EKS-BOT-00073

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-BOT-00073

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	306.1	2.4E-91	2	293	292

Status

Unreviewed

Ensembl Protein

ENSBTAP00000022252

UniProt Accession

F1MPI8;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK8

Gene Synonyms/Alias

CDK8;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000016737	ENSBTAP00000022252	ENSBTAT00000022252

Organism

Bos taurus

Functional Description

Protein Length

422

Protein Sequence
(FASTA)

KDDKDYALKQ IEGTGISMSA CREIALLREL KHPNVISLQK VFLSHADRKV WLLFDYAEHD 60

LWHIIKFHRA SKANKKPVQL PRGMVKSLLY QILDGIHYLH ANWVLHRDLK PANILVMGEG 120

PERGRVKIAD MGFARLFNSP LKPLADLDPV VVTFWYRAPE LLLGARHYTK AIEDIWAIGC 180

IFAELLTSEP IFHCRQEDIK TSNPYHHDQL DRIFNVMGFP ADKDWEDIKK MPEHSTLMKD 240

FRRNTYTNCS LIKYMEKHKV KPDSKAFHLL QKLLTMDPIK RITSEQAMQD PYFLEDPLPT 300

SDVFAGCQIP YPKREFLTEE EPDDKGDKKN QQQQPGNNHT NGTGHPGNQD SSHTQGPPLK 360

KVRVVPPTTT SGGLIMTSDY QRSNPHAAYP NPGPSTSQPQ SSMGYSTTSQ QPPQYSHQTH 420

RY 422

Nucleotide Sequence
(FASTA)

AAAGATGATA AAGACTATGC TTTAAAACAA ATAGAAGGAA CCGGGATCTC TATGTCGGCA 60

TGTAGAGAAA TAGCACTACT TCGAGAACTT AAGCACCCAA ATGTCATCTC TCTTCAAAAG 120

GTGTTTCTGT CTCACGCAGA CAGGAAAGTG TGGCTTCTGT TTGACTATGC TGAACATGAC 180

CTCTGGCATA TAATCAAGTT TCACAGAGCT TCTAAAGCAA ACAAGAAGCC AGTTCAGTTA 240

CCTCGGGGGA TGGTGAAGTC ACTATTGTAT CAGATTCTGG ATGGGATCCA CTACCTGCAT 300

GCTAACTGGG TGTTGCACAG GGATTTGAAA CCTGCTAATA TTTTAGTTAT GGGTGAAGGT 360

CCTGAGCGAG GAAGAGTAAA AATTGCTGAT ATGGGCTTTG CCCGATTATT TAATTCACCT 420

TTGAAGCCTT TAGCAGATTT GGATCCAGTA GTAGTTACAT TCTGGTACCG AGCCCCAGAA 480

TTACTTCTTG GAGCAAGACA TTATACCAAA GCTATTGAAG ATATTTGGGC TATAGGGTGT 540

ATATTTGCAG AACTACTAAC GTCAGAACCA ATATTTCACT GTCGACAAGA GGACATCAAA 600

ACTAGTAATC CTTATCACCA TGACCAGCTG GACAGAATAT TCAATGTAAT GGGATTTCCT 660

GCAGATAAAG ATTGGGAAGA TATAAAAAAG ATGCCTGAAC ATTCAACATT AATGAAAGAT 720

TTCAGAAGAA ATACGTATAC CAACTGCAGC CTTATCAAGT ATATGGAAAA ACATAAAGTT 780

AAACCAGATA GTAAAGCATT CCACTTGCTT CAGAAGTTGC TTACCATGGA CCCAATAAAG 840

CGAATTACCT CAGAGCAGGC TATGCAGGAT CCCTATTTCC TAGAAGACCC GCTTCCTACA 900

TCAGATGTTT TTGCCGGTTG TCAGATCCCT TACCCCAAAC GAGAATTTTT AACAGAAGAA 960

GAACCTGATG ACAAAGGAGA CAAAAAGAAC CAGCAGCAGC AGCCGGGCAA TAACCACACG 1020

AATGGGACCG GCCACCCAGG GAACCAAGAC AGCAGTCACA CCCAGGGACC CCCGTTGAAG 1080

AAAGTGAGAG TCGTCCCTCC TACCACTACC TCAGGTGGAC TGATCATGAC CTCAGACTAT 1140

CAGCGTTCCA ATCCGCATGC TGCCTACCCC AACCCCGGAC CAAGCACATC GCAGCCGCAG 1200

AGCAGCATGG GGTACTCAAC TACCTCCCAG CAGCCTCCAC AGTACTCCCA CCAGACACAT 1260

CGGTACTGA 1269

Domain Profile

S: 23    tgevvAlKkirlekekegvpitalrEisllkelkhknivkLlevva.kdkkklyLvfefl  81

         +++ +AlK+i    e +g++++a+rEi+ll+elkh+n+++L++v+  ++++k++L+f+++

Q: 2     DDKDYALKQI----EGTGISMSACREIALLRELKHPNVISLQKVFLsHADRKVWLLFDYA  57

         5788******....999****************************94555**********

S: 82    eqdLkkllkkkkkk.......klsleevkslllqlleglaylHsnkilHRDlKpqNlLis  134

         e+dL++++k ++++       +l++ +vksll+q+l+g++ylH+n++lHRDlKp+N+L++

Q: 58    EHDLWHIIKFHRASkankkpvQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVM  117

         ***********9999999999***************************************

S: 135   ke....gklklaDfGlarafssplk...tytkevvTlwYraPelLlgakeYstav.DiWs  186

          e    g++k+aD+G+ar f+splk   +++++vvT+wYraPelLlga++Y++a+ DiW+

Q: 118   GEgperGRVKIADMGFARLFNSPLKplaDLDPVVVTFWYRAPELLLGARHYTKAIeDIWA  177

         9988889*************99999665699************************99***

S: 187   vgcilaelltrkplfqgkse.........idqlerifkllgtpsekvwpevsklpeyk..  235

         +gci+aellt++p+f++++e         +dql+rif+++g p +k+w++++k+pe++

Q: 178   IGCIFAELLTSEPIFHCRQEdiktsnpyhHDQLDRIFNVMGFPADKDWEDIKKMPEHStl  237

         *********************************************************966

S: 236   .ksfpkkkkk..klkekvkklk....ekaldllekllaldpkkRisakealqhkyf  284

          k+f++++++  +l ++++k k    +ka++ll+kll++dp kRi++++a+q++yf

Q: 238   mKDFRRNTYTncSLIKYMEKHKvkpdSKAFHLLQKLLTMDPIKRITSEQAMQDPYF  293

         44777777764455666644333354679**************************9

Domain Sequence
(FASTA)

DDKDYALKQI EGTGISMSAC REIALLRELK HPNVISLQKV FLSHADRKVW LLFDYAEHDL 60

WHIIKFHRAS KANKKPVQLP RGMVKSLLYQ ILDGIHYLHA NWVLHRDLKP ANILVMGEGP 120

ERGRVKIADM GFARLFNSPL KPLADLDPVV VTFWYRAPEL LLGARHYTKA IEDIWAIGCI 180

FAELLTSEPI FHCRQEDIKT SNPYHHDQLD RIFNVMGFPA DKDWEDIKKM PEHSTLMKDF 240

RRNTYTNCSL IKYMEKHKVK PDSKAFHLLQ KLLTMDPIKR ITSEQAMQDP YF 292

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>