EKS-BOT-00462

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-BOT-00462

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	431.6	1.4E-129	25	313	289

Status

Unreviewed

Ensembl Protein

ENSBTAP00000021507

UniProt Accession

E1B8P9;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK3

Gene Synonyms/Alias

MAPK3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000016156	ENSBTAP00000021507	ENSBTAT00000021507

Organism

Bos taurus

Functional Description

Protein Length

362

Protein Sequence
(FASTA)

MAAAAAAQGG GEIVKGQPFD VGPRYTQLQY IGEGAYGMVS SAYDHVRKTR VAIKKISPFE 60

HQTYCQRTLR EIQILLRFRH ENVIGIRDIL RAPTLEAMRD VYIVQDLMET DLYKLLKSQQ 120

LSNDHVCYFL YQILRGLKYI HSANVLHRDL KPSNLLINTT CDLKICDFGL ARIADPEHDH 180

TGFLTEYVAT RWYRAPEIML NSKGYTKSID IWSVGCILAE MLSNRPIFPG KHYLDQLNHI 240

LGILGSPSQE DLNCIINMKA RNYLQSLPSK TKVAWAKLFP KSDPKALDLL DRMLTFNPNK 300

RITVEEALAH PYLEQYYDPT DEPVAEEPFT FDMELDDLPK ERLKELIFQE TARFQPGVLE 360

AS 362

Nucleotide Sequence
(FASTA)

ATGGCGGCGG CGGCGGCGGC TCAGGGGGGC GGGGAGATAG TAAAGGGGCA GCCGTTCGAC 60

GTGGGCCCGC GCTACACGCA GCTGCAGTAC ATCGGCGAGG GCGCGTACGG CATGGTCAGC 120

TCAGCTTACG ACCACGTGCG CAAGACTCGA GTGGCCATCA AGAAAATCAG CCCCTTTGAG 180

CATCAGACCT ACTGCCAGCG CACATTGCGA GAGATTCAGA TTCTGCTGCG CTTCCGCCAT 240

GAGAACGTCA TTGGCATCCG AGACATTCTG CGGGCACCCA CCCTGGAAGC CATGAGGGAT 300

GTCTACATCG TACAGGACCT GATGGAGACA GACCTGTACA AATTGCTCAA AAGCCAGCAG 360

CTGAGCAACG ACCATGTATG CTACTTCCTG TACCAGATCC TGCGGGGCCT GAAGTATATC 420

CACTCCGCCA ACGTGCTCCA CCGGGATTTA AAGCCCTCCA ACCTGCTCAT CAACACCACC 480

TGCGACCTTA AGATCTGTGA TTTCGGTCTT GCCCGGATTG CTGATCCCGA GCATGACCAC 540

ACTGGCTTTC TGACGGAATA CGTGGCCACA CGCTGGTACC GGGCCCCAGA GATCATGCTT 600

AACTCCAAGG GCTACACCAA GTCCATCGAC ATCTGGTCTG TGGGCTGCAT TCTGGCTGAG 660

ATGCTCTCCA ACCGGCCCAT CTTCCCCGGC AAGCACTACC TGGACCAGCT CAACCACATT 720

CTGGGTATTC TAGGCTCCCC ATCCCAGGAG GACCTGAATT GTATCATCAA CATGAAGGCC 780

CGAAACTACC TACAGTCTCT GCCCTCCAAG ACCAAGGTGG CCTGGGCCAA GCTTTTTCCT 840

AAGTCAGACC CCAAAGCTCT TGACCTGCTG GACCGGATGT TGACCTTTAA CCCCAACAAA 900

CGGATCACAG TGGAAGAAGC GCTGGCTCAC CCCTACCTGG AGCAGTACTA TGACCCAACG 960

GATGAGCCAG TGGCCGAGGA ACCTTTCACC TTCGACATGG AGCTGGATGA TCTACCCAAG 1020

GAACGACTGA AGGAGCTCAT CTTCCAGGAG ACAGCCCGCT TCCAGCCTGG GGTGCTGGAA 1080

GCCTCCTAA 1089

Domain Profile

S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60

         y++l+++geGayg+v sa+d+ +++rvaikk+s pf+++t ++rtlRE+++l +++heN+

Q: 25    YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKIS-PFEHQTYCQRTLREIQILLRFRHENV  83

         7899****************************9.**************************

S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHs  120

         i + d++++ + le+++dvY+v++lmetdL+k++ksq+ls++h+ ++lyqilrglky+Hs

Q: 84    IGIRDILRAPT-LEAMRDVYIVQDLMETDLYKLLKSQQLSNDHVCYFLYQILRGLKYIHS  142

         *********99.************************************************

S: 121   anviHrDlKPsNllvnedcelkildFGlarsadkekekk..lteyvatrwYraPeillsl  178

         anv+HrDlKPsNll+n++c+lki+dFGlar+ad+e++++  lteyvatrwYraPei+l++

Q: 143   ANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTgfLTEYVATRWYRAPEIMLNS  202

         ***********************************99999********************

S: 179   keytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearn  238

         k ytk++DiWsvGCIlaE+l+++p+fpgk+++dql++il +lg+ps+e+l++i + +arn

Q: 203   KGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARN  262

         ************************************************************

S: 239   yikslpkkkkkdfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289

         y++slp+k+k  +++lfpk++++aldLl+++L+++p+kRi+veeaL+hpYl

Q: 263   YLQSLPSKTKVAWAKLFPKSDPKALDLLDRMLTFNPNKRITVEEALAHPYL  313

         **************************************************7

Domain Sequence
(FASTA)

YTQLQYIGEG AYGMVSSAYD HVRKTRVAIK KISPFEHQTY CQRTLREIQI LLRFRHENVI 60

GIRDILRAPT LEAMRDVYIV QDLMETDLYK LLKSQQLSND HVCYFLYQIL RGLKYIHSAN 120

VLHRDLKPSN LLINTTCDLK ICDFGLARIA DPEHDHTGFL TEYVATRWYR APEIMLNSKG 180

YTKSIDIWSV GCILAEMLSN RPIFPGKHYL DQLNHILGIL GSPSQEDLNC IINMKARNYL 240

QSLPSKTKVA WAKLFPKSDP KALDLLDRML TFNPNKRITV EEALAHPYL 289

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0031143	; C:pseudopodium
GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0051216	; P:cartilage development
GO:0071260	; P:cellular response to mechanical stimulus
GO:0070498	; P:interleukin-1-mediated signaling pathway
GO:0031663	; P:lipopolysaccharide-mediated signaling pathway
GO:0000165	; P:MAPK cascade
GO:2000657	; P:negative regulation of apolipoprotein binding
GO:0009887	; P:organ morphogenesis
GO:0035066	; P:positive regulation of histone acetylation
GO:0033129	; P:positive regulation of histone phosphorylation
GO:0045944	; P:positive regulation of transcription from RNA polymerase II promoter
GO:0051090	; P:regulation of sequence-specific DNA binding transcription factor activity
GO:0006974	; P:response to DNA damage stimulus
GO:0043330	; P:response to exogenous dsRNA
GO:0019233	; P:sensory perception of pain
GO:0006351	; P:transcription, DNA-dependent

KEGG

bta:531391

;

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR008349	; MAPK_ERK1/2.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01770

; ERK1ERK2MAPK.

Created Date

20-Feb-2013