EKS-BOT-00294
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-BOT-00294
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
Other/IKK442.09.8E-1339293285
StatusUnreviewed
Ensembl ProteinENSBTAP00000023134
UniProt AccessionE1BKP4;
Protein Name
Protein Synonyms/Alias
Gene NameTBK1
Gene Synonyms/Alias TBK1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSBTAG00000017401ENSBTAP00000023134ENSBTAT00000023134
OrganismBos taurus
Functional Description
Protein Length729
Protein Sequence
(FASTA)
MQSTSNHLWL LSDILGQGAT ANVFRGRHKK TGDLFAIKVF NNISFLRPVD VQMREFEVLK 60
KLNHKNIVKL FAIEEETTTR HKVLIMEFCP CGSLYTVLEE PSNAYGLPES EFLIVLRDVV 120
GGMNHLRENG IVHRDIKPGN IMRVIGEDGQ SVYKLTDFGA ARELEDDEQF VSLYGTEEYL 180
HPDMYERAVL RKDHQKKYGA TVDLWSIGVT FYHAATGSLP FRPFEGPRRN KEVMYKIITG 240
KPSGAISGVQ KAENGPIDWS GDMPVSCSLS RGLQVLLTPV LANILEADQE KCWGFDQFFA 300
ETSDILHRMI VHVFSLQQMT AHKVYIHGYN TATVFHELVY KQTKIISSNQ ELIYEGRRLV 360
LEPGRLAQHF PKTSEENPIF VVSREPLSTI GLIYEKISLP KVHPRYDLDG DASMAKAMTG 420
VVCYACRIAS TLLLYQELVR KGIRWLIELV KDDYNETVHK KTEVVITLDF CIRNIEKTVK 480
VYEKLMKINL EAAELGEISD IHTKLLRLSS SQGTIETSLQ DIESKLSPGG LLADTWTHQE 540
GTHPKDRHVE KLQVLLNCIT EIYYQFKKDK AERRLAYNEE QIHKFDKQKL YYHATKAMTH 600
FTDECVKKYE AFLDKSEEWM RKMLHLRKQL LSLTNQCFDI EEEVSKYQEY TNELQETLPQ 660
KMFAASSGIK HTMTPIYPCS NTLVEMTLGM KKLKEEMEGV VKELAENNHI LERFGSLTMD 720
GGLRNVDCL 729
Nucleotide Sequence
(FASTA)
ATGCAGAGCA CTTCTAATCA TCTGTGGCTT TTATCTGATA TTTTAGGCCA AGGAGCTACT 60
GCAAATGTTT TTCGTGGAAG ACATAAGAAA ACTGGTGACT TATTTGCTAT CAAAGTATTT 120
AATAACATAA GCTTCCTTCG TCCAGTGGAT GTTCAAATGA GAGAATTTGA AGTGTTAAAA 180
AAACTGAATC ACAAAAACAT TGTCAAATTA TTTGCTATTG AAGAGGAGAC AACAACAAGA 240
CATAAAGTAC TTATTATGGA ATTTTGTCCA TGTGGGAGTT TATACACTGT TTTAGAAGAA 300
CCATCTAATG CCTATGGACT ACCAGAGTCT GAGTTTCTAA TTGTTTTGCG AGATGTGGTG 360
GGTGGAATGA ATCATCTCCG AGAGAATGGC ATAGTTCACC GTGATATCAA GCCAGGAAAT 420
ATCATGCGTG TGATAGGAGA AGACGGACAG TCTGTGTACA AACTCACAGA TTTTGGTGCA 480
GCTAGAGAAT TAGAAGATGA TGAGCAGTTT GTTTCTCTGT ATGGCACAGA AGAATATTTG 540
CATCCTGATA TGTATGAGAG AGCAGTGCTA AGAAAAGATC ATCAGAAGAA ATATGGAGCA 600
ACTGTGGATC TTTGGAGCAT TGGGGTAACA TTTTACCATG CAGCTACTGG ATCACTGCCA 660
TTTAGACCAT TTGAAGGGCC ACGTAGGAAT AAGGAAGTGA TGTATAAAAT AATTACTGGA 720
AAGCCTTCTG GTGCAATATC TGGAGTACAG AAAGCAGAAA ATGGACCAAT TGACTGGAGT 780
GGAGACATGC CTGTTTCTTG TAGTCTTTCT CGGGGTCTTC AAGTTCTGCT TACTCCTGTT 840
CTTGCAAACA TCCTTGAGGC AGATCAAGAA AAGTGTTGGG GTTTTGACCA GTTTTTTGCA 900
GAAACTAGTG ATATACTTCA CCGGATGATA GTTCATGTCT TTTCACTACA ACAAATGACA 960
GCTCATAAAG TTTATATTCA TGGCTATAAT ACTGCTACTG TATTTCATGA ACTAGTATAT 1020
AAACAAACCA AAATTATTTC TTCAAATCAA GAGCTTATAT ATGAAGGACG ACGTTTAGTT 1080
CTAGAACCTG GAAGACTGGC ACAGCATTTC CCTAAAACTT CTGAGGAAAA CCCTATCTTT 1140
GTAGTAAGCC GGGAACCTCT GAGTACCATA GGATTGATAT ATGAAAAAAT TTCCCTCCCT 1200
AAAGTACATC CACGTTATGA TTTAGATGGG GATGCCAGCA TGGCTAAGGC AATGACAGGA 1260
GTTGTGTGTT ATGCCTGTAG AATTGCCAGT ACCTTGCTGC TTTATCAGGA ATTAGTGCGA 1320
AAGGGAATAC GATGGTTGAT AGAGTTAGTT AAAGATGACT ATAATGAAAC TGTTCACAAA 1380
AAGACAGAAG TTGTGATCAC ATTGGATTTC TGCATCAGAA ACATTGAAAA AACTGTGAAA 1440
GTATATGAAA AGTTGATGAA GATCAACCTA GAAGCAGCAG AGTTAGGTGA AATTTCAGAC 1500
ATACACACCA AGCTGTTGAG ACTTTCCAGT TCTCAGGGAA CAATAGAAAC CAGTCTCCAG 1560
GATATTGAAA GCAAATTGTC TCCAGGTGGA TTGCTTGCCG ATACATGGAC CCATCAAGAA 1620
GGCACTCATC CCAAAGATAG ACATGTAGAA AAGCTACAAG TCCTGTTAAA TTGCATCACA 1680
GAGATTTACT ATCAGTTCAA AAAAGACAAA GCAGAACGTA GACTAGCTTA TAATGAAGAA 1740
CAAATCCACA AATTTGATAA GCAAAAACTG TATTATCATG CAACAAAAGC TATGACCCAC 1800
TTTACGGATG AATGTGTTAA AAAGTATGAG GCTTTCTTGG ATAAGTCAGA AGAATGGATG 1860
AGAAAGATGC TTCACCTTAG GAAACAGTTA TTATCCCTAA CTAATCAGTG TTTTGATATT 1920
GAAGAAGAAG TATCAAAGTA TCAAGAATAT ACTAATGAGT TACAAGAAAC TTTGCCACAG 1980
AAAATGTTCG CAGCCTCCAG TGGAATCAAA CATACCATGA CCCCAATTTA TCCATGTTCT 2040
AACACATTAG TAGAAATGAC TCTTGGTATG AAGAAATTAA AGGAAGAAAT GGAAGGGGTA 2100
GTTAAAGAAC TTGCTGAAAA TAATCATATT TTAGAAAGGT TTGGCTCATT AACCATGGAT 2160
GGTGGCCTTC GCAATGTCGA CTGTCTTTAG 2190
Domain Profile
S: 1     WelkelLGeGafgnvikarnkktgekiavkvikeesslrprevqvrelevlrklnhkniv  60
         W l+++LG+Ga++nv+++r+kktg+ +a+kv++++s+lrp++vq+re+evl+klnhkniv
Q: 9     WLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIV  68
         999*********************************************************
S: 61    klvdveeelnlasarlkvlvleyCsgGdlrkvLeepenayGLkesevlvvLsdvvaglry  120
         kl+++eee   +++r+kvl++e+C +G+l++vLeep+nayGL+ese+l+vL+dvv g+++
Q: 69    KLFAIEEE---TTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNH  125
         ********...*************************************************
S: 121   LrenkivhRDlkPenivllkgedgksiykltDlGaareldddekvvslvGteeYlaPely  180
         Lren+ivhRD+kP+ni++++gedg+s+ykltD+Gaarel+dde++vsl+GteeYl+P++y
Q: 126   LRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMY  185
         ************************************************************
S: 181   e........qkkytatvDlWsiGvllyeaitGslPflpfegprr....lykkitkkpaka  228
         e        qkky+atvDlWsiGv++y+a+tGslPf+pfegprr    +yk+it kp++a
Q: 186   EravlrkdhQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRnkevMYKIITGKPSGA  245
         ************************************************************
S: 229   iagteka.ngevefssslPlsaslssglqeklekllanllevdeekrw  275
         i+g++ka ng++++s ++P+s+sls+glq  l+++lan+le+d+ek+w
Q: 246   ISGVQKAeNGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCW  293
         *******9***************************************9
Domain Sequence
(FASTA)
WLLSDILGQG ATANVFRGRH KKTGDLFAIK VFNNISFLRP VDVQMREFEV LKKLNHKNIV 60
KLFAIEEETT TRHKVLIMEF CPCGSLYTVL EEPSNAYGLP ESEFLIVLRD VVGGMNHLRE 120
NGIVHRDIKP GNIMRVIGED GQSVYKLTDF GAARELEDDE QFVSLYGTEE YLHPDMYERA 180
VLRKDHQKKY GATVDLWSIG VTFYHAATGS LPFRPFEGPR RNKEVMYKII TGKPSGAISG 240
VQKAENGPID WSGDMPVSCS LSRGLQVLLT PVLANILEAD QEKCW 285
KeywordATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00276
EKS-ANC-00284
EKS-CAJ-00300
EKS-CAF-00300
EKS-CAP-00328
EKS-CII-00172
EKS-CIS-00060
EKS-EQC-00285
EKS-FEC-00282
EKS-GAG-00247
EKS-GAA-00362
EKS-GOG-00293
EKS-HOS-00300
EKS-ICT-00277
EKS-LOA-00305
EKS-MAM-00297
EKS-MEG-00235
EKS-MUM-00325
EKS-MUP-00291
EKS-MYL-00295
EKS-NOL-00270
EKS-ORN-00380
EKS-ORA-00260
EKS-ORC-00275
EKS-OTG-00299
EKS-PAT-00278
EKS-PES-00261
EKS-PEM-00163
EKS-POA-00286
EKS-PTV-00050
EKS-RAN-00309
EKS-SAH-00276
EKS-TAG-00309
EKS-TEN-00379
EKS-VIP-00025
EKS-XET-00366
EKS-XIM-00372
Gene Ontology
GO:0005524; F:ATP binding
GO:0003676; F:nucleic acid binding
GO:0004672; F:protein kinase activity
GO:0002218; P:activation of innate immune response
GO:0050830; P:defense response to Gram-positive bacterium
GO:0010629; P:negative regulation of gene expression
GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0032727; P:positive regulation of interferon-alpha production
GO:0045359; P:positive regulation of interferon-beta biosynthetic process
GO:0032728; P:positive regulation of interferon-beta production
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter
KEGG
bta:533141;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
Pfam
PF00069; Pkinase; 1.
SMARTs
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
Prints
Created Date20-Feb-2013