| Tag | Content |
|---|
| EKPD ID | EPS-BOT-00005 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| DSP/aDSP | 170.2 | 2.6E-50 | 20 | 158 | 139 |
|
| Status | Reviewed |
| Ensembl Protein | ENSBTAP00000023205 |
| UniProt Accession | Q5BIP9; Q32KN1; |
| Protein Name | Dual specificity protein phosphatase 18 |
| Protein Synonyms/Alias | |
| Gene Name | DUSP18 |
| Gene Synonyms/Alias | DUSP18; |
| Ensembl Information | |
| Organism | Bos taurus |
| Functional Description | Can dephosphorylate single and diphosphorylatedsynthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine (By similarity). |
| Protein Length | 188 |
Protein Sequence
(FASTA) | | MTASPCAFPV QFRQPSVSGL SQITSSLYIS SGVAANNRLM LSSNRISTVI NVSVEVVNAL 60 | | YEDIHYVQVP VADTPTSRLC DFFDPIADHI HSVEMKQGRT LLHCAAGVSR SAALCLAYLM 120 | | KYHAMSLLDA HTWTKSCRPI IRPNNGFWEQ LIHYEFQLFG RNTVHMVSSP VGMIPDIYEK 180 | | EVRQMIPL 188 |
|
Nucleotide Sequence
(FASTA) | | ATGACAGCAT CCCCGTGTGC CTTCCCAGTT CAGTTCCGGC AGCCCTCGGT CAGTGGCCTC 60 | | TCACAGATCA CCAGTAGCCT GTATATCAGC AGCGGGGTGG CCGCCAACAA CAGGCTCATG 120 | | CTCTCCAGCA ACCGCATCAG CACGGTCATC AATGTCTCAG TGGAGGTGGT GAACGCCTTG 180 | | TACGAGGACA TTCACTATGT GCAGGTGCCC GTGGCCGACA CGCCCACCTC GCGGCTCTGT 240 | | GACTTCTTCG ACCCCATCGC AGACCACATC CACAGCGTGG AGATGAAGCA GGGCCGCACC 300 | | CTGCTGCACT GCGCCGCCGG CGTCAGCCGC TCGGCTGCCC TCTGCCTCGC CTATCTCATG 360 | | AAGTACCACG CCATGTCCCT GCTGGACGCC CACACGTGGA CCAAGTCCTG CCGGCCCATC 420 | | ATCCGGCCCA ACAACGGCTT TTGGGAGCAG CTCATCCACT ATGAGTTCCA GCTATTTGGC 480 | | AGGAATACCG TGCACATGGT CAGCTCCCCC GTGGGCATGA TCCCTGACAT CTACGAGAAG 540 | | GAGGTCCGTC AGATGATTCC ACTCTGA 567 |
|
| Domain Profile | S: 2 vteilpglylgdqataldrreLsklgitvvinaslsvikvqviPeylikkgityknipvd 61 | +++i+++ly+++ a++r++Ls + i++vin+s++v++ ++i+y+++pv | Q: 20 LSQITSSLYISSGVAANNRLMLSSNRISTVINVSVEVVN-------ALYEDIHYVQVPVA 72 | 689************************************.......5579********** |
| S: 62 DsdvtdllqyfdeaaefideakekggkvlvHCaaGvsRSatlvlaYLmkveglslsdAie 121 | D++++ l+++fd++a++i+++++k+g++l+HCaaGvsRSa+l+laYLmk++ +sl dA++ | Q: 73 DTPTSRLCDFFDPIADHIHSVEMKQGRTLLHCAAGVSRSAALCLAYLMKYHAMSLLDAHT 132 | ************************************************************ |
| S: 122 avkrkrpsiepnegfleQLlelekkl 147 | ++k++rp+i+pn+gf+eQL+++e +l | Q: 133 WTKSCRPIIRPNNGFWEQLIHYEFQL 158 | ***********************998 |
|
Domain Sequence
(FASTA) | | LSQITSSLYI SSGVAANNRL MLSSNRISTV INVSVEVVNA LYEDIHYVQV PVADTPTSRL 60 | | CDFFDPIADH IHSVEMKQGR TLLHCAAGVS RSAALCLAYL MKYHAMSLLD AHTWTKSCRP 120 | | IIRPNNGFWE QLIHYEFQL 139 |
|
| Keyword | Complete proteome; Cytoplasm; Hydrolase; Membrane; Mitochondrion; Mitochondrion inner membrane; Nucleus; Protein phosphatase; Reference proteome. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | | GO:0005743 | ; C:mitochondrial inner membrane | | GO:0005634 | ; C:nucleus | | GO:0017017 | ; F:MAP kinase tyrosine/serine/threonine phosphatase activity | | GO:0004725 | ; F:protein tyrosine phosphatase activity | | GO:0008138 | ; F:protein tyrosine/serine/threonine phosphatase activity | | GO:0035335 | ; P:peptidyl-tyrosine dephosphorylation |
|
| KEGG | |
| InterPros | |
| Pfam | |
| SMARTs | |
| Prosites | |
| Prints | |
| Created Date | 20-Feb-2013 |