EKS-BOT-00258

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-BOT-00258

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Abl	552.2	1.7E-166	288	539	252

Status

Unreviewed

Ensembl Protein

ENSBTAP00000020006

UniProt Accession

F1MWH8;

Protein Name

Protein Synonyms/Alias

Gene Name

ABL2

Gene Synonyms/Alias

ABL2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000015026	ENSBTAP00000020006	ENSBTAT00000020006

Organism

Bos taurus

Functional Description

Protein Length

1182

Protein Sequence
(FASTA)

MGQQVGRVGE APGLQQSQPR GIRGSSAARP SGRRRDLVGR TAEAGFNIFT QHDHFASCLE 60

DGFEGDKTGG SSPEALHRPY GCDVEPQALN EAIRWSSKEN LLGATESDPN LFVALYDFVA 120

SGDNTLSITK GEKLRVLGYN QNGEWSEVRS KNGQGWVPSN YITPVNSLEK HSWYHGPVSR 180

SAAEYLLSSL INGSFLVRES ESSPGQLSIS LRYEGRVYHY RINTTTDGKV YVTAESRFST 240

LAELVHHHST VADGLVTTLH YPAPKCNKPT VYGVSPIHDK WEMERTDITM KHKLGGGQYG 300

EVYVGVWKKY SLTVAVKTLK EDTMEVEEFL KEAAVMKEIK HPNLVQLLGV CTLEPPFYIV 360

TEYMPYGNLL DYLRECNREE VTAVVLLYMA TQISSAMEYL EKKNFIHRDL AARNCLVGEN 420

HVVKVADFGL SRLMTGDTYT AHAGAKFPIK WTAPESLAYN TFSIKSDVWA FGVLLWEIAT 480

YGMSPYPGID LSQVYDLLEK GYRMEQPEGC PPKVYELMRA CWKWSPADRP SFAETHQAFE 540

TMFHDSSISE EVAEELGRAA AASSVVPYLP RLPLLPSKTR TLKKQGENKE NIEGAQDATE 600

DSASSSAPGF IRSAQAPSGS PALPRKQRDK SPSSLLEDAK ETCFTRDRKG GFFSSFMKKR 660

NAPTPPKRSS SFREMENQPH KKYELTGNFS SVASLQHAEG FSLTPAQQEA SLVPPKCYGG 720

SFAQRNLCND DGGGGGGSGA AGGGWSGITG FFTPRLIKKT LGLRAGKPTA SDDTSKPFPR 780

SNSTSSVSSG LPEQDRMAMT LPRNCQRSKL QLERTVSTSS QPEENVDRAN DTLPKKSEEG 840

AAPTRERPKA KLLPRGGTAL PLRTPSGDPA TTEKDSPGLG VAGVAAAPKS KERNGGARLG 900

MAGVPEDGEQ TGWASPAKTA AVLPTTHNHK VPVLISPTLK HTPADVQLIG TDSQGNKFKL 960

LSEHQVTSSG DKDRPRRVKP KCAPPPPPVM RLLQHPSVCS DSTEEPAAPT AVQPKSETQE 1020

GGKKAAPGAV PTSGKAGRPV MPPPQVPLPT SSGSPAKMAN GTAGTKVALR KTKQAAEKIS 1080

ADKISKEALL ECADLLSSAI TEPVPNSQLV DTGHQLLDYC SGYVDCIPQT RNKFAFREAV 1140

SKLELSLQEL QVSSAAAGVP GANPVLNNLL SCVQEISDVV QR 1182

Nucleotide Sequence
(FASTA)

ATGGGGCAGC AGGTGGGCCG CGTCGGGGAG GCTCCGGGGC TTCAGCAGTC GCAACCCCGC 60

GGGATCCGGG GCAGCAGCGC AGCCAGGCCC TCTGGTCGCA GGCGGGACTT GGTGGGGCGC 120

ACCGCAGAGG CCGGCTTCAA TATCTTCACC CAGCATGATC ACTTTGCCAG CTGTTTGGAG 180

GATGGATTTG AGGGAGACAA GACTGGAGGC AGTAGTCCAG AAGCCTTGCA TCGCCCCTAC 240

GGTTGTGATG TTGAACCCCA GGCCCTGAAC GAAGCCATCA GGTGGAGCTC CAAGGAGAAC 300

CTGCTTGGAG CCACCGAGAG TGACCCTAAT CTCTTTGTTG CACTTTATGA TTTTGTAGCA 360

AGTGGTGATA ACACACTCAG CATCACTAAA GGTGAAAAGC TCCGAGTCCT TGGTTACAAC 420

CAGAATGGAG AGTGGAGCGA AGTTCGCTCT AAGAATGGCC AAGGCTGGGT GCCAAGCAAC 480

TACATCACCC CTGTGAACAG CCTGGAAAAA CATTCCTGGT ATCATGGACC TGTGTCTCGC 540

AGTGCAGCAG AGTACCTACT CAGCAGTCTG ATCAATGGCA GCTTCCTGGT GCGAGAGAGT 600

GAGAGCAGCC CCGGGCAGCT GTCAATCTCG CTCAGGTACG AGGGGCGTGT GTATCACTAC 660

AGGATCAATA CCACCACAGA TGGCAAGGTA TACGTAACTG CTGAGAGCCG CTTCAGCACC 720

TTGGCTGAGC TTGTTCACCA TCACTCCACG GTGGCTGATG GGCTGGTGAC AACCCTACAC 780

TATCCAGCAC CCAAGTGTAA TAAGCCTACA GTCTACGGTG TGTCCCCCAT CCACGACAAG 840

TGGGAAATGG AACGAACAGA TATTACCATG AAGCACAAAC TTGGGGGTGG TCAGTATGGA 900

GAGGTTTACG TTGGCGTCTG GAAGAAATAC AGCCTTACAG TTGCTGTGAA AACATTGAAG 960

GAAGATACTA TGGAGGTGGA GGAATTTCTC AAGGAAGCTG CAGTGATGAA GGAAATCAAG 1020

CATCCTAACC TGGTACAGCT ATTAGGTGTG TGTACCTTGG AGCCACCATT TTACATTGTG 1080

ACTGAATACA TGCCTTATGG GAACTTGCTT GATTATCTCC GAGAATGCAA CCGAGAAGAG 1140

GTGACTGCAG TTGTACTGCT TTACATGGCC ACTCAGATCT CGTCTGCAAT GGAGTATTTA 1200

GAGAAGAAGA ATTTCATCCA CAGGGATCTT GCAGCTCGTA ACTGCCTGGT GGGAGAAAAC 1260

CATGTGGTGA AAGTGGCTGA TTTTGGCTTA AGTAGACTGA TGACCGGAGA CACCTATACT 1320

GCTCATGCTG GAGCCAAATT TCCTATTAAA TGGACAGCAC CAGAGAGTCT TGCCTACAAT 1380

ACTTTCTCAA TTAAATCTGA CGTCTGGGCT TTTGGGGTGC TCTTATGGGA AATTGCTACA 1440

TATGGAATGT CACCATATCC AGGTATTGAC CTGTCTCAGG TCTATGATCT ACTGGAAAAA 1500

GGATACCGAA TGGAGCAGCC TGAAGGATGT CCCCCTAAGG TGTATGAACT TATGAGAGCA 1560

TGCTGGAAGT GGAGCCCTGC CGACAGGCCC TCTTTTGCAG AAACACATCA AGCTTTTGAA 1620

ACCATGTTCC ACGACTCTAG CATTTCTGAA GAGGTTGCTG AGGAGCTTGG GAGGGCCGCC 1680

GCCGCCTCGT CTGTGGTTCC ATATCTGCCT CGACTGCCTC TGCTTCCTTC CAAGACCCGG 1740

ACGCTGAAGA AGCAGGGGGA GAACAAGGAG AACATCGAGG GGGCACAAGA TGCCACAGAA 1800

GATTCTGCTT CCAGTTCAGC ACCAGGGTTC ATTAGAAGTG CACAGGCCCC CAGTGGGTCC 1860

CCAGCACTGC CTCGAAAGCA GAGAGACAAG TCACCCAGCA GCCTCTTGGA AGATGCCAAA 1920

GAGACATGCT TCACCAGAGA TAGGAAGGGA GGCTTCTTCA GCTCCTTTAT GAAAAAGAGA 1980

AACGCTCCCA CACCCCCCAA ACGCAGCAGC TCCTTCCGAG AAATGGAGAA CCAGCCCCAC 2040

AAGAAATACG AACTGACGGG TAACTTCTCA TCTGTTGCTT CTCTGCAGCA TGCTGAAGGG 2100

TTCTCTCTCA CTCCTGCCCA GCAAGAAGCG AGTCTGGTGC CACCCAAGTG CTATGGGGGT 2160

AGCTTTGCAC AGAGGAACCT CTGTAATGAC GACGGTGGCG GGGGTGGGGG CAGCGGTGCT 2220

GCTGGGGGCG GGTGGTCTGG CATCACAGGC TTCTTTACAC CACGCTTAAT CAAAAAGACG 2280

CTGGGCTTAC GAGCAGGTAA ACCCACAGCC AGTGATGACA CATCCAAGCC TTTTCCAAGG 2340

TCAAACTCTA CATCTTCCGT GTCCTCAGGG CTTCCAGAGC AGGATAGGAT GGCAATGACC 2400

CTTCCCAGGA ACTGCCAGAG GTCCAAACTC CAGCTGGAAA GGACAGTGTC CACCTCTTCT 2460

CAGCCAGAAG AGAATGTGGA CAGGGCCAAT GACACGCTTC CAAAAAAATC AGAGGAAGGT 2520

GCCGCTCCGA CCAGGGAGAG ACCAAAAGCC AAACTTCTGC CCAGAGGAGG CACCGCTCTT 2580

CCTCTCAGAA CCCCCTCTGG GGATCCAGCC ACTACAGAGA AGGATTCTCC AGGGTTGGGG 2640

GTGGCTGGAG TGGCAGCTGC CCCCAAGAGC AAGGAGAGGA ATGGTGGGGC ACGACTTGGC 2700

ATGGCTGGAG TCCCAGAGGA TGGCGAGCAG ACCGGCTGGG CTTCTCCAGC CAAGACTGCC 2760

GCGGTCCTCC CAACCACTCA TAACCACAAA GTGCCCGTCC TTATCTCACC CACTCTGAAG 2820

CACACTCCAG CTGACGTGCA GCTCATTGGC ACAGACTCTC AGGGGAATAA ATTCAAGCTC 2880

TTATCAGAGC ATCAGGTCAC TTCCTCTGGA GACAAGGACC GACCCCGCCG GGTAAAACCA 2940

AAGTGTGCCC CGCCCCCACC ACCAGTGATG AGACTACTGC AGCATCCGTC CGTGTGCTCA 3000

GACTCCACGG AAGAGCCAGC CGCCCCGACT GCAGTCCAGC CCAAGTCAGA AACACAGGAG 3060

GGAGGGAAAA AGGCGGCTCC AGGGGCGGTG CCCACCAGTG GGAAAGCTGG GAGGCCTGTG 3120

ATGCCTCCAC CTCAAGTGCC TCTGCCCACA TCTTCCGGCT CGCCAGCCAA AATGGCCAAT 3180

GGCACAGCAG GTACTAAAGT GGCTCTGAGA AAAACCAAAC AGGCGGCCGA GAAAATCTCA 3240

GCCGACAAAA TCAGCAAGGA GGCCCTGCTG GAATGTGCCG ACCTACTGTC CAGTGCCATC 3300

ACGGAACCTG TGCCCAACAG CCAGCTGGTG GACACTGGCC ACCAGCTGCT CGACTACTGC 3360

TCAGGCTACG TGGACTGCAT CCCTCAAACT CGCAACAAAT TTGCCTTCCG AGAGGCTGTG 3420

AGCAAACTGG AACTCAGCCT GCAGGAGCTG CAGGTGTCTT CTGCAGCCGC TGGCGTGCCC 3480

GGGGCAAACC CTGTCCTTAA CAACTTACTG TCATGTGTAC AGGAAATCAG TGATGTGGTG 3540

CAGAGGTAG 3549

Domain Profile

S: 1     iimkhklgggqygevyegvwkkysltvavktlkedtmeveeflkeaavmkelkhpnlvql  60

         i+mkhklgggqygevy+gvwkkysltvavktlkedtmeveeflkeaavmke+khpnlvql

Q: 288   ITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQL  347

         89**********************************************************

S: 61    lgvctreppfyiitefmsygnlldylreadreeveavvllymatqissameylekknfih  120

         lgvct eppfyi+te+m+ygnlldylre++reev+avvllymatqissameylekknfih

Q: 348   LGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIH  407

         ************************************************************

S: 121   rdlaarnclvgenklvkvadfglsrlmkedtytahagakfpikwtapeslaynkfsiksd  180

         rdlaarnclvgen++vkvadfglsrlm++dtytahagakfpikwtapeslayn+fsiksd

Q: 408   RDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSD  467

         ************************************************************

S: 181   vwafgvllweiatygmspypgidlsqvyellekgyrmerpegcppkvyelmracwkwsps  240

         vwafgvllweiatygmspypgidlsqvy+llekgyrme+pegcppkvyelmracwkwsp+

Q: 468   VWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPA  527

         ************************************************************

S: 241   drpsfaeihqal  252

         drpsfae+hqa+

Q: 528   DRPSFAETHQAF  539

         *********986

Domain Sequence
(FASTA)

ITMKHKLGGG QYGEVYVGVW KKYSLTVAVK TLKEDTMEVE EFLKEAAVMK EIKHPNLVQL 60

LGVCTLEPPF YIVTEYMPYG NLLDYLRECN REEVTAVVLL YMATQISSAM EYLEKKNFIH 120

RDLAARNCLV GENHVVKVAD FGLSRLMTGD TYTAHAGAKF PIKWTAPESL AYNTFSIKSD 180

VWAFGVLLWE IATYGMSPYP GIDLSQVYDL LEKGYRMEQP EGCPPKVYEL MRACWKWSPA 240

DRPSFAETHQ AF 252

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0015629	; C:actin cytoskeleton
GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0030145	; F:manganese ion binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0051017	; P:actin filament bundle assembly
GO:0071300	; P:cellular response to retinoic acid
GO:0018108	; P:peptidyl-tyrosine phosphorylation
GO:0010976	; P:positive regulation of neuron projection development
GO:0051353	; P:positive regulation of oxidoreductase activity

KEGG

bta:511845

;

InterPros

IPR015015	; F-actin_binding.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF08919	; F_actin_bind; 1.
PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00808	; FABD; 1.
SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013