EKS-BOT-00346

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-BOT-00346

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Ack	393.9	3.2E-118	116	377	262

Status

Unreviewed

Ensembl Protein

ENSBTAP00000023593

UniProt Accession

E1BD38;

Protein Name

Protein Synonyms/Alias

Gene Name

TNK1

Gene Synonyms/Alias

TNK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000017739	ENSBTAP00000023593	ENSBTAT00000023593

Organism

Bos taurus

Functional Description

Protein Length

663

Protein Sequence
(FASTA)

MLPEAGSLWL LRLLRDLQLA QFYRPILEEL NVTRPEHFDF VRAEDLDGIG MGRPAQRRLA 60

EALKRHRSGL KSKNWVYKIL GGFASGQKET TPPSDSLPSL PEPDGRLKCL IPNRAVCRGE 120

LLGSGCFGMV HRGLWTLPSG QTVPVAVKSL RVGPEGPEGT ELEDFLREVS VMMNLEHPHV 180

LRLHGLVLGQ PLQMVMELAP LGSLHARLTA PAPTPPLALA LLCLFLRQVA GAMAYLGARG 240

LVHRDLATRN LLLASPRTIK VADFGLVRPL GGARGRYIMG GPRRIPFAWC APESLRHGAF 300

SSASDVWMYG VTLWEMFAGG EEPWAGVPPY LILQRLEKDR ARLPKPPLCS RALYTLALRC 360

WASHPADRPT FSDLEGLLQE AWPPEGRCVR EVMEAGALRM EPGDPITIIE GSPFTSSHSP 420

DSTTWKGQNG RTFKVGSFPA SAVTLVDPPA TRPILRGTPA RVERHQRNAD GDRGKAKLQD 480

APQARGQRRN VALQRTKGIS KSLESVLSLG PRPTGGGSSP PELRHARTGP QGPPSRSPRL 540

PMATSSSQPS RERPPWPKRE YPQSHPVGAP GASKAAIPSG RPLSDPELQR RVLEVELSVH 600

GVTHQECQAA LRATGGDVVS AIRNLKVEQL FYLSSWSRAD CRRILERYQW DLSAASRYVL 660

ARP 663

Nucleotide Sequence
(FASTA)

ATGCTCCCTG AGGCGGGTTC CCTGTGGCTG CTGCGGCTGC TCCGAGACCT CCAGCTGGCC 60

CAGTTTTACC GGCCCATCCT GGAGGAGCTT AACGTGACTC GGCCGGAGCA CTTCGACTTT 120

GTAAGAGCTG AAGATCTGGA TGGCATTGGC ATGGGCCGGC CTGCCCAACG TAGACTGGCT 180

GAAGCTCTGA AGAGGCACCG TTCGGGGCTC AAGTCTAAGA ATTGGGTCTA CAAGATCCTT 240

GGGGGCTTTG CCTCTGGGCA AAAGGAGACC ACCCCACCCT CAGATAGCCT TCCATCCCTC 300

CCTGAGCCAG ATGGGAGACT CAAGTGTCTG ATCCCAAACC GGGCTGTGTG CCGAGGGGAG 360

CTTTTGGGCT CCGGCTGCTT TGGCATGGTG CACCGAGGGC TGTGGACACT ACCCAGCGGC 420

CAGACTGTCC CAGTGGCTGT CAAGTCCCTC CGGGTGGGTC CCGAAGGTCC CGAGGGCACT 480

GAGCTAGAGG ACTTCCTGAG AGAAGTGTCT GTCATGATGA ACTTGGAGCA TCCACACGTG 540

CTGCGTCTGC ACGGCCTTGT ACTGGGTCAG CCTCTGCAGA TGGTGATGGA GCTGGCGCCC 600

CTGGGCTCCC TGCACGCGCG TCTGACGGCC CCAGCCCCCA CGCCCCCGCT GGCCCTGGCC 660

TTGCTCTGCC TCTTCCTGCG GCAGGTGGCG GGGGCCATGG CGTACCTGGG GGCCCGTGGG 720

CTGGTCCACC GAGACCTGGC CACGCGCAAC CTGCTGCTGG CTTCACCGCG CACCATCAAG 780

GTGGCTGACT TCGGGCTGGT GCGACCGCTG GGCGGCGCCC GGGGCCGCTA CATCATGGGC 840

GGGCCCCGAC GCATCCCCTT TGCCTGGTGT GCGCCCGAGA GCCTGCGCCA CGGGGCCTTC 900

TCGTCTGCCT CGGACGTGTG GATGTATGGG GTGACGCTGT GGGAGATGTT CGCTGGGGGC 960

GAGGAGCCCT GGGCCGGGGT CCCGCCATAC CTCATCCTGC AACGGCTGGA GAAGGACCGA 1020

GCCCGCCTGC CCAAGCCTCC TCTCTGCTCC AGGGCCCTCT ACACCCTGGC CTTGCGCTGC 1080

TGGGCCTCCC ACCCTGCTGA CCGGCCCACC TTTTCCGACC TAGAGGGGCT GCTTCAAGAG 1140

GCCTGGCCTC CTGAGGGACG TTGTGTGAGG GAGGTCATGG AGGCCGGTGC TCTGAGGATG 1200

GAGCCTGGTG ACCCCATCAC TATCATTGAG GGCAGCCCTT TCACCTCTTC CCACAGCCCT 1260

GACTCCACAA CCTGGAAGGG CCAGAACGGT CGCACGTTCA AAGTGGGCAG CTTCCCAGCC 1320

TCAGCGGTGA CACTGGTAGA CCCACCAGCC ACCCGCCCCA TCCTCAGAGG CACCCCTGCC 1380

CGGGTAGAGC GACACCAGAG AAACGCAGAT GGGGACAGAG GGAAGGCAAA GCTTCAGGAT 1440

GCCCCTCAGG CTCGGGGCCA GAGAAGGAAT GTGGCTCTGC AGAGGACTAA AGGCATTTCC 1500

AAGAGTCTGG AGTCGGTTCT TTCCCTGGGT CCCCGCCCCA CAGGAGGCGG GTCGAGCCCC 1560

CCTGAACTTC GACATGCCAG AACTGGGCCC CAGGGACCCC CAAGCCGGTC ACCCCGCCTT 1620

CCCATGGCCA CCAGCTCTTC CCAGCCTTCC AGGGAGCGGC CTCCCTGGCC CAAAAGAGAA 1680

TACCCCCAGA GTCACCCCGT AGGAGCACCT GGAGCCAGCA AAGCCGCCAT CCCCTCCGGA 1740

CGACCCTTGT CTGACCCTGA GCTGCAGAGG AGGGTTTTGG AGGTGGAGCT GAGTGTGCAC 1800

GGAGTCACCC ACCAGGAGTG CCAGGCTGCT CTAAGAGCCA CCGGGGGAGA TGTGGTTTCT 1860

GCCATACGGA ACCTCAAGGT AGAGCAGCTT TTCTACCTCA GTAGCTGGTC CAGAGCGGAC 1920

TGCCGGCGCA TCCTGGAGCG TTACCAGTGG GACCTCTCGG CCGCCAGCCG CTATGTCCTG 1980

GCCCGGCCCT GA 1992

Domain Profile

S: 1     iklleklGeGsfgvvkrgeWsapsgksvqvavkvlk..sdkllstelddflrevsvllkl  58

         ++++e+lG+G+fg+v+rg W+ psg++v+vavk+l+  ++   +tel+dflrevsv+++l

Q: 116   VCRGELLGSGCFGMVHRGLWTLPSGQTVPVAVKSLRvgPEGPEGTELEDFLREVSVMMNL  175

         56889******************************9999*********************

S: 59    ehenlvrlyGvvltqplklvtelaelgslldrlrkeakrdsllvallleyavqiaeglay  118

         eh++++rl+G+vl+qpl++v+ela+lgsl++rl+++a +++l++all+ +++q+a ++ay

Q: 176   EHPHVLRLHGLVLGQPLQMVMELAPLGSLHARLTAPAPTPPLALALLCLFLRQVAGAMAY  235

         ************************************************************

S: 119   leskrlvhrdlaarnlllaskklvkisdfGlvralgeeedlyvlaenkkvPfaWcaPesl  178

         l+++ lvhrdla+rnlllas++++k++dfGlvr+lg ++++y +  ++++PfaWcaPesl

Q: 236   LGARGLVHRDLATRNLLLASPRTIKVADFGLVRPLGGARGRYIMGGPRRIPFAWCAPESL  295

         ************************************************************

S: 179   rtrkfssasdvWafGvtlWemfsyGeePWvglsglqilkkidkekerlekPeacpediys  238

         r+ +fssasdvW++GvtlWemf+ GeePW+g++++ il++++k+++rl+kP++c++++y+

Q: 296   RHGAFSSASDVWMYGVTLWEMFAGGEEPWAGVPPYLILQRLEKDRARLPKPPLCSRALYT  355

         ************************************************************

S: 239   lllkcWakkpadrpkfsalkek  260

         l+l+cWa++padrp+fs+l++

Q: 356   LALRCWASHPADRPTFSDLEGL  377

         *******************976

Domain Sequence
(FASTA)

VCRGELLGSG CFGMVHRGLW TLPSGQTVPV AVKSLRVGPE GPEGTELEDF LREVSVMMNL 60

EHPHVLRLHG LVLGQPLQMV MELAPLGSLH ARLTAPAPTP PLALALLCLF LRQVAGAMAY 120

LGARGLVHRD LATRNLLLAS PRTIKVADFG LVRPLGGARG RYIMGGPRRI PFAWCAPESL 180

RHGAFSSASD VWMYGVTLWE MFAGGEEPWA GVPPYLILQR LEKDRARLPK PPLCSRALYT 240

LALRCWASHP ADRPTFSDLE GL 262

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>

Gene Ontology

GO:0005829	; C:cytosol
GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0030308	; P:negative regulation of cell growth
GO:0046580	; P:negative regulation of Ras protein signal transduction

KEGG

bta:510356

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714

; Pkinase_Tyr; 1.

SMARTs

SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

Created Date

20-Feb-2013