EKS-BOT-00178

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-BOT-00178

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/SRPK	856.6	6.4E-258	64	637	574

Status

Unreviewed

Ensembl Protein

ENSBTAP00000022396

UniProt Accession

E1BNV4;

Protein Name

Protein Synonyms/Alias

Gene Name

SRPK1

Gene Synonyms/Alias

SRPK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000016838	ENSBTAP00000022396	ENSBTAT00000022396

Organism

Bos taurus

Functional Description

Protein Length

639

Protein Sequence
(FASTA)

MNMFVLFLRS ETQPRGSAPH SESDPPEQEE EILGSDDDEQ EDPNDYCKGG YHLVKIGDLF 60

NGRYHVIRKL GWGHFSTVWL SWDIQGKKFV AMKVVKSAEH YTETALDEIR LLKSVRNSDP 120

NDPNREMVVQ LLDDFKISGV NGTHICMVFE VLGHHLLKWI IKSNYQGLPL PCVKKIIQQV 180

LQGLDYLHTK CRIIHTDIKP ENILLSVNEQ YIRRLAAEAT EWQRSGAPPP SGSAVSTAPQ 240

PKPADKMSKN KKKKLKKKQK RQAELLEKRM QEIEEMEKES GPGQKRPNQQ EESERPVERP 300

LKENPPNKMT QEKLEESSTI HQDQTLTGRG IEGGAAEINC NGVIEIINFT ENSNKETLRL 360

KEDLRNANDC DIQNLKQEPS LLSSQNGDSS TSQETDSCTP VTSEVSDTMM CQSSSNVDQS 420

FSEQDISQLQ ESIRAEIPCE DEQEQEHNGP LDNKGKSTAG NFLVNPLEPK NAEKLQVKIA 480

DLGNACWVHK HFTEDIQTRQ YRSLEVLIGS GYNTPADIWS TACMAFELAT GDYLFEPHSG 540

EEYTRDEDHI ALIIELLGKV PRKLIVAGKY SKEFFTKKGD LKHITKLKPW GLFEVLVEKY 600

EWPQEEAAGF TDFLLPMLEL IPEKRATAAD CLRHPWLNS 639

Nucleotide Sequence
(FASTA)

ATGAACATGT TTGTATTATT TCTTAGATCT GAAACTCAGC CCCGAGGCTC TGCTCCGCAC 60

TCTGAAAGTG ACCCGCCCGA GCAAGAAGAG GAGATCCTGG GATCTGATGA TGATGAGCAG 120

GAAGATCCCA ATGATTACTG CAAAGGAGGT TACCATCTTG TGAAAATTGG AGATCTGTTC 180

AATGGGAGAT ATCATGTGAT CCGAAAGTTG GGCTGGGGAC ACTTTTCAAC TGTGTGGCTA 240

TCATGGGATA TTCAGGGAAA GAAGTTCGTG GCAATGAAAG TAGTTAAAAG TGCTGAACAT 300

TATACTGAAA CTGCACTTGA TGAAATCCGG TTGCTGAAAT CAGTTCGTAA TTCAGATCCT 360

AATGATCCAA ATAGAGAAAT GGTTGTTCAA CTACTAGATG ACTTTAAAAT ATCAGGAGTT 420

AATGGAACAC ATATCTGCAT GGTATTTGAA GTTCTGGGGC ATCATCTACT CAAGTGGATC 480

ATCAAGTCCA ATTATCAAGG GCTTCCTCTG CCTTGTGTCA AAAAAATTAT TCAGCAAGTG 540

TTACAGGGTC TGGATTATTT ACACACCAAG TGCCGTATCA TCCACACTGA CATTAAACCA 600

GAAAACATCC TGTTGTCAGT GAATGAACAA TACATCCGGA GGCTGGCTGC AGAAGCAACA 660

GAATGGCAGC GCTCTGGAGC TCCTCCACCT TCCGGATCTG CAGTCAGTAC CGCACCCCAA 720

CCTAAACCAG CTGACAAAAT GTCAAAGAAT AAGAAGAAGA AATTGAAGAA GAAGCAGAAG 780

CGCCAGGCAG AATTACTAGA GAAGCGAATG CAGGAGATTG AGGAAATGGA GAAAGAGTCG 840

GGCCCCGGGC AAAAAAGACC AAACCAGCAA GAAGAATCAG AGAGGCCTGT TGAAAGACCT 900

TTGAAAGAGA ACCCACCTAA TAAAATGACC CAAGAAAAAC TTGAAGAGTC AAGTACCATT 960

CACCAGGATC AGACACTTAC AGGACGTGGT ATAGAGGGTG GTGCAGCAGA AATTAATTGC 1020

AATGGAGTAA TTGAAATCAT TAATTTTACT GAGAACAGTA ATAAAGAAAC ATTGAGGCTT 1080

AAAGAGGATC TACGTAATGC TAATGACTGT GATATCCAAA ATTTGAAGCA GGAACCTAGT 1140

TTACTAAGTT CCCAAAATGG AGACAGCAGC ACATCTCAAG AAACAGACTC TTGTACACCT 1200

GTAACCTCTG AGGTGTCCGA TACCATGATG TGCCAGTCTT CATCAAACGT AGACCAATCA 1260

TTCAGTGAAC AGGACATCAG CCAACTTCAA GAAAGCATTC GGGCAGAGAT ACCCTGTGAA 1320

GATGAACAAG AGCAAGAACA TAATGGACCA CTAGACAACA AAGGAAAATC CACTGCTGGA 1380

AATTTTCTTG TTAACCCCCT TGAGCCAAAA AATGCAGAAA AGCTCCAAGT GAAGATCGCT 1440

GATCTTGGAA ATGCCTGTTG GGTGCACAAA CATTTCACCG AAGATATTCA AACAAGGCAG 1500

TATCGCTCCT TGGAAGTTTT GATAGGATCT GGCTATAATA CCCCTGCTGA CATTTGGAGC 1560

ACAGCATGCA TGGCCTTTGA ACTGGCCACA GGCGACTATT TATTTGAACC TCATTCGGGG 1620

GAGGAGTATA CTCGAGATGA AGATCACATT GCATTGATCA TAGAACTTCT GGGGAAGGTG 1680

CCTCGCAAGC TCATTGTGGC AGGAAAATAT TCCAAGGAAT TTTTCACCAA AAAAGGTGAC 1740

CTGAAACACA TCACGAAGCT GAAACCCTGG GGCCTTTTTG AGGTTCTAGT GGAGAAGTAT 1800

GAGTGGCCTC AGGAAGAGGC AGCCGGCTTC ACAGATTTCT TACTGCCCAT GTTGGAGCTG 1860

ATCCCCGAGA AGAGGGCCAC TGCTGCCGAT TGTCTCCGGC ACCCTTGGCT CAACTCTTAA 1920

Domain Profile

S: 1     yhvirkLGWGhfstvWLawdlqekrfvalkvvksaehytetaldeikllksvresdpsdp  60

         yhvirkLGWGhfstvWL+wd+q+k+fva+kvvksaehytetaldei+llksvr+sdp+dp

Q: 64    YHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETALDEIRLLKSVRNSDPNDP  123

         9***********************************************************

S: 61    krekvvqllddfkisGvnGvhvclvfevLGenLlkliiksnyrGlpleqvkkiirqvLeg  120

         +re+vvqllddfkisGvnG+h+c+vfevLG++Llk+iiksny+Glpl++vkkii+qvL+g

Q: 124   NREMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSNYQGLPLPCVKKIIQQVLQG  183

         ************************************************************

S: 121   LdylhekCkiihtdikPenvLlavddeyirrlaaeatewqkagakppsgsavstapqkka  180

         Ldylh+kC+iihtdikPen+Ll+v+++yirrlaaeatewq++ga+ppsgsavstapq+k+

Q: 184   LDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQRSGAPPPSGSAVSTAPQPKP  243

         ************************************************************

S: 181   ieklsknkkkklkkkqkrqaellekrlqeleele..........................  214

         ++k+sknkkkklkkkqkrqaellekr+qe+ee+e

Q: 244   ADKMSKNKKKKLKKKQKRQAELLEKRMQEIEEMEkesgpgqkrpnqqeeserpverplke  303

         ************************************************************

S: 215   ..........aaeanseaedqelkedaekgeleeieadveeevanedeaseeee......  258

                   ++e++++ +dq+l+ +  +g+++ei+++ ++e++n +e+s++e+

Q: 304   nppnkmtqekLEESSTIHQDQTLTGRGIEGGAAEINCNGVIEIINFTENSNKETlrlked  363

         *********999999**********************************99999999999

S: 259   ..............essltsssdaesksgelseastellsesleqlacgsvls.......  297

                       e sl+ss++ +s+++++++++t+++se++++++c+s+++

Q: 364   lrnandcdiqnlkqEPSLLSSQNGDSSTSQETDSCTPVTSEVSDTMMCQSSSNvdqsfse  423

         99999999**99999************************************999******

S: 298   ........................................vnplepknadkikvkiadLG  317

                                                 vnplepkna+k++vkiadLG

Q: 424   qdisqlqesiraeipcedeqeqehngpldnkgkstagnflVNPLEPKNAEKLQVKIADLG  483

         ************************************************************

S: 318   naCwvhkhftediqtrqyrslevliGagygtpadiWstaClafeLatGdyLfephsgedy  377

         naCwvhkhftediqtrqyrslevliG+gy+tpadiWstaC+afeLatGdyLfephsge+y

Q: 484   NACWVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACMAFELATGDYLFEPHSGEEY  543

         ************************************************************

S: 378   srdedhiakiiellGkiPrklilkGkysreffnkkgeLrhitkLkpwsLlevLvekyews  437

         +rdedhia iiellGk+Prkli++Gkys+eff+kkg+L+hitkLkpw+L+evLvekyew+

Q: 544   TRDEDHIALIIELLGKVPRKLIVAGKYSKEFFTKKGDLKHITKLKPWGLFEVLVEKYEWP  603

         ************************************************************

S: 438   keeaaefsdfLlPmleldpekrasaaeclkhpwL  471

         +eeaa f+dfLlPmlel+pekra+aa+cl+hpwL

Q: 604   QEEAAGFTDFLLPMLELIPEKRATAADCLRHPWL  637

         *********************************8

Domain Sequence
(FASTA)

YHVIRKLGWG HFSTVWLSWD IQGKKFVAMK VVKSAEHYTE TALDEIRLLK SVRNSDPNDP 60

NREMVVQLLD DFKISGVNGT HICMVFEVLG HHLLKWIIKS NYQGLPLPCV KKIIQQVLQG 120

LDYLHTKCRI IHTDIKPENI LLSVNEQYIR RLAAEATEWQ RSGAPPPSGS AVSTAPQPKP 180

ADKMSKNKKK KLKKKQKRQA ELLEKRMQEI EEMEKESGPG QKRPNQQEES ERPVERPLKE 240

NPPNKMTQEK LEESSTIHQD QTLTGRGIEG GAAEINCNGV IEIINFTENS NKETLRLKED 300

LRNANDCDIQ NLKQEPSLLS SQNGDSSTSQ ETDSCTPVTS EVSDTMMCQS SSNVDQSFSE 360

QDISQLQESI RAEIPCEDEQ EQEHNGPLDN KGKSTAGNFL VNPLEPKNAE KLQVKIADLG 420

NACWVHKHFT EDIQTRQYRS LEVLIGSGYN TPADIWSTAC MAFELATGDY LFEPHSGEEY 480

TRDEDHIALI IELLGKVPRK LIVAGKYSKE FFTKKGDLKH ITKLKPWGLF EVLVEKYEWP 540

QEEAAGFTDF LLPMLELIPE KRATAADCLR HPWL 574

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007059	; P:chromosome segregation
GO:0045071	; P:negative regulation of viral genome replication
GO:0045070	; P:positive regulation of viral genome replication

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 2.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013