EKS-BOT-00097

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-BOT-00097

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Atypical/PIKK	377.6	5.9E-113	3718	4067	350

Status

Unreviewed

Ensembl Protein

ENSBTAP00000022631

UniProt Accession

E1BLB6;

Protein Name

Protein Synonyms/Alias

Gene Name

PRKDC

Gene Synonyms/Alias

PRKDC;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000017019	ENSBTAP00000022631	ENSBTAT00000022631

Organism

Bos taurus

Functional Description

Protein Length

4127

Protein Sequence
(FASTA)

MADSGSGVRG SLLQLQESLS AADRCSAAVA SGQLLRGLGQ ECVLSSGPAL LALHTSLVFS 60

KDFGLLVFVR KSLSIDEFRD CREEALKFLC VFLEKIGQKI IPYSLDIKNI CTSVYTKDKA 120

AKCRIPALEL LIKLLQTLRS SRLMDELRVG ELFTKFYGEL ALKAKIPDTV LEKIYELLGV 180

LGEVHPSEMI NNSDKLFRAF LGELKTQMTS TVREPKLAVL AGCLKGLASL MCNFTKSMEE 240

DPQTSREIFD FALKAIRPQI DLKRYAVPLA GLSLFTLHAS QFSTCLLDNY ASLFEVLSKW 300

CSHMNVELKK AAHSALESFL KQVSLLVAHD AEAHRGPLRF FMEQFYSIIR NVDANSKDLS 360

IAIRGYGLFA GPCKAVNARD VDLMFVELIQ RCRQLFLMEA DAAEDHVYQL PSFLQSVASV 420

LLHLDAVPEV HSPVLEHLVV MQMDSFPQYS PKMQLVCCRA IVRLFLALAE KGPILWSCIG 480

AMVHQSLIRI CSKPVILQKG AEPESEDPGA LGEARTGKWR VPTYRDYVDL FRSLLSCDQT 540

MDSLLADEAF VFVNSSLQSL NRLLYDEFVK SVLKIVEKLD LTLEKQSVGE QEDENKAAGI 600

WVIPTSDPAA NLHPAKPKDF SAFINLVEFC REILPEKHVE FFGPWVHSFS YQLILQSTRL 660

PLISGFYKLL SLAVRNAKKI KYFEGVGPKS QKPSPEDPEK HSCFALFAKF GKEVSVKMKQ 720

YKDELLASCL TFVLSLPHDI IALDVRAYVP ALQMAFKLGL SYAPLAEAGL NALEEWSVYI 780

CKHVIQPYYK DILPSLDGYL KTSALSALTD ETRSNWEVSA LSRAVQKGFT KDVLKHLKRT 840

KNISSNEALS LEETRVRVVQ VLGRLGGQIN KNLLTAASPE ERARGCVAWD RERRLSFAVP 900

FMDMKPVIHL DLFLPRVTEL ALSAGDRHTK VAACELLHSV VMFMLGKATQ MPDGGQGPPP 960

LYQLYKRTFP VLLRLACDVD QVTRQLYEPL VMQLIHWFTN NKKFESQDTV ALLEAILDGI 1020

VDPVDSTLRD FCGRCIREFL KWSIKQTTPQ QQENSPVNTK SLFKRLYSFA LHPSAFKRLG 1080

ASLAFNNIYR EFREEEALVE QFVFEALVTY MESLALAHTD EQSLGTVQQC CDAVDHLGRI 1140

IEKKHVSLNK AKKRRCPRGF PPMASLCLSD VVQWLFTNCG RPQTECRHKS IELFYKLVPL 1200

LPGNRSPSSW LRDLVQKEGV PFLVSTFEGG GARDQPAGLL AQPTLRHLQG PFSLRAALQW 1260

MDALLAALEC YNTFLDAGTL SAAEVLGAET QSSLWEAVAF FLESIALHDI AAAQKCFGVG 1320

TTGDRPSPQE GDRYSYSKCT VVVRVLEFST TLLGTCPDGW KLLGKDSCSA DLMRLLVRTL 1380

CAPSSVGFNV GDVRVMEQLP DVCVALLRAL KTSPHQDMLE ARLREEVTAE SIGELCAVDL 1440

YGPDAHMKRA RLASLVLACK QLHKAGFLHV IMPSQSADEQ HSLGMKLLSL VYKSIAPGHE 1500

GLSLSSLDPS CRRFARELLE LAFACGGLCE RLVGLLLDTA VVSTPSSGGT QRNVVSFSHG 1560

QYFYNLFSET VNTELLRNLD LAVSELMKSS MGNPKMVSTV LNGLLDQSYR DRASQKHQGL 1620

KLVSTILQSW GCCSTWWAGD ATPDSKTAVL TLLAKILQID SSVSFNTSHS AFPEVFTTFV 1680

SLLGDPKLDL HLKGQAVALL PFFSSLTGDR LQELRHILEK LIVSHFPMRS GEFPPGTLRY 1740

SNYVDCMKKF LDALELSQSP MLMELMTEVL CREQQHVLEE LFQSTFRKIA RKSSCATQLG 1800

LLESVYRKFS RDDLLPSATR QAVVGRALLT LLRHCGLGAL RDFFSRTVVE AIDVLKSRFT 1860

KLNESAFDTQ ITKKMGYYKM LEVMYSRLPK DDVHSKESKI NQVFHGSSVT EGNELTKTLI 1920

KLCHDAFSEN MAGEAQLLER RRLYHCAAYT CAIALVRCVF TELRFYQGFL FSEKPEKNLL 1980

IFENLIDLKR CYTFPIEVEV PMERKKKYIE IRREAREAAN EDSGGPQYMS SLSYLADSSL 2040

SEEMSQFDFS TGVQSYSYGS QDPQSSAGHF RRRERQDPDG PGDVLDLDVD ELSQHECMAP 2100

LVALVQHMQR LEAALPGEEG SVPRNLPPWM KFLHDKLGNP SVSLNIRLFL AKLVVNTEEV 2160

FRPHARHWLG PLLQLVVSEN NGGDGIHYLV VEIVATVLSW TGIATPVGVP KDEVLANRLL 2220

HFLMKHVFHQ KRAVFRHNLE IIKTLVECWK DCLSVPYRLI FDKFSSKDPN SKDNSVGIQL 2280

LGIVMANNLP PYDPKCGVES VRYFEALVSN MSFVRYKEVY AASAEVLGLV LRYLSGREKM 2340

LEESVHELVV KQLKRHQNTL EDKFIVCLSR ATKNFPPLAD RFMNSVLFLL PRFHGVMKTL 2400

CLEVVLCRAE ETPDLYLQLK SKDFVQVMRH RDDERQKVCL DIISKMMARL RPAELRELLS 2460

AVVEFLAHPA VLCRERMYAI LMWVHDNYRD PESQADEDSR EVFKLAKDVL IQGLTDENPG 2520

LQLTIRNFWS HETRLPSNTL DRLLALNSLY SPKIEVHFLS LATDFLLEMT SLSPDFRTSL 2580

FEHPLSECEF QEYTIDPDWR FRSTVLTPMF VETQASQSTL QARTQEGSIS ARRAMAGQVR 2640

ATQQQLDFTP TQSAGGRVLS HWLTAGSTDP LGGSLAPTAE ASSASLLFAH KRPERPRGTP 2700

LKPVGPEFGK KRLGLLEDEV DDGAQAPDNR AEILRLRRRF LKDQEKLSLI YARKGVVEQK 2760

REKEIKSELK MKHEAQVVLY RSYRRGDLPD IQIPHSSLIT PLQAVAQRDP LVARQLFGSL 2820

CSGILRESGE RRTVAEGRGA AQKLLQDFTH FLDTSFSFFP PFVSCIQEIS CQHADLLSLD 2880

PALVSGAGLA GLQQPGAICL LEEALLRLAP QEPPAKRARG RPSLPPDVGR WMELAKLYRS 2940

IGEYDILRGI FSSEIGTKQI TQDALLAEAR SDYSEAARLY NEALNTQEWA DGEPTEAEKD 3000

FWELASLDCY NQLAEWTSLE YCSTASADGE GTLDLSKMWS EPFYQETCLP YMVRSKLKLL 3060

LRGEGDQALL TFVDEALTSE LRKALLELRY SQELSLLYLL QDDIDRAKYY IQNCIQMFMQ 3120

NYSSIDVLLH RSRLTKLQSV QTFIEIQEFI SFISKQGNLS SHVPLKRLVK TWTNRYPDAK 3180

MDPMNVWDDI ITNRCFFLSK IEEKLCLLPD SEGASEDGAE MDSQAQEEDA RALITSCSFS 3240

MRMQMAESAR KQNNFSLALK LLKELHRESK AREDWLVMWV QAYCRLSHSR ARAQRRPEQL 3300

CTALRTASLL AENTLSTSTL ASRDHHVLLG TTYRILADAL CDEPTCLAEI GESKARSVVE 3360

LSGSSSEDAD KVMAGLYQRA FHHLSEAVRA AEEEAGPLAR GQGPTAGVTV AYLTLAEFCD 3420

QQLRRQEEGM SVLGSAELLT YPALVVDKML KALKFHSSEA RLKFPRLLQI VTQYPEETLG 3480

LMTREISSVP CWEFIGWIGH MLPLLDKEEA VAIQRTVEDI ADHYPQAIVY PFMISSESYC 3540

FRDTSAGHKN KEFVARIKAK LDREGVVQDF INALEQLSNP EMLFKDWMED VKVELGKTPV 3600

DKKNIQRMYE RMHAALGDPQ APGLGSFRRR FIQAFGKEFD KHFGRGGSKL PGMKLQDFYT 3660

IAGSLLERML RASNAPGNLR ECSPWMSNFR VEFLRAELEV PGQYDGRSKP MPEHHARIAG 3720

FDERVKVMAS IRKPKRIVIR GHDEREYPFL VKGGEDLRQD HRIQQLLQVM NSVLAHDAAC 3780

GQRGLQMTTY HVVPMTSRLG LIEWIENTCT LKELLLSSMS REEKKAYTSD PRAPASEYRE 3840

WLTMMVGKCD PGAYARMFRV ANRTEAVTSF RKRESRVPAD LLKRAFLKMS TGPEAFLALR 3900

NHFTTSHALL CVGHWVLGIG DRHLNNFMVS LETGGVIGID FGHAFGSATQ VLRVPELMPF 3960

RLTRQFINLM SPLKETGLVS SVMVCALRAF RSRADLLTTT MDVFVKEPSF DWKNFEQTML 4020

RKGGSWIKEI NVTEQNWYPR QKIHYAKRKL AGANPAVITC NELLLGHEKE SAFRDYVAVA 4080

QGSREHSVRA QEPESGLSEE AQVRCLIDQA TDPNILGRTW EGWEPWM 4127

Nucleotide Sequence
(FASTA)

ATGGCCGATT CGGGGTCCGG CGTGCGGGGC TCCTTACTGC AGCTACAAGA GTCCCTGTCC 60

GCTGCCGATC GCTGCAGCGC GGCGGTGGCC AGTGGTCAGC TGCTGCGGGG CCTGGGGCAG 120

GAGTGCGTGC TGAGCTCTGG CCCCGCGCTG CTGGCATTAC ACACTTCCTT AGTTTTTTCC 180

AAAGATTTTG GTTTGCTTGT ATTTGTTCGG AAATCACTTA GCATTGATGA ATTTCGTGAT 240

TGTAGAGAAG AAGCCCTAAA GTTTTTATGT GTTTTCTTAG AAAAAATTGG CCAGAAGATC 300

ATACCTTATT CTCTAGATAT TAAGAATATT TGTACCAGTG TTTACACAAA AGATAAAGCT 360

GCTAAATGTA GAATTCCAGC CCTAGAACTT CTTATTAAGT TACTTCAGAC TTTGAGAAGT 420

TCTAGACTCA TGGATGAATT AAGAGTTGGA GAGTTATTTA CCAAATTCTA TGGAGAACTT 480

GCATTGAAAG CAAAAATACC AGATACAGTT TTAGAAAAAA TATATGAGCT CCTAGGAGTA 540

TTAGGTGAAG TTCATCCTAG CGAGATGATA AACAATTCGG ATAAACTCTT CCGGGCTTTT 600

CTGGGTGAAC TTAAGACCCA GATGACATCG ACAGTGAGAG AACCCAAACT TGCGGTGCTG 660

GCGGGGTGTC TGAAGGGACT GGCGTCACTT ATGTGTAACT TCACCAAGTC CATGGAGGAA 720

GATCCCCAGA CTTCAAGAGA GATTTTTGAT TTTGCATTAA AGGCAATCCG TCCTCAGATT 780

GATCTGAAGA GATACGCCGT GCCTCTGGCT GGCCTGTCCT TATTCACCCT GCACGCATCT 840

CAGTTTAGCA CCTGCCTTCT GGACAACTAC GCTTCTTTAT TTGAAGTCCT ATCGAAGTGG 900

TGCAGCCACA TGAATGTGGA ATTGAAGAAA GCTGCACACT CAGCCCTGGA GTCTTTTCTG 960

AAACAGGTTT CCTTGTTGGT GGCGCACGAT GCCGAGGCAC ACAGGGGCCC CCTGCGCTTC 1020

TTCATGGAGC AGTTCTACAG CATCATCAGG AACGTGGACG CCAACAGCAA GGACCTGTCC 1080

ATCGCCATCC GCGGATACGG GCTCTTCGCA GGGCCGTGCA AGGCAGTGAA TGCCCGAGAC 1140

GTGGACTTGA TGTTCGTGGA GCTCATCCAG CGGTGCCGGC AGCTGTTCCT CATGGAGGCG 1200

GACGCTGCCG AGGACCATGT GTACCAGCTG CCCAGCTTCC TGCAGTCTGT GGCCAGTGTC 1260

CTGCTGCACC TTGATGCCGT TCCTGAGGTG CACTCGCCTG TCCTGGAACA CCTCGTGGTC 1320

ATGCAGATGG ACAGTTTCCC CCAGTACAGC CCCAAGATGC AGCTGGTGTG CTGCAGGGCC 1380

ATCGTGCGCT TGTTCCTGGC CCTGGCGGAG AAGGGGCCCA TCCTCTGGAG CTGCATTGGT 1440

GCTATGGTGC ATCAAAGTTT AATCAGAATA TGTTCTAAGC CAGTGATCCT TCAAAAGGGA 1500

GCCGAGCCCG AGTCTGAGGA CCCTGGAGCG TTGGGGGAAG CCAGGACCGG CAAGTGGAGA 1560

GTGCCCACCT ACAGAGACTA TGTGGACCTG TTCAGGAGCC TGCTGAGCTG TGACCAGACG 1620

ATGGATTCTC TCTTAGCAGA TGAAGCATTT GTCTTTGTGA ATTCCTCCCT TCAAAGTCTG 1680

AATCGTTTGC TATATGATGA ATTTGTAAAA TCAGTTTTGA AGATCGTTGA AAAACTGGAT 1740

CTTACACTGG AAAAGCAGAG TGTTGGGGAA CAAGAGGATG AAAACAAAGC TGCTGGCATT 1800

TGGGTGATCC CGACCTCAGA TCCAGCTGCT AACCTGCATC CTGCGAAACC CAAAGACTTC 1860

TCCGCTTTCA TCAACCTGGT GGAGTTCTGC AGGGAGATTC TTCCTGAGAA ACATGTAGAA 1920

TTTTTTGGGC CATGGGTACA TTCCTTCTCA TACCAGTTAA TTCTGCAGTC TACACGGTTG 1980

CCACTCATTA GTGGTTTCTA CAAACTGCTT TCTCTTGCTG TGAGAAATGC CAAGAAGATA 2040

AAGTATTTTG AGGGCGTTGG TCCAAAGAGT CAGAAACCGT CTCCCGAGGA TCCAGAGAAG 2100

CATTCCTGCT TTGCTTTGTT TGCAAAATTT GGTAAAGAGG TGTCAGTTAA GATGAAGCAG 2160

TACAAAGATG AACTCCTGGC CTCCTGTTTG ACCTTTGTCC TATCCTTGCC ACATGACATC 2220

ATCGCACTTG ACGTCAGAGC CTACGTCCCC GCGTTGCAGA TGGCTTTTAA ACTGGGCCTG 2280

AGCTATGCCC CACTGGCAGA AGCCGGCCTG AATGCCCTGG AAGAATGGTC AGTTTATATC 2340

TGCAAACATG TAATTCAACC CTATTATAAG GATATTCTGC CTAGCCTTGA TGGATATCTG 2400

AAAACTTCAG CCTTATCAGC ATTGACAGAT GAGACCCGGA GTAACTGGGA AGTGTCAGCG 2460

CTTTCTCGGG CTGTCCAGAA AGGATTTACT AAAGACGTGT TAAAGCATCT GAAACGGACA 2520

AAAAACATTT CATCTAATGA AGCGCTGTCC TTAGAAGAAA CACGGGTTCG AGTAGTGCAA 2580

GTACTTGGCC GTCTCGGGGG ACAGATCAAC AAAAACCTGC TAACAGCGGC GTCCCCTGAG 2640

GAGCGGGCCA GGGGCTGTGT GGCTTGGGAC CGAGAAAGGA GGCTCAGCTT CGCAGTGCCC 2700

TTCATGGACA TGAAGCCCGT CATTCACCTG GACCTGTTCC TGCCGCGTGT CACAGAGCTG 2760

GCACTCTCTG CGGGTGACAG ACACACCAAG GTTGCGGCCT GTGAACTTCT GCACAGCGTG 2820

GTTATGTTTA TGCTGGGAAA AGCCACTCAG ATGCCTGACG GTGGCCAGGG CCCCCCACCC 2880

CTGTACCAGC TCTATAAGCG CACGTTTCCT GTGCTGCTTC GACTGGCGTG TGACGTAGAC 2940

CAGGTGACAA GGCAGCTATA TGAACCTCTG GTCATGCAGC TGATTCACTG GTTCACCAAC 3000

AACAAGAAGT TTGAGAGTCA GGACACGGTT GCCCTGCTGG AGGCAATACT GGATGGAATT 3060

GTGGACCCTG TGGACAGCAC TTTAAGAGAT TTTTGTGGTC GGTGTATTCG GGAATTCCTC 3120

AAATGGTCCA TTAAGCAGAC AACGCCGCAG CAGCAGGAGA ACAGTCCAGT AAACACCAAG 3180

TCACTCTTCA AGCGACTGTA CAGCTTTGCA CTTCACCCCA GTGCTTTCAA AAGACTGGGA 3240

GCATCGCTTG CTTTTAATAA TATCTACAGG GAGTTCAGAG AGGAGGAGGC TCTGGTGGAA 3300

CAGTTTGTGT TTGAAGCCCT GGTCACGTAC ATGGAAAGCC TGGCCTTAGC GCACACAGAC 3360

GAGCAGTCTT TGGGTACGGT TCAGCAGTGC TGCGATGCTG TCGACCACCT GGGGCGCATC 3420

ATCGAGAAGA AGCACGTTTC CTTAAACAAA GCTAAAAAGC GACGCTGTCC CCGAGGCTTC 3480

CCACCTATGG CATCCTTGTG CCTGTCGGAC GTGGTCCAGT GGCTTTTCAC CAACTGCGGG 3540

AGGCCCCAGA CGGAATGTCG ACACAAGTCC ATAGAACTCT TCTATAAGCT TGTTCCTTTG 3600

CTGCCAGGCA ACAGGTCCCC TTCCTCATGG CTGAGAGACC TGGTCCAGAA GGAAGGCGTC 3660

CCCTTCCTCG TGAGCACCTT CGAGGGCGGA GGAGCCCGGG ACCAGCCGGC CGGCCTGCTG 3720

GCCCAGCCCA CCCTCCGCCA CCTGCAGGGC CCTTTCAGCC TGCGCGCCGC CCTGCAGTGG 3780

ATGGATGCAC TGCTGGCTGC GCTGGAGTGC TACAACACCT TCCTGGATGC GGGCACCCTC 3840

AGCGCCGCCG AGGTCCTGGG TGCTGAAACG CAGTCTTCAC TTTGGGAAGC AGTGGCTTTC 3900

TTCTTAGAGA GCATCGCCCT GCACGACATC GCGGCAGCAC AAAAGTGCTT TGGCGTGGGG 3960

ACCACGGGTG ACAGGCCCAG CCCGCAGGAG GGCGACAGGT ACAGCTACAG CAAGTGCACG 4020

GTGGTCGTCC GGGTCCTGGA GTTCTCCACG ACGCTGCTGG GCACCTGCCC CGACGGCTGG 4080

AAGCTCCTTG GGAAAGACTC GTGCAGCGCA GACCTCATGA GGCTCCTGGT GAGGACATTG 4140

TGTGCACCCT CAAGTGTGGG CTTCAACGTT GGAGATGTGC GGGTGATGGA GCAGCTCCCT 4200

GACGTGTGTG TGGCCCTGCT GAGGGCCCTG AAGACATCTC CACACCAGGA CATGCTGGAG 4260

GCCCGCCTCC GGGAAGAGGT CACGGCAGAA AGCATTGGGG AGCTGTGTGC TGTTGACCTG 4320

TATGGCCCGG ACGCTCACAT GAAGAGGGCC AGACTGGCTT CTCTCGTGTT GGCTTGTAAG 4380

CAGCTGCACA AGGCTGGCTT TCTGCATGTC ATAATGCCGT CTCAGTCTGC AGATGAGCAG 4440

CATTCTCTCG GCATGAAGCT TCTTTCCTTG GTTTATAAAA GCATTGCCCC TGGACATGAG 4500

GGGCTGAGTC TGTCCTCCCT GGACCCCAGC TGCCGGCGGT TCGCACGTGA GCTTCTGGAG 4560

CTGGCCTTTG CGTGCGGAGG ACTGTGTGAG CGCCTGGTGG GTCTCCTCCT GGACACAGCT 4620

GTGGTATCCA CGCCATCCTC AGGAGGCACC CAGAGGAACG TTGTCAGCTT CTCTCATGGA 4680

CAGTATTTCT ACAACCTGTT CTCAGAAACA GTCAACACTG AACTGTTGAG AAATCTGGAT 4740

CTTGCCGTAT CAGAGCTCAT GAAGTCATCT ATGGGTAATC CCAAAATGGT GAGCACCGTT 4800

CTGAACGGCC TGTTGGATCA GAGCTACCGG GACCGAGCTA GCCAGAAGCA CCAAGGCCTG 4860

AAACTGGTCA GCACCATCCT GCAGAGTTGG GGGTGCTGCA GCACGTGGTG GGCCGGGGAC 4920

GCCACCCCTG ACAGCAAAAC TGCGGTGCTC ACCTTACTGG CAAAAATTCT GCAGATCGAT 4980

TCATCGGTAT CCTTTAATAC AAGTCACAGT GCCTTCCCGG AAGTTTTTAC AACATTTGTG 5040

AGTCTACTTG GTGATCCAAA ATTGGATCTA CATTTAAAGG GCCAGGCCGT GGCACTGCTC 5100

CCCTTCTTCT CCAGCCTCAC GGGGGACCGT CTGCAGGAGC TCAGACACAT TCTTGAGAAG 5160

CTCATCGTCT CTCATTTCCC CATGAGGTCT GGAGAGTTTC CCCCGGGGAC TCTGCGCTAC 5220

AGTAACTACG TGGATTGTAT GAAAAAGTTT CTGGATGCAT TGGAGTTATC CCAGAGTCCT 5280

ATGTTGATGG AGTTGATGAC AGAAGTTCTG TGTCGGGAAC AGCAGCATGT TCTGGAAGAA 5340

TTATTTCAGT CTACTTTCAG GAAGATTGCC AGAAAGAGTT CATGTGCCAC GCAGTTGGGC 5400

CTTCTGGAAA GCGTGTACCG GAAGTTCAGC AGGGACGATC TGCTTCCCAG CGCCACCCGC 5460

CAGGCGGTAG TGGGCCGGGC CCTTCTCACT CTGCTGCGGC ACTGTGGTCT GGGGGCTCTG 5520

AGGGACTTCT TCAGCAGAAC TGTGGTGGAG GCTATCGATG TGTTGAAGTC CAGGTTTACA 5580

AAGCTGAATG AATCTGCCTT TGACACTCAA ATCACCAAGA AGATGGGATA TTACAAGATG 5640

CTAGAGGTGA TGTACTCTCG TCTTCCAAAA GATGATGTCC ACTCCAAGGA ATCTAAAATT 5700

AACCAGGTGT TCCACGGCTC GAGCGTCACA GAAGGAAATG AACTTACAAA GACATTGATT 5760

AAGCTGTGCC ATGATGCCTT CTCGGAGAAC ATGGCTGGGG AGGCCCAGCT GCTGGAGCGC 5820

CGGCGGCTGT ACCACTGTGC CGCCTACACC TGCGCCATTG CCCTCGTCCG CTGCGTCTTC 5880

ACGGAGCTCA GGTTTTACCA GGGCTTCCTG TTCAGTGAGA AACCAGAGAA GAACTTGCTC 5940

ATTTTTGAAA ATCTGATAGA CCTGAAGCGC TGCTACACGT TTCCCATAGA AGTGGAGGTT 6000

CCTATGGAAA GAAAGAAAAA GTACATTGAA ATTAGGAGAG AAGCCAGGGA GGCGGCAAAT 6060

GAAGATTCAG GTGGCCCCCA ATACATGTCT TCACTATCAT ATCTGGCAGA CAGCAGCCTG 6120

AGCGAGGAAA TGAGTCAGTT CGATTTTTCA ACTGGAGTCC AGAGCTACTC GTATGGGTCC 6180

CAAGACCCTC AGTCCAGTGC TGGTCATTTC CGGAGACGGG AGCGTCAGGA CCCTGACGGC 6240

CCAGGCGACG TGCTGGACCT GGACGTGGAT GAGCTCAGCC AGCACGAGTG CATGGCCCCC 6300

CTGGTGGCCC TGGTCCAGCA CATGCAAAGA CTTGAGGCTG CGCTGCCCGG AGAGGAGGGT 6360

TCAGTGCCAA GAAATCTTCC TCCTTGGATG AAATTTCTTC ATGACAAACT GGGAAATCCA 6420

TCAGTGTCAT TAAATATCCG TCTTTTCTTA GCCAAGCTGG TTGTTAATAC AGAAGAAGTC 6480

TTCCGGCCTC ATGCGAGGCA CTGGCTGGGC CCCTTGCTGC AGCTGGTGGT CTCTGAGAAC 6540

AACGGCGGGG ACGGGATCCA CTATCTAGTG GTTGAGATCG TGGCCACGGT CCTTTCGTGG 6600

ACGGGAATAG CCACCCCTGT GGGGGTCCCT AAAGATGAAG TGTTAGCGAA TCGATTGCTC 6660

CATTTCCTAA TGAAACATGT TTTTCATCAA AAAAGAGCTG TGTTTCGACA TAACCTTGAA 6720

ATCATAAAGA CCCTCGTTGA GTGCTGGAAG GATTGTCTGT CCGTCCCTTA CAGGTTAATA 6780

TTTGACAAGT TTTCCAGTAA AGACCCTAAT TCTAAAGACA ATTCTGTAGG AATTCAGTTG 6840

TTGGGTATTG TAATGGCCAA CAACTTGCCT CCCTACGACC CAAAGTGTGG CGTGGAAAGT 6900

GTCCGGTACT TTGAAGCTCT GGTCAGTAAC ATGTCCTTTG TCAGATATAA AGAGGTGTAT 6960

GCAGCGTCAG CGGAGGTCCT GGGGCTTGTT CTCCGGTATC TCAGTGGGAG AGAGAAGATG 7020

CTAGAGGAGT CTGTGCATGA ACTGGTGGTG AAGCAGCTGA AGCGGCATCA GAACACGCTG 7080

GAGGACAAGT TCATCGTGTG CCTGAGCAGA GCCACGAAGA ACTTCCCTCC TCTGGCTGAC 7140

AGGTTCATGA ACAGCGTGCT CTTCCTGCTG CCGAGGTTCC ACGGCGTGAT GAAGACACTG 7200

TGTCTGGAGG TGGTGCTGTG TCGTGCGGAG GAGACCCCTG ACCTGTACCT GCAGCTGAAG 7260

AGCAAGGATT TCGTTCAGGT CATGAGGCAC AGAGATGATG AGAGACAGAA AGTGTGTTTG 7320

GACATAATTT CCAAGATGAT GGCACGGCTG AGACCGGCAG AGCTCCGGGA GCTCCTGAGC 7380

GCCGTGGTGG AGTTCCTGGC TCACCCTGCA GTGCTGTGCC GTGAGCGGAT GTACGCCATC 7440

CTCATGTGGG TCCATGACAA CTACAGAGAC CCAGAGAGTC AGGCAGATGA AGACTCGCGT 7500

GAAGTATTCA AGCTGGCGAA AGATGTGTTG ATCCAAGGGC TGACCGACGA GAACCCTGGG 7560

CTTCAATTAA CTATTCGGAA CTTCTGGAGC CATGAAACTA GGTTGCCTTC AAATACCTTG 7620

GACCGATTGC TGGCCCTAAA TTCCTTATAT TCTCCTAAGA TAGAAGTGCA CTTCTTGAGT 7680

TTAGCAACAG ATTTCCTGCT TGAAATGACC AGCCTGAGCC CCGACTTCCG GACTTCCCTG 7740

TTTGAGCACC CTCTGTCAGA GTGTGAGTTT CAGGAGTATA CCATTGACCC TGACTGGCGC 7800

TTCCGGAGTA CGGTCCTCAC ACCAATGTTT GTTGAGACTC AGGCGTCTCA GAGCACGCTC 7860

CAGGCCCGGA CCCAGGAAGG GTCCATCTCG GCTCGCAGGG CGATGGCTGG GCAGGTCCGG 7920

GCCACCCAGC AGCAGCTCGA CTTCACGCCC ACACAGAGCG CAGGGGGAAG AGTGCTCTCC 7980

CACTGGCTGA CGGCGGGCAG CACCGACCCT CTGGGCGGCA GCCTGGCCCC CACCGCCGAG 8040

GCCTCGTCTG CGTCCCTGCT GTTTGCCCAC AAGAGGCCCG AGAGGCCCCG GGGGACGCCC 8100

CTGAAGCCCG TGGGGCCTGA ATTTGGGAAG AAAAGGCTGG GACTCCTTGA GGATGAGGTG 8160

GACGACGGAG CACAAGCTCC AGATAATCGT GCAGAAATAC TGCGATTACG CAGACGATTT 8220

CTAAAGGACC AAGAAAAGCT GAGTTTGATT TATGCCAGGA AAGGTGTTGT GGAGCAAAAG 8280

CGAGAAAAGG AGATCAAGAG TGAGTTGAAA ATGAAGCACG AGGCTCAGGT CGTCTTGTAC 8340

AGAAGTTACC GCCGGGGAGA CCTTCCTGAC ATCCAGATTC CACACAGCAG CCTGATCACC 8400

CCGCTGCAGG CTGTGGCCCA GAGAGACCCG CTCGTCGCGA GGCAGCTCTT CGGCAGCCTG 8460

TGCTCGGGGA TCCTGAGGGA GTCGGGCGAG CGCAGGACAG TGGCTGAGGG GCGGGGCGCC 8520

GCCCAGAAGC TCCTACAGGA CTTCACGCAC TTTCTGGACA CCAGCTTCTC CTTCTTCCCG 8580

CCCTTCGTGT CCTGCATCCA GGAGATCAGC TGCCAACACG CTGACCTGCT GAGCCTCGAT 8640

CCGGCTCTGG TCAGTGGGGC TGGCCTGGCG GGCCTGCAGC AGCCCGGGGC CATCTGCCTG 8700

CTGGAGGAGG CGCTGTTGCG ACTGGCACCC CAGGAGCCGC CCGCCAAGCG TGCGCGGGGG 8760

AGGCCCAGCC TGCCCCCCGA CGTCGGCAGG TGGATGGAAC TTGCCAAACT GTACAGGTCG 8820

ATCGGGGAGT ATGACATCCT CCGTGGTATT TTCAGCAGTG AGATTGGAAC AAAGCAGATC 8880

ACTCAGGACG CACTGTTAGC AGAGGCAAGA AGTGACTATT CTGAAGCTGC CAGGCTATAT 8940

AACGAGGCCC TCAACACACA AGAGTGGGCA GATGGCGAGC CCACGGAAGC TGAGAAGGAC 9000

TTCTGGGAAC TCGCATCCCT TGACTGCTAC AACCAGCTGG CCGAGTGGAC GTCGCTGGAG 9060

TACTGCTCCA CGGCTAGCGC TGATGGCGAG GGCACCCTGG ACCTGAGCAA GATGTGGAGC 9120

GAGCCCTTCT ATCAGGAGAC CTGCCTGCCA TACATGGTAC GCAGCAAGCT GAAGCTGCTG 9180

CTGCGCGGGG AGGGCGACCA GGCACTGCTG ACCTTTGTGG ACGAGGCACT GACCTCCGAG 9240

CTGCGGAAGG CCCTGCTCGA GCTCCGCTAC AGCCAGGAGC TGAGTCTCCT CTACCTCCTG 9300

CAGGACGACA TTGACAGGGC CAAGTATTAC ATCCAGAACT GCATCCAGAT GTTCATGCAG 9360

AACTATTCCA GTATTGATGT CCTCTTACAC AGAAGTAGAC TCACCAAATT GCAGTCTGTA 9420

CAGACGTTCA TAGAAATTCA GGAGTTCATC AGCTTTATTA GCAAACAAGG TAATTTATCA 9480

TCTCACGTTC CCCTGAAGAG ACTTGTGAAA ACCTGGACAA ATCGATACCC TGATGCTAAA 9540

ATGGACCCGA TGAACGTCTG GGATGATATC ATCACGAATC GATGTTTCTT TCTCAGCAAA 9600

ATAGAGGAGA AGCTCTGTCT CCTTCCAGAC AGCGAAGGTG CGAGTGAGGA CGGGGCCGAG 9660

ATGGACTCAC AGGCTCAGGA AGAAGACGCA CGGGCCCTGA TCACGAGCTG CAGCTTCTCC 9720

ATGAGGATGC AGATGGCCGA GAGCGCGAGG AAGCAGAACA ATTTCTCACT CGCCTTGAAG 9780

CTGCTGAAGG AGCTGCACAG AGAGTCGAAA GCCCGGGAGG ACTGGCTGGT GATGTGGGTG 9840

CAGGCCTACT GCCGGCTCAG CCACAGCCGG GCCCGGGCCC AGCGCCGGCC CGAGCAGCTG 9900

TGCACGGCGC TCAGGACTGC GTCCCTGCTG GCTGAGAACA CATTGAGCAC AAGCACCCTG 9960

GCTTCCCGTG ACCATCACGT CCTCCTGGGT ACGACCTACC GGATCCTAGC TGATGCTCTC 10020

TGTGACGAGC CCACCTGCCT TGCTGAGATT GGGGAGAGTA AGGCCAGGAG TGTCGTGGAG 10080

CTGTCTGGGT CCAGCTCGGA GGATGCAGAC AAGGTCATGG CAGGTTTATA CCAGAGAGCG 10140

TTCCACCACC TTTCTGAGGC TGTGCGGGCA GCAGAGGAGG AGGCCGGGCC CTTGGCACGG 10200

GGCCAGGGCC CTACAGCCGG CGTGACCGTG GCTTACCTGA CACTCGCCGA GTTCTGTGAC 10260

CAGCAGCTCC GCAGGCAGGA GGAGGGCATG TCCGTCCTTG GGTCCGCAGA GCTGCTCACG 10320

TATCCAGCCC TTGTGGTGGA CAAGATGCTG AAGGCATTGA AGTTTCACTC GAGCGAGGCC 10380

CGGCTGAAGT TCCCCCGGCT CCTGCAAATT GTCACACAGT ATCCAGAGGA GACGCTGGGC 10440

CTGATGACCA GAGAGATCTC TTCTGTCCCT TGCTGGGAGT TCATCGGCTG GATTGGCCAC 10500

ATGCTGCCCT TGCTGGACAA AGAGGAGGCG GTTGCCATCC AGCGCACCGT GGAGGACATT 10560

GCTGACCACT ACCCGCAGGC CATCGTCTAC CCGTTCATGA TAAGTAGCGA AAGCTACTGC 10620

TTCAGAGACA CTTCTGCTGG TCATAAAAAC AAGGAGTTTG TGGCCAGGAT TAAAGCTAAG 10680

CTGGATCGAG AAGGCGTGGT TCAGGATTTC ATTAACGCCC TGGAGCAGCT CTCCAACCCT 10740

GAGATGCTTT TTAAGGACTG GATGGAGGAC GTTAAGGTTG AACTAGGGAA AACACCTGTG 10800

GATAAAAAGA ACATTCAGAG AATGTATGAG AGGATGCATG CAGCCCTGGG AGACCCACAG 10860

GCTCCTGGCC TTGGGAGTTT TCGAAGGAGG TTTATCCAGG CTTTTGGAAA GGAATTTGAT 10920

AAGCACTTTG GGAGAGGAGG CTCTAAACTC CCAGGCATGA AGCTCCAGGA CTTCTACACC 10980

ATCGCTGGCT CGCTACTGGA GAGGATGCTC AGGGCCTCAA ATGCGCCGGG GAACCTGAGG 11040

GAATGTTCTC CCTGGATGAG CAACTTCAGG GTGGAATTCC TGAGAGCGGA GCTGGAGGTC 11100

CCTGGTCAGT ACGATGGCAG AAGCAAACCA ATGCCCGAGC ACCACGCGCG GATCGCAGGC 11160

TTCGACGAGC GGGTCAAAGT GATGGCCTCG ATCAGGAAAC CCAAGCGCAT CGTGATTCGC 11220

GGCCACGATG AACGGGAGTA TCCCTTCCTG GTGAAGGGCG GCGAGGATCT GCGCCAAGAC 11280

CACCGCATCC AGCAGCTGCT CCAGGTCATG AACAGCGTCC TGGCCCACGA TGCCGCCTGC 11340

GGCCAGAGGG GCCTGCAAAT GACCACCTAC CACGTGGTGC CCATGACCTC CAGGCTGGGG 11400

CTAATCGAAT GGATTGAAAA CACCTGCACG TTGAAGGAAC TTCTTCTGAG CAGCATGTCG 11460

CGGGAGGAGA AGAAAGCCTA CACCAGTGAC CCCCGGGCGC CTGCATCTGA GTACAGAGAA 11520

TGGCTGACCA TGATGGTGGG AAAGTGTGAC CCTGGGGCCT ATGCCCGCAT GTTCAGAGTA 11580

GCTAATCGCA CTGAAGCAGT CACATCTTTT AGGAAAAGAG AAAGTAGAGT GCCTGCAGAT 11640

CTCTTAAAGC GGGCCTTCCT GAAGATGAGC ACTGGCCCCG AGGCCTTCTT AGCCCTTCGC 11700

AACCACTTCA CCACCTCCCA CGCACTCCTG TGCGTCGGCC ACTGGGTTCT GGGCATTGGA 11760

GACCGGCATC TGAACAACTT CATGGTGAGC CTGGAGACGG GCGGCGTGAT CGGGATTGAC 11820

TTCGGACATG CGTTCGGCTC TGCCACCCAG GTCCTGCGGG TCCCTGAGCT AATGCCTTTC 11880

CGGCTGACTC GCCAGTTCAT CAACCTGATG TCACCACTGA AGGAGACGGG GCTCGTGAGC 11940

AGCGTCATGG TGTGTGCGCT GAGGGCCTTC CGCTCGCGCG CCGACCTGCT CACCACCACC 12000

ATGGACGTGT TCGTGAAGGA GCCGTCCTTT GACTGGAAGA ATTTTGAACA GACAATGCTG 12060

AGAAAAGGAG GATCGTGGAT TAAAGAAATA AATGTAACTG AACAAAATTG GTATCCACGG 12120

CAGAAGATTC ATTATGCTAA GAGAAAGCTA GCAGGTGCCA ATCCAGCAGT TATTACTTGT 12180

AATGAGCTTC TCCTGGGCCA TGAGAAGGAG TCTGCCTTCA GAGACTACGT CGCTGTGGCA 12240

CAAGGAAGCC GAGAGCACAG CGTTCGTGCC CAGGAGCCTG AGAGTGGACT TTCAGAAGAG 12300

GCCCAAGTGA GGTGCCTGAT TGACCAGGCA ACTGACCCTA ACATCCTCGG CAGAACTTGG 12360

GAAGGGTGGG AGCCCTGGAT GTGA 12384

Domain Profile

S: 1     iagfderveilaskqkpkklllrGsdgkeypyLvkgkeDlrqdervlqlfslvNtlLakd  60

         iagfderv+++as +kpk++++rG+d++eyp+Lvkg eDlrqd+r++ql++++N +La+d

Q: 3718  IAGFDERVKVMASIRKPKRIVIRGHDEREYPFLVKGGEDLRQDHRIQQLLQVMNSVLAHD  3777

         89**********************************************************

S: 61    ketsrrkLkirtykVvplstrsgliewventvsLkellkkl..vekkavlldqpi..syr  116

         +++ +r L+++ty+Vvp+++r+gliew+ent +Lkell     +e+k+++ ++p+    +

Q: 3778  AACGQRGLQMTTYHVVPMTSRLGLIEWIENTCTLKELLLSSmsREEKKAYTSDPRapASE  3837

         *************************************998777999*********9999*

S: 117   ykdlstvqarkpklkhlkls.........levfkevlenlvpkdllkklllekfpspeew  167

         y ++ t++  k +  ++  +         +++f+++++  vp+dllk+++l++++ pe++

Q: 3838  YREWLTMMVGKCDPGAYARMfrvanrteaVTSFRKRESR-VPADLLKRAFLKMSTGPEAF  3896

         *****************99999****************9.********************

S: 168   felrkaytrslAvislvgyiLgLgdrhlenllidqetgevvhidfgvafekaktqlkvpe  227

         ++lr+++t s+A+ ++ +++Lg+gdrhl+n+++  etg v+ idfg+af++a++ l+vpe

Q: 3897  LALRNHFTTSHALLCVGHWVLGIGDRHLNNFMVSLETGGVIGIDFGHAFGSATQVLRVPE  3956

         ************************************************************

S: 228   kvPFRLTrnivnalgvtgveGvfrasceavlrvlreskeklltiLevflydplvdwkk..  285

          +PFRLTr+++n++ +++++G+ ++ ++ +lr++r+  + l+t+++vf+++p++dwk+

Q: 3957  LMPFRLTRQFINLMSPLKETGLVSSVMVCALRAFRSRADLLTTTMDVFVKEPSFDWKNfe  4016

         ************************************************************

S: 286   ....kkktsketeeelaekakaealkikkllskvekaenavatrdllllee  332

              k++s+++e++++e+++++++ki+++++k+++a++av+t+++lll++

Q: 4017  qtmlRKGGSWIKEINVTEQNWYPRQKIHYAKRKLAGANPAVITCNELLLGH  4067

         **9999****************************************99987

Domain Sequence
(FASTA)

IAGFDERVKV MASIRKPKRI VIRGHDEREY PFLVKGGEDL RQDHRIQQLL QVMNSVLAHD 60

AACGQRGLQM TTYHVVPMTS RLGLIEWIEN TCTLKELLLS SMSREEKKAY TSDPRAPASE 120

YREWLTMMVG KCDPGAYARM FRVANRTEAV TSFRKRESRV PADLLKRAFL KMSTGPEAFL 180

ALRNHFTTSH ALLCVGHWVL GIGDRHLNNF MVSLETGGVI GIDFGHAFGS ATQVLRVPEL 240

MPFRLTRQFI NLMSPLKETG LVSSVMVCAL RAFRSRADLL TTTMDVFVKE PSFDWKNFEQ 300

TMLRKGGSWI KEINVTEQNW YPRQKIHYAK RKLAGANPAV ITCNELLLGH 350

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005958	; C:DNA-dependent protein kinase-DNA ligase 4 complex
GO:0005667	; C:transcription factor complex
GO:0005524	; F:ATP binding
GO:0003677	; F:DNA binding
GO:0004677	; F:DNA-dependent protein kinase activity
GO:0006915	; P:apoptotic process
GO:0002326	; P:B cell lineage commitment
GO:0007420	; P:brain development
GO:0032869	; P:cellular response to insulin stimulus
GO:0006303	; P:double-strand break repair via nonhomologous end joining
GO:0035234	; P:germ cell programmed cell death
GO:0007507	; P:heart development
GO:0033152	; P:immunoglobulin V(D)J recombination
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0043065	; P:positive regulation of apoptotic process
GO:0045944	; P:positive regulation of transcription from RNA polymerase II promoter
GO:0002328	; P:pro-B cell differentiation
GO:0031648	; P:protein destabilization
GO:0010332	; P:response to gamma radiation
GO:0001756	; P:somitogenesis
GO:0033077	; P:T cell differentiation in thymus
GO:0002360	; P:T cell lineage commitment
GO:0033153	; P:T cell receptor V(D)J recombination
GO:0000723	; P:telomere maintenance

KEGG

InterPros

IPR011989	; ARM-like.
IPR016024	; ARM-type_fold.
IPR003152	; FATC.
IPR011009	; Kinase-like_dom.
IPR012582	; NUC194.
IPR000403	; PI3/4_kinase_cat_dom.
IPR018936	; PI3/4_kinase_CS.
IPR003151	; PIK-rel_kinase_FAT.
IPR014009	; PIK_FAT.

Pfam

PF02259	; FAT; 1.
PF02260	; FATC; 1.
PF08163	; NUC194; 1.
PF00454	; PI3_PI4_kinase; 1.

SMARTs

SM00146

; PI3Kc; 1.

Prosites

PS51189	; FAT; 1.
PS51190	; FATC; 1.
PS00915	; PI3_4_KINASE_1; 1.
PS00916	; PI3_4_KINASE_2; 1.
PS50290	; PI3_4_KINASE_3; 1.

Prints

Created Date

20-Feb-2013