EKS-BOT-00125

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-BOT-00125

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/PSK	531.2	4.2E-160	98	355	258

Status

Reviewed

Ensembl Protein

ENSBTAP00000024011

UniProt Accession

Q0V7M1;

Protein Name

Serine/threonine-protein kinase H1

Protein Synonyms/Alias

Protein serine kinase H1; PSK-H1;

Gene Name

PSKH1

Gene Synonyms/Alias

PSKH1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000018037	ENSBTAP00000024011	ENSBTAT00000024011

Organism

Bos taurus

Functional Description

May be a SFC-associated serine kinase (splicing factorcompartment-associated serine kinase) with a role in intranuclear SR protein (non-snRNP splicing factors containing a serine/arginine-rich domain) trafficking and pre-mRNA processing (By similarity).

Protein Length

424

Protein Sequence
(FASTA)

MGCGTSKVLP EPPKDVQLDL VKKVEPFSGT KSDVYKHFIT EVDSVGPLKG GFPAASQGAN 60

PSPGTPRTSH TEPPSEPPRR ARVAKYRAKF DPRVTAKYDI KALIGRGSFS RVVRVEHRAT 120

RQPYAIKMIE TKYREGREVC ESELRVLRRV RHANIIQLVE VFETQERVYM VMELATGGEL 180

FDRIIAKGSF TERDATRVLQ MVLDGVRYLH ALGITHRDLK PENLLYYHPG TDSKIIITDF 240

GLASARKKGD DCLMKTTCGT PEYIAPEVLV RKPYTNSVDM WALGVIAYIL LSGTMPFEDD 300

NRTRLYRQIL RGKYSYSGEP WPSVSNLAKD FIDRLLTVDP GARMTALQAL RHPWVVSMAA 360

SSSMKNLHRS ISQNLLKRAS SRCQSTKSAQ STRSSRSTRS NKSRRVRERE LRELNLRYQQ 420

QYNG 424

Nucleotide Sequence
(FASTA)

ATGGGCTGTG GGACAAGCAA GGTCCTTCCT GAGCCGCCCA AGGATGTCCA GCTGGATCTG 60

GTCAAGAAGG TGGAGCCCTT CAGTGGCACT AAGAGTGATG TGTACAAGCA CTTCATCACA 120

GAGGTGGACA GCGTTGGCCC TCTCAAAGGT GGGTTCCCAG CAGCCAGTCA GGGTGCAAAC 180

CCCAGCCCTG GTACCCCTCG CACCAGCCAC ACAGAGCCTC CCTCGGAACC ACCACGCAGG 240

GCCAGGGTAG CTAAGTACAG GGCCAAGTTC GACCCCCGTG TGACGGCCAA ATACGACATC 300

AAAGCTCTGA TCGGCCGAGG CAGCTTCAGC CGAGTGGTAC GAGTGGAGCA TCGGGCCACC 360

CGGCAGCCTT ACGCCATTAA GATGATCGAG ACCAAGTACC GGGAGGGGCG GGAGGTGTGT 420

GAGTCAGAGC TGCGCGTGCT GCGCCGGGTG CGCCACGCCA ACATCATCCA GCTGGTGGAA 480

GTGTTTGAGA CTCAGGAGCG CGTGTATATG GTGATGGAGC TGGCCACTGG CGGAGAGCTC 540

TTCGACCGCA TCATTGCCAA GGGCTCTTTC ACTGAGCGCG ACGCCACTCG GGTGCTACAG 600

ATGGTATTGG ACGGCGTCCG ATACCTGCAC GCACTGGGCA TCACACACCG GGACCTCAAG 660

CCAGAGAATC TGCTCTACTA CCACCCTGGC ACCGACTCCA AGATCATCAT CACTGACTTC 720

GGCCTGGCCA GTGCCCGCAA GAAGGGTGAT GACTGCCTGA TGAAGACCAC CTGTGGCACG 780

CCTGAGTACA TTGCCCCTGA GGTCTTGGTC CGCAAACCCT ACACCAACTC TGTCGACATG 840

TGGGCACTGG GCGTCATCGC CTACATCCTG CTCAGTGGCA CCATGCCCTT CGAGGATGAC 900

AACCGCACCC GGCTGTACCG GCAGATCCTC CGGGGCAAGT ACAGCTACTC GGGGGAGCCC 960

TGGCCCAGTG TGTCCAATCT GGCCAAGGAC TTCATTGACC GCCTGCTGAC GGTGGACCCT 1020

GGCGCCCGTA TGACTGCACT GCAGGCCCTG AGGCATCCGT GGGTGGTGAG CATGGCAGCC 1080

TCTTCGTCTA TGAAGAATCT GCACCGCTCC ATCTCCCAGA ACCTCCTCAA ACGCGCCTCC 1140

TCACGCTGCC AGAGCACTAA ATCTGCCCAG TCCACACGGT CCAGCCGCTC AACACGCTCC 1200

AACAAGTCCC GCCGAGTGCG GGAGCGAGAG CTGCGGGAGC TCAACTTGCG CTACCAGCAG 1260

CAGTACAACG GCTGA 1275

Domain Profile

S: 1     ydikaligkgsfsrvvrvehratrkpfaikvvetkeregreaveselrvlrrvshafiiq  60

         ydikalig+gsfsrvvrvehratr+p+aik++etk+regre++eselrvlrrv+ha+iiq

Q: 98    YDIKALIGRGSFSRVVRVEHRATRQPYAIKMIETKYREGREVCESELRVLRRVRHANIIQ  157

         9***********************************************************

S: 61    lvevfeteekvylvmelatggelfdrviakgsfterdatrvlkmvldgvrylhalrithr  120

         lvevfet+e+vy+vmelatggelfdr+iakgsfterdatrvl+mvldgvrylhal+ithr

Q: 158   LVEVFETQERVYMVMELATGGELFDRIIAKGSFTERDATRVLQMVLDGVRYLHALGITHR  217

         ************************************************************

S: 121   dlkpenllyydpgeeskilitdfglayaakksddllmkttcgtpeyiapevllrkpytns  180

         dlkpenllyy+pg++ski+itdfgla+a+kk+dd+lmkttcgtpeyiapevl+rkpytns

Q: 218   DLKPENLLYYHPGTDSKIIITDFGLASARKKGDDCLMKTTCGTPEYIAPEVLVRKPYTNS  277

         ************************************************************

S: 181   vdmwalgviayillsgilpfdddsrtrlyrkilkgkysylgepwpsvselakdfidklle  240

         vdmwalgviayillsg++pf+dd+rtrlyr+il+gkysy+gepwpsvs+lakdfid+ll+

Q: 278   VDMWALGVIAYILLSGTMPFEDDNRTRLYRQILRGKYSYSGEPWPSVSNLAKDFIDRLLT  337

         ************************************************************

S: 241   vdagerlsasqalkhewv  258

         vd+g+r++a+qal+h+wv

Q: 338   VDPGARMTALQALRHPWV  355

         *****************8

Domain Sequence
(FASTA)

YDIKALIGRG SFSRVVRVEH RATRQPYAIK MIETKYREGR EVCESELRVL RRVRHANIIQ 60

LVEVFETQER VYMVMELATG GELFDRIIAK GSFTERDATR VLQMVLDGVR YLHALGITHR 120

DLKPENLLYY HPGTDSKIII TDFGLASARK KGDDCLMKTT CGTPEYIAPE VLVRKPYTNS 180

VDMWALGVIA YILLSGTMPF EDDNRTRLYR QILRGKYSYS GEPWPSVSNL AKDFIDRLLT 240

VDPGARMTAL QALRHPWV 258

Keyword

ATP-binding; Cell membrane; Complete proteome; Cytoplasm; Cytoskeleton; Endoplasmic reticulum; Golgi apparatus; Kinase; Lipoprotein; Membrane; Myristate; Nucleotide-binding; Nucleus; Palmitate; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Dipodomys ordii"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005789	; C:endoplasmic reticulum membrane
GO:0005794	; C:Golgi apparatus
GO:0005815	; C:microtubule organizing center
GO:0016607	; C:nuclear speck
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

bta:509656

;

InterPros

IPR020636	; Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013