EKS-BOT-00248

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-BOT-00248

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	314.1	6.5E-94	1	240	240

Status

Unreviewed

Ensembl Protein

ENSBTAP00000023759

UniProt Accession

F1MVZ2;

Protein Name

Protein Synonyms/Alias

Gene Name

BRSK2

Gene Synonyms/Alias

BRSK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000017861	ENSBTAP00000023759	ENSBTAT00000023759

Organism

Bos taurus

Functional Description

Protein Length

706

Protein Sequence
(FASTA)

GLVKLGIHCV TCQKVAVKIV NREKLSESVL MKVEREIAIL KLIEHPHVLI RHDVYENKKY 60

LYLVLEHVSG GELFDYLVKK GRLTPKEARK FFRQIISALD FCHSHSICHR DLKPENLLLD 120

EKNNIRIADF GMASLQVGDS LLETSCGSPH YACPEVIRGE KYDGRKADVW SCGVILFALL 180

VGALPFDDDN LRQLLEKVKR GVFHMPHFIP PDCQSLLRGM IEVDAARRLT LEHIQKHIWY 240

IGGKNEPEPE QPVPRKVQIR SLPSLEDIDP DVLDSMHSLG CFRDRNKLLQ DLLSEEENQE 300

KMIYFLLLDR KERYPSHEDE DLPPRNEIDP PRKRVDSPML NRHGKRRPER KSMEVLSVTD 360

GGSPVPARRA LEMAQHGQRS RSISGASSGL STSPLSSPRV TPHPSPRGSP LPTPKGTPVH 420

TPKESPAGTP NPTPPSSPSV GGVPWRTRLN SIKNSFLGSP RFHRRKLQVP TPEEMSNLTP 480

ESSPELAKKS WFGNFISLEK EEQIFVVIKD KPLSSIKADI VHAFLSIPSL SHSVISQTSF 540

RAEYKATGGP AVFQKPVKFQ VDITYTEGGA AQKENGIYSV TFTLLSGPSR RFKRVVETIQ 600

AQLLSTHEQP SAQHLSDTTN CMEMMTGRLS KCGSPLSNFF DVIKQLFSDE KNGQAAQAPS 660

TPAKRSAHGP LGDSAAAGPG PGGDAEYPAG KDKARTGLPA ARREQP 706

Nucleotide Sequence
(FASTA)

GGCCTGGTGA AGCTGGGGAT CCACTGTGTC ACGTGCCAGA AGGTGGCCGT CAAGATCGTC 60

AACCGGGAGA AGCTCAGCGA GTCTGTACTG ATGAAGGTGG AGCGGGAGAT CGCGATCCTG 120

AAGCTGATCG AGCACCCCCA CGTCCTCATA AGACACGACG TCTATGAAAA CAAAAAATAT 180

TTATACCTGG TGCTAGAACA TGTGTCTGGT GGAGAGCTCT TTGACTACCT GGTCAAGAAG 240

GGGAGGCTGA CCCCCAAAGA GGCCCGGAAG TTCTTCCGCC AGATCATCTC TGCGCTGGAC 300

TTCTGCCACA GCCACTCCAT ATGCCACAGG GATCTGAAAC CAGAAAACCT TCTGCTGGAC 360

GAGAAGAATA ACATCCGGAT CGCAGACTTC GGCATGGCGT CGCTGCAGGT TGGCGACAGC 420

CTGCTGGAGA CCAGCTGCGG GTCGCCCCAC TATGCCTGTC CGGAGGTGAT CCGGGGGGAG 480

AAATACGACG GCCGCAAGGC AGACGTGTGG AGCTGCGGCG TGATTCTGTT CGCGCTGCTG 540

GTGGGGGCGC TGCCATTCGA CGACGACAAC CTGCGGCAGC TGCTGGAGAA GGTGAAGCGC 600

GGCGTCTTCC ACATGCCGCA CTTCATCCCG CCCGACTGCC AGAGCCTGCT GCGCGGCATG 660

ATCGAGGTGG ACGCGGCGCG GCGCCTCACG CTAGAGCACA TTCAGAAACA CATATGGTAT 720

ATAGGAGGCA AGAACGAGCC GGAGCCGGAG CAGCCTGTCC CTCGCAAGGT GCAGATCCGC 780

TCCCTGCCCA GCCTGGAGGA CATCGACCCC GACGTGCTGG ACAGCATGCA CTCGCTCGGC 840

TGCTTCCGGG ACCGCAACAA GTTGCTGCAG GACCTGCTGT CCGAGGAGGA GAATCAGGAG 900

AAGATGATCT ACTTCCTCCT CCTGGACCGG AAAGAGAGGT ACCCGAGCCA CGAGGATGAG 960

GACCTGCCGC CCAGGAACGA GATAGACCCG CCCCGGAAGC GTGTGGACTC CCCGATGCTC 1020

AACCGGCACG GCAAGCGGCG GCCCGAGCGG AAGTCCATGG AGGTGCTGAG CGTCACGGAC 1080

GGCGGCTCCC CCGTGCCTGC ACGGCGGGCC CTGGAGATGG CCCAGCACGG CCAGAGGTCC 1140

AGGTCCATCA GTGGGGCCTC CTCGGGCCTG TCCACCAGCC CGCTCAGCAG CCCCCGGGTG 1200

ACCCCTCACC CCTCTCCGAG GGGCAGTCCC CTCCCTACCC CCAAGGGGAC GCCTGTGCAC 1260

ACGCCCAAGG AGAGCCCGGC GGGCACGCCC AACCCCACGC CGCCGTCCAG CCCCAGCGTG 1320

GGAGGGGTGC CCTGGAGGAC GCGGCTCAAC TCCATCAAGA ACAGCTTCCT GGGGTCGCCC 1380

CGCTTCCACC GCCGGAAACT GCAAGTTCCG ACGCCCGAGG AGATGTCCAA CCTGACCCCG 1440

GAGTCGTCCC CAGAGCTCGC CAAGAAGTCC TGGTTCGGGA ACTTCATCAG CCTGGAGAAG 1500

GAGGAGCAGA TTTTCGTGGT CATCAAGGAC AAGCCGCTGA GCTCCATCAA AGCCGACATC 1560

GTCCACGCCT TCCTGTCGAT CCCCAGCCTC AGCCACAGCG TCATCTCCCA GACGAGCTTC 1620

CGGGCCGAGT ACAAGGCGAC GGGGGGCCCG GCTGTGTTCC AGAAGCCGGT CAAGTTCCAG 1680

GTGGACATCA CGTACACAGA GGGCGGGGCC GCGCAGAAGG AGAACGGCAT CTACTCGGTC 1740

ACGTTCACGC TCCTGTCTGG CCCAAGCCGC CGCTTCAAGA GGGTCGTGGA GACCATTCAG 1800

GCCCAGCTGC TGAGCACACA CGAGCAACCC TCTGCCCAGC ACTTGTCAGA CACCACTAAC 1860

TGTATGGAAA TGATGACGGG GAGGCTTTCC AAATGTGGCA GCCCATTGAG TAACTTCTTT 1920

GACGTAATTA AACAACTTTT TTCAGACGAG AAGAACGGGC AGGCGGCCCA GGCCCCCAGC 1980

ACGCCCGCCA AGCGGAGTGC CCACGGCCCA CTCGGGGACT CCGCGGCCGC TGGCCCCGGC 2040

CCTGGAGGGG ACGCCGAGTA CCCAGCGGGC AAGGACAAGG CCAGGACGGG GCTGCCCGCC 2100

GCCCGCCGGG AGCAGCCTTA G 2121

Domain Profile

S: 13    gkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpniikllevietkkk  72

         g Vkl +h  t +kvavKi++++klse+ l k++rEi+ilk ++hp+++  ++v+e+kk+

Q: 1     GLVKLGIHCVTCQKVAVKIVNREKLSESVLMKVEREIAILKLIEHPHVLIRHDVYENKKY  60

         679*********************************************************

S: 73    lylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgivHrDlKpeNllld  132

         lylvle++sggeLfdy+++kgrl+ keark+f+q++sa++++hs++i+HrDlKpeNllld

Q: 61    LYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICHRDLKPENLLLD  120

         ************************************************************

S: 133   kkenikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkvDvWslGvvLyalv  192

         +k+ni+iaDFG+a+l   ++llet+cGsp+Ya+Pe+++g+kY+g+k+DvWs+Gv+L+al+

Q: 121   EKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDGRKADVWSCGVILFALL  180

         ************************************************************

S: 193   tgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpekRatieeilkhewl  252

         +g+lPfd++nl++llek+++g +++p+ + ++++sLlr +++vd+++R+t+e+i+kh w+

Q: 181   VGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVDAARRLTLEHIQKHIWY  240

         **********************************************************95

Domain Sequence
(FASTA)

GLVKLGIHCV TCQKVAVKIV NREKLSESVL MKVEREIAIL KLIEHPHVLI RHDVYENKKY 60

LYLVLEHVSG GELFDYLVKK GRLTPKEARK FFRQIISALD FCHSHSICHR DLKPENLLLD 120

EKNNIRIADF GMASLQVGDS LLETSCGSPH YACPEVIRGE KYDGRKADVW SCGVILFALL 180

VGALPFDDDN LRQLLEKVKR GVFHMPHFIP PDCQSLLRGM IEVDAARRLT LEHIQKHIWY 240

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Gallus gallus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Otolemur garnettii"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0050321	; F:tau-protein kinase activity
GO:0007409	; P:axonogenesis
GO:0030010	; P:establishment of cell polarity
GO:0018105	; P:peptidyl-serine phosphorylation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013