EPS-BOT-00128
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEPS-BOT-00128
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
PPP/PP7467.32.2E-140125456332
StatusUnreviewed
Ensembl ProteinENSBTAP00000020539
UniProt AccessionE1B9Y5;
Protein NameSerine/threonine-protein phosphatase
Protein Synonyms/Alias
Gene NamePPEF2
Gene Synonyms/Alias
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSBTAG00000015449ENSBTAP00000020539ENSBTAT00000020539
OrganismBos taurus
Functional Description
Protein Length660
Protein Sequence
(FASTA)
LGPRSPISQT GFSICVTAFR AAALIQRWYR RYVARLEMRR RCTWSIFQSI EYAGQQDQVK 60
LHNFFSYLVD HFTPSSHNER ELNRQFVPEA SETQNCGDYD SIEVPDSYTG PRLSFPLLPD 120
HATALVEAFR RKQRLHARYV LNLLHEARKH LVQLPNINQV STCYSEEITV CGDLHGQLDD 180
LIFIFYKKNG LPSPERAYVF NGDFVDRGKD SVEILMVLFA FMLVYPKEFH LNRGNHEDHI 240
VNLRYGFTKE VMHKYKIHGK KILKLLQDVF CWLPLATLVD EKVLILHGGV SDRTDLELLA 300
KLDRHKMKEV LHKPTQISRK SSEQSKLREA GGLESAESEV DSDAEEQPQP TPEEWRQVVD 360
ILWSDPMAQE GCRANTVRGG GCYFGPNVTE RLLQKYHLQF LIRSHECKPE GYEFCHSRKV 420
LTIFSASNYY EVGSNRGAYV KLGPELTPHI MQFQANKATH MLTMRQRISR VEESALRALR 480
EKLFAHSSDI LVEFKKHDKD ETGLIALSDW AAAVESVLHL GLPWRMLRPQ LVSSLTDNKL 540
AYKSWLENLA KEKLSQQNIQ SSLLETLYRN RSNLETIFRI IDSDHSGSIS LDEFRHTWKL 600
FSSHMNIDIT DDCICDLARS IDFNKDGHID INEFLEAFRL VEQSCSGGDV SDCPQVTNSS 660
Nucleotide Sequence
(FASTA)
CTAGGCCCCA GGAGTCCCAT CTCACAAACT GGCTTTTCCA TCTGTGTCAC AGCCTTCAGG 60
GCAGCAGCCC TGATCCAGAG GTGGTACCGA CGCTACGTGG CCCGCCTGGA GATGAGGCGG 120
CGCTGCACCT GGAGCATCTT CCAGTCCATC GAGTATGCCG GGCAGCAAGA CCAGGTCAAG 180
CTCCACAATT TCTTCAGCTA CCTTGTGGAT CACTTCACCC CCAGCAGTCA CAATGAGAGG 240
GAGCTAAACC GGCAGTTTGT CCCGGAAGCC TCCGAAACGC AGAACTGCGG TGACTACGAC 300
TCCATCGAGG TACCGGACAG TTACACAGGG CCACGCCTCT CCTTCCCACT CCTTCCTGAC 360
CATGCAACTG CCCTGGTGGA AGCTTTCAGA CGAAAACAAA GGCTCCATGC TCGCTATGTC 420
TTGAATCTTT TGCATGAAGC CAGGAAACAC CTGGTACAAC TGCCAAACAT CAACCAGGTC 480
TCCACTTGTT ACAGCGAGGA AATCACAGTG TGTGGAGATT TACATGGCCA GTTGGATGAC 540
TTAATATTTA TATTTTATAA GAAGAACGGC CTCCCATCAC CAGAGCGGGC CTATGTGTTC 600
AATGGCGACT TTGTGGACCG AGGGAAGGAT TCAGTCGAGA TCCTAATGGT TCTGTTTGCC 660
TTCATGTTGG TTTACCCAAA AGAGTTCCAT CTTAACCGAG GAAACCATGA GGACCATATT 720
GTGAACTTAC GATATGGTTT TACCAAGGAA GTGATGCATA AATATAAGAT ACACGGCAAG 780
AAAATACTAA AACTACTGCA AGATGTGTTC TGCTGGCTTC CACTGGCCAC TCTGGTTGAT 840
GAGAAAGTCC TGATTCTTCA CGGTGGAGTG TCAGACAGGA CTGACTTGGA GCTCTTGGCT 900
AAACTAGACA GGCACAAGAT GAAAGAGGTT TTGCATAAGC CAACACAAAT CTCCAGAAAA 960
AGTTCTGAGC AGAGTAAACT TAGAGAAGCA GGGGGTCTAG AGTCAGCTGA GTCAGAAGTG 1020
GACTCAGATG CCGAGGAGCA GCCGCAGCCC ACACCGGAGG AGTGGAGGCA GGTGGTGGAT 1080
ATACTGTGGA GTGACCCCAT GGCTCAGGAG GGCTGCAGGG CCAACACCGT TCGAGGAGGC 1140
GGCTGTTATT TTGGGCCTAA TGTGACAGAG CGGTTACTAC AGAAGTACCA CCTGCAGTTC 1200
CTGATCCGCT CACACGAGTG CAAACCTGAA GGCTATGAAT TCTGCCACAG TCGCAAGGTG 1260
TTAACCATCT TTTCTGCCTC CAACTACTAC GAAGTTGGCA GCAACAGAGG AGCCTATGTC 1320
AAACTGGGGC CAGAACTGAC CCCACACATC ATGCAGTTTC AAGCTAACAA GGCAACCCAC 1380
ATGCTTACCA TGAGGCAAAG GATTAGCAGA GTGGAGGAGT CAGCTCTGAG AGCCCTACGG 1440
GAGAAGTTAT TTGCCCATTC CTCAGATATT CTTGTTGAAT TTAAGAAGCA TGATAAAGAT 1500
GAAACTGGTC TAATCGCCCT GAGCGACTGG GCTGCAGCCG TGGAGTCCGT GCTGCACCTG 1560
GGGCTGCCCT GGCGGATGCT GAGGCCACAG CTGGTGAGCA GCTTGACGGA TAACAAGCTG 1620
GCGTACAAGT CCTGGCTGGA GAACTTGGCC AAAGAAAAAC TGAGCCAACA GAACATACAG 1680
TCAAGTTTGC TGGAAACACT GTATCGCAAC CGATCCAACC TGGAGACCAT TTTTAGGATC 1740
ATAGACAGTG ATCACTCAGG GTCCATCTCA CTGGACGAGT TCAGGCATAC TTGGAAGCTA 1800
TTCAGCTCTC ATATGAACAT TGACATCACA GACGACTGCA TCTGTGACCT TGCCCGGAGC 1860
ATTGACTTCA ACAAGGATGG CCACATTGAC ATCAATGAAT TCCTGGAGGC CTTCCGCCTT 1920
GTGGAGCAAT CCTGCTCAGG GGGTGATGTC TCAGATTGCC CACAAGTCAC AAACAGTAGT 1980
Domain Profile
S: 4     llevfkkkrilhakyvlevlfeakkvlkqlpnishvstavskevtvvGdlhGklddlllv  63
         l+e+f++k++lha+yvl++l+ea+k l qlpni++vst+ s+e+tv+GdlhG+lddl+++
Q: 125   LVEAFRRKQRLHARYVLNLLHEARKHLVQLPNINQVSTCYSEEITVCGDLHGQLDDLIFI  184
         89********************************************************99
S: 64    lk.knGlPsernpyvfnGdfvdrGkrglevllvllslflvfPnavylnrGnhedkvmnar  122
         ++ knGlPs +++yvfnGdfvdrGk ++e+l+vl +++lv+P++ +lnrGnhed+++n+r
Q: 185   FYkKNGLPSPERAYVFNGDFVDRGKDSVEILMVLFAFMLVYPKEFHLNRGNHEDHIVNLR  244
         86379*******************************************************
S: 123   yGfekevlskykrkgkrilrileevyewlPlgsivdsrvlvvhGGlsestsldllksver  182
         yGf+kev++kyk +gk+il++l++v+ wlPl+++vd++vl++hGG+s+ t+l+ll +++r
Q: 245   YGFTKEVMHKYKIHGKKILKLLQDVFCWLPLATLVDEKVLILHGGVSDRTDLELLAKLDR  304
         ************************************************************
S: 183   kkrksvllpPeessrd................lgrldtdgepreslteteweqiidilws  226
         +k+k vl +P++ sr+                   +d d+e + + t +ew+q++dilws
Q: 305   HKMKEVLHKPTQISRKsseqsklreagglesaESEVDSDAEEQPQPTPEEWRQVVDILWS  364
         ***************9*************99989999999999999**************
S: 227   dPratnGlvPntlrGaGvyfGPdvtedflkkyelklvirsheckpegyeilhdgkvvtif  286
         dP a++G+  nt+rG+G+yfGP+vte +l+ky+l+++irsheckpegye++h  kv+tif
Q: 365   DPMAQEGCRANTVRGGGCYFGPNVTERLLQKYHLQFLIRSHECKPEGYEFCHSRKVLTIF  424
         ************************************************************
S: 287   sasnyyeegsnkgayiklnsqltprfvqyiva  318
         sasnyye+gsn+gay+kl  +ltp+++q+++ 
Q: 425   SASNYYEVGSNRGAYVKLGPELTPHIMQFQAN  456
         *****************************976
Domain Sequence
(FASTA)
LVEAFRRKQR LHARYVLNLL HEARKHLVQL PNINQVSTCY SEEITVCGDL HGQLDDLIFI 60
FYKKNGLPSP ERAYVFNGDF VDRGKDSVEI LMVLFAFMLV YPKEFHLNRG NHEDHIVNLR 120
YGFTKEVMHK YKIHGKKILK LLQDVFCWLP LATLVDEKVL ILHGGVSDRT DLELLAKLDR 180
HKMKEVLHKP TQISRKSSEQ SKLREAGGLE SAESEVDSDA EEQPQPTPEE WRQVVDILWS 240
DPMAQEGCRA NTVRGGGCYF GPNVTERLLQ KYHLQFLIRS HECKPEGYEF CHSRKVLTIF 300
SASNYYEVGS NRGAYVKLGP ELTPHIMQFQ AN 332
KeywordCalcium; Complete proteome; Hydrolase; Iron; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Mustela putorius furo"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>
EPS-AIM-00047
EPS-ANC-00049
EPS-CAE-00022
EPS-CAF-00049
EPS-DAR-00076
EPS-DRM-00063
EPS-EQC-00119
EPS-GAM-00040
EPS-GAG-00043
EPS-GAA-00064
EPS-LAC-00050
EPS-LOA-00128
EPS-MEG-00044
EPS-MUP-00116
EPS-ORN-00167
EPS-ORC-00127
EPS-ORL-00056
EPS-OTG-00136
EPS-TAG-00044
EPS-TAR-00062
EPS-TEN-00164
EPS-XIM-00070
Gene Ontology
GO:0005509; F:calcium ion binding
GO:0005506; F:iron ion binding
GO:0030145; F:manganese ion binding
GO:0004721; F:phosphoprotein phosphatase activity
GO:0050906; P:detection of stimulus involved in sensory perception
GO:0043409; P:negative regulation of MAPK cascade
GO:0010801; P:negative regulation of peptidyl-threonine phosphorylation
KEGG
InterPros
IPR011992; EF-hand-like_dom.
IPR018247; EF_Hand_1_Ca_BS.
IPR018249; EF_HAND_2.
IPR002048; EF_hand_Ca-bd.
IPR000048; IQ_motif_EF-hand-BS.
IPR004843; Metallo_PEstase_dom.
IPR013235; PPP_dom.
IPR012008; Ser/Thr-Pase_EF-hand_contain.
IPR006186; Ser/Thr-sp_prot-phosphatase.
Pfam
PF00149; Metallophos; 1.
PF08321; PPP5; 1.
SMARTs
SM00054; EFh; 3.
SM00015; IQ; 1.
SM00156; PP2Ac; 1.
Prosites
PS00018; EF_HAND_1; 3.
PS50222; EF_HAND_2; 3.
PS00125; SER_THR_PHOSPHATASE; 1.
Prints
PR00114; STPHPHTASE.
Created Date20-Feb-2013