EKS-BOT-00145

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-BOT-00145

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/CDC7	547.0	1.3E-164	58	571	514

Status

Unreviewed

Ensembl Protein

ENSBTAP00000021696

UniProt Accession

Q32PH9; F1N271;

Protein Name

Protein Synonyms/Alias

Cell division cycle 7 homolog (S. cerevisiae);

Gene Name

CDC7L1

Gene Synonyms/Alias

CDC7L1; CDC7;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000016307	ENSBTAP00000021696	ENSBTAT00000021696

Organism

Bos taurus

Functional Description

Protein Length

576

Protein Sequence
(FASTA)

MEPALGIQMD EPMAFSPLGG RFQAEGSLKK QEQNFKPPGV KKDIEKLYEA VPQLGNLFKI 60

KDKIGEGTFS SVYLATAQLQ VGPEEKIALK HLIPTSHPIR IAAELQCLTV AGGQDNVMGV 120

KYCFRKNDHV VIAMPYLEHE SFLDILNSLS FQEVREYMFN LFKALKRIHQ FGIVHRDVKP 180

SNFLYNRRLK KYALVDFGLA QGTHDTKIEL LKFVQSEAHQ ESCSQNKSYV ITGNKISLSG 240

PAAPKELDQQ STPKTSVKRP YTNTQTQTKH GKDGKEGSVG LSVQRSVFGE RNFNIHSSIS 300

HESPAVKLMK QSKTVDLLSR KLGTKKKTIS TKVMNSGVMR KTASSCPATL TCDCYATDKV 360

CSICLSRRQQ VAPRAGTPGF RAPEVLTKCP NQTTAIDMWS AGVIFLSLLS GRYPFYKASD 420

DLTALAQIMT IRGTRETIQA AKTFGKSILC SKEVPAQDLR KLCEKLRGIN STTPKLISDI 480

QECSSHDPAF SEKTENHKIV HFIQTPQAQP SGNPSYKGDG NGCGGNFEES ATNLEGWDEV 540

PDEAYDLLDK LLDLNPASRI TAEEALLHPF FKDMSL 576

Nucleotide Sequence
(FASTA)

ATGGAGCCTG CTTTGGGGAT TCAGATGGAT GAGCCAATGG CTTTTTCTCC CCTTGGTGGC 60

CGGTTTCAGG CGGAAGGCTC ATTAAAAAAA CAAGAGCAGA ATTTTAAACC ACCAGGTGTT 120

AAAAAAGATA TTGAAAAGCT TTATGAAGCT GTACCACAGC TTGGTAATCT GTTTAAGATT 180

AAGGACAAAA TTGGAGAAGG CACTTTCAGC TCTGTTTATT TGGCTACAGC ACAGTTACAA 240

GTTGGACCTG AAGAGAAAAT TGCTCTAAAA CACTTAATTC CAACAAGTCA CCCCATAAGA 300

ATTGCAGCTG AACTTCAGTG CTTAACTGTG GCTGGGGGGC AAGACAATGT CATGGGAGTT 360

AAATACTGCT TTAGGAAAAA TGATCATGTG GTTATTGCTA TGCCATATCT GGAGCATGAG 420

TCCTTTTTGG ACATTTTGAA TTCTCTTTCT TTTCAAGAAG TACGGGAATA TATGTTTAAT 480

CTGTTCAAAG CTTTGAAACG CATTCATCAG TTTGGTATTG TTCACCGTGA TGTTAAGCCC 540

AGCAATTTTT TATATAATAG GCGCTTGAAA AAGTATGCCT TGGTAGACTT TGGTTTGGCC 600

CAAGGAACCC ATGATACTAA AATAGAGCTG CTCAAATTTG TCCAGTCTGA AGCTCACCAG 660

GAAAGCTGTT CACAAAATAA ATCCTATGTA ATCACCGGCA ACAAGATTTC ATTGAGTGGC 720

CCAGCAGCAC CTAAAGAGCT GGATCAGCAA TCTACCCCAA AAACTTCTGT TAAAAGGCCC 780

TACACAAACA CACAAACTCA GACTAAACAC GGAAAAGATG GAAAGGAGGG ATCTGTAGGC 840

CTTTCTGTCC AGCGCTCTGT TTTTGGAGAA AGAAATTTCA ATATACACAG CTCCATTTCA 900

CATGAGAGCC CTGCAGTGAA ACTTATGAAG CAGTCAAAGA CGGTGGATTT ACTGTCTAGA 960

AAATTAGGAA CAAAAAAGAA GACCATTTCT ACCAAAGTTA TGAATAGTGG TGTGATGAGG 1020

AAAACTGCCA GTTCTTGCCC AGCTACCCTG ACCTGTGACT GTTACGCAAC AGATAAAGTT 1080

TGCAGTATTT GCCTTTCAAG GCGGCAACAG GTTGCACCCA GGGCAGGTAC ACCAGGATTC 1140

AGAGCACCAG AGGTCTTGAC GAAGTGCCCC AATCAAACTA CAGCAATTGA CATGTGGTCT 1200

GCAGGCGTCA TATTCCTTTC TTTGCTTAGT GGAAGATATC CATTTTATAA AGCAAGTGAT 1260

GATTTAACTG CTTTGGCTCA AATTATGACA ATTCGTGGAA CCAGGGAAAC TATCCAGGCT 1320

GCTAAAACTT TTGGCAAGTC AATATTGTGT AGCAAAGAGG TTCCAGCACA AGACTTGAGA 1380

AAACTTTGTG AGAAGCTTAG AGGTATAAAT TCTACCACTC CTAAATTAAT AAGTGATATA 1440

CAGGAGTGCA GTTCTCATGA CCCAGCTTTT TCAGAGAAGA CAGAAAACCA TAAAATTGTT 1500

CACTTCATAC AGACACCTCA AGCGCAGCCC TCAGGGAATC CATCATATAA AGGTGACGGT 1560

AATGGCTGTG GGGGCAATTT TGAGGAGTCT GCTACCAATC TAGAAGGCTG GGATGAGGTG 1620

CCCGATGAAG CTTATGACCT GCTTGATAAA CTCCTAGATC TGAATCCAGC TTCAAGAATA 1680

ACAGCAGAGG AAGCTTTGTT GCATCCATTT TTTAAAGATA TGAGTTTATG A 1731

Domain Profile

S: 1     fkikdkiGeGtfssvylataqleegleekialkhliptshPeriaaeLelltvlgGqenv  60

         fkikdkiGeGtfssvylataql++g+eekialkhliptshP+riaaeL++ltv+gGq+nv

Q: 58    FKIKDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPIRIAAELQCLTVAGGQDNV  117

         9***********************************************************

S: 61    vglkecfrkndsvvivlpylehesfldllrslsfqevreYlrnLlvalkrvhkfgivhrD  120

         +g+k+cfrknd+vvi++pylehesfld+l+slsfqevreY++nL++alkr+h+fgivhrD

Q: 118   MGVKYCFRKNDHVVIAMPYLEHESFLDILNSLSFQEVREYMFNLFKALKRIHQFGIVHRD  177

         ************************************************************

S: 121   vkpsnfLynrrlkkfaLvDfGLaq..............seaqkeecsrn...........  155

         vkpsnfLynrrlkk+aLvDfGLaq              sea++e+cs+n

Q: 178   VKPSNFLYNRRLKKYALVDFGLAQgthdtkiellkfvqSEAHQESCSQNksyvitgnkis  237

         *************************************************88888888774

S: 156   llsaavekevd.................................................  166

         l   a++ke+d

Q: 238   LSGPAAPKELDqqstpktsvkrpytntqtqtkhgkdgkegsvglsvqrsvfgernfnihs  297

         333445666669999*********************************************

S: 167   .....................................................tcdcygt  173

                                                              tcdcy+t

Q: 298   sishespavklmkqsktvdllsrklgtkkktistkvmnsgvmrktasscpatlTCDCYAT  357

         ************************************************************

S: 174   dkvcsvclsrrqqvanraGtpGfraPevLlkipdqttaiDiwsaGvilLsllsgryPffk  233

         dkvcs+clsrrqqva+raGtpGfraPevL+k+p+qttaiD+wsaGvi+LsllsgryPf+k

Q: 358   DKVCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYK  417

         ************************************************************

S: 234   asddlealaeivtilGsreiikaakafgksvllskevp......................  271

         asddl+ala+i+ti+G+re+i+aak+fgks+l+skevp

Q: 418   ASDDLTALAQIMTIRGTRETIQAAKTFGKSILCSKEVPaqdlrklceklrginsttpkli  477

         ************************************************************

S: 272   ...................................................dsdsye...  277

Q: 478   sdiqecsshdpafsektenhkivhfiqtpqaqpsgnpsykgdgngcggnfeE----Satn  533

         ********99999999999999999999999999888888866666665540....0455

S: 278   .......PdeaydlldkllelnPakritaeealkhpff  308

                Pdeaydlldkll+lnPa+ritaeeal+hpff

Q: 534   legwdevPDEAYDLLDKLLDLNPASRITAEEALLHPFF  571

         5666888******************************8

Domain Sequence
(FASTA)

FKIKDKIGEG TFSSVYLATA QLQVGPEEKI ALKHLIPTSH PIRIAAELQC LTVAGGQDNV 60

MGVKYCFRKN DHVVIAMPYL EHESFLDILN SLSFQEVREY MFNLFKALKR IHQFGIVHRD 120

VKPSNFLYNR RLKKYALVDF GLAQGTHDTK IELLKFVQSE AHQESCSQNK SYVITGNKIS 180

LSGPAAPKEL DQQSTPKTSV KRPYTNTQTQ TKHGKDGKEG SVGLSVQRSV FGERNFNIHS 240

SISHESPAVK LMKQSKTVDL LSRKLGTKKK TISTKVMNSG VMRKTASSCP ATLTCDCYAT 300

DKVCSICLSR RQQVAPRAGT PGFRAPEVLT KCPNQTTAID MWSAGVIFLS LLSGRYPFYK 360

ASDDLTALAQ IMTIRGTRET IQAAKTFGKS ILCSKEVPAQ DLRKLCEKLR GINSTTPKLI 420

SDIQECSSHD PAFSEKTENH KIVHFIQTPQ AQPSGNPSYK GDGNGCGGNF EESATNLEGW 480

DEVPDEAYDL LDKLLDLNPA SRITAEEALL HPFF 514

Keyword

ATP-binding; Cell cycle; Cell division; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0051301	; P:cell division
GO:0008284	; P:positive regulation of cell proliferation
GO:0033261	; P:regulation of S phase

KEGG

bta:516094

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 2.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013