EKS-BOT-00012
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-BOT-00012
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph424.51.2E-127597847251
StatusUnreviewed
Ensembl ProteinENSBTAP00000020455
UniProt AccessionF1MII5;
Protein Name
Protein Synonyms/Alias
Gene NameEPHB1
Gene Synonyms/Alias
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSBTAG00000015377ENSBTAP00000020455ENSBTAT00000020455
OrganismBos taurus
Functional Description
Protein Length953
Protein Sequence
(FASTA)
MDTRTATAEL GWTANPASGW EEVSGYDENL NTIRTYQVCN VFEPNQNNWL LTTFINRRGA 60
HRIYTEMRFT VRDCSSLPNV PGSCKETFNL YYYETDSVIA TKKSAFWSEA PYLKVDTIAA 120
DESFSQVDFG GRLMKVNTEV RSFGPLTRNG FYLAFQDYGA CMSLLSVRVF FKKCPSIVQN 180
FAVFPETMTG AESTSLVIAR GTCIPNAEEV DVPIKLYCNG DGEWMVPIGR CTCKPGYEPE 240
NSVACKACPA GMFKASQEAE VCSHCPSNSR SPSEASPICT CRTGYYRADF DPPEVACTSV 300
PSGPRNVISI VNETSIILEW HPPRETGGRD DVTYNIICKK CRADRRSCSR CDDNVEFVPR 360
QLGLTECRVS ISSLWAHTPY TFDIQAVNGV SSKSPFPPQH VSVNITTNQA APSTVPIMHQ 420
VSATMRSITL SWPQPEQPNG IILDYEIRYY EKEHNEFNSS MARSQTNTAR IDGLRPGMVY 480
VVQVRARTVA GYGKFSGKMC FQTLTDDDYK SELREQLPLI AGSAAAGVVF VVSLVAISIV 540
CSRKRAYSKE AVYSDKLQHY STGRGSPGMK IYIDPFTYED PNEAVREFAK EIDVSFVKIE 600
EVIGAGEFGE VYKGRLKLPG KREIYVAIKT LKAGYSEKQR RDFLSEASIM GQFDHPNIIR 660
LEGVVTKSRP VMIITEFMEN GALDSFLRAQ ELKPSSMPYA LAKKVGLLYY LHRSLASGQL 720
VNSNLVCKVS DFGLSRYLQD DTSDPTYTSS LGGKIPVRWT APEAIAYRKF TSASDVWSYG 780
IVMWEVMSFG ERPYWDMSNQ DVINAIEQDY RLPPPMDCPA ALHQLMLDCW QKDRNSRPRF 840
AEIVNTLDKM IRNPASLKTV ATITAVPSQP LLDRSIPDFT AFTTVDDWLS AIKMVQYRDS 900
FLTAGFTSLQ LVTQMTSEDL LRIGVTLAGH QKKILNSILS MRVQMSQSPT AMA 953
Nucleotide Sequence
(FASTA)
ATGGACACCA GGACGGCTAC TGCAGAGCTG GGCTGGACCG CCAATCCCGC ATCAGGGTGG 60
GAAGAAGTCA GTGGCTACGA TGAAAATCTG AACACCATCC GCACCTACCA GGTGTGTAAT 120
GTCTTCGAGC CCAATCAGAA CAACTGGCTG CTCACCACCT TCATCAATCG GCGGGGGGCC 180
CATCGCATCT ACACGGAGAT GCGCTTCACT GTGAGGGACT GCAGCAGCCT CCCCAACGTC 240
CCAGGCTCCT GCAAGGAGAC CTTCAACTTG TACTACTACG AGACTGACTC TGTCATTGCC 300
ACCAAGAAGT CGGCCTTCTG GTCCGAGGCC CCCTACCTCA AAGTGGACAC TATTGCAGCA 360
GATGAGAGCT TCTCTCAGGT GGACTTTGGG GGAAGATTGA TGAAGGTCAA CACAGAAGTC 420
AGGAGCTTTG GGCCTCTTAC ACGGAATGGT TTTTACCTCG CTTTCCAGGA TTATGGAGCC 480
TGTATGTCTC TCCTTTCTGT CCGTGTCTTC TTCAAAAAGT GTCCCAGCAT TGTGCAAAAT 540
TTTGCAGTGT TCCCAGAGAC TATGACTGGG GCAGAGAGCA CATCTCTGGT CATTGCTCGG 600
GGCACGTGCA TCCCCAATGC AGAGGAAGTG GATGTGCCCA TTAAACTCTA CTGCAACGGG 660
GACGGGGAGT GGATGGTGCC CATCGGGCGC TGCACCTGTA AGCCTGGCTA TGAACCCGAG 720
AACAGCGTGG CCTGCAAGGC TTGCCCTGCA GGGATGTTCA AGGCCAGCCA GGAAGCTGAG 780
GTCTGCTCTC ACTGCCCTTC CAACAGCCGA TCCCCTTCAG AGGCATCTCC CATCTGCACC 840
TGCAGGACCG GCTACTACCG AGCGGATTTT GACCCCCCAG AAGTGGCATG CACTAGTGTC 900
CCATCAGGTC CCCGCAATGT CATCTCCATC GTCAATGAGA CATCCATCAT TCTGGAGTGG 960
CACCCTCCTC GGGAGACGGG TGGGCGGGAT GACGTGACCT ACAACATCAT CTGTAAGAAG 1020
TGCCGGGCAG ACCGCCGGAG CTGCTCCCGC TGTGACGACA ACGTGGAGTT CGTGCCCAGG 1080
CAGCTGGGCC TGACTGAGTG CCGCGTCTCC ATCAGCAGCC TGTGGGCCCA TACCCCGTAT 1140
ACCTTTGACA TCCAGGCTGT CAATGGGGTC TCCAGCAAGA GTCCCTTTCC CCCACAGCAC 1200
GTCTCTGTCA ACATCACCAC AAACCAAGCT GCCCCTTCCA CTGTTCCCAT CATGCACCAG 1260
GTCAGTGCCA CCATGAGGAG CATCACATTG TCATGGCCAC AGCCGGAGCA ACCCAACGGC 1320
ATCATCCTGG ACTATGAGAT CCGGTACTAT GAGAAGGAAC ACAATGAGTT CAACTCCTCC 1380
ATGGCCAGGA GCCAGACCAA CACCGCGCGG ATTGACGGCC TGCGGCCCGG CATGGTGTAC 1440
GTGGTCCAGG TGCGCGCCCG CACCGTGGCC GGCTACGGAA AGTTCAGTGG CAAGATGTGC 1500
TTCCAGACCT TGACGGACGA TGATTACAAG TCCGAGCTGC GGGAGCAGCT GCCCCTGATC 1560
GCTGGCTCAG CGGCAGCTGG GGTGGTGTTT GTGGTGTCCC TGGTGGCCAT CTCCATCGTC 1620
TGCAGCAGGA AACGTGCTTA CAGCAAAGAA GCTGTGTACA GTGATAAGCT CCAGCATTAC 1680
AGCACGGGCC GAGGCTCCCC AGGGATGAAG ATCTACATTG ACCCCTTCAC TTACGAGGAC 1740
CCCAACGAAG CTGTCCGGGA GTTTGCGAAG GAGATTGATG TCTCTTTTGT GAAAATCGAA 1800
GAGGTCATCG GAGCAGGAGA GTTTGGAGAG GTGTACAAGG GGCGTTTGAA ACTTCCAGGC 1860
AAAAGGGAAA TCTATGTGGC CATTAAGACG CTGAAGGCTG GGTACTCAGA GAAGCAGCGA 1920
CGGGACTTTC TGAGTGAGGC GAGCATCATG GGGCAGTTTG ACCATCCCAA CATCATTCGC 1980
CTGGAGGGTG TGGTCACCAA GAGCCGGCCG GTCATGATCA TCACGGAGTT CATGGAGAAT 2040
GGCGCTTTGG ATTCTTTTCT CAGGGCACAA GAGCTGAAGC CCTCCTCAAT GCCTTATGCC 2100
CTAGCCAAGA AGGTTGGCCT GCTCTATTAC CTCCACCGTA GTTTGGCCTC AGGTCAACTG 2160
GTCAACAGTA ACTTGGTATG CAAGGTGTCC GACTTTGGCC TTTCCCGCTA CCTCCAGGAT 2220
GACACCTCAG ATCCCACCTA CACCAGCTCC TTGGGAGGCA AGATCCCCGT GAGATGGACG 2280
GCTCCAGAGG CCATCGCCTA CCGCAAGTTC ACGTCTGCCA GCGACGTCTG GAGCTACGGG 2340
ATTGTCATGT GGGAAGTCAT GTCATTTGGA GAGAGACCCT ACTGGGACAT GTCCAACCAA 2400
GATGTCATCA ATGCCATCGA GCAGGACTAC CGGCTGCCCC CTCCCATGGA CTGCCCAGCT 2460
GCTCTGCACC AGCTCATGCT GGACTGTTGG CAGAAGGACC GTAACAGCCG GCCCCGCTTT 2520
GCAGAGATCG TCAACACCCT GGACAAGATG ATCCGGAACC CGGCAAGTCT CAAGACTGTG 2580
GCTACCATCA CCGCCGTGCC TTCCCAGCCC CTACTCGACC GCTCCATCCC AGACTTCACA 2640
GCCTTCACCA CCGTGGATGA CTGGCTCAGC GCCATCAAGA TGGTCCAGTA CAGGGACAGC 2700
TTCCTCACTG CCGGCTTCAC GTCCCTCCAG CTGGTCACCC AGATGACATC AGAAGACCTC 2760
CTGAGAATAG GGGTCACCCT GGCAGGTCAT CAGAAGAAGA TCCTGAACAG CATTCTGTCT 2820
ATGAGGGTCC AGATGAGTCA GTCACCAACG GCAATGGCAT GA 2862
Domain Profile
S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60
         vkie+viGaGefGev++Grlklpgkrei+vaiktlkag++ekqrrdflseasi+Gqfdhp
Q: 597   VKIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMGQFDHP  656
         79**********************************************************
S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120
         niirleGvvtks+pvmi+te+mengaldsflr ++ + +     +m + +a  +     +
Q: 657   NIIRLEGVVTKSRPVMIITEFMENGALDSFLRAQELKPS-----SMPYALAKKV---GLL  708
         ********************************9987665.....5666676554...445
S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvledds.eaaytts.ggkipirwtapeaiay  178
          y+hr+la+ + lvnsnlvckvsdfGlsr l+dd+ +++yt+s ggkip+rwtapeaiay
Q: 709   YYLHRSLASGQ-LVNSNLVCKVSDFGLSRYLQDDTsDPTYTSSlGGKIPVRWTAPEAIAY  767
         7******9876.8******************99999*****999****************
S: 179   rkftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlml  238
         rkftsasdvwsyGiv+wev+s+Gerpywdmsnqdvi+aie++yrlpppmdcpaal+qlml
Q: 768   RKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPMDCPAALHQLML  827
         ************************************************************
S: 239   dcwqkdraerpkfeqivsil  258
         dcwqkdr++rp+f++iv++l
Q: 828   DCWQKDRNSRPRFAEIVNTL  847
         *****************975
Domain Sequence
(FASTA)
VKIEEVIGAG EFGEVYKGRL KLPGKREIYV AIKTLKAGYS EKQRRDFLSE ASIMGQFDHP 60
NIIRLEGVVT KSRPVMIITE FMENGALDSF LRAQELKPSS MPYALAKKVG LLYYLHRSLA 120
SGQLVNSNLV CKVSDFGLSR YLQDDTSDPT YTSSLGGKIP VRWTAPEAIA YRKFTSASDV 180
WSYGIVMWEV MSFGERPYWD MSNQDVINAI EQDYRLPPPM DCPAALHQLM LDCWQKDRNS 240
RPRFAEIVNT L 251
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00006
EKS-CAJ-00006
EKS-CAF-00006
EKS-CAP-00013
EKS-DAR-00002
EKS-EQC-00006
EKS-FEC-00003
EKS-GAM-00002
EKS-GAG-00006
EKS-GAA-00007
EKS-GOG-00005
EKS-HOS-00006
EKS-ICT-00005
EKS-LOA-00005
EKS-MAM-00005
EKS-MEG-00005
EKS-MIM-00001
EKS-MOD-00007
EKS-MUM-00006
EKS-MUP-00006
EKS-MYL-00006
EKS-NOL-00005
EKS-ORN-00008
EKS-ORC-00006
EKS-ORL-00006
EKS-OTG-00004
EKS-PAT-00006
EKS-PES-00006
EKS-PEM-00001
EKS-POA-00004
EKS-PTV-00003
EKS-RAN-00006
EKS-SAH-00004
EKS-TAG-00013
EKS-TAR-00007
EKS-TEN-00005
EKS-TUT-00002
EKS-XET-00003
EKS-XIM-00006
Gene Ontology
GO:0030424; C:axon
GO:0031901; C:early endosome membrane
GO:0005887; C:integral to plasma membrane
GO:0045121; C:membrane raft
GO:0005524; F:ATP binding
GO:0008046; F:axon guidance receptor activity
GO:0005005; F:transmembrane-ephrin receptor activity
GO:0001525; P:angiogenesis
GO:0048593; P:camera-type eye morphogenesis
GO:0031589; P:cell-substrate adhesion
GO:0021952; P:central nervous system projection neuron axonogenesis
GO:0060997; P:dendritic spine morphogenesis
GO:0050965; P:detection of temperature stimulus involved in sensory perception of pain
GO:0030010; P:establishment of cell polarity
GO:0061351; P:neural precursor cell proliferation
GO:0021631; P:optic nerve morphogenesis
GO:0051965; P:positive regulation of synapse assembly
GO:0070372; P:regulation of ERK1 and ERK2 cascade
GO:0046328; P:regulation of JNK cascade
GO:0031290; P:retinal ganglion cell axon guidance
KEGG
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR009030; Growth_fac_rcpt.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR021129; SAM_type1.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR020635; Tyr_kinase_cat_dom.
IPR016257; Tyr_kinase_ephrin_rcpt.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07714; Pkinase_Tyr; 1.
PF00536; SAM_1; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00790; RECEPTOR_TYR_KIN_V_1; 1.
PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013