EKS-BOT-00312
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-BOT-00312
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
STE/STE20353.47.8E-106247498252
StatusUnreviewed
Ensembl ProteinENSBTAP00000013449
UniProt AccessionE1B7J7;
Protein Name
Protein Synonyms/Alias
Gene NamePAK3
Gene Synonyms/Alias PAK3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSBTAG00000015670ENSBTAP00000013449ENSBTAT00000013449
OrganismBos taurus
Functional Description
Protein Length523
Protein Sequence
(FASTA)
MAPEEKNKKA RLRSIFPGGG DKTNKKKEKE RPEISLPSDF EHTIHVGFDA VTGEFTPDLY 60
GSQMCPGKLP EGIPEQWARL LQTSNITKLE QKKNPQAVLD VLKFYDSKET VNNQKYMSFT 120
SGDKSAHGYI AAHPSSTKTA SEPPLAPPVS EEEDEEEEEE EDDNEPPPVI APRPEHTKSI 180
YTRSVVESIA SPAAPNKEVT PPSAENANSS TLYRNTDRQR KKSKMTDEEI LEKLRSIVSV 240
GDPKKKYTRF EKIGQGASGT VYTALDIATG QEVAIKQMNL QQQPKKELII NEILVMRENK 300
NPNIVNYLDS YLVGDELWVV MEYLAGGSLT DVVTETCMDE GQIAAVCREC LQALDFLHSN 360
QVIHRDIKSD NILLGMDGSV KLTDFGFCAQ ITPEQSKRST MVGTPYWMAP EVVTRKAYGP 420
KVDIWSLGIM AIEMVEGEPP YLNENPLRAL YLIATNGTPE LQNPERLSAV FRDFLNRCLE 480
MDVDRRGSAK ELLQHPFLKL AKPLSSLTPL IIAAKEAIKN SSR 523
Nucleotide Sequence
(FASTA)
ATGGCCCCTG AAGAGAAGAA TAAGAAAGCC AGGCTTCGCT CTATCTTCCC AGGAGGAGGG 60
GATAAAACCA ATAAGAAGAA AGAGAAAGAG CGCCCAGAGA TCTCTCTTCC TTCAGACTTT 120
GAACATACGA TTCATGTGGG GTTTGATGCA GTCACCGGGG AATTCACTCC AGATCTCTAT 180
GGCTCACAGA TGTGCCCAGG GAAGCTCCCA GAGGGAATTC CTGAGCAATG GGCACGATTA 240
CTCCAAACCT CCAACATAAC AAAGCTGGAA CAGAAGAAGA ACCCCCAAGC TGTTCTAGAT 300
GTTCTCAAAT TCTATGATTC CAAAGAAACA GTCAACAACC AGAAATACAT GAGCTTTACA 360
TCAGGAGATA AAAGCGCACA CGGATACATA GCAGCCCATC CTTCGAGTAC AAAAACAGCA 420
TCAGAGCCTC CTTTGGCTCC TCCTGTGTCT GAAGAAGAAG ATGAAGAAGA GGAAGAAGAA 480
GAAGATGACA ATGAGCCCCC ACCAGTCATT GCACCAAGAC CAGAGCATAC AAAATCAATC 540
TACACTCGTT CCGTGGTTGA ATCAATTGCT TCACCAGCAG CACCAAATAA AGAGGTCACA 600
CCACCTTCTG CTGAGAACGC CAATTCCAGT ACTTTGTATA GAAACACAGA TCGGCAAAGG 660
AAAAAATCCA AAATGACAGA TGAGGAGATC CTAGAGAAGC TAAGAAGCAT TGTGAGTGTT 720
GGTGACCCAA AGAAAAAATA CACAAGATTT GAAAAAATAG GTCAAGGGGC CTCAGGTACT 780
GTTTATACAG CGCTGGACAT TGCCACAGGA CAAGAGGTGG CCATAAAGCA GATGAACCTT 840
CAACAGCAGC CCAAAAAGGA ATTAATTATT AATGAAATTC TGGTCATGAG GGAAAATAAG 900
AACCCCAATA TTGTTAATTA TTTAGATAGC TACTTAGTGG GTGATGAACT GTGGGTAGTC 960
ATGGAATACT TGGCTGGTGG CTCTTTGACT GATGTGGTCA CAGAGACCTG TATGGATGAA 1020
GGACAGATAG CAGCTGTCTG CAGAGAGTGC CTCCAAGCTT TGGATTTCTT GCACTCAAAC 1080
CAAGTGATCC ACAGAGACAT AAAGAGTGAC AATATTCTCC TTGGGATGGA TGGCTCTGTC 1140
AAACTGACTG ATTTTGGGTT CTGTGCCCAG ATCACCCCTG AGCAAAGTAA ACGAAGCACG 1200
ATGGTGGGAA CTCCCTATTG GATGGCACCT GAGGTAGTGA CTCGAAAAGC CTATGGTCCG 1260
AAAGTTGATA TCTGGTCTCT GGGAATTATG GCGATTGAAA TGGTAGAAGG CGAACCCCCT 1320
TACCTTAACG AAAATCCACT CAGGGCATTA TATCTGATAG CCACTAATGG AACCCCAGAG 1380
CTGCAGAATC CTGAGAGACT GTCTGCTGTA TTCCGTGACT TTTTAAATCG CTGTCTTGAG 1440
ATGGATGTGG ATAGGCGAGG ATCCGCCAAG GAGCTTTTGC AGCATCCATT TTTAAAATTA 1500
GCCAAGCCTC TCTCCAGCCT GACTCCTCTG ATTATTGCTG CAAAAGAAGC GATTAAGAAC 1560
AGCAGCCGCT AG 1572
Domain Profile
S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpnive  60
         y+ +e+ig+Ga+g+vy+a ++ tg+ vaik++nl++q+k+e++++ei v+++ k+pniv+
Q: 247   YTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVN  306
         7889********************************************************
S: 61    ylesflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkvi  120
         yl+s+l+ +elw+vmeylagGsl+d+v+   ++ ++E qia+++re+l+aL++lHs++vi
Q: 307   YLDSYLVGDELWVVMEYLAGGSLTDVVT---ETCMDEGQIAAVCRECLQALDFLHSNQVI  363
         ****************************...9****************************
S: 121   HrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqeekgYdek  180
         Hrdik++niLl ++g+VkL+dfg++aq++ +++kr+t+vgtpywmAPEv++  +k Y  k
Q: 364   HRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVT--RKAYGPK  421
         ***************************************************..9******
S: 181   aDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfskefkefvekclqk  240
         +DiwslGI+aie++egepP+ +++pl+al++i++n +p+l++++++s  f++f+++cl+ 
Q: 422   VDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEM  481
         ************************************************************
S: 241   npekRpsasellkhkFl  257
         ++++R sa+ell+h+Fl
Q: 482   DVDRRGSAKELLQHPFL  498
         ****************7
Domain Sequence
(FASTA)
YTRFEKIGQG ASGTVYTALD IATGQEVAIK QMNLQQQPKK ELIINEILVM RENKNPNIVN 60
YLDSYLVGDE LWVVMEYLAG GSLTDVVTET CMDEGQIAAV CRECLQALDF LHSNQVIHRD 120
IKSDNILLGM DGSVKLTDFG FCAQITPEQS KRSTMVGTPY WMAPEVVTRK AYGPKVDIWS 180
LGIMAIEMVE GEPPYLNENP LRALYLIATN GTPELQNPER LSAVFRDFLN RCLEMDVDRR 240
GSAKELLQHP FL 252
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>
EKS-AIM-00289
EKS-ANC-00301
EKS-CAJ-00318
EKS-CAF-00314
EKS-CAP-00346
EKS-DRM-00156
EKS-EQC-00303
EKS-FEC-00298
EKS-GAG-00263
EKS-GAA-00397
EKS-GOG-00308
EKS-HOS-00319
EKS-LOA-00320
EKS-MEG-00252
EKS-MOD-00306
EKS-MUM-00344
EKS-MUP-00311
EKS-MYL-00310
EKS-NOL-00286
EKS-ORN-00407
EKS-ORA-00271
EKS-ORC-00295
EKS-ORL-00373
EKS-OTG-00319
EKS-PAT-00295
EKS-PES-00281
EKS-POA-00302
EKS-RAN-00327
EKS-SAH-00294
EKS-TAG-00326
EKS-TAR-00408
EKS-TEN-00404
EKS-VIP-00035
EKS-XET-00380
EKS-XIM-00398
EKS-SCP-00076
Gene Ontology
GO:0005524; F:ATP binding
GO:0004708; F:MAP kinase kinase activity
GO:0004674; F:protein serine/threonine kinase activity
GO:0007409; P:axonogenesis
GO:0016358; P:dendrite development
GO:0030833; P:regulation of actin filament polymerization
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000095; PAK_box_Rho-bd.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00786; PBD; 1.
PF00069; Pkinase; 1.
SMARTs
SM00285; PBD; 1.
SM00220; S_TKc; 1.
Prosites
PS50108; CRIB; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013