EKS-BOT-00456

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-BOT-00456

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CK1/CK1	463.0	2.7E-139	43	304	262

Status

Reviewed

Ensembl Protein

ENSBTAP00000023329

UniProt Accession

P35509;

Protein Name

Casein kinase I isoform gamma-3

Protein Synonyms/Alias

CKI-gamma 3;

Gene Name

CSNK1G3

Gene Synonyms/Alias

CSNK1G3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000017550	ENSBTAP00000023329	ENSBTAT00000023329

Organism

Bos taurus

Functional Description

Casein kinases are operationally defined by theirpreferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity).

Protein Length

422

Protein Sequence
(FASTA)

MENKKKDKDK SDDRMARPSG RLGHNTRGTG SSSSGVLMVG PNFRVGKKIG CGNFGELRLG 60

KNLYTNEYVA IKLEPMKSRA PQLHLEYRFY KQLGSGDGIP QVYYFGPCGK YNAMVLELLG 120

PSLEDLFDLC DRTFSLKTVL MIAIQLISRM EYVHSKNLIY RDVKPENFLI GRPGNKTQQV 180

IHIIDFGLAK EYIDPETKKH IPYREHKSLT GTARYMSINT HLGKEQSRRD DLEALGHMFM 240

YFLRGSLPWQ GLKADTLKER YQKIGDTKRA TPIEVLCENF PEMATYLRYV RRLDFFEKPD 300

YDYLRKLFTD LFDRKGYMFD YEYDWIGKQL PTPVGAVQQD PALSSNREAH PHRDKIQSKN 360

QVVSSTNGEL NTDDPTAGRS NAPITAPTEV EVMDETNCQK VLNMWCCCFF KRRKRKTIQR 420

HK 422

Nucleotide Sequence
(FASTA)

ATGGAAAATA AAAAGAAAGA CAAGGACAAA TCAGATGATA GAATGGCACG ACCTAGTGGT 60

CGGCTGGGAC ATAACACTCG AGGAACTGGT TCTTCATCCT CTGGAGTTTT AATGGTTGGA 120

CCTAACTTTA GAGTTGGAAA AAAAATTGGA TGTGGGAATT TTGGAGAACT ACGATTAGGG 180

AAAAATTTGT ATACAAATGA ATATGTGGCC ATTAAATTGG AGCCCATGAA ATCCAGAGCA 240

CCACAGCTAC ATTTGGAATA CAGATTCTAC AAGCAGTTAG GATCTGGAGA TGGTATACCT 300

CAAGTTTACT ATTTTGGCCC TTGTGGTAAA TACAACGCTA TGGTGCTGGA ACTACTGGGA 360

CCTAGTTTGG AAGATTTGTT TGATTTGTGT GACAGAACAT TTTCTCTTAA AACGGTTCTC 420

ATGATAGCTA TCCAACTGAT TTCTCGCATG GAATATGTCC ATTCAAAGAA CTTGATATAC 480

AGAGATGTAA AACCTGAGAA CTTCTTAATA GGCCGGCCGG GAAACAAAAC CCAGCAAGTT 540

ATTCATATTA TAGATTTTGG TTTGGCAAAG GAATATATTG ATCCAGAAAC AAAGAAACAC 600

ATACCATACA GAGAACACAA GAGCCTTACA GGAACAGCTA GATATATGAG CATAAACACA 660

CATTTAGGGA AAGAACAAAG TAGAAGAGAT GACTTAGAAG CGTTAGGTCA CATGTTCATG 720

TATTTTCTGA GAGGCAGTCT TCCTTGGCAA GGTTTAAAGG CTGACACATT AAAGGAGAGG 780

TATCAGAAAA TTGGAGATAC AAAACGAGCC ACACCAATAG AAGTGTTATG TGAAAATTTT 840

CCAGAAATGG CAACATATCT TCGTTATGTA AGAAGGCTAG ATTTTTTTGA AAAACCAGAT 900

TATGACTACC TAAGAAAACT TTTTACTGAC TTGTTTGATC GAAAAGGATA TATGTTTGAT 960

TATGAATATG ACTGGATTGG TAAACAGTTG CCTACTCCAG TGGGTGCAGT TCAGCAAGAT 1020

CCTGCTCTGT CATCAAACAG AGAAGCACAT CCCCACAGAG ATAAGATACA ATCCAAAAAT 1080

CAGGTTGTAA GTTCTACAAA TGGAGAATTA AACACAGATG ACCCTACTGC AGGACGTTCA 1140

AATGCACCCA TCACAGCCCC TACAGAAGTA GAGGTGATGG ATGAAACCAA CTGCCAGAAA 1200

GTGTTGAACA TGTGGTGCTG CTGTTTTTTC AAACGAAGGA AAAGGAAAAC CATACAGCGC 1260

CACAAATGA 1269

Domain Profile

S: 1     yrvvkkiGsGsfGdiylgknlasgeevaikleskkskapqlklesrvykilqggvgiPev  60

         +rv+kkiG+G+fG+++lgknl+++e+vaikle++ks+apql+le+r+yk+l +g giP+v

Q: 43    FRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGIPQV  102

         89**********************************************************

S: 61    ryfgkekkynvlvldllGpsledlfdlcerkfslktvllladqlisrieyvhskeliyrd  120

         +yfg+++kyn++vl+llGpsledlfdlc+r+fslktvl++a+qlisr+eyvhsk+liyrd

Q: 103   YYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRD  162

         ************************************************************

S: 121   ikPdnfllgigrkgkk....vylidfGlakkyrdaktkkhipyreeksltGtaryasint  176

         +kP+nfl  igr g+k    +++idfGlak+y+d++tkkhipyre+ksltGtary+sint

Q: 163   VKPENFL--IGRPGNKtqqvIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINT  220

         *******..55555555566****************************************

S: 177   hlgkeqsrrddleslgyvllyflrgslPWqglkaatkkqkyekisekklstsievlcegf  236

         hlgkeqsrrddle+lg++++yflrgslPWqglka+t k++y+ki+++k++t+ievlce+f

Q: 221   HLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENF  280

         ************************************************************

S: 237   PeefatylkyvrklkfeekPdyeyl  261

         P e+atyl+yvr+l+f+ekPdy+yl

Q: 281   P-EMATYLRYVRRLDFFEKPDYDYL  304

         *.8********************97

Domain Sequence
(FASTA)

FRVGKKIGCG NFGELRLGKN LYTNEYVAIK LEPMKSRAPQ LHLEYRFYKQ LGSGDGIPQV 60

YYFGPCGKYN AMVLELLGPS LEDLFDLCDR TFSLKTVLMI AIQLISRMEY VHSKNLIYRD 120

VKPENFLIGR PGNKTQQVIH IIDFGLAKEY IDPETKKHIP YREHKSLTGT ARYMSINTHL 180

GKEQSRRDDL EALGHMFMYF LRGSLPWQGL KADTLKERYQ KIGDTKRATP IEVLCENFPE 240

MATYLRYVRR LDFFEKPDYD YL 262

Keyword

ATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase; Wnt signaling pathway.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>