EKS-BOT-00159
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-BOT-00159
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/RSKb497.77.0E-150422679258
StatusUnreviewed
Ensembl ProteinENSBTAP00000023465
UniProt AccessionF1MZW8;
Protein NameRibosomal protein S6 kinase
Protein Synonyms/Alias
Gene NameRPS6KA3
Gene Synonyms/Alias RPS6KA3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSBTAG00000017639ENSBTAP00000023465ENSBTAT00000023465
OrganismBos taurus
Functional Description
Protein Length740
Protein Sequence
(FASTA)
MPLAQLADPW QKMAVESPSD SAENGQQIMD EPMGEEEINP QTEEGSIKEI AITHHVKEGH 60
EKADPSQFEL LKVLGQGSFG KVFLVKKISG SDARQLYAMK VLKKATLKVR DRVRTKMERD 120
ILVEVNHPFI VKLHYAFQTE GKLYLILDFL RGGDLFTRLS KEVMFTEEDV KFYLAELALA 180
LDHLHSLGII YRDLTPENIL LDEEGHIKLT DFGLSKESID HEKKAYSFCG TVEYMAPEVV 240
NRRGHTQSAD WWSFGVLMFE MLTGTLPFQG KDRKETMTMI LKAKLGMPQF LSPEAQSLLR 300
MLFKRNPANR LGAGPDGVEE IKRHSFFSTI DWNKLYRREI HPPFKPATGR PEDTFYFDPE 360
FTAKTPKDSP GIPPSANAHQ LFRGFSFVAI TSDDESQAMQ TVGVHSIVQQ LHRNSIQFTD 420
GYEVKEDIGV GSYSVCKRCI HKATNMEFAV KIIDKSKRDP TEEIEILLRY GQHPNIITLK 480
DVYDDGKYVY VVTELMKGGE LLDKILRQKF FSEREASAVL FTITKTVEYL HAQGVVHRDL 540
KPSNILYVDE SGNPESIRIC DFGFAKQLRA ENGLLMTPCY TANFVAPEVL KRQGYDAACD 600
IWSLGVLLYT MLTGYTPFAN GPDDTPEEIL ARIGSGKFSL SGGYWNSVSD TAKDLVSKML 660
HVDPHQRLTA ALVLRHPWIV HWDQLPQYQL NRQDAPHLVK GAMAATYSAL NRNQSPVLEP 720
VGRSTLAQRR GIKKITSTAL 740
Nucleotide Sequence
(FASTA)
ATGCCGCTGG CGCAGCTGGC GGACCCGTGG CAGAAGATGG CTGTGGAGAG CCCATCCGAC 60
AGCGCTGAGA ATGGACAGCA AATTATGGAT GAACCTATGG GAGAGGAAGA GATTAATCCA 120
CAAACTGAAG AAGGCAGTAT CAAAGAAATT GCAATCACAC ATCATGTAAA GGAAGGACAT 180
GAAAAGGCAG ATCCTTCCCA ATTTGAACTT TTAAAAGTAT TAGGGCAGGG ATCATTTGGA 240
AAGGTTTTCT TAGTCAAAAA AATCTCAGGC TCTGATGCTA GACAGCTTTA CGCCATGAAA 300
GTACTGAAGA AGGCCACACT GAAAGTTCGA GACCGTGTTC GGACAAAAAT GGAGCGTGAT 360
ATCTTGGTAG AAGTTAACCA TCCTTTTATC GTCAAGTTGC ATTATGCTTT TCAAACTGAA 420
GGGAAGTTGT ATCTTATATT GGACTTTCTC AGGGGAGGAG ATTTGTTTAC ACGCTTATCC 480
AAAGAGGTGA TGTTCACAGA AGAAGATGTC AAATTCTACT TGGCCGAACT TGCACTTGCT 540
TTAGACCATC TACACAGCCT GGGAATAATC TATAGAGACT TAACACCAGA AAACATTCTT 600
CTTGATGAAG AAGGTCATAT CAAGTTAACA GACTTTGGCC TAAGTAAAGA GTCTATTGAC 660
CATGAAAAGA AAGCATATTC TTTTTGTGGA ACTGTGGAAT ACATGGCTCC AGAAGTAGTT 720
AATCGTCGAG GTCATACTCA GAGTGCAGAC TGGTGGTCTT TTGGTGTGTT GATGTTTGAG 780
ATGCTCACTG GTACACTACC TTTCCAAGGA AAAGATCGAA AAGAAACAAT GACTATGATT 840
CTTAAAGCCA AACTTGGGAT GCCACAGTTT TTGAGCCCAG AAGCCCAGAG TCTTTTACGA 900
ATGCTTTTCA AACGAAATCC TGCAAACAGA TTAGGTGCAG GACCAGATGG AGTTGAAGAA 960
ATTAAAAGAC ATTCATTTTT CTCAACTATA GACTGGAATA AACTGTATAG AAGAGAAATT 1020
CATCCACCTT TTAAACCTGC AACTGGCAGG CCTGAAGATA CTTTCTATTT TGATCCTGAG 1080
TTTACTGCAA AAACTCCCAA AGATTCACCT GGCATTCCAC CTAGTGCTAA TGCACATCAG 1140
CTTTTTCGAG GGTTTAGTTT TGTTGCTATT ACCTCAGATG ATGAAAGCCA AGCTATGCAG 1200
ACAGTTGGTG TGCATTCAAT TGTTCAGCAG TTGCACAGGA ACAGTATCCA GTTTACTGAT 1260
GGGTATGAAG TAAAAGAAGA TATTGGAGTT GGCTCCTACT CTGTTTGCAA GAGATGTATA 1320
CATAAAGCCA CAAACATGGA GTTTGCAGTG AAGATTATTG ATAAAAGCAA GAGAGACCCT 1380
ACAGAAGAAA TTGAAATTCT TCTTCGTTAT GGACAGCATC CAAACATTAT TACTCTAAAG 1440
GATGTATATG ATGATGGAAA ATATGTGTAT GTAGTGACAG AACTTATGAA AGGGGGTGAA 1500
TTGCTGGATA AAATTCTTAG GCAGAAATTT TTCTCTGAGC GAGAGGCCAG TGCTGTCCTG 1560
TTTACTATTA CCAAAACTGT TGAATATCTT CATGCACAAG GGGTGGTTCA CAGAGACTTG 1620
AAACCTAGCA ACATTCTTTA TGTGGATGAA TCTGGCAATC CAGAATCTAT TCGCATTTGT 1680
GATTTTGGCT TTGCTAAACA ACTAAGAGCA GAAAATGGTC TTCTCATGAC TCCTTGTTAT 1740
ACGGCAAATT TTGTTGCACC AGAGGTTTTA AAACGACAAG GCTATGATGC TGCTTGTGAC 1800
ATATGGAGTC TTGGTGTCCT CCTCTACACA ATGCTTACTG GTTACACTCC ATTTGCAAAT 1860
GGCCCTGATG ATACACCAGA GGAAATACTG GCTCGAATAG GCAGTGGAAA ATTCTCACTC 1920
AGTGGTGGCT ACTGGAATTC TGTTTCAGAC ACAGCAAAGG ACCTGGTGTC AAAGATGCTT 1980
CATGTGGACC CTCACCAGAG ACTGACCGCT GCCCTTGTGC TCAGACATCC TTGGATTGTC 2040
CACTGGGACC AACTGCCGCA ATACCAACTC AACAGACAGG ATGCACCACA TCTGGTCAAG 2100
GGTGCCATGG CAGCTACATA CTCTGCTTTA AACCGTAATC AGTCACCAGT TTTGGAACCA 2160
GTAGGCCGCT CTACTCTTGC TCAGCGGAGA GGTATTAAAA AAATCACCTC TACAGCCCTG 2220
TGA 2223
Domain Profile
S: 1     yevkedlGvGsysvckrcvhkatnqefavkiidkskrdtseeieillryeqhpnivtlkd  60
         yevked+GvGsysvckrc+hkatn+efavkiidkskrd++eeieillry+qhpni+tlkd
Q: 422   YEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKD  481
         789*********************************************************
S: 61    vyddgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheqGvvhrdlk  120
         vyddgkyvy+v+el+kGGelld+i+++kffsereasa+l+t++k+veylh+qGvvhrdlk
Q: 482   VYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLK  541
         ************************************************************
S: 121   penilyvdesdnaesikiidfGfaklkraengllktpcytlnfvapevlkrqGydeacdl  180
         p+nilyvdes+n+esi+i+dfGfak++raengll+tpcyt+nfvapevlkrqGyd+acd+
Q: 542   PSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDI  601
         ************************************************************
S: 181   wslGvllytmlaGyvpfangpedtaeeilakikeGkfslsGeawdsvseeakdlvskllt  240
         wslGvllytml+Gy+pfangp+dt+eeila+i++GkfslsG++w+svs++akdlvsk+l+
Q: 602   WSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLH  661
         ************************************************************
S: 241   vdpakrlkleqllkhswl  258
         vdp++rl+++ +l+h+w+
Q: 662   VDPHQRLTAALVLRHPWI  679
         *****************8
Domain Sequence
(FASTA)
YEVKEDIGVG SYSVCKRCIH KATNMEFAVK IIDKSKRDPT EEIEILLRYG QHPNIITLKD 60
VYDDGKYVYV VTELMKGGEL LDKILRQKFF SEREASAVLF TITKTVEYLH AQGVVHRDLK 120
PSNILYVDES GNPESIRICD FGFAKQLRAE NGLLMTPCYT ANFVAPEVLK RQGYDAACDI 180
WSLGVLLYTM LTGYTPFANG PDDTPEEILA RIGSGKFSLS GGYWNSVSDT AKDLVSKMLH 240
VDPHQRLTAA LVLRHPWI 258
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00152
EKS-CAJ-00163
EKS-CAF-00166
EKS-CAP-00159
EKS-CII-00107
EKS-CIS-00193
EKS-DAR-00451
EKS-DRM-00076
EKS-EQC-00160
EKS-FEC-00150
EKS-GAG-00136
EKS-GAA-00190
EKS-GOG-00160
EKS-HOS-00165
EKS-ICT-00155
EKS-LAC-00169
EKS-LOA-00158
EKS-MAM-00157
EKS-MEG-00126
EKS-MOD-00159
EKS-MUM-00166
EKS-MUP-00164
EKS-MYL-00170
EKS-ORN-00199
EKS-ORA-00139
EKS-ORC-00147
EKS-ORL-00187
EKS-OTG-00165
EKS-PES-00141
EKS-PEM-00086
EKS-POA-00156
EKS-RAN-00157
EKS-SAH-00154
EKS-SUS-00138
EKS-TAG-00188
EKS-TAR-00207
EKS-TEN-00201
EKS-TUT-00150
EKS-VIP-00076
EKS-XIM-00196
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0043027; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0004713; F:protein tyrosine kinase activity
GO:0007243; P:intracellular protein kinase cascade
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter
GO:0032496; P:response to lipopolysaccharide
GO:0002224; P:toll-like receptor signaling pathway
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR016239; Ribosomal_S6_kinase_II.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
IPR008266; Tyr_kinase_AS.
Pfam
PF00069; Pkinase; 2.
PF00433; Pkinase_C; 1.
SMARTs
SM00133; S_TK_X; 1.
SM00220; S_TKc; 2.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 2.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00108; PROTEIN_KINASE_ST; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
Created Date20-Feb-2013