EKS-BOT-00115
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-BOT-00115
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/MLCK398.71.1E-119314567254
StatusReviewed
Ensembl ProteinENSBTAP00000019875
UniProt AccessionA4IFM7;
Protein NameMyosin light chain kinase 2, skeletal/cardiac muscle
Protein Synonyms/Alias MLCK2;
Gene NameMYLK2
Gene Synonyms/Alias MYLK2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSBTAG00000014930ENSBTAP00000019875ENSBTAT00000019875
OrganismBos taurus
Functional DescriptionImplicated in the level of global muscle contraction andcardiac function. Phosphorylates a specific serine in the N- terminus of a myosin light chain (By similarity).
Protein Length623
Protein Sequence
(FASTA)
MATENGAVEL EIPSSSTDTA PKAAAGEGPP AAEKDPGPPD PQKDPGPPDP EKDAGPPNPE 60
KELESPDPKK EPDPDSTKDT EAPAPEKGDG ASAQPSASSQ GPEGEGGLQG EPAEGSAGQP 120
AALPQETATA EASVKKPEAE QGTPGSQDPG EAKEQKKVAE GQAPSKKGSP AFLHSPSCPA 180
AISSLEKPLA EKPLDETLEL IFEGVPVTPG PTETEPAKVA EGEKNLPGGS QKEGEEKAAG 240
HAGQDGVQGD TSRGIEFQAV PSERSEVGQA LSPTAKEEDC FQILDDCPPP PAPFPHRIVE 300
LRPGNINSQF SLNSKEALGG GKFGAVCTCT EKATGLKLAA KVIKKQTPKD KEMVLLEIEV 360
MNQLNHRNLI QLYAAIETPH EIVLFMEYIE GGELFERIVD EDYQLTEVDT MVFVRQICDG 420
ILFMHKMRVL HLDLKPENIL CVNTTGHLVK IIDFGLARRY NPNEKLKVNF GTPEFLSPEV 480
VNYDQISDKT DMWSLGVITY MLLSGLSPFL GDDDTETLNN VLSSNWYFDE ETFEAVSDEA 540
KDFVSNLIVK DQRARMSAAQ CLAHPWLNNL AEKAKRCNRR LKSQILLKKY LMKRRWKKNF 600
IAVSAANRFK KISSSGALMA LGV 623
Nucleotide Sequence
(FASTA)
ATGGCGACGG AAAACGGAGC AGTGGAGCTG GAAATCCCAA GCTCATCAAC AGACACAGCA 60
CCAAAGGCTG CAGCAGGTGA AGGACCCCCA GCTGCAGAGA AAGACCCTGG GCCCCCAGAT 120
CCACAGAAGG ATCCTGGGCC CCCAGATCCA GAGAAGGATG CTGGTCCCCC AAACCCAGAG 180
AAAGAACTTG AGTCCCCAGA CCCAAAGAAA GAACCTGATC CCGACTCGAC GAAAGATACT 240
GAAGCCCCGG CCCCAGAGAA AGGGGACGGG GCCTCAGCCC AACCCTCAGC CAGCAGCCAG 300
GGCCCTGAGG GAGAAGGAGG CCTGCAGGGA GAGCCTGCAG AGGGCTCGGC TGGGCAGCCG 360
GCAGCCCTGC CCCAGGAGAC AGCGACAGCC GAGGCCAGCG TCAAAAAGCC CGAGGCTGAG 420
CAGGGGACCC CCGGCAGCCA GGACCCTGGA GAAGCCAAGG AGCAAAAGAA GGTAGCAGAG 480
GGCCAAGCGC CGAGCAAGAA GGGCTCACCC GCCTTTCTGC ACAGCCCCAG CTGCCCCGCC 540
GCCATCTCGA GCCTTGAGAA GCCACTGGCC GAGAAGCCCC TAGATGAGAC GTTAGAGCTT 600
ATCTTTGAAG GAGTGCCTGT GACCCCTGGC CCCACAGAAA CTGAGCCAGC CAAGGTAGCA 660
GAAGGAGAGA AGAACCTCCC GGGAGGCAGC CAGAAGGAAG GAGAAGAGAA GGCTGCAGGC 720
CACGCTGGCC AGGATGGGGT GCAAGGGGAC ACCTCGAGGG GGATCGAATT CCAGGCCGTT 780
CCCTCGGAGA GATCGGAGGT GGGGCAGGCC CTCAGTCCCA CAGCCAAGGA GGAGGACTGC 840
TTCCAGATTT TGGATGACTG CCCACCGCCC CCAGCCCCCT TCCCCCACCG CATTGTGGAG 900
CTGAGGCCCG GGAACATCAA CAGTCAATTC AGTCTGAACT CCAAGGAGGC ACTGGGCGGC 960
GGCAAGTTTG GAGCGGTCTG TACCTGCACA GAGAAGGCCA CAGGCCTCAA GCTGGCCGCC 1020
AAGGTCATCA AGAAACAGAC ACCCAAAGAC AAGGAAATGG TGTTGCTGGA GATTGAGGTT 1080
ATGAACCAGC TGAACCACCG CAACCTGATC CAGCTTTATG CGGCCATCGA GACCCCGCAT 1140
GAGATCGTCC TCTTCATGGA GTACATCGAG GGCGGCGAGC TCTTCGAGAG GATTGTGGAC 1200
GAGGACTACC AGCTGACTGA GGTGGACACC ATGGTGTTTG TCAGGCAGAT CTGCGATGGC 1260
ATCCTCTTCA TGCACAAGAT GAGAGTTTTG CATCTGGACC TCAAGCCAGA GAACATCCTG 1320
TGCGTCAACA CCACGGGCCA TTTGGTGAAG ATCATTGACT TCGGCCTGGC ACGGAGGTAT 1380
AACCCCAACG AGAAGCTGAA GGTGAATTTT GGGACCCCAG AGTTCCTATC CCCTGAGGTG 1440
GTGAATTATG ACCAAATCTC CGATAAGACA GACATGTGGA GCCTGGGGGT CATCACCTAT 1500
ATGCTCCTGA GTGGTCTCTC CCCCTTCCTG GGAGACGATG ACACAGAGAC CCTGAACAAC 1560
GTTCTATCAA GCAACTGGTA CTTTGATGAG GAAACCTTTG AGGCCGTGTC AGACGAGGCC 1620
AAAGACTTCG TCTCCAACCT CATCGTCAAG GACCAGCGGG CCCGGATGAG CGCTGCCCAG 1680
TGCCTCGCCC ACCCCTGGCT CAACAACCTG GCAGAGAAGG CCAAGCGCTG TAACCGCCGC 1740
CTCAAGTCCC AGATCTTGCT TAAGAAATAC CTCATGAAGA GGCGCTGGAA GAAAAACTTC 1800
ATTGCTGTCA GCGCTGCCAA CCGCTTCAAG AAGATCAGCA GCTCGGGGGC ACTCATGGCT 1860
CTGGGGGTCT GA 1872
Domain Profile
S: 3     ikeelgkGkfgvvvkavekstgkklaakivkvrkekdkeevkkEieilnqlrHekliqly  62
          ke+lg Gkfg+v++++ek+tg klaak++k +++kdke+v  Eie++nql+H++liqly
Q: 314   SKEALGGGKFGAVCTCTEKATGLKLAAKVIKKQTPKDKEMVLLEIEVMNQLNHRNLIQLY  373
         6899********************************************************
S: 63    dafeskeeivlvlElveggelferiveedyeltEeevvlfvrqvlealeylHkkgivHld  122
         +a+e+ +eivl++E++eggelferiv+edy+ltE ++++fvrq+++++ ++Hk++++Hld
Q: 374   AAIETPHEIVLFMEYIEGGELFERIVDEDYQLTEVDTMVFVRQICDGILFMHKMRVLHLD  433
         ************************************************************
S: 123   lkpenillqskkskqiKlidFGlarklkkkeklkvlfgtpefvaPEvvnkepvslatDmW  182
         lkpenil+++++++ +K+idFGlar+++++eklkv+fgtpef++PEvvn++++s +tDmW
Q: 434   LKPENILCVNTTGHLVKIIDFGLARRYNPNEKLKVNFGTPEFLSPEVVNYDQISDKTDMW  493
         ************************************************************
S: 183   svGvityvLlsGlsPFlgdndeetlenvssakydfdeeafkevseeakdFiskllvkekk  242
         s+Gvity+LlsGlsPFlgd+d+etl+nv s+++ fdee+f++vs+eakdF+s+l+vk+++
Q: 494   SLGVITYMLLSGLSPFLGDDDTETLNNVLSSNWYFDEETFEAVSDEAKDFVSNLIVKDQR  553
         ************************************************************
S: 243   kRmsaeeaLkhkwl  256
         +Rmsa+++L+h+wl
Q: 554   ARMSAAQCLAHPWL  567
         *************8
Domain Sequence
(FASTA)
SKEALGGGKF GAVCTCTEKA TGLKLAAKVI KKQTPKDKEM VLLEIEVMNQ LNHRNLIQLY 60
AAIETPHEIV LFMEYIEGGE LFERIVDEDY QLTEVDTMVF VRQICDGILF MHKMRVLHLD 120
LKPENILCVN TTGHLVKIID FGLARRYNPN EKLKVNFGTP EFLSPEVVNY DQISDKTDMW 180
SLGVITYMLL SGLSPFLGDD DTETLNNVLS SNWYFDEETF EAVSDEAKDF VSNLIVKDQR 240
ARMSAAQCLA HPWL 254
KeywordAcetylation; ATP-binding; Calmodulin-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>
EKS-AIM-00105
EKS-CAJ-00117
EKS-CAF-00118
EKS-CAP-00112
EKS-EQC-00111
EKS-FEC-00107
EKS-GAG-00095
EKS-GOG-00114
EKS-HOS-00117
EKS-ICT-00109
EKS-LOA-00111
EKS-MAM-00113
EKS-MIM-00051
EKS-MOD-00113
EKS-MUM-00116
EKS-MUP-00117
EKS-NOL-00106
EKS-ORC-00108
EKS-OTG-00118
EKS-RAN-00113
EKS-SAH-00107
EKS-SUS-00101
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0004687; F:myosin light chain kinase activity
GO:0055007; P:cardiac muscle cell differentiation
GO:0055008; P:cardiac muscle tissue morphogenesis
GO:0007274; P:neuromuscular synaptic transmission
GO:0018107; P:peptidyl-threonine phosphorylation
GO:0010628; P:positive regulation of gene expression
GO:0046777; P:protein autophosphorylation
GO:0032971; P:regulation of muscle filament sliding
GO:0014816; P:satellite cell differentiation
GO:0035914; P:skeletal muscle cell differentiation
GO:0006941; P:striated muscle contraction
KEGG
bta:533378;
InterPros
IPR020636; Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013