EKS-BOT-00124
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-BOT-00124
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Met435.66.5E-13110841336253
StatusUnreviewed
Ensembl ProteinENSBTAP00000020028
UniProt AccessionE1BCZ6;
Protein Name
Protein Synonyms/Alias
Gene NameMST1R
Gene Synonyms/Alias MST1R;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSBTAG00000015046ENSBTAP00000020028ENSBTAT00000020028
OrganismBos taurus
Functional Description
Protein Length1396
Protein Sequence
(FASTA)
MELHPPLFQP FLLLLLLLPT LPAVPETGGS WQCPRIPYAA SRDFAVEYSV PSFSPGGPVQ 60
AVATYEGGRE GSAVFVATRN RLHVLGPDLQ PVESLATGPA GAPGCQTCAA CGPGPHGPPG 120
DTDTQVLVLE PALPALISCG SSLRGRCFLH ELEPGGTALH LAPPVCLFSE HNRPEDCPDC 180
VASPLGTLVT VVEQGQASYL YVASSLDSAV AASFSPLSVS IRRLKADGSG FAAGFAALSV 240
LPQHLDSYRI EYVYSFHAGA FVYFLTVQPA DVAAAPGTLH TRLARLSAVE TDLGDYRELV 300
LHCHFAPKRR RRAAHEGGQP YPVLRAAHAA PVGGHLAAEL SIPEGQEVLF GVFSASRDSS 360
PGADPNSVVC AFPVHLLDTL IEKGVEHCCE PPVPPGLRRG LDFFQLPSFC PDAPGLGASS 420
PNISCRHFPL LVSGNLLRVD LFNGLLGPVE VTALYVTRLD NVTVAHMGTA DGRILQVELA 480
RSLNYLLYVS NFSLGSNGQP VHRDVRRLGD HLLFASGDQV FQVPIRGPGC RHFLTCGRCL 540
RAQRFMGCGW CGGMCGRQKE CPGSWQQDYC PPVLTEFYPR SGPLRGSTRL TLCGSNFYLY 600
PSGLVPEGTH QVTVGRSPCR LLPKGNSDLS RLPRKDFIED FECELEPLST QVAGPANVSL 660
TVTNMPLGRH FRVEGTSMLG GFSFMEPVLT AVRPFFGPRA GGTCLTLEGR GLSIGTSQTV 720
LVNGTECPLK QVSEGQLLCT TPPGAATASV PIRLQVGGAE VPGSWNFHYR EDPIVLGISP 780
KCGYTGSHVT IRGQHLTSAW HLTLSFHDGV RAVENRCEGQ LPEQHRCRLP EYVVRGRRGW 840
VTGNLSVRGD GAPGYTLPGF RFLPPPHPPS KDLAPLKPEE HAIKFEYIGL GTVADCVAVN 900
VTVSGKSCQH ELRGDVVVCP LPPSLQLGKD GAPLQVCVDG RCYTLGKVVR PGLEGVPQST 960
LLGVLLALLL LVAVLAAILV FSYRWRKQLV LSSNLEDLAS LDRTPGAMPL PLLRSGSDYR 1020
NGLAPPITGQ DSSTQVHRIS SSDSGDGSRV PLLRKGSIQL GDLDSVLLSE VKDVLIPHER 1080
VVTHADRVIG KGHFGVVYHG EYKDEAQNRI HCASITEVQE VEAFLREGLL MRRLHHPNVL 1140
ALIGIVLPPE GLPRVLLPYM RHGDLLQFIR SPQRNPTVKD LISFGLQVAH GMEYLAEQKF 1200
VHRDLAARNC MLDESFTVKV ADFGLARDVL DKEYYSVQQH RHARLPVKWM ALESLQTYRF 1260
TTKSDVWSYG VLLWELLTRG APPYPHIDPF DLTHFLAQGR RLPQPEYCPD SLYTVMQHCW 1320
AADPMARPTF GELAGEVALV VAALRGDHYV QLPVAYVNVG PGAPDKAIMP LEQSPSPTVH 1380
RSPGRPRPLS EPLRPT 1396
Nucleotide Sequence
(FASTA)
ATGGAGCTCC ACCCGCCGCT GTTCCAGCCT TTCCTCTTAC TGCTGCTGCT GCTGCCGACG 60
CTGCCGGCGG TGCCCGAGAC TGGCGGGTCC TGGCAGTGCC CGCGCATCCC GTATGCTGCT 120
TCCCGCGACT TTGCAGTGGA GTACTCGGTG CCCAGCTTCT CTCCCGGCGG TCCGGTACAA 180
GCCGTTGCAA CCTACGAGGG CGGCAGGGAA GGGAGTGCGG TGTTCGTGGC CACACGCAAT 240
CGCCTGCATG TGCTTGGACC TGATCTGCAG CCAGTTGAGA GCCTGGCCAC CGGCCCTGCT 300
GGGGCCCCTG GCTGCCAGAC GTGTGCGGCC TGTGGCCCAG GCCCCCACGG CCCGCCCGGA 360
GACACAGATA CGCAGGTTCT GGTGTTGGAA CCCGCGCTTC CCGCACTGAT CAGCTGTGGC 420
TCCAGCCTTC GTGGCCGCTG CTTCCTGCAT GAGCTAGAGC CGGGCGGGAC AGCCCTGCAC 480
CTGGCGCCAC CGGTCTGCCT TTTCTCAGAG CACAATCGGC CAGAGGACTG TCCTGACTGT 540
GTAGCCAGCC CTCTGGGCAC CCTCGTGACT GTGGTTGAGC AGGGCCAGGC ATCCTATTTG 600
TACGTGGCAT CGTCACTGGA CTCGGCGGTG GCCGCCAGCT TCAGCCCACT CTCGGTGTCC 660
ATCCGGCGGC TCAAGGCCGA CGGTTCAGGA TTTGCAGCAG GCTTCGCAGC GCTCTCGGTG 720
CTGCCCCAGC ACCTCGATTC CTACCGCATC GAATATGTGT ACAGTTTCCA CGCCGGAGCC 780
TTCGTCTATT TCCTGACGGT ACAGCCCGCC GACGTGGCAG CTGCTCCTGG CACCTTGCAC 840
ACGCGCCTGG CACGGCTCAG CGCTGTCGAG ACCGACCTGG GAGACTACCG AGAGCTGGTC 900
CTCCACTGCC ATTTCGCCCC TAAACGTCGG CGACGTGCAG CCCATGAGGG CGGGCAACCC 960
TACCCGGTGC TGCGGGCGGC CCACGCTGCT CCAGTGGGCG GCCACCTAGC CGCTGAGCTG 1020
AGCATCCCTG AGGGGCAGGA AGTGCTCTTC GGTGTTTTCT CGGCTAGCAG AGACAGCAGC 1080
CCAGGTGCAG ATCCCAACTC TGTGGTCTGT GCGTTCCCCG TCCACCTGCT GGACACTCTC 1140
ATCGAAAAGG GCGTAGAGCA CTGTTGTGAG CCTCCGGTCC CCCCTGGCCT CCGGCGAGGG 1200
CTGGACTTCT TCCAGTTGCC CAGTTTTTGC CCAGATGCGC CTGGTCTGGG GGCCTCCAGC 1260
CCCAATATCA GCTGCCGCCA CTTCCCTCTG CTCGTCAGCG GCAACCTCTT ACGGGTGGAC 1320
CTATTCAACG GGCTGTTGGG ACCAGTGGAG GTCACGGCAC TGTACGTGAC GCGCCTTGAC 1380
AACGTCACAG TGGCCCACAT GGGCACAGCC GATGGGCGCA TCCTGCAGGT GGAGCTGGCC 1440
AGGTCTCTCA ACTACTTGCT GTACGTGTCC AACTTCTCAC TGGGCAGCAA TGGGCAGCCC 1500
GTGCATCGGG ATGTCAGACG CCTTGGGGAC CACCTGCTTT TTGCCTCTGG GGACCAGGTC 1560
TTCCAGGTAC CGATTCGGGG CCCTGGCTGC CGCCACTTCC TCACCTGTGG GCGCTGCCTG 1620
CGGGCACAGC GTTTCATGGG CTGTGGATGG TGTGGGGGCA TGTGTGGCCG GCAGAAGGAG 1680
TGTCCTGGCT CCTGGCAACA GGACTACTGC CCACCAGTGC TTACTGAGTT CTATCCCCGC 1740
AGTGGACCCC TAAGGGGCAG CACAAGGCTG ACCCTATGTG GCTCCAACTT CTACCTGTAC 1800
CCTTCTGGTC TGGTGCCTGA AGGCACCCAT CAGGTCACTG TGGGTCGAAG TCCCTGCCGA 1860
CTGTTACCTA AAGGCAACTC AGACCTCAGC CGACTGCCCC GGAAGGACTT CATAGAGGAT 1920
TTTGAGTGTG AGCTGGAGCC CTTGAGCACG CAGGTAGCCG GGCCTGCCAA CGTCAGCCTC 1980
ACTGTGACCA ATATGCCACT GGGCAGGCAC TTCCGGGTAG AAGGTACCTC CATGCTAGGA 2040
GGCTTCTCTT TCATGGAGCC AGTGCTGACA GCAGTCCGAC CCTTCTTTGG CCCTCGGGCA 2100
GGAGGTACCT GCCTCACCCT TGAAGGCCGA GGCCTGTCTA TTGGCACCAG CCAGACTGTG 2160
CTGGTCAATG GGACTGAGTG CCCACTGAAA CAGGTCAGCG AGGGGCAGCT TTTATGCACC 2220
ACGCCCCCTG GGGCCGCTAC TGCCAGCGTT CCCATTCGCC TGCAGGTAGG GGGCGCCGAG 2280
GTGCCTGGCT CTTGGAACTT CCACTACCGG GAAGACCCCA TCGTCCTGGG CATCAGCCCC 2340
AAATGTGGCT ATACTGGCTC CCACGTCACC ATCCGCGGCC AGCATCTGAC TTCAGCATGG 2400
CACCTCACGC TGTCATTCCA TGATGGGGTC AGGGCAGTGG AGAACAGGTG TGAGGGGCAG 2460
CTCCCGGAGC AACACAGGTG CCGCCTGCCC GAATACGTGG TCCGAGGCCG CCGAGGGTGG 2520
GTGACAGGGA ACCTGAGTGT CCGTGGGGAT GGAGCTCCTG GCTACACACT GCCTGGCTTT 2580
CGCTTCCTGC CTCCACCCCA CCCACCCAGC AAGGACCTGG CCCCCCTGAA GCCTGAGGAG 2640
CACGCCATTA AGTTTGAGTA CATCGGGCTG GGCACTGTGG CTGACTGCGT GGCTGTGAAT 2700
GTGACTGTGA GTGGCAAGAG CTGCCAGCAC GAGCTGCGGG GGGATGTGGT AGTCTGCCCC 2760
CTGCCCCCCT CCCTGCAACT TGGCAAGGAC GGTGCTCCTC TGCAGGTCTG TGTGGATGGT 2820
AGGTGCTACA CCCTGGGCAA GGTAGTGCGG CCAGGTCTGG AAGGGGTCCC CCAGAGCACG 2880
CTCCTCGGTG TCCTCCTGGC TCTGCTCCTG CTTGTGGCTG TGCTGGCTGC CATACTGGTC 2940
TTCAGTTACC GCTGGAGGAA GCAGCTAGTT CTTTCTTCGA ACCTGGAAGA CTTGGCCTCC 3000
CTGGACCGGA CCCCTGGAGC CATGCCTCTG CCTCTGCTCC GCTCAGGCTC TGACTACAGA 3060
AATGGCCTTG CCCCTCCTAT CACTGGCCAG GATTCCTCCA CTCAGGTCCA CAGAATATCC 3120
TCCTCAGACA GCGGGGATGG GTCCCGTGTC CCATTGCTGC GGAAAGGATC CATCCAGCTT 3180
GGGGACCTGG ACTCTGTGCT CCTGTCTGAG GTCAAGGATG TACTGATTCC CCATGAAAGG 3240
GTGGTCACCC ACGCTGACCG AGTCATTGGC AAAGGCCATT TTGGAGTTGT CTACCATGGA 3300
GAATACAAAG ATGAGGCCCA GAATCGAATC CACTGTGCCA GCATCACAGA GGTGCAGGAG 3360
GTGGAGGCCT TCCTGCGCGA GGGGCTGCTC ATGCGCCGTC TGCACCACCC GAACGTGCTG 3420
GCTCTCATTG GCATTGTGCT GCCCCCGGAA GGGCTGCCCC GTGTGCTGCT GCCCTACATG 3480
CGCCACGGAG ACCTGCTGCA GTTCATCCGC TCACCCCAGC GGAATCCCAC AGTAAAGGAC 3540
CTCATCAGCT TCGGCCTGCA GGTGGCCCAC GGCATGGAGT ACCTGGCCGA GCAGAAGTTT 3600
GTGCACCGGG ATCTGGCTGC TCGGAACTGC ATGCTGGATG AGTCATTCAC GGTCAAGGTG 3660
GCTGACTTTG GTCTGGCCCG TGATGTCCTG GACAAGGAGT ACTACAGTGT CCAGCAGCAC 3720
CGCCACGCTC GCTTGCCTGT CAAGTGGATG GCGCTGGAGA GCCTGCAGAC CTACAGATTC 3780
ACCACCAAGT CTGACGTGTG GTCGTATGGT GTGCTGTTAT GGGAGCTGCT GACACGGGGT 3840
GCCCCTCCAT ACCCCCACAT CGACCCTTTT GATCTTACTC ACTTCCTGGC CCAGGGTCGG 3900
CGCCTACCCC AGCCTGAGTA TTGCCCAGAT TCTCTGTACA CTGTGATGCA GCACTGCTGG 3960
GCGGCGGACC CCATGGCACG ACCCACCTTC GGAGAGCTAG CAGGGGAAGT GGCACTCGTG 4020
GTGGCTGCGC TGCGAGGGGA CCACTACGTG CAGCTGCCCG TGGCCTACGT GAACGTGGGC 4080
CCTGGTGCCC CTGACAAGGC AATCATGCCC TTGGAACAGT CACCGTCCCC AACAGTGCAC 4140
AGGAGCCCAG GGCGGCCCCG GCCCCTCTCA GAGCCACTGA GACCCACGTG A 4191
Domain Profile
S: 2     dkeeviGkGhfGvvykgelsdsaskkikvavksleritdiekveeflreglvmkeldhpn  61
         + ++viGkGhfGvvy+ge++d+a+++i++a      it++++ve+flregl+m+ l+hpn
Q: 1084  HADRVIGKGHFGVVYHGEYKDEAQNRIHCA-----SITEVQEVEAFLREGLLMRRLHHPN  1138
         7899*************************8.....4799*********************
S: 62    vlsllGialddeglplvvlpymkkGdlksfirneernltvkdllefalqvakgmeylask  121
         vl+l+Gi+l++eglp v+lpym++Gdl +fir+++rn+tvkdl++f+lqva+gmeyla++
Q: 1139  VLALIGIVLPPEGLPRVLLPYMRHGDLLQFIRSPQRNPTVKDLISFGLQVAHGMEYLAEQ  1198
         ************************************************************
S: 122   kfvhrdlaarnclldekltvkvadfGlardvldkelyvveeerdarlpvkwlaleslqtf  181
         kfvhrdlaarnc+lde++tvkvadfGlardvldke+y+v+++r+arlpvkw+aleslqt+
Q: 1199  KFVHRDLAARNCMLDESFTVKVADFGLARDVLDKEYYSVQQHRHARLPVKWMALESLQTY  1258
         ************************************************************
S: 182   kqfttksdvwsfGvllwelltrgatpysevasfdltlylkegrrlrkpeycpdklydvml  241
         + fttksdvws+Gvllwelltrga+py+++++fdlt++l++grrl++peycpd+ly vm+
Q: 1259  R-FTTKSDVWSYGVLLWELLTRGAPPYPHIDPFDLTHFLAQGRRLPQPEYCPDSLYTVMQ  1317
         *.**********************************************************
S: 242   kcwkakpaerpqfsdlvsi  260
         +cw a+p +rp+f +l   
Q: 1318  HCWAADPMARPTFGELAGE  1336
         **************99765
Domain Sequence
(FASTA)
HADRVIGKGH FGVVYHGEYK DEAQNRIHCA SITEVQEVEA FLREGLLMRR LHHPNVLALI 60
GIVLPPEGLP RVLLPYMRHG DLLQFIRSPQ RNPTVKDLIS FGLQVAHGME YLAEQKFVHR 120
DLAARNCMLD ESFTVKVADF GLARDVLDKE YYSVQQHRHA RLPVKWMALE SLQTYRFTTK 180
SDVWSYGVLL WELLTRGAPP YPHIDPFDLT HFLAQGRRLP QPEYCPDSLY TVMQHCWAAD 240
PMARPTFGEL AGE 253
KeywordComplete proteome; Disulfide bond; Membrane; Receptor; Reference proteome; Transmembrane; Transmembrane helix.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Pan troglodytes"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00116
EKS-CAJ-00126
EKS-CAF-00127
EKS-CAP-00121
EKS-DAR-00380
EKS-ECT-00004
EKS-EQC-00120
EKS-FEC-00115
EKS-GAG-00104
EKS-GAA-00144
EKS-GOG-00123
EKS-HOS-00126
EKS-ICT-00116
EKS-LOA-00119
EKS-MAM-00120
EKS-MEG-00094
EKS-MOD-00121
EKS-MUM-00125
EKS-MUP-00125
EKS-MYL-00134
EKS-NOL-00116
EKS-ORN-00151
EKS-ORA-00102
EKS-ORC-00116
EKS-PAT-00112
EKS-PTV-00106
EKS-RAN-00121
EKS-SAH-00116
EKS-SOA-00004
EKS-SUS-00110
EKS-TAG-00153
EKS-TEN-00144
EKS-XET-00103
EKS-XIM-00148
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005886; C:plasma membrane
GO:0001725; C:stress fiber
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
GO:0004872; F:receptor activity
GO:0007275; P:multicellular organismal development
GO:0043406; P:positive regulation of MAP kinase activity
GO:0051897; P:positive regulation of protein kinase B signaling cascade
GO:0009615; P:response to virus
KEGG
InterPros
IPR013783; Ig-like_fold.
IPR014756; Ig_E-set.
IPR002909; IPT_TIG_rcpt.
IPR011009; Kinase-like_dom.
IPR003659; Plexin-like.
IPR016201; Plexin-like_fold.
IPR002165; Plexin_repeat.
IPR000719; Prot_kinase_cat_dom.
IPR001627; Semaphorin/CD100_Ag.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR015943; WD40/YVTN_repeat-like_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF01437; PSI; 1.
PF01403; Sema; 1.
PF01833; TIG; 2.
SMARTs
SM00429; IPT; 3.
SM00423; PSI; 1.
SM00630; Sema; 1.
SM00219; TyrKc; 1.
Prosites
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS51004; SEMA; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013