EKS-BOT-00147

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-BOT-00147

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/FGFR	554.5	3.6E-167	476	752	277

Status

Unreviewed

Ensembl Protein

ENSBTAP00000020550

UniProt Accession

A4IFL5; F1MKA3;

Protein Name

Fibroblast growth factor receptor

Protein Synonyms/Alias

Gene Name

FGFR1

Gene Synonyms/Alias

FGFR1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000015457	ENSBTAP00000020550	ENSBTAT00000020550

Organism

Bos taurus

Functional Description

Protein Length

820

Protein Sequence
(FASTA)

MWSRKCLLFW AVLVTATLCT AKPAPTLPEQ AQPWGAPVEV ESLLVHPGDL LQLRCRLRDD 60

VQSINWLRDG VQLADSNRTR ITGEEVEVRG SVPADSGLYA CVTSSPSGSD TTYFSVNVSD 120

ALPSSEDDDD DDDSSSEEKE TDNTKPNPVA PYWTSPEKME KKLHAVPAAK TVKFKCPSSG 180

TPNPTLRWLK NGKEFKPDHR IGGYKVRYAT WSIIMDSVVP SDKGNYTCIV ENEYGSINHT 240

YQLDVVERSP HRPILQAGLP ANKTVALGSN VEFMCKVYSD PQPHIQWLKH IEVNGSKIGP 300

DNLPYVQILK TAGVNTTDKE MEVLHLRNVS FEDAGEYTCL AGNSIGLSHH SAWLTVLEAL 360

EERPAVMTSP LYLEIIIYCT GAFLISCMVG SVIIYKMKSG TKKSDFHSQM AVHKLAKSIP 420

LRRQVTVSAD SSASMNSGVL LVRPSRLSSS GTPMLAGVSE YELPEDPRWE LPRDRLVLGK 480

PLGEGCFGQV VLAEAIGLDK DRPNRVTKVA VKMLKSDATE KDLSDLISEM EMMKMIGKHK 540

NIINLLGACT QDGPLYVIVE YASKGNLREY LQARRPPGLE YCYNPSHHPE EQLSSKDLVS 600

CAYQVARGME YLASKKCIHR DLAARNVLVT EDNVMKIADF GLARDIHHID YYKKTTNGRL 660

PVKWMAPEAL FDRIYTHQSD VWSFGVLLWE IFTLGGSPYP GVPVEELFKL LKEGHRMDKP 720

SNCTNELYMM MRDCWHAVPS QRPTFKQLVE DLDRIVALTS NQEYLDLSMP LDQYSPSFPD 780

TRSSTCSSGE DSVFSHEPLP EEPCLPRHPA QLANGGLKRR 820

Nucleotide Sequence
(FASTA)

ATGTGGAGCC GGAAGTGTCT CCTCTTCTGG GCCGTGCTGG TCACAGCCAC GCTCTGCACT 60

GCCAAGCCGG CCCCGACCTT GCCGGAGCAA GCCCAGCCCT GGGGAGCCCC TGTGGAAGTG 120

GAGTCCCTCC TGGTCCACCC CGGTGACCTG CTGCAGCTCC GCTGTCGGCT GCGGGACGAT 180

GTTCAGAGCA TCAACTGGCT GCGGGACGGG GTGCAGCTGG CGGACAGCAA CCGCACGCGC 240

ATCACCGGGG AGGAGGTGGA GGTTCGGGGC TCCGTGCCCG CCGACTCAGG CCTCTACGCC 300

TGCGTGACCA GCAGCCCCTC CGGCAGTGAC ACCACCTACT TCTCCGTCAA CGTCTCAGAT 360

GCGCTCCCCT CGTCGGAGGA CGATGATGAC GACGATGACT CCTCTTCGGA GGAGAAGGAA 420

ACAGATAACA CCAAACCAAA CCCCGTGGCT CCGTACTGGA CGTCACCAGA AAAGATGGAA 480

AAGAAACTGC ACGCAGTGCC AGCTGCCAAG ACAGTGAAGT TCAAATGCCC TTCCAGTGGG 540

ACCCCGAACC CCACACTGCG CTGGCTGAAA AACGGCAAAG AATTCAAGCC CGACCACAGG 600

ATCGGAGGCT ACAAGGTCCG TTATGCCACC TGGAGCATCA TTATGGACTC CGTGGTGCCT 660

TCGGATAAGG GCAACTACAC CTGCATCGTG GAGAACGAAT ACGGCAGCAT CAACCATACC 720

TACCAGCTTG ATGTTGTGGA GCGGTCCCCT CACCGGCCCA TCCTGCAGGC GGGCTTGCCA 780

GCCAACAAGA CGGTGGCCCT GGGCAGCAAC GTGGAGTTCA TGTGCAAGGT GTACAGTGAC 840

CCGCAGCCCC ACATCCAGTG GCTGAAGCAC ATTGAGGTGA ACGGGAGTAA GATTGGGCCG 900

GACAACCTGC CTTATGTCCA GATCTTGAAG ACGGCCGGAG TTAACACCAC CGACAAAGAG 960

ATGGAGGTGC TGCACTTAAG GAATGTCTCC TTTGAGGACG CGGGGGAGTA TACATGCTTG 1020

GCGGGTAACT CTATCGGACT CTCCCATCAC TCTGCATGGC TGACCGTTCT GGAAGCCCTG 1080

GAAGAGAGAC CGGCGGTGAT GACCTCGCCG CTGTACCTGG AGATCATCAT CTATTGCACG 1140

GGGGCCTTCC TCATCTCCTG CATGGTGGGG TCTGTCATCA TCTACAAGAT GAAGAGCGGC 1200

ACAAAGAAGA GTGACTTCCA CAGCCAGATG GCCGTGCACA AGCTGGCCAA GAGCATCCCT 1260

CTGCGCAGAC AGGTAACAGT GTCGGCTGAC TCCAGCGCGT CCATGAACTC CGGGGTCCTG 1320

CTAGTTCGGC CCTCGCGTCT CTCCTCCAGC GGCACCCCTA TGCTGGCCGG GGTCTCTGAA 1380

TATGAGCTTC CCGAAGACCC TCGCTGGGAG CTGCCTCGGG ACAGACTGGT TTTAGGCAAG 1440

CCCCTGGGAG AGGGCTGCTT TGGGCAGGTG GTGCTGGCGG AGGCCATCGG GCTGGACAAG 1500

GACAGACCCA ACCGTGTGAC CAAAGTGGCC GTGAAGATGC TGAAGTCGGA TGCAACAGAG 1560

AAAGACCTGT CGGACCTGAT CTCCGAGATG GAGATGATGA AGATGATTGG AAAACACAAG 1620

AACATCATCA ATCTGCTGGG GGCCTGTACA CAGGATGGTC CCTTGTATGT CATCGTGGAG 1680

TACGCCTCCA AGGGCAATCT CCGAGAGTAC CTGCAGGCCC GGAGGCCGCC AGGGCTGGAG 1740

TACTGCTACA ACCCCAGCCA CCACCCCGAG GAGCAGCTCT CCTCCAAGGA CCTGGTGTCC 1800

TGCGCCTACC AGGTGGCCCG AGGCATGGAG TATCTTGCCT CCAAGAAGTG CATCCACCGG 1860

GACCTGGCCG CCAGGAACGT CCTGGTGACG GAGGACAACG TGATGAAGAT CGCGGACTTC 1920

GGTCTTGCTC GAGACATCCA CCACATCGAC TACTATAAAA AGACAACCAA CGGCCGACTG 1980

CCCGTCAAAT GGATGGCACC GGAGGCCTTG TTTGACCGGA TCTACACCCA CCAGAGCGAC 2040

GTGTGGTCTT TTGGGGTGCT CCTCTGGGAA ATCTTCACTC TGGGCGGCTC CCCATACCCT 2100

GGGGTCCCCG TGGAGGAGCT TTTCAAGCTG CTGAAGGAGG GTCATCGTAT GGACAAGCCC 2160

AGTAACTGCA CCAACGAGCT CTACATGATG ATGAGAGATT GCTGGCACGC GGTCCCCTCT 2220

CAGAGACCCA CCTTCAAGCA GCTGGTGGAA GACCTGGACC GCATCGTGGC CTTGACCTCC 2280

AACCAGGAGT ACCTGGACCT GTCAATGCCC CTGGACCAAT ACTCCCCCAG CTTCCCCGAC 2340

ACCCGCAGCT CCACCTGCTC CTCCGGGGAG GATTCCGTCT TTTCTCACGA GCCCTTGCCC 2400

GAGGAACCCT GCCTGCCCCG ACACCCGGCC CAGCTGGCCA ACGGCGGACT CAAACGGCGC 2460

TGA 2463

Domain Profile

S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60

         lvlgk+lGeG+fGqvv aeaigldkd++++ ++vavkmlk+dat+kdl+dl+seme++k+

Q: 476   LVLGKPLGEGCFGQVVLAEAIGLDKDRPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKM  535

         79**********************************************************

S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120

         iGkhkniinllGactq+Gplyviveya+kGnlre+l+arrp+g e+++++s+++eeql++

Q: 536   IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHHPEEQLSS  595

         ************************************************************

S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180

         kdlvs+ayqvarGmeylaskkcihrdlaarnvlvtednv+kiadfGlard+h+idyykkt

Q: 596   KDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKT  655

         ************************************************************

S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240

         tnGrlpvkwmapealfdr+yt+qsdvwsfGvllwei+tlGgspypg++veelfkllkeGh

Q: 656   TNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGH  715

         ************************************************************

S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277

         rm+kp++ct+ely++mr+cwha++s+rptfkqlvedl

Q: 716   RMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL  752

         ***********************************97

Domain Sequence
(FASTA)

LVLGKPLGEG CFGQVVLAEA IGLDKDRPNR VTKVAVKMLK SDATEKDLSD LISEMEMMKM 60

IGKHKNIINL LGACTQDGPL YVIVEYASKG NLREYLQARR PPGLEYCYNP SHHPEEQLSS 120

KDLVSCAYQV ARGMEYLASK KCIHRDLAAR NVLVTEDNVM KIADFGLARD IHHIDYYKKT 180

TNGRLPVKWM APEALFDRIY THQSDVWSFG VLLWEIFTLG GSPYPGVPVE ELFKLLKEGH 240

RMDKPSNCTN ELYMMMRDCW HAVPSQRPTF KQLVEDL 277

Keyword

ATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0005007	; F:fibroblast growth factor-activated receptor activity
GO:0008201	; F:heparin binding
GO:0001525	; P:angiogenesis
GO:0060117	; P:auditory receptor cell development
GO:0060445	; P:branching involved in salivary gland morphogenesis
GO:0048469	; P:cell maturation
GO:0002062	; P:chondrocyte differentiation
GO:0030326	; P:embryonic limb morphogenesis
GO:0035607	; P:fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development
GO:0001701	; P:in utero embryonic development
GO:0042472	; P:inner ear morphogenesis
GO:0060484	; P:lung-associated mesenchyme development
GO:0048762	; P:mesenchymal cell differentiation
GO:0030901	; P:midbrain development
GO:0042474	; P:middle ear morphogenesis
GO:0043066	; P:negative regulation of apoptotic process
GO:0000122	; P:negative regulation of transcription from RNA polymerase II promoter
GO:0001759	; P:organ induction
GO:0042473	; P:outer ear morphogenesis
GO:0048339	; P:paraxial mesoderm development
GO:0018108	; P:peptidyl-tyrosine phosphorylation
GO:0060045	; P:positive regulation of cardiac muscle cell proliferation
GO:0045787	; P:positive regulation of cell cycle
GO:0043406	; P:positive regulation of MAP kinase activity
GO:0090080	; P:positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
GO:0002053	; P:positive regulation of mesenchymal cell proliferation
GO:0045666	; P:positive regulation of neuron differentiation
GO:0010976	; P:positive regulation of neuron projection development
GO:0010863	; P:positive regulation of phospholipase C activity
GO:0046777	; P:protein autophosphorylation
GO:0060665	; P:regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
GO:0048378	; P:regulation of lateral mesodermal cell fate specification
GO:0007605	; P:sensory perception of sound
GO:0001657	; P:ureteric bud development
GO:0021847	; P:ventricular zone neuroblast division

KEGG

bta:281768

;

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016248	; Tyr_kinase_fibroblast_GF_rcpt.

Pfam

PF07679	; I-set; 3.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00408	; IGc2; 3.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013