EKS-BOT-00257
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-BOT-00257
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Abl555.41.8E-167246497252
StatusUnreviewed
Ensembl ProteinENSBTAP00000023920
UniProt AccessionF1MXG8;
Protein Name
Protein Synonyms/Alias
Gene NameABL1
Gene Synonyms/Alias ABL1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSBTAG00000017976ENSBTAP00000023920ENSBTAT00000023920
OrganismBos taurus
Functional Description
Protein Length1136
Protein Sequence
(FASTA)
YLECVCGEVG VGGRKGRVLT SLSFSSLSLP EALQRPVASD FEPQGLSEAA RWNSKENLLA 60
GPSENDPNLF VALYDFVASG DNTLSITKGE KLRVLGYNHN GEWCEAQTKN GQGWVPSNYI 120
TPVNSLEKHS WYHGPVSRNA AEYLLSSGIN GSFLVRESES SPGQRSISLR YEGRVYHYRI 180
NTASDGKLYV SSESRFNTLA ELVHHHSTVA DGLITTLHYP APKRNKPTVY GVSPNYDKWE 240
MERTDITMKH KLGGGQYGEV YEGVWKKYSL TVAVKTLKED TMEVEEFLKE AAVMKEIKHP 300
NLVQLLGVCT REPPFYIITE FMTYGNLLDY LRDCNRQEVN AVVLLYMATQ ISSAMEYLEK 360
KNFIHRDLAA RNCLVGENHL VKVADFGLSR LMTGDTYTAH AGAKFPIKWT APESLAYNKF 420
SIKSDIWAFG VLLWEIATYG MSPYPGIDLS QVYELLEKDY RMERPEGCPE KVYELMRACW 480
QWNPSDRPSF AEIHQAFETM FQESSISDEV EKELGKKGMR GVAGTLLQAP ELPTKTRTSR 540
RAAEHKDSPD MPETPHSKGP GETDPVDHEP AVSPLLPRKE RGPPDGSLNE DERLLPKDKK 600
TNLFSALIKK KKKTAPTPPK RSSSFREMDG PPERKAASEE EGREISNGAL APAPPDAVES 660
AKSPKPSGGA GVPNGAFRES GGAGFRSPHL WKKSSTLTSS RLAAGEEESG SGASKRFLRS 720
CSASCVPHGA KDTEWRSVTL PRDLQSTGRQ FDSSTFGGHK SEKPALPRKR ASENRSDQMT 780
RGTVTPPPRL VKKTEEAADE VFKDAAEASP GSSPPSLTPK PIRRQGAAAP PSSPPHKEEA 840
GRPSAAGMPA EPAPPTSRAG LGASGGPSKA AATAAEEPRG RRHKPTSESP GRDRGKLSKL 900
KPAPPPPPPT SAGKAGKSSQ SPSQEAAGEA GAGAKVKPAA LAADAVNSDT AKSGQLGEGA 960
KKPVLPSMPK PPASTKPAGT PTSPAPTPAT LPSAPSALAG DQPSSTAFIP LISTRVSLRK 1020
TRQPPERIAS GAITKGMVLD GTEALCLAIS KNSEQMASHS AVLEAGKNLY TFCVSYVDSI 1080
QQMRNKFAFR EAINKLENNL RELQICPATA GGGPAATQDF SKLLSSVKEI SDIVQR 1136
Nucleotide Sequence
(FASTA)
TACCTGGAGT GTGTGTGTGG GGAAGTGGGG GTAGGTGGAA GGAAGGGTAG GGTGTTAACA 60
TCCTTATCTT TTTCTTCTCT TTCTCTTCCA GAAGCCCTTC AGAGGCCAGT AGCATCTGAC 120
TTCGAGCCCC AAGGTCTGAG CGAAGCAGCT CGTTGGAACT CTAAGGAAAA CCTTCTTGCT 180
GGTCCCAGTG AAAATGACCC CAACCTTTTT GTTGCACTGT ATGACTTTGT GGCCAGTGGG 240
GATAACACTT TAAGCATAAC TAAAGGTGAA AAGCTCCGGG TCTTAGGCTA CAATCACAAT 300
GGGGAGTGGT GTGAAGCCCA AACCAAAAAT GGCCAAGGCT GGGTCCCAAG CAACTACATC 360
ACACCGGTCA ACAGCCTGGA GAAGCACTCC TGGTACCACG GGCCTGTGTC CCGCAACGCC 420
GCCGAGTACC TTCTGAGCAG CGGGATCAAC GGCAGCTTCT TGGTTCGGGA GAGCGAGAGT 480
AGTCCTGGGC AGAGGTCCAT CTCACTGAGA TACGAAGGAA GGGTGTACCA CTACCGCATC 540
AACACTGCTT CTGATGGCAA GCTCTACGTC TCCTCCGAGA GCCGCTTCAA CACGTTGGCC 600
GAGCTGGTCC ATCACCACTC CACTGTGGCC GACGGGCTCA TCACCACTCT CCACTACCCG 660
GCCCCCAAGC GCAACAAGCC CACCGTCTAC GGCGTGTCCC CCAACTACGA CAAGTGGGAG 720
ATGGAGCGCA CGGACATCAC CATGAAGCAC AAGCTGGGGG GCGGCCAGTA CGGGGAGGTG 780
TACGAAGGCG TGTGGAAGAA ATACAGCCTG ACGGTGGCCG TGAAGACCCT GAAGGAGGAT 840
ACCATGGAGG TGGAGGAGTT CTTGAAAGAG GCTGCAGTAA TGAAAGAGAT CAAGCACCCC 900
AACTTAGTAC AGTTACTCGG GGTCTGCACC CGGGAGCCCC CATTCTACAT AATCACTGAG 960
TTCATGACCT ATGGGAACCT GCTGGACTAC CTGAGGGACT GTAACCGGCA GGAGGTGAAC 1020
GCCGTGGTGC TGCTGTATAT GGCCACGCAG ATCTCGTCCG CCATGGAGTA CCTGGAGAAG 1080
AAAAACTTCA TCCACAGAGA TCTTGCTGCC CGAAACTGCC TGGTAGGGGA AAACCACTTG 1140
GTGAAGGTGG CTGATTTTGG CCTGAGCAGG CTGATGACAG GGGACACCTA CACAGCCCAC 1200
GCCGGGGCCA AGTTCCCCAT CAAGTGGACG GCGCCCGAGA GCCTGGCCTA CAACAAGTTC 1260
TCCATCAAGT CGGACATCTG GGCATTTGGA GTGTTGCTTT GGGAAATTGC TACCTATGGC 1320
ATGTCACCTT ACCCAGGAAT TGACCTGTCC CAGGTGTATG AGCTGTTGGA GAAAGACTAC 1380
CGCATGGAGC GCCCAGAAGG CTGCCCAGAG AAGGTCTACG AACTCATGCG AGCATGTTGG 1440
CAGTGGAATC CCTCTGACCG GCCCTCCTTC GCTGAGATCC ACCAAGCCTT TGAAACGATG 1500
TTCCAGGAAT CCAGCATATC AGACGAAGTG GAAAAGGAGT TGGGGAAGAA AGGCATGCGA 1560
GGGGTTGCAG GTACCCTGCT GCAGGCCCCA GAACTGCCCA CCAAGACGAG AACCTCCAGG 1620
AGAGCTGCTG AGCACAAAGA CAGCCCCGAC ATGCCCGAGA CACCCCACTC CAAGGGCCCA 1680
GGAGAGACTG ATCCTGTGGA CCACGAACCC GCTGTATCTC CACTGCTCCC TCGAAAAGAA 1740
CGGGGTCCTC CGGATGGCAG CCTCAATGAG GATGAGCGCC TGCTTCCCAA AGACAAGAAG 1800
ACCAACCTGT TCAGCGCCTT GATCAAGAAG AAGAAGAAAA CCGCCCCAAC CCCTCCCAAA 1860
CGCAGCAGCT CCTTCCGGGA GATGGATGGC CCGCCTGAGC GGAAAGCGGC CAGCGAGGAG 1920
GAAGGTCGTG AAATCAGCAA CGGGGCGCTG GCACCGGCAC CCCCGGATGC AGTGGAGTCG 1980
GCCAAGTCCC CAAAGCCCAG CGGCGGGGCC GGGGTCCCCA ACGGAGCCTT CCGGGAGTCT 2040
GGGGGCGCGG GCTTCCGGTC GCCCCACCTG TGGAAAAAGT CCAGCACTCT GACCAGCAGC 2100
CGGCTGGCTG CCGGTGAAGA GGAGAGCGGC AGCGGCGCCA GCAAGCGCTT CCTGAGGTCC 2160
TGCTCGGCCT CCTGCGTGCC CCACGGCGCC AAGGACACAG AGTGGCGGTC AGTCACCCTG 2220
CCTCGGGACC TGCAGTCCAC CGGCAGGCAG TTCGACTCGT CCACCTTTGG AGGCCACAAA 2280
AGCGAGAAGC CGGCCCTGCC TCGAAAGCGG GCAAGCGAGA ACAGGTCTGA CCAGATGACC 2340
AGAGGCACGG TTACCCCGCC GCCCCGGCTG GTGAAGAAAA CCGAGGAGGC CGCCGACGAG 2400
GTCTTTAAGG ATGCGGCTGA GGCCAGCCCA GGCTCCAGCC CACCCAGCCT GACGCCAAAA 2460
CCAATTCGGA GGCAGGGTGC GGCCGCACCT CCCTCCAGCC CTCCCCACAA GGAGGAGGCC 2520
GGCAGGCCCA GTGCCGCGGG GATGCCCGCT GAGCCGGCAC CCCCCACCAG CCGGGCCGGG 2580
CTAGGAGCCT CCGGAGGACC CAGCAAGGCT GCCGCCACTG CTGCAGAGGA GCCCCGGGGG 2640
AGGAGGCACA AGCCCACCTC TGAGTCCCCA GGGAGAGACA GGGGGAAGCT GTCCAAGCTC 2700
AAACCCGCCC CGCCACCCCC GCCACCCACC TCCGCTGGCA AAGCCGGGAA GTCCTCGCAG 2760
AGCCCGAGCC AGGAAGCGGC CGGGGAGGCA GGCGCCGGGG CAAAGGTGAA ACCTGCAGCT 2820
CTGGCTGCGG ATGCCGTAAA CAGCGACACC GCCAAGTCTG GCCAGCTGGG AGAGGGCGCC 2880
AAGAAGCCCG TGCTCCCATC CATGCCAAAG CCGCCGGCAT CCACCAAGCC GGCGGGGACC 2940
CCGACCAGCC CCGCCCCCAC CCCCGCCACC TTGCCGTCAG CACCCTCTGC CCTGGCAGGG 3000
GACCAGCCGT CCTCCACCGC CTTCATTCCA CTCATATCGA CCCGCGTGTC TCTTCGGAAA 3060
ACCCGGCAGC CTCCTGAACG GATCGCCAGT GGCGCCATCA CCAAGGGCAT GGTGCTGGAT 3120
GGCACGGAGG CCCTGTGCCT GGCCATCTCC AAGAACTCAG AGCAGATGGC CAGCCACAGC 3180
GCCGTGCTCG AAGCCGGCAA AAACCTCTAC ACATTCTGCG TGAGCTACGT GGACTCCATC 3240
CAGCAAATGA GGAACAAATT CGCCTTCCGC GAGGCCATCA ACAAACTGGA GAACAACCTC 3300
CGGGAGCTGC AGATCTGCCC AGCAACAGCA GGTGGTGGCC CAGCGGCCAC TCAGGACTTC 3360
AGCAAACTCC TCAGCTCCGT GAAGGAGATC AGCGACATCG TGCAGAGGTA G 3411
Domain Profile
S: 1     iimkhklgggqygevyegvwkkysltvavktlkedtmeveeflkeaavmkelkhpnlvql  60
         i+mkhklgggqygevyegvwkkysltvavktlkedtmeveeflkeaavmke+khpnlvql
Q: 246   ITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQL  305
         89**********************************************************
S: 61    lgvctreppfyiitefmsygnlldylreadreeveavvllymatqissameylekknfih  120
         lgvctreppfyiitefm+ygnlldylr+++r+ev+avvllymatqissameylekknfih
Q: 306   LGVCTREPPFYIITEFMTYGNLLDYLRDCNRQEVNAVVLLYMATQISSAMEYLEKKNFIH  365
         ************************************************************
S: 121   rdlaarnclvgenklvkvadfglsrlmkedtytahagakfpikwtapeslaynkfsiksd  180
         rdlaarnclvgen+lvkvadfglsrlm++dtytahagakfpikwtapeslaynkfsiksd
Q: 366   RDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSD  425
         ************************************************************
S: 181   vwafgvllweiatygmspypgidlsqvyellekgyrmerpegcppkvyelmracwkwsps  240
         +wafgvllweiatygmspypgidlsqvyellek+yrmerpegcp+kvyelmracw+w+ps
Q: 426   IWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPS  485
         ************************************************************
S: 241   drpsfaeihqal  252
         drpsfaeihqa+
Q: 486   DRPSFAEIHQAF  497
         *********986
Domain Sequence
(FASTA)
ITMKHKLGGG QYGEVYEGVW KKYSLTVAVK TLKEDTMEVE EFLKEAAVMK EIKHPNLVQL 60
LGVCTREPPF YIITEFMTYG NLLDYLRDCN RQEVNAVVLL YMATQISSAM EYLEKKNFIH 120
RDLAARNCLV GENHLVKVAD FGLSRLMTGD TYTAHAGAKF PIKWTAPESL AYNKFSIKSD 180
IWAFGVLLWE IATYGMSPYP GIDLSQVYEL LEKDYRMERP EGCPEKVYEL MRACWQWNPS 240
DRPSFAEIHQ AF 252
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00218
EKS-ANC-00228
EKS-CAE-00214
EKS-CAJ-00243
EKS-CAF-00245
EKS-CAP-00293
EKS-CII-00141
EKS-CIS-00017
EKS-DAR-00593
EKS-DAN-00005
EKS-DRM-00121
EKS-EQC-00230
EKS-FEC-00244
EKS-GAG-00198
EKS-GAA-00320
EKS-GOG-00256
EKS-HOS-00245
EKS-ICT-00225
EKS-LAC-00270
EKS-LOA-00268
EKS-MAM-00261
EKS-MEG-00204
EKS-MIM-00012
EKS-MOD-00237
EKS-MUM-00242
EKS-MUP-00256
EKS-MYL-00237
EKS-NOL-00240
EKS-ORN-00335
EKS-ORA-00227
EKS-ORC-00244
EKS-ORL-00286
EKS-OTG-00264
EKS-PAT-00226
EKS-PES-00229
EKS-PEM-00134
EKS-POA-00230
EKS-PTV-00011
EKS-RAN-00271
EKS-SAH-00243
EKS-SUS-00223
EKS-TAG-00253
EKS-TAR-00332
EKS-TAS-00010
EKS-TEN-00297
EKS-TUT-00026
EKS-XET-00314
EKS-XIM-00328
Gene Ontology
GO:0005730; C:nucleolus
GO:0048471; C:perinuclear region of cytoplasm
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0030145; F:manganese ion binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0030036; P:actin cytoskeleton organization
GO:0006975; P:DNA damage induced protein phosphorylation
GO:0071901; P:negative regulation of protein serine/threonine kinase activity
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0043065; P:positive regulation of apoptotic process
GO:0051353; P:positive regulation of oxidoreductase activity
GO:0051726; P:regulation of cell cycle
GO:2001020; P:regulation of response to DNA damage stimulus
GO:0042770; P:signal transduction in response to DNA damage
KEGG
InterPros
IPR015015; F-actin_binding.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF08919; F_actin_bind; 1.
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00808; FABD; 1.
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013