EKS-BOT-00153
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-BOT-00153
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/NDR506.03.3E-1526981003306
StatusUnreviewed
Ensembl ProteinENSBTAP00000020062
UniProt AccessionE1BCH5;
Protein Name
Protein Synonyms/Alias
Gene NameLATS1
Gene Synonyms/Alias LATS1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSBTAG00000015076ENSBTAP00000020062ENSBTAT00000020062
OrganismBos taurus
Functional Description
Protein Length1123
Protein Sequence
(FASTA)
MKRSEKPEGY RQMRPKTFPA SNYTGSSRQM LQEIRESLRN LSKPSDAAKA EQNMGKMSSE 60
DPRQVRNPPK FGMHHKALLE IRNSLQPFAN ETSRSPSEVN PQMLQDLQAA GFDEDMVIQA 120
LQKTNNRSIE AAIEFISKMS YQDPRREQMA AAAARPINAN LKPGSVQQSI NRKQSWKGSK 180
ESLVPQRHGP PLGESGAYRS ESPNSQTDVG RPLSGSGITA FTPAHPSNGQ RVNPPPPPQV 240
RSVTPPPPPR GQTPPPRGTT PPPPSWEPNS QTKRYSGNMD YVISRISPVP PGAWQEGYPP 300
PPLNTSPMNP PNQGQRGINS VPVGRQPIIM QSSNKFNFPP GRPGIQNGSG QTDFMMHQNV 360
VPAGAVNRQP PPPYPLTPTN GQSPSALQTG GSAAPSSYTN GNIPQAMMVP NRNSHNMELY 420
NINIPGLQTT WPQSSSAPAQ SSPSSGHEIP TWQPNIPVRS NSFNNPLGNR TNHSANSQPS 480
ATTVTAITPA PIQQPVKSIR VLKPELQTAL APTHPSWIPQ PVQSVQPSPF SEGAVMPPVA 540
EAPNYQGPPP PYPKHLLHQN PSVPPYESVS KSSKEDQPSL PKEDESEKSY DNVDTGDKEK 600
KQITTSPITV RKNKKDEERR ESRIQSYSPQ AFKFFMEQHV ENVLKSHQQR LHRKKQLENE 660
MMRVGLSQDA QDQMRKMLCQ KESNYIRLKR AKMDKSMFVK IKTLGIGAFG EVCLARKVDT 720
KALYATKTLR KKDVLLRNQV AHVKAERDIL AEADNEWVVR LYYSFQDKDN LYFVMDYIPG 780
GDMMSLLIRM GIFPENLARF YIAELTCAVE SVHKMGFIHR DIKPDNILID RDGHIKLTDF 840
GLCTGFRWTH DSKYYQSGDH PRQDSMDFSN EWGDPSNCRC GDRLKPLERR AARQHQRCLA 900
HSLVGTPNYI APEVLLRTGY TQLCDWWSVG VILFEMLVGQ PPFLAQTPFE TQVKVINWQT 960
SLHIPPQAKL SPEASDLIIK LCRGPEDRLG KNGADEIKAH PFFKTIDFSS DLRQQSASYI 1020
PKITHPTDTS NFDPVDPDKL RSDDNEEENV NDTLNGWYKN GKHPEHAFYE FTFRRFFDDN 1080
GYPYNYPKPI EYEYINSQGS EQQSDEDDQH TGSEMKNRDL VYV 1123
Nucleotide Sequence
(FASTA)
ATGAAGAGGA GTGAAAAGCC AGAAGGATAT AGACAAATGA GGCCTAAGAC CTTTCCTGCC 60
AGTAACTACA CTGGCAGCAG TCGGCAGATG CTGCAAGAAA TTCGGGAATC CCTTAGGAAC 120
TTATCCAAAC CCTCGGATGC TGCTAAGGCT GAGCAAAACA TGGGTAAAAT GTCATCTGAA 180
GATCCGCGGC AAGTCAGAAA TCCACCCAAG TTTGGGATGC ATCATAAAGC CTTGCTGGAA 240
ATTCGAAACT CTCTACAGCC ATTTGCAAAT GAAACAAGTC GGAGTCCTTC AGAAGTTAAT 300
CCACAAATGC TTCAAGACTT GCAAGCTGCT GGATTTGATG AGGATATGGT TATACAAGCT 360
CTTCAGAAAA CTAATAACAG AAGTATAGAA GCCGCAATTG AATTCATCAG TAAAATGAGT 420
TATCAAGATC CTCGACGGGA ACAGATGGCT GCAGCAGCTG CCAGACCTAT TAATGCCAAC 480
TTGAAGCCAG GGAGTGTGCA ACAATCAATT AACCGCAAAC AGAGCTGGAA GGGTTCTAAA 540
GAATCCTTAG TTCCTCAGAG ACATGGTCCA CCACTAGGAG AAAGTGGAGC GTACCGTTCT 600
GAAAGTCCCA ACTCACAGAC AGATGTAGGA AGACCTTTGT CAGGATCTGG TATAACAGCG 660
TTTACTCCAG CTCATCCTAG CAATGGACAG AGAGTGAACC CCCCACCACC TCCTCAAGTA 720
AGGAGTGTCA CTCCTCCACC CCCTCCAAGA GGCCAGACTC CCCCTCCAAG AGGTACAACT 780
CCGCCTCCCC CATCATGGGA ACCAAACTCT CAAACAAAGC GCTATTCTGG GAACATGGAC 840
TACGTCATCT CCCGAATCTC TCCAGTTCCA CCTGGAGCCT GGCAGGAGGG CTATCCTCCA 900
CCACCTCTTA ACACATCCCC GATGAATCCT CCTAATCAGG GACAGAGAGG CATTAATTCT 960
GTTCCTGTTG GCAGACAGCC AATCATCATG CAGAGTTCTA ACAAATTTAA TTTTCCACCC 1020
GGGAGACCTG GAATTCAGAA TGGTAGCGGT CAGACTGATT TTATGATGCA CCAGAATGTT 1080
GTCCCTGCTG GCGCTGTCAA TCGGCAGCCA CCCCCTCCAT ATCCTCTGAC CCCAACTAAT 1140
GGACAAAGCC CCTCTGCTTT ACAAACAGGG GGTTCTGCTG CTCCATCATC ATACACAAAT 1200
GGGAACATTC CTCAAGCTAT GATGGTGCCA AACAGAAATA GTCATAACAT GGAACTTTAT 1260
AACATTAATA TACCTGGACT GCAAACAACT TGGCCTCAGT CATCATCTGC TCCTGCCCAG 1320
TCATCCCCAA GCAGTGGACA TGAAATCCCT ACATGGCAAC CTAACATACC AGTGAGGTCA 1380
AATTCTTTTA ATAATCCATT GGGAAACAGA ACAAATCATT CTGCTAATTC TCAACCTTCG 1440
GCTACAACAG TCACTGCTAT TACACCAGCT CCCATTCAAC AGCCTGTGAA AAGTATACGT 1500
GTATTGAAAC CAGAGCTGCA GACTGCTTTA GCACCTACAC ACCCTTCTTG GATACCACAG 1560
CCTGTTCAGA GTGTCCAACC TAGTCCTTTT TCTGAGGGTG CTGTTATGCC ACCTGTTGCT 1620
GAAGCTCCAA ACTATCAAGG TCCGCCACCA CCTTATCCTA AGCATCTGCT ACACCAAAAC 1680
CCATCTGTTC CTCCATATGA ATCGGTCAGT AAGTCTAGCA AAGAGGATCA GCCAAGCTTG 1740
CCTAAGGAAG ATGAGAGTGA AAAAAGTTAT GACAATGTTG ATACTGGAGA TAAAGAAAAG 1800
AAACAGATTA CCACTTCACC TATCACCGTT AGGAAAAACA AGAAAGATGA AGAGCGAAGG 1860
GAATCTCGTA TTCAAAGTTA TTCTCCTCAG GCATTTAAAT TCTTCATGGA GCAACATGTA 1920
GAAAACGTGC TCAAATCTCA TCAGCAACGT CTACATCGTA AAAAACAATT AGAGAACGAA 1980
ATGATGCGGG TTGGATTATC TCAAGATGCC CAAGATCAAA TGAGAAAGAT GCTTTGCCAA 2040
AAAGAGTCTA ATTACATCCG TCTTAAGAGG GCTAAAATGG ACAAGTCTAT GTTTGTGAAG 2100
ATAAAGACAT TAGGAATAGG AGCATTTGGT GAAGTCTGTC TAGCAAGAAA AGTAGATACC 2160
AAGGCTTTGT ATGCAACAAA AACTCTTCGA AAGAAAGATG TTCTGCTTCG AAATCAAGTT 2220
GCTCATGTCA AAGCTGAGAG AGATATCCTG GCCGAAGCTG ACAACGAATG GGTAGTTCGT 2280
CTTTATTATT CATTCCAAGA CAAAGACAAT TTATACTTTG TAATGGACTA TATTCCTGGG 2340
GGTGATATGA TGAGCCTATT AATTAGAATG GGCATCTTTC CAGAAAATCT GGCACGATTC 2400
TACATAGCAG AACTTACCTG TGCAGTCGAA AGTGTTCATA AAATGGGTTT TATTCATAGA 2460
GATATTAAAC CTGATAACAT TTTGATTGAT CGTGATGGTC ATATTAAATT GACTGACTTC 2520
GGCCTCTGCA CTGGCTTCAG ATGGACACAT GACTCTAAGT ACTACCAGAG TGGTGACCAT 2580
CCACGGCAGG ATAGCATGGA TTTCAGTAAT GAATGGGGTG ACCCCTCTAA CTGTCGATGT 2640
GGTGATAGAC TGAAACCACT GGAGCGGAGA GCTGCACGCC AGCACCAGCG GTGTCTCGCA 2700
CATTCTTTGG TTGGGACTCC TAATTATATT GCGCCTGAAG TCTTGTTACG AACAGGCTAT 2760
ACACAGTTGT GTGATTGGTG GAGTGTTGGT GTCATTCTTT TTGAAATGTT GGTAGGACAG 2820
CCGCCTTTCT TGGCACAGAC ACCATTTGAA ACACAAGTGA AGGTTATCAA CTGGCAAACA 2880
TCTCTTCACA TCCCACCGCA AGCTAAACTG AGTCCTGAAG CCTCTGATCT TATTATTAAA 2940
CTCTGCCGAG GACCAGAAGA TCGCTTAGGC AAGAATGGTG CTGACGAAAT AAAAGCTCAT 3000
CCATTTTTTA AAACAATTGA TTTTTCCAGT GACTTGAGAC AGCAATCTGC TTCATACATT 3060
CCTAAAATCA CACACCCAAC AGATACATCA AATTTTGATC CTGTTGATCC TGACAAGTTA 3120
CGGAGTGATG ATAATGAGGA AGAAAATGTA AATGACACTC TCAACGGATG GTATAAAAAT 3180
GGAAAGCACC CTGAACATGC TTTCTATGAA TTTACCTTTC GGAGGTTTTT TGATGACAAT 3240
GGCTACCCTT ATAATTATCC AAAACCTATT GAATATGAAT ATATTAATTC ACAAGGCTCA 3300
GAGCAGCAGT CAGATGAAGA TGATCAGCAC ACAGGCTCAG AGATGAAAAA TCGTGATCTA 3360
GTGTATGTTT GA 3372
Domain Profile
S: 1     feklkvigkGafGevrlvrkkdtkevyalkilrkkdllkknqvahvkaerdilaeadsew  60
         f k+k++g+GafGev+l+rk dtk++ya+k+lrkkd+l +nqvahvkaerdilaead+ew
Q: 698   FVKIKTLGIGAFGEVCLARKVDTKALYATKTLRKKDVLLRNQVAHVKAERDILAEADNEW  757
         889*********************************************************
S: 61    vvklyysfqdkenlylvmeylPGGdlmtllikkeilkeelarfyiaelvlavesvhklGf  120
         vv+lyysfqdk+nly+vm+y+PGGd+m+lli+++i++e+larfyiael++avesvhk+Gf
Q: 758   VVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMGIFPENLARFYIAELTCAVESVHKMGF  817
         ************************************************************
S: 121   ihrdlkPdnllidakGhikltdfGlctGlkkthrseyykelekakeddlease.......  173
         ihrd+kPdn+lid++GhikltdfGlctG+++th+s+yy++ ++ ++d++++s+       
Q: 818   IHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHDSKYYQSGDHPRQDSMDFSNewgdpsn  877
         ***************************************************999******
S: 174   .....elkvlerrkkkknrrllayslvGtpdyiapevlekkgynklcdwWslGvilyeml  228
              +lk+lerr++++++r+la+slvGtp+yiapevl+++gy++lcdwWs+Gvil+eml
Q: 878   crcgdRLKPLERRAARQHQRCLAHSLVGTPNYIAPEVLLRTGYTQLCDWWSVGVILFEML  937
         ************************************************************
S: 229   vGypPflaetpqetykkvinwketlkfpeevelseeakdlierliadaekrlgkkGvdei  288
         vG+pPfla+tp et+ kvinw+++l++p++++ls+ea+dli +l+  +e+rlgk+G+dei
Q: 938   VGQPPFLAQTPFETQVKVINWQTSLHIPPQAKLSPEASDLIIKLCRGPEDRLGKNGADEI  997
         ************************************************************
S: 289   kkhpff  294
         k+hpff
Q: 998   KAHPFF  1003
         *****9
Domain Sequence
(FASTA)
FVKIKTLGIG AFGEVCLARK VDTKALYATK TLRKKDVLLR NQVAHVKAER DILAEADNEW 60
VVRLYYSFQD KDNLYFVMDY IPGGDMMSLL IRMGIFPENL ARFYIAELTC AVESVHKMGF 120
IHRDIKPDNI LIDRDGHIKL TDFGLCTGFR WTHDSKYYQS GDHPRQDSMD FSNEWGDPSN 180
CRCGDRLKPL ERRAARQHQR CLAHSLVGTP NYIAPEVLLR TGYTQLCDWW SVGVILFEML 240
VGQPPFLAQT PFETQVKVIN WQTSLHIPPQ AKLSPEASDL IIKLCRGPED RLGKNGADEI 300
KAHPFF 306
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00146
EKS-ANC-00146
EKS-CAE-00122
EKS-CAJ-00158
EKS-CAF-00161
EKS-CAP-00153
EKS-CII-00092
EKS-DAR-00439
EKS-DRM-00073
EKS-EQC-00151
EKS-ERE-00024
EKS-FEC-00144
EKS-GAG-00131
EKS-GAA-00180
EKS-GOG-00152
EKS-HOS-00159
EKS-ICT-00147
EKS-LAC-00162
EKS-LOA-00153
EKS-MAM-00150
EKS-MEG-00121
EKS-MOD-00153
EKS-MUM-00158
EKS-MUP-00158
EKS-MYL-00161
EKS-NOL-00146
EKS-OCP-00100
EKS-ORN-00188
EKS-ORA-00131
EKS-ORC-00144
EKS-ORL-00175
EKS-OTG-00159
EKS-PAT-00144
EKS-PES-00136
EKS-POA-00150
EKS-PTV-00143
EKS-RAN-00150
EKS-SAH-00148
EKS-SUS-00134
EKS-TAG-00181
EKS-TAR-00197
EKS-TAS-00057
EKS-TEN-00188
EKS-TUT-00146
EKS-VIP-00072
EKS-XET-00142
EKS-XIM-00182
Gene Ontology
GO:0005737; C:cytoplasm
GO:0000922; C:spindle pole
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0051220; P:cytoplasmic sequestering of protein
GO:0000086; P:G2/M transition of mitotic cell cycle
GO:0035329; P:hippo signaling cascade
GO:0009755; P:hormone-mediated signaling pathway
GO:0030216; P:keratinocyte differentiation
GO:0090090; P:negative regulation of canonical Wnt receptor signaling pathway
GO:0045736; P:negative regulation of cyclin-dependent protein kinase activity
GO:0033138; P:positive regulation of peptidyl-serine phosphorylation
GO:0030833; P:regulation of actin filament polymerization
GO:0000819; P:sister chromatid segregation
KEGG
bta:535935;
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR000719; Prot_kinase_cat_dom.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
IPR009060; UBA-like.
IPR000449; UBA/transl_elong_EF1B_N.
IPR015940; UBA/transl_elong_EF1B_N_euk.
Pfam
PF00069; Pkinase; 2.
PF00433; Pkinase_C; 1.
PF00627; UBA; 1.
SMARTs
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS50030; UBA; 1.
Prints
Created Date20-Feb-2013