++gkG++g+vy++l+ ++g+l+avK+v++++ +k ++ ke+++l+eE++llk+lk

Q: 1060  WTKGEILGKGAYGTVYCGLT-SQGQLIAVKQVALDTsDKLATVKEYQKLQEEVDLLKALK  1118

         89*****************8.89***********8614556678****************

S: 60    HenivkyyGveveeeelkiflEyvegGslssllekygkleesvikkytkqileglayLHe  119

         H niv y+G++ ee+ l+if+E+v+gGs+ss+++++g+l e+v++kyt+qil+g+ayLHe

Q: 1119  HVNIVAYLGTCLEENILSIFMEFVPGGSISSIINRFGPLPEMVFCKYTEQILQGVAYLHE  1178

         ************************************************************

S: 120   kkivHRDiKgaNilldssgvvklsDFGaskrlaelntkaae...lesltGtlaymaPEvi  176

         +++vHRDiKg+N++l+ +g++kl DFG++krla++  + ++   l+s++Gt+++maPEvi

Q: 1179  NCVVHRDIKGNNVMLMPTGIIKLIDFGCAKRLAWAGLNGTHsdmLKSMHGTPYWMAPEVI  1238

         **********************************999988877899**************

S: 177   kkkekgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakk.tkPeipeklsee  235

         +++  gygrk+DiWs+gc+v+em+tgk+P a++ +++a+mf +ga++  +P++p+ +se+

Q: 1239  NES--GYGRKSDIWSIGCTVFEMATGKPPLASM-DRMAAMFYIGAHRgLMPPLPDCFSEN  1295

         988..****************************.9**********9979***********

S: 236   gkdflekcleldpkkrpsaeeLLkhefl  263

         + df++ cl++d+++rpsa +LLkh+fl

Q: 1296  AADFVRACLTRDQHERPSAVQLLKHSFL  1323

         **************************96

Domain Sequence
(FASTA)

WTKGEILGKG AYGTVYCGLT SQGQLIAVKQ VALDTSDKLA TVKEYQKLQE EVDLLKALKH 60

VNIVAYLGTC LEENILSIFM EFVPGGSISS IINRFGPLPE MVFCKYTEQI LQGVAYLHEN 120

CVVHRDIKGN NVMLMPTGII KLIDFGCAKR LAWAGLNGTH SDMLKSMHGT PYWMAPEVIN 180

ESGYGRKSDI WSIGCTVFEM ATGKPPLASM DRMAAMFYIG AHRGLMPPLP DCFSENAADF 240

VRACLTRDQH ERPSAVQLLK HSFL 264

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013