EKS-BOT-00061

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-BOT-00061

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	387.1	4.9E-116	165	446	282

Status

Unreviewed

Ensembl Protein

ENSBTAP00000022303

UniProt Accession

A6QR30;

Protein Name

Protein Synonyms/Alias

PCTK1 protein;

Gene Name

PCTK1

Gene Synonyms/Alias

PCTK1; CDK16;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000016769	ENSBTAP00000022303	ENSBTAT00000022303

Organism

Bos taurus

Functional Description

Protein Length

496

Protein Sequence
(FASTA)

MDRMKKIKRQ LSMTLRGGRG IDKTNGAPEQ IGLDESGGGG GSDLGEAPTR AAPGEPRSVR 60

GPLSSAPEIV HEDLKMGSDG ESDQASATSS DEVQSPVRVR MRNHPPRKIS TEDINKRLSL 120

PADIRLPEGY LEKLTLNSPI FDKPLSRRLR RVSLSEIGFG KLETYIKLDK LGEGTYATVY 180

KGKSKLTDNL VALKEIRLEH EEGAPCTAIR EVSLLKDLKH ANIVTLHDII HTEKSLTLVF 240

EYLDKDLKQY LDDCGNIINM HNVKLFLFQL LRGLAYCHRQ KVLHRDLKPQ NLLINERGEL 300

KLADFGLARA KSIPTKTYSN EVVTLWYRPP DILLGSTDYS TQIDMWGVGC IFYEMATGRP 360

LFPGSTVEEQ LHFIFRILGT PNEDTWPGIL SNEEFRTYNY PKYRAEALLS HAPRVDSDGA 420

DLLTKLLQFE GRNRISAEDA MKHPFFLSLG DRIHKLPDTT SIFALKEIQL QKEASIRSSS 480

MPDSGRPAYR VVDTEF 496

Nucleotide Sequence
(FASTA)

ATGGATCGGA TGAAGAAGAT CAAACGGCAG CTGTCAATGA CACTCCGAGG GGGCCGAGGT 60

ATAGATAAGA CCAATGGTGC CCCTGAACAG ATAGGCCTGG ATGAGAGTGG TGGGGGCGGC 120

GGCAGTGACC TTGGAGAGGC CCCCACACGT GCTGCCCCTG GGGAACCTCG CTCTGTACGG 180

GGCCCACTCA GCTCTGCACC AGAGATTGTG CATGAGGACT TGAAGATGGG GTCTGATGGG 240

GAAAGTGACC AGGCTTCAGC CACGTCCTCC GATGAGGTGC AGTCACCAGT GAGGGTGCGC 300

ATGCGCAACC ATCCCCCACG CAAGATCTCC ACTGAGGACA TCAACAAGCG CCTATCACTA 360

CCAGCCGACA TCCGGCTGCC TGAGGGCTAC CTTGAGAAGC TGACCCTCAA CAGCCCCATC 420

TTTGACAAGC CCCTCAGCCG CCGTCTCCGC CGTGTCAGCT TGTCTGAGAT CGGCTTTGGG 480

AAACTGGAGA CCTACATCAA GCTGGACAAG CTGGGAGAGG GTACCTATGC CACTGTCTAC 540

AAAGGCAAAA GCAAGCTCAC AGACAACCTT GTGGCACTCA AGGAGATCAG ACTGGAACAC 600

GAAGAGGGGG CACCCTGCAC CGCCATCCGG GAAGTGTCCC TGCTCAAGGA CCTCAAACAC 660

GCCAACATCG TCACGCTACA TGACATTATT CACACGGAGA AGTCCCTCAC CCTTGTCTTT 720

GAGTACCTGG ACAAGGACCT GAAGCAGTAC CTGGATGACT GTGGGAACAT CATCAACATG 780

CACAACGTGA AACTGTTCCT GTTCCAGCTG CTCCGTGGCC TGGCCTACTG CCACCGGCAG 840

AAGGTGCTAC ACCGAGACCT CAAGCCACAG AACCTACTCA TCAATGAGCG AGGAGAGCTC 900

AAGCTGGCTG ACTTCGGCCT GGCCCGGGCC AAGTCAATTC CAACGAAGAC CTACTCCAAC 960

GAGGTGGTAA CACTGTGGTA CCGGCCCCCT GACATCCTGC TCGGGTCCAC GGACTACTCC 1020

ACTCAGATTG ACATGTGGGG TGTGGGCTGC ATCTTCTATG AGATGGCCAC AGGCCGGCCC 1080

CTCTTCCCAG GCTCCACAGT GGAGGAGCAG CTGCACTTCA TCTTCCGCAT CTTGGGAACC 1140

CCAAATGAAG ATACATGGCC AGGCATCCTG TCCAATGAAG AGTTCAGGAC ATACAACTAC 1200

CCCAAGTACC GAGCCGAGGC CCTTTTGAGC CATGCACCCC GAGTTGACAG CGACGGGGCT 1260

GACCTCCTCA CCAAGCTGCT GCAGTTTGAA GGTCGCAATC GGATCTCCGC AGAGGATGCC 1320

ATGAAACATC CATTCTTCCT CAGTCTGGGG GATCGGATCC ACAAACTTCC TGACACTACT 1380

TCCATATTTG CACTAAAGGA GATCCAGCTA CAAAAGGAGG CCAGCATTCG ATCTTCGTCA 1440

ATGCCTGACT CAGGCAGGCC AGCTTACCGA GTGGTGGACA CCGAATTTTA A 1491

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         y kl+k+geGty++vyk+k+k t+++vAlK+irle+e eg p+ta+rE+sllk+lkh+ni

Q: 165   YIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHE-EGAPCTAIREVSLLKDLKHANI  223

         7799********************************9.9*********************

S: 61    vkLlevvakdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlleglaylHsnk  120

         v+L+++++ ++k+l+Lvfe+l++dLk++l+++ +  +++++vk +l+qll+glay+H++k

Q: 224   VTLHDIIH-TEKSLTLVFEYLDKDLKQYLDDCGN-IINMHNVKLFLFQLLRGLAYCHRQK  281

         ********.99***********************.*************************

S: 121   ilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLlgakeYst  180

         +lHRDlKpqNlLi+++g+lklaDfGlara s p+kty++evvTlwYr+P++Llg+++Yst

Q: 282   VLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYST  341

         ************************************************************

S: 181   avDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklpeyk.ksfp  239

         ++D+W+vgci+ e++t +plf+g++  +ql+ if++lgtp+e++wp++ + +e++ +++p

Q: 342   QIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPNEDTWPGILSNEEFRtYNYP  401

         *******************************************************889**

S: 240   kkkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf  284

         k++++ l ++ +++++++ dll+kll+++ ++Risa++a++h++f

Q: 402   KYRAEALLSHAPRVDSDGADLLTKLLQFEGRNRISAEDAMKHPFF  446

         *******************************************98

Domain Sequence
(FASTA)

YIKLDKLGEG TYATVYKGKS KLTDNLVALK EIRLEHEEGA PCTAIREVSL LKDLKHANIV 60

TLHDIIHTEK SLTLVFEYLD KDLKQYLDDC GNIINMHNVK LFLFQLLRGL AYCHRQKVLH 120

RDLKPQNLLI NERGELKLAD FGLARAKSIP TKTYSNEVVT LWYRPPDILL GSTDYSTQID 180

MWGVGCIFYE MATGRPLFPG STVEEQLHFI FRILGTPNED TWPGILSNEE FRTYNYPKYR 240

AEALLSHAPR VDSDGADLLT KLLQFEGRNR ISAEDAMKHP FF 282

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

bta:613810

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013