EKS-BOT-00160

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-BOT-00160

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/RSKb	496.3	1.9E-149	418	675	258

Status

Unreviewed

Ensembl Protein

ENSBTAP00000037744

UniProt Accession

A4IFF4;

Protein Name

Ribosomal protein S6 kinase

Protein Synonyms/Alias

Gene Name

RPS6KA1

Gene Synonyms/Alias

RPS6KA1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000014447	ENSBTAP00000037744	ENSBTAT00000037922

Organism

Bos taurus

Functional Description

Protein Length

735

Protein Sequence
(FASTA)

MPLAQLKEPW PLMELVPLDP ENGQASGEEA GLQPSKDEGV LKEISITHHV KAGSEKADPS 60

HFELLKVLGQ GSFGKVFLVR KVTRPDSGHL YAMKVLKKAT LKVRDRVRTK MERDILADVN 120

HPFVVKLHYA FQTEGKLYLI LDFLRGGDLF TRLSKEVMFT EEDVKFYLAE LALGLDHLHS 180

LGIIYRDLKP ENILLDEEGH IKLTDFGLSK EAIDHEKKAY SFCGTVEYMA PEVVNRQGHT 240

HSADWWSYGV LMFEMLTGSL PFQGKDRKET MTLILKAKLG MPQFLSTEAQ SLLRALFKRN 300

PANRLGSGPD GAEEIKRHVF YSTIDWNKLY RREIKPPFKP AVAQPDDTFY FDTEFTSRTP 360

KDSPGIPPSA GAHQLFRGFS FVATGLMEDD GKPRATQAPL HAVVQQLHGK NLVFSDGYVV 420

KETIGVGSYS ECKRCVHKAT NMEYAVKVID KSKRDPSEEI EILLRYGQHP NIITLKDVYD 480

DGKHVYLVTE LMRGGELLDK ILRQKFFSER EASFVLHTIS KTVEYLHSQG VVHRDLKPSN 540

ILYVDESGNP ECLRICDFGF AKQLRAENGL LMTPCYTANF VAPEVLKRQG YDEGCDIWSL 600

GILLYTMLAG YTPFANGPSD TPEEILTRIG SGKFTLSGGN WNTVSDTAKD LVSKMLHVDP 660

HQRLTAKQVL QHPWITQKDK LPQSQLSHQD LQLVKGAMAA TYSALNSSKP TPQLKPIESS 720

ILAQRRVRKL PSTTL 735

Nucleotide Sequence
(FASTA)

ATGCCGCTCG CCCAGCTCAA GGAGCCCTGG CCGCTCATGG AGCTGGTGCC GCTGGACCCG 60

GAGAATGGTC AAGCCTCAGG GGAGGAAGCT GGGCTTCAGC CATCCAAGGA TGAGGGCGTT 120

CTCAAGGAGA TCTCCATCAC ACACCATGTC AAGGCTGGCT CGGAGAAGGC CGACCCATCC 180

CATTTTGAGC TCCTCAAGGT CCTGGGCCAA GGATCCTTTG GCAAAGTCTT CCTGGTACGA 240

AAGGTCACCC GACCTGACAG TGGACACTTG TACGCCATGA AGGTACTAAA GAAGGCAACG 300

CTGAAAGTGC GTGACCGCGT TCGGACCAAA ATGGAGAGAG ACATCCTGGC TGACGTAAAC 360

CACCCGTTTG TGGTGAAGCT GCACTACGCC TTCCAGACTG AGGGCAAGCT CTACCTTATC 420

CTGGACTTCC TGCGTGGCGG GGACCTCTTC ACCCGGCTCT CTAAAGAGGT TATGTTCACG 480

GAGGAGGATG TGAAGTTTTA CCTGGCCGAG CTGGCTTTGG GCCTGGATCA CCTGCACAGT 540

CTAGGCATCA TTTACAGAGA CCTGAAGCCT GAGAACATCC TTCTGGATGA GGAAGGCCAC 600

ATCAAACTCA CTGACTTCGG TTTGAGCAAG GAGGCCATCG ACCATGAGAA GAAGGCCTAT 660

TCCTTCTGCG GGACAGTGGA GTACATGGCC CCTGAGGTTG TCAACCGCCA GGGCCATACC 720

CACAGTGCAG ACTGGTGGTC CTATGGGGTG TTGATGTTTG AGATGCTGAC GGGCTCCCTG 780

CCCTTCCAGG GGAAGGACCG GAAGGAGACT ATGACCCTGA TTCTGAAGGC AAAGCTGGGC 840

ATGCCCCAGT TTCTAAGCAC GGAAGCCCAG AGCCTCCTGA GGGCCCTGTT CAAGCGGAAT 900

CCTGCCAACC GGCTCGGCTC CGGCCCTGAT GGGGCAGAGG AAATCAAGCG GCATGTCTTC 960

TACTCCACCA TTGACTGGAA TAAGCTGTAC CGGCGTGAGA TCAAGCCACC CTTCAAGCCG 1020

GCCGTGGCGC AACCCGATGA CACCTTCTAC TTTGACACTG AGTTCACGTC CCGCACACCC 1080

AAGGACTCCC CAGGCATCCC TCCCAGTGCC GGTGCCCATC AGCTGTTCCG CGGCTTCAGT 1140

TTCGTGGCCA CCGGCCTAAT GGAGGATGAC GGCAAGCCTC GGGCCACACA GGCGCCCCTG 1200

CACGCGGTGG TACAGCAATT ACATGGGAAG AACCTGGTTT TTAGCGATGG CTACGTGGTA 1260

AAAGAGACGA TTGGTGTGGG CTCCTACTCT GAGTGCAAGC GCTGTGTCCA CAAAGCCACC 1320

AACATGGAGT ATGCTGTCAA GGTCATCGAC AAGAGCAAGC GAGACCCCTC GGAAGAGATT 1380

GAAATTCTTC TGCGGTACGG GCAGCACCCC AACATCATCA CTCTGAAAGA TGTGTACGAT 1440

GACGGCAAGC ACGTGTACCT GGTGACAGAG CTGATGCGGG GAGGGGAGCT GCTGGATAAG 1500

ATCCTGCGGC AGAAGTTCTT CTCGGAACGC GAGGCCAGCT TCGTCCTGCA CACCATCAGC 1560

AAGACCGTGG AGTACCTGCA CTCCCAGGGG GTCGTGCACA GGGACCTCAA GCCCAGCAAC 1620

ATCCTGTACG TGGACGAGTC TGGGAACCCC GAGTGCCTGC GCATCTGTGA CTTTGGCTTT 1680

GCCAAGCAGC TGCGGGCTGA GAACGGGCTC CTCATGACAC CTTGCTACAC CGCCAACTTC 1740

GTGGCACCCG AGGTCCTGAA GCGCCAGGGC TATGATGAAG GCTGCGACAT TTGGAGCCTG 1800

GGCATTCTGC TGTACACCAT GCTGGCGGGA TACACTCCAT TTGCCAATGG ACCCAGTGAC 1860

ACACCAGAGG AAATCCTGAC CCGGATCGGC AGTGGCAAGT TTACTCTCAG TGGGGGAAAC 1920

TGGAACACAG TTTCAGACAC AGCCAAGGAC CTGGTGTCCA AGATGCTGCA CGTGGACCCC 1980

CACCAGCGCC TCACAGCCAA GCAGGTCCTG CAGCACCCGT GGATCACCCA GAAAGACAAG 2040

CTTCCGCAGA GCCAGCTGTC ACATCAGGAC CTGCAGCTTG TGAAGGGAGC CATGGCAGCT 2100

ACCTACTCAG CACTCAACAG CTCCAAGCCC ACCCCTCAGC TGAAGCCCAT CGAGTCGTCT 2160

ATCCTGGCCC AGCGGCGGGT GAGGAAGCTG CCGTCCACCA CCCTGTGA 2208

Domain Profile

S: 1     yevkedlGvGsysvckrcvhkatnqefavkiidkskrdtseeieillryeqhpnivtlkd  60

         y+vke++GvGsys ckrcvhkatn+e+avk+idkskrd+seeieillry+qhpni+tlkd

Q: 418   YVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEIEILLRYGQHPNIITLKD  477

         689*********************************************************

S: 61    vyddgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheqGvvhrdlk  120

         vyddgk+vylv+el++GGelld+i+++kffsereas +l+t++k+veylh+qGvvhrdlk

Q: 478   VYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTISKTVEYLHSQGVVHRDLK  537

         ************************************************************

S: 121   penilyvdesdnaesikiidfGfaklkraengllktpcytlnfvapevlkrqGydeacdl  180

         p+nilyvdes+n+e+++i+dfGfak++raengll+tpcyt+nfvapevlkrqGyde+cd+

Q: 538   PSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDI  597

         ************************************************************

S: 181   wslGvllytmlaGyvpfangpedtaeeilakikeGkfslsGeawdsvseeakdlvskllt  240

         wslG+llytmlaGy+pfangp+dt+eeil++i++Gkf+lsG++w++vs++akdlvsk+l+

Q: 598   WSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSDTAKDLVSKMLH  657

         ************************************************************

S: 241   vdpakrlkleqllkhswl  258

         vdp++rl+++q+l+h+w+

Q: 658   VDPHQRLTAKQVLQHPWI  675

         *****************8

Domain Sequence
(FASTA)

YVVKETIGVG SYSECKRCVH KATNMEYAVK VIDKSKRDPS EEIEILLRYG QHPNIITLKD 60

VYDDGKHVYL VTELMRGGEL LDKILRQKFF SEREASFVLH TISKTVEYLH SQGVVHRDLK 120

PSNILYVDES GNPECLRICD FGFAKQLRAE NGLLMTPCYT ANFVAPEVLK RQGYDEGCDI 180

WSLGILLYTM LAGYTPFANG PSDTPEEILT RIGSGKFTLS GGNWNTVSDT AKDLVSKMLH 240

VDPHQRLTAK QVLQHPWI 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005819	; C:spindle
GO:0005524	; F:ATP binding
GO:0043027	; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007243	; P:intracellular protein kinase cascade
GO:0043066	; P:negative regulation of apoptotic process
GO:2000491	; P:positive regulation of hepatic stellate cell activation
GO:0045944	; P:positive regulation of transcription from RNA polymerase II promoter

KEGG

bta:533908

;

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR016239	; Ribosomal_S6_kinase_II.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 2.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 2.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 2.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00108	; PROTEIN_KINASE_ST; 2.

Prints

Created Date

20-Feb-2013