EKS-BOT-00187

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-BOT-00187

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Ryk	483.0	2.3E-145	305	573	269

Status

Unreviewed

Ensembl Protein

ENSBTAP00000022607

UniProt Accession

F1MGI6;

Protein Name

Protein Synonyms/Alias

Gene Name

RYK

Gene Synonyms/Alias

RYK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000016999	ENSBTAP00000022607	ENSBTAT00000022607

Organism

Bos taurus

Functional Description

Protein Length

584

Protein Sequence
(FASTA)

GGMRAPPGPL CTPQGVVPVS FPKSSSVLQG KGAFVCRHLS EKSLSKSLGL DAELYYVRND 60

LISHYALSFN LLVPSETNFL HFTWHAKSKV EYKLGFQVDN FVAMDMPQVN ISAQGEVPRT 120

LSAVFRVELS CTGKVDSEVM ILMQLNLTVN SSKNFTVLNF KRRKMCYKKL EEVKTSALDK 180

NTSRTIYDPV HAAPTTSTRV FYISVGVCCA VIFLVAIILA VLHLHSMKRI ELDDSISASS 240

SSQGLSQPST QTTQYLRADT PNNATPITSS SGYPTLRIEK NDLRSVTLLE AKAKVKDIAI 300

SRERITLKDV LQEGTFGRIF HGILVDEKDP NKEKQAFVKT VKDTDQASEI QVTMMLTESC 360

KLRGLHHRNL LPITNVCIEE GEKPMVILPY MNWGNLKLFL RQCKLVEANN PQAISQQDLV 420

HMAIQIACGM SYLARREVIH KDLAARNCVI DDTLQVKITD NALSRDLFPM DYHCLGDNEN 480

RPVRWMALES LVNNEFSSAS DVWAFGVTLW ELMTLGQTPY VDIDPFEMAA YLKDGYRIAQ 540

PINCPDELFA VMACCWALDP EERPKFQQLV QCLTEFHAAL GAYV 584

Nucleotide Sequence
(FASTA)

GGAGGTATGA GAGCCCCACC TGGACCTCTC TGCACACCAC AAGGTGTTGT GCCTGTCTCT 60

TTTCCTAAAT CCTCATCAGT TTTGCAGGGT AAAGGGGCTT TTGTCTGTAG GCACTTATCT 120

GAGAAGTCTT TGTCCAAAAG CCTAGGTCTT GATGCAGAAC TTTATTATGT GAGAAATGAC 180

CTTATTAGTC ACTACGCTCT ATCCTTTAAC CTGTTAGTAC CCAGCGAGAC AAATTTCCTG 240

CACTTCACTT GGCATGCAAA GTCCAAGGTT GAATATAAGC TGGGATTCCA AGTAGACAAT 300

TTTGTGGCTA TGGACATGCC CCAGGTCAAC ATTTCTGCTC AGGGGGAAGT TCCACGCACT 360

TTATCAGCAG TGTTTCGGGT CGAGCTTTCC TGTACTGGCA AAGTAGATTC TGAGGTTATG 420

ATACTCATGC AGCTCAACTT GACAGTAAAT TCTTCAAAAA ACTTTACAGT CTTAAATTTT 480

AAACGAAGGA AAATGTGCTA TAAAAAACTT GAAGAAGTAA AAACTTCAGC CTTGGACAAA 540

AACACTAGCA GAACTATTTA TGATCCTGTA CATGCAGCTC CAACCACTTC TACGCGTGTG 600

TTTTATATCA GCGTAGGGGT TTGCTGTGCA GTAATATTTC TTGTAGCAAT AATATTAGCT 660

GTTTTGCACC TTCATAGTAT GAAAAGGATT GAACTGGATG ACAGCATCAG TGCCAGCAGT 720

AGTTCCCAAG GGCTGTCTCA GCCATCTACC CAGACGACTC AGTATCTGAG AGCCGACACA 780

CCCAACAATG CAACTCCTAT TACCAGCTCC TCAGGTTATC CTACCTTGCG GATAGAGAAG 840

AATGACCTGA GAAGTGTCAC TCTTTTGGAG GCGAAAGCTA AGGTGAAGGA TATCGCAATA 900

TCCAGGGAGA GGATAACTCT AAAAGATGTA CTCCAAGAAG GTACTTTTGG GCGTATTTTC 960

CATGGGATTT TAGTAGATGA AAAAGATCCA AATAAAGAAA AACAAGCATT TGTGAAAACA 1020

GTTAAAGATA CAGATCAAGC TTCTGAAATT CAGGTGACAA TGATGCTCAC CGAAAGTTGT 1080

AAGCTCCGAG GTCTTCATCA CAGAAATCTT CTTCCTATTA CCAATGTGTG TATAGAAGAA 1140

GGAGAAAAGC CCATGGTGAT ATTGCCTTAC ATGAATTGGG GGAATCTTAA ATTGTTTTTA 1200

CGGCAGTGCA AATTAGTAGA GGCCAATAAT CCGCAGGCAA TTTCTCAACA AGACCTGGTC 1260

CACATGGCTA TTCAGATTGC CTGTGGAATG AGCTATCTGG CCAGAAGGGA AGTCATCCAC 1320

AAAGACCTGG CTGCTAGGAA CTGCGTCATT GATGACACAC TTCAAGTTAA GATCACAGAC 1380

AATGCCCTCT CTAGAGACTT GTTCCCCATG GACTATCATT GTTTGGGAGA CAATGAAAAC 1440

AGGCCGGTTA GGTGGATGGC TCTTGAAAGT CTGGTTAATA ATGAGTTCTC CAGCGCTAGT 1500

GATGTGTGGG CCTTTGGAGT GACGCTGTGG GAACTCATGA CTCTGGGCCA GACACCCTAC 1560

GTGGACATCG ACCCGTTTGA GATGGCCGCA TACTTGAAAG ATGGTTACCG GATAGCCCAG 1620

CCAATCAACT GTCCTGATGA ACTATTTGCC GTGATGGCTT GTTGCTGGGC CTTAGATCCG 1680

GAGGAGAGGC CCAAGTTCCA GCAGCTGGTC CAGTGTCTCA CAGAGTTCCA TGCAGCCCTG 1740

GGGGCCTATG TCTGA 1755

Domain Profile

S: 1     lrlkellqeGtfGriyrGkledekdtnkekavlvktvkd..qaseiqvalllqealllyg  58

         ++lk++lqeGtfGri++G+l dekd+nkek+++vktvkd  qaseiqv+++l+e+++l+g

Q: 305   ITLKDVLQEGTFGRIFHGILVDEKDPNKEKQAFVKTVKDtdQASEIQVTMMLTESCKLRG  364

         6799*********************************95438******************

S: 59    vshrnilsvllvsieeaekPlvvypalnkgnlkkflricklkdkekaqalstkqlvelai  118

         ++hrn+l++++v+iee ekP+v++p++n+gnlk flr+ckl++++++qa+s+++lv++ai

Q: 365   LHHRNLLPITNVCIEEGEKPMVILPYMNWGNLKLFLRQCKLVEANNPQAISQQDLVHMAI  424

         ************************************************************

S: 119   qiasalaylhkrevvhkdiaarncviddelqvkltdsalsrdlfPadydclGdnenrPlk  178

         qia++++yl++rev+hkd+aarncvidd+lqvk+td+alsrdlfP+dy+clGdnenrP++

Q: 425   QIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYHCLGDNENRPVR  484

         ************************************************************

S: 179   WlslealqkeeyssasdvWalGvllWelvtlgksPyaeidpfeleaylkdGyrlaqPvnc  238

         W++le+l+++e+ssasdvWa+Gv+lWel+tlg++Py++idpfe++aylkdGyr+aqP+nc

Q: 485   WMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQPINC  544

         ************************************************************

S: 239   PdelftvmaccWallpeerPsfeqlvscl  267

         Pdelf+vmaccWal+peerP+f+qlv+cl

Q: 545   PDELFAVMACCWALDPEERPKFQQLVQCL  573

         ****************************8

Domain Sequence
(FASTA)

ITLKDVLQEG TFGRIFHGIL VDEKDPNKEK QAFVKTVKDT DQASEIQVTM MLTESCKLRG 60

LHHRNLLPIT NVCIEEGEKP MVILPYMNWG NLKLFLRQCK LVEANNPQAI SQQDLVHMAI 120

QIACGMSYLA RREVIHKDLA ARNCVIDDTL QVKITDNALS RDLFPMDYHC LGDNENRPVR 180

WMALESLVNN EFSSASDVWA FGVTLWELMT LGQTPYVDID PFEMAAYLKD GYRIAQPINC 240

PDELFAVMAC CWALDPEERP KFQQLVQCL 269

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR003306	; WIF.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF02019	; WIF; 1.

SMARTs

SM00219

; TyrKc; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50814	; WIF; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013