EKS-BOT-00440

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-BOT-00440

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/DMPK	488.1	7.2E-147	18	286	269

Status

Unreviewed

Ensembl Protein

ENSBTAP00000021879

UniProt Accession

E1BP72;

Protein Name

Protein Synonyms/Alias

Gene Name

CDC42BPB

Gene Synonyms/Alias

CDC42BPB;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000016456	ENSBTAP00000021879	ENSBTAT00000021879

Organism

Bos taurus

Functional Description

Protein Length

1656

Protein Sequence
(FASTA)

AKPFTQLVKE MQLHREDFEI IKVIGRGAFG EVAVVKMKNT ERIYAMKILN KWEMLKRAET 60

ACFREERDVL VNGDCQWITT LHYAFQDENY LYLVMDYYVG GDLLTLLSKF EDKLPEDMAR 120

FYIGEMVLAI DSIHQLHYVH SNRDIKPDNV LLDVNGHIRL ADFGSCLKMN DDGTVQSSVA 180

VGTPDYISPE ILQAMEDGMG KYGPECDWWS LGVCMYEMLY GETPFYAESL VETYGKIMNH 240

EERFQFPSHV TDVSEEARDL IQRLICSRER RLGQNGVEDF KKHAFFQGLN WENIRNLEAP 300

YIPDVSSPSD TSNFDVDDDV LRNIEVLPPG SHTGFSGLHL PFIGFTFTTE SCFSDRGSLK 360

SILQSSTLTR DEGVQRDLEA SLQVEAYERR IRRLEQERLE LSRKLQESTQ TVQSLHGSAR 420

TLGGAARDKE IKRLNEEIER LKNKIADSSR LERQLEDTVT LRQEHEDSAQ RLKGLEKQYR 480

VVRQEKEDLH KQLIEASERL KSQARELKDA HQQRKLALQE FSELNERMAE LRSQKQKVSR 540

QLRDREEEVE AAMQKIDALR QEVRRADKGR KELEVQLEDA VAEASKERKL REHSENFSKQ 600

VESELEALKM KQGGRGPGAA LEHQQEISKI KSELEKKVLF YEEELVRREA SHVLEVKNVK 660

KEVHDSESQQ LALQKEVMVL KDKLEKSRRE RHSEMEEAVG TIRDKYERER AMLFEENKKL 720

TAENEKLCSF VDKLTAQNRQ LEDELQDLAA KKESVAHWEA QIAEIIQWVS DEKDARGYLQ 780

ALASKMTEEL ETLRSSSLGS RTLDPLWKVR RSQKLDMSAR LELQSALEAE IRAKQLVQEE 840

LRKVKDVNLS FESKLKDSEA KNRELLEEME ILKKKMEEKF RADTGLKLPD FQDSIFEYFN 900

TAPLAHDLTF RSSSTSEQET QAPKPEASLG VSVAAGAEQP EDVARAPPRL PAVPLPSAQT 960

LALAGPKPKA HQLSIKSFSS PTQCSHCTSL MVGLIRQGYA CDVCSFACHV SCRDRAPQVC 1020

PIPPEQSKRP LGVDVQRGIG TAYKGYVKIP KPTGVKKGWQ RAFAVVCDCR LFLYDLPEGK 1080

SAQPGVLASQ VLDLRDEEFS VSSVLASDVI HASRRDIPCI FRVTASLLGA PSKTSSLLIL 1140

TENENEKRKW VGILEGLQAI LQKNRLQSQA VHVPQEAYDS SLPLIKAVLT AAILDGDRIA 1200

IGLEEGLYVI EVTRDVIVRV ADYKKVYQIE LAPKERVAVL LCGRNHHVHL CPWSSFDGAE 1260

SNMDIKLPET KGCQLIVTGT LKKSGPTCLF VAVKRLVLCY EIQRTKPLHR KLSELVAPGN 1320

VQWMAAVKDR LCVGYPSGFS LLSTQGDGQA LNLVNPNDPS LTFLSQQSFD ALCAVELKSE 1380

EYLLCFSHMG LYVDPQGRRS RAQELMWPAA PVACSCSPTH VTVYSEYGVD VFDVRTMEWV 1440

QTVGLRRIRP LNLEGSLNLL NCEPPRLIYF KSKASGTVLN VPDTSDNSRK QMLRTRSKRR 1500

FVFKVPEEER LQQRREMLRD PELRSKMISN PTNFNHVAHM GPGDGMQVLM DLPLSAVPPA 1560

QEERPGPAPA SLSRPPPPRN KPYVSWPSSG RGSEPGVAVP LRSMSDRQDF DKEPDSDSTK 1620

HSTPSNSSNP SGPPSPTSPP RSQLPLESLE QPSRDA 1656

Nucleotide Sequence
(FASTA)

GCAAAACCGT TTACACAACT GGTGAAGGAA ATGCAGCTTC ATCGAGAAGA CTTTGAGATC 60

ATTAAAGTGA TTGGAAGAGG TGCTTTTGGT GAGGTTGCTG TTGTCAAAAT GAAGAACACT 120

GAACGAATAT ACGCCATGAA AATCCTTAAC AAGTGGGAAA TGCTGAAAAG AGCAGAGACG 180

GCCTGTTTCC GGGAAGAGCG AGACGTGCTG GTGAACGGGG ACTGTCAGTG GATCACCACG 240

CTGCACTACG CCTTCCAGGA CGAGAACTAC CTGTACTTGG TCATGGATTA CTACGTGGGT 300

GGCGATTTAC TGACCCTGCT CAGTAAATTT GAAGACAAGC TTCCAGAAGA TATGGCAAGA 360

TTCTACATCG GTGAAATGGT GTTGGCGATC GATTCCATCC ATCAGCTTCA TTACGTACAC 420

AGTAACAGAG ACATTAAACC TGACAATGTC CTTCTGGATG TAAATGGTCA TATCCGCCTG 480

GCCGACTTTG GATCCTGTTT GAAGATGAAT GACGATGGAA CTGTGCAGTC CTCCGTGGCC 540

GTGGGCACCC CGGACTACAT CTCCCCAGAG ATCCTGCAGG CGATGGAGGA CGGCATGGGC 600

AAGTACGGCC CCGAGTGCGA CTGGTGGTCT CTGGGCGTCT GCATGTACGA GATGCTGTAT 660

GGAGAGACCC CGTTCTACGC CGAGTCCCTC GTGGAGACCT ATGGGAAGAT CATGAACCAT 720

GAAGAGCGGT TTCAGTTCCC GTCCCACGTC ACAGACGTGT CCGAGGAGGC CAGAGACCTC 780

ATCCAGAGGC TGATCTGCAG CCGGGAGCGC CGGCTGGGGC AGAACGGGGT GGAGGACTTC 840

AAGAAGCATG CCTTCTTCCA AGGGCTGAAC TGGGAGAACA TCCGGAACCT GGAGGCGCCC 900

TACATCCCGG ATGTGAGCAG TCCTTCCGAC ACGTCCAACT TCGACGTGGA CGACGACGTG 960

CTTCGGAACA TCGAAGTGTT ACCTCCTGGT TCTCACACGG GCTTCTCTGG ATTGCACTTG 1020

CCATTCATCG GGTTCACGTT CACCACGGAA AGCTGCTTCT CTGACCGGGG CTCTCTGAAG 1080

AGCATCCTGC AGTCCAGCAC ACTGACCAGA GATGAGGGCG TGCAGCGCGA TCTGGAGGCC 1140

AGCCTGCAGG TGGAGGCCTA CGAGAGACGC ATCCGGAGGC TGGAGCAGGA GAGGCTGGAG 1200

CTGAGCCGGA AGCTGCAGGA GTCCACACAG ACCGTCCAGT CCCTCCATGG CTCAGCCCGG 1260

ACCCTGGGCG GTGCAGCCCG GGACAAAGAG ATCAAACGGC TGAACGAAGA GATCGAACGT 1320

TTGAAGAATA AGATAGCAGA CTCCAGTCGG CTGGAACGGC AGCTCGAGGA CACGGTGACT 1380

CTCCGCCAGG AGCACGAGGA TTCCGCGCAG CGGCTGAAGG GCCTGGAGAA GCAGTACCGC 1440

GTGGTGCGGC AGGAGAAGGA GGACCTCCAC AAGCAATTGA TCGAGGCTTC CGAGCGGTTA 1500

AAGTCCCAGG CCCGAGAGCT GAAAGACGCC CACCAGCAGC GGAAGCTGGC CCTGCAGGAG 1560

TTCTCGGAGC TCAACGAACG CATGGCTGAG CTGCGCTCCC AGAAGCAGAA GGTGTCACGG 1620

CAGCTGCGGG ACCGAGAGGA GGAGGTGGAG GCGGCCATGC AGAAGATCGA CGCACTGAGG 1680

CAGGAGGTCC GCAGGGCCGA CAAGGGCCGG AAGGAGCTGG AGGTGCAGCT CGAGGACGCG 1740

GTGGCCGAGG CCTCCAAGGA GCGAAAGCTG CGGGAGCACA GTGAGAACTT TTCCAAGCAA 1800

GTGGAGAGCG AGCTCGAGGC CCTCAAGATG AAGCAGGGGG GCCGTGGGCC AGGTGCCGCC 1860

CTAGAACATC AGCAGGAGAT TTCCAAGATA AAATCTGAGC TCGAGAAGAA AGTCCTGTTT 1920

TATGAAGAGG AGCTGGTGAG ACGCGAGGCC TCCCACGTGC TGGAGGTGAA GAACGTGAAG 1980

AAGGAGGTGC ACGACTCCGA AAGCCAGCAG CTGGCCCTGC AGAAAGAGGT GATGGTGCTG 2040

AAGGACAAGC TGGAGAAGTC CCGGCGAGAG CGGCACAGCG AGATGGAGGA GGCCGTGGGC 2100

ACCATCAGGG ATAAGTACGA GCGGGAGAGG GCGATGCTGT TCGAGGAGAA CAAGAAGCTG 2160

ACTGCCGAGA ACGAGAAGCT CTGCTCCTTT GTGGACAAGC TCACGGCTCA GAATAGGCAG 2220

CTGGAGGATG AGCTGCAGGA TCTGGCAGCC AAGAAGGAGT CGGTCGCCCA CTGGGAGGCC 2280

CAGATTGCAG AAATCATCCA GTGGGTCAGC GACGAGAAGG ACGCCCGGGG TTACCTCCAG 2340

GCCCTGGCCT CTAAGATGAC CGAAGAGCTC GAGACGCTGC GGAGCTCCAG TCTGGGATCG 2400

AGGACGCTGG ACCCGCTCTG GAAAGTTCGC CGCAGTCAGA AGCTGGACAT GTCTGCACGG 2460

CTGGAACTGC AGTCGGCCCT GGAAGCGGAG ATCCGGGCCA AGCAGCTTGT GCAGGAGGAG 2520

CTGAGGAAGG TCAAGGACGT GAACCTCTCC TTTGAAAGCA AACTAAAGGA TTCTGAAGCC 2580

AAAAATAGAG AACTACTAGA AGAAATGGAA ATTTTGAAGA AGAAGATGGA AGAAAAGTTT 2640

AGAGCAGATA CTGGACTCAA ACTTCCAGAT TTTCAGGATT CTATTTTTGA GTATTTCAAC 2700

ACTGCACCTC TTGCACATGA TCTGACATTT AGAAGCAGCT CCACTAGTGA GCAAGAAACC 2760

CAAGCTCCAA AGCCAGAGGC GTCCTTAGGG GTCTCTGTGG CCGCGGGCGC AGAGCAGCCG 2820

GAGGACGTGG CCCGGGCCCC TCCGAGGCTG CCGGCTGTAC CGCTGCCCAG CGCACAGACC 2880

CTCGCTCTGG CGGGACCAAA GCCAAAGGCA CACCAGCTGA GCATCAAGTC CTTCTCCAGC 2940

CCCACGCAAT GCAGCCACTG CACCTCCCTG ATGGTGGGGC TGATCCGCCA GGGCTACGCC 3000

TGCGACGTGT GCTCGTTTGC CTGCCACGTG TCCTGCAGAG ACCGCGCCCC CCAAGTGTGC 3060

CCCATCCCCC CCGAGCAGTC CAAGCGGCCT CTAGGTGTGG ACGTGCAGAG AGGCATCGGA 3120

ACAGCCTACA AGGGCTACGT GAAGATCCCC AAACCAACCG GGGTGAAGAA GGGGTGGCAG 3180

CGAGCCTTCG CGGTGGTCTG TGACTGCAGG CTCTTCCTGT ACGACCTGCC CGAGGGCAAG 3240

TCCGCCCAGC CCGGCGTCCT GGCCAGCCAA GTCCTGGACC TCAGAGATGA AGAGTTCTCT 3300

GTGAGCTCCG TCCTGGCTTC AGACGTCATA CATGCCTCAC GCCGAGATAT TCCATGTATA 3360

TTCAGGGTGA CGGCCTCTCT CTTAGGTGCC CCTTCTAAGA CCAGCTCGCT GCTCATCCTG 3420

ACAGAGAACG AAAATGAGAA GCGGAAATGG GTGGGGATCT TGGAGGGCCT GCAGGCCATC 3480

CTCCAGAAGA ACCGCCTGCA GAGCCAGGCG GTGCACGTGC CCCAGGAGGC CTACGACAGC 3540

TCGCTGCCCC TCATCAAGGC CGTGCTCACG GCCGCCATCC TGGACGGGGA CCGGATCGCT 3600

ATTGGCCTCG AGGAAGGGCT CTACGTCATA GAGGTGACCC GGGATGTGAT CGTCCGTGTG 3660

GCTGACTACA AGAAGGTGTA CCAGATCGAG CTCGCCCCCA AAGAGAGAGT CGCCGTCCTC 3720

CTCTGCGGCC GGAACCACCA CGTCCACCTC TGTCCGTGGT CCTCCTTCGA TGGGGCCGAG 3780

AGCAACATGG ACATCAAGCT TCCGGAGACA AAAGGCTGCC AGCTCATAGT GACCGGGACG 3840

CTGAAGAAGA GCGGCCCCAC CTGCCTGTTT GTGGCAGTGA AGCGGCTGGT CCTTTGCTAT 3900

GAGATCCAGA GAACTAAGCC TTTGCACAGG AAGCTCAGCG AGCTTGTGGC CCCTGGCAAT 3960

GTGCAGTGGA TGGCCGCAGT CAAGGACAGG CTCTGTGTTG GCTACCCTTC CGGGTTCTCT 4020

CTGTTGAGCA CCCAGGGAGA TGGGCAGGCT CTAAACCTGG TAAATCCCAA TGACCCCTCG 4080

CTTACGTTCC TCTCACAACA GTCTTTTGAT GCCCTTTGTG CTGTGGAGCT CAAAAGTGAG 4140

GAGTACCTGC TTTGCTTCAG CCACATGGGA CTGTACGTGG ACCCACAAGG TCGGAGGTCA 4200

CGCGCTCAGG AGCTCATGTG GCCTGCGGCG CCCGTTGCCT GTAGTTGCAG CCCCACGCAC 4260

GTCACGGTGT ATAGCGAGTA CGGCGTGGAC GTCTTCGACG TGCGCACCAT GGAGTGGGTG 4320

CAGACGGTCG GCTTGCGCAG GATCCGGCCC CTGAACTTGG AAGGCAGCCT CAACCTCCTC 4380

AACTGCGAGC CTCCCCGCCT GATCTATTTC AAGAGCAAGG CCTCGGGAAC CGTGCTCAAC 4440

GTGCCCGACA CCTCGGACAA CAGCCGGAAG CAGATGCTGC GGACCCGGAG CAAGAGGCGC 4500

TTCGTCTTCA AGGTCCCGGA GGAGGAGCGG CTGCAGCAGC GGCGAGAGAT GCTGAGAGAC 4560

CCGGAGCTGC GGTCCAAGAT GATCTCCAAC CCCACCAACT TCAACCACGT GGCCCACATG 4620

GGCCCGGGCG ACGGCATGCA GGTGCTCATG GACCTGCCTC TGAGCGCCGT GCCCCCCGCC 4680

CAGGAGGAGA GGCCGGGCCC TGCCCCCGCC AGCCTGTCCC GCCCACCTCC GCCCAGGAAC 4740

AAGCCCTACG TCTCGTGGCC CTCGTCAGGT AGGGGATCTG AACCAGGAGT GGCTGTGCCG 4800

CTAAGGAGTA TGTCTGACCG TCAGGACTTT GACAAAGAGC CTGATTCAGA TTCCACCAAA 4860

CATTCGACTC CATCCAACAG CTCCAACCCC AGCGGCCCGC CGAGCCCCAC CTCCCCCCCC 4920

AGGAGCCAGC TGCCCCTCGA GAGCCTGGAG CAGCCGTCCC GCGACGCCTG A 4971

Domain Profile

S: 1     feilkviGrGafgevavvrekatekvyamkilkklellkraesaffreerdvlvkadsew  60

         fei+kviGrGafgevavv++k+te++yamkil+k+e+lkrae+a+freerdvlv++d++w

Q: 18    FEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGDCQW  77

         89**********************************************************

S: 61    ivqlqyafqdekylylvmeylvGGdlltllskyedklpeelarfylaelvlaldsvhelg  120

         i++l+yafqde+ylylvm+y+vGGdlltllsk+edklpe++arfy+ e+vla+ds+h+l+

Q: 78    ITTLHYAFQDENYLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAIDSIHQLH  137

         ************************************************************

S: 121   yvh..rdikpdnilldksGhikladfGsclklnedgtvkssvavGtpdyispevlkalee  178

         yvh  rdikpdn+lld++Ghi+ladfGsclk+n+dgtv+ssvavGtpdyispe+l+a+e+

Q: 138   YVHsnRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEILQAMED  197

         ***999******************************************************

S: 179   gkgeygkecdwwslGvilyellvgetpfyaeslvetyskilnhkeslkfpede.kvseea  237

         g+g+yg+ecdwwslGv++ye+l+getpfyaeslvety+ki+nh+e+++fp+++ +vseea

Q: 198   GMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFPSHVtDVSEEA  257

         ****************************************************99******

S: 238   kdlikklltsreerlgregiedlkkhpff  266

         +dli++l++sre+rlg++g+ed+kkh+ff

Q: 258   RDLIQRLICSRERRLGQNGVEDFKKHAFF  286

         ****************************9

Domain Sequence
(FASTA)

FEIIKVIGRG AFGEVAVVKM KNTERIYAMK ILNKWEMLKR AETACFREER DVLVNGDCQW 60

ITTLHYAFQD ENYLYLVMDY YVGGDLLTLL SKFEDKLPED MARFYIGEMV LAIDSIHQLH 120

YVHSNRDIKP DNVLLDVNGH IRLADFGSCL KMNDDGTVQS SVAVGTPDYI SPEILQAMED 180

GMGKYGPECD WWSLGVCMYE MLYGETPFYA ESLVETYGKI MNHEERFQFP SHVTDVSEEA 240

RDLIQRLICS RERRLGQNGV EDFKKHAFF 269

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0042641	; C:actomyosin
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0005543	; F:phospholipid binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005083	; F:small GTPase regulator activity
GO:0031532	; P:actin cytoskeleton reorganization
GO:0031032	; P:actomyosin structure organization
GO:0016477	; P:cell migration
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR001180	; Citron.
IPR011009	; Kinase-like_dom.
IPR014930	; Myotonic_dystrophy_kinase_coil.
IPR000095	; PAK_box_Rho-bd.
IPR011993	; PH_like_dom.
IPR017892	; Pkinase_C.
IPR001849	; Pleckstrin_homology.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR026611	; Ser/Thr_kinase_MRCK.

Pfam

PF00130	; C1_1; 1.
PF00780	; CNH; 1.
PF08826	; DMPK_coil; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 1.
SM00036	; CNH; 1.
SM00285	; PBD; 1.
SM00233	; PH; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50219	; CNH; 1.
PS50108	; CRIB; 1.
PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00479	; ZF_DAG_PE_1; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

Created Date

20-Feb-2013