EKS-BOT-00283

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-BOT-00283

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	406.8	5.3E-122	190	477	288

Status

Unreviewed

Ensembl Protein

ENSBTAP00000024095

UniProt Accession

F1MH84;

Protein Name

Protein Synonyms/Alias

Activin receptor type-2B;

Gene Name

ACVR2B

Gene Synonyms/Alias

ACVR2B;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000018105	ENSBTAP00000024095	ENSBTAT00000024095

Organism

Bos taurus

Functional Description

Protein Length

512

Protein Sequence
(FASTA)

MTAPWAALAL LWGSLCAGSG RGEAETRECI YYNANWELER TNQSGLERCE GERDKRLHCY 60

ASWRNSSGTI ELVKKGCWLD DFNCYDRQEC VATEENPQVY FCCCEGNFCN ERFTHLPEAG 120

GPEVTYEPPP TAPTLLTVLA YSLLPVGGLS LIALLAFWMY RHRKPPYGHV DIHEDPGPPP 180

PSPLVGLKPL QLLEIKARGR FGCVWKAQLM NDFVAVKIFP LQDKQSWQSE REIFSTPGMK 240

HENLLQFIAA EKRGSSLEAE LWLITAFHDK GSLTDYLKGN IITWNELCHV AETMSRGLSY 300

LHEDVPWCRG EGHKPSIAHR DFKSKNVLLK SDLTAVLADF GLAVRFEPGK PPGDTHGQVG 360

TRRYMAPEVL EGAINFQRDA FLRIDMYAMG LVLWELVSRC KAADGPVDEY MLPFEEEIGQ 420

HPSLEELQEV VVHKKMRPAI KDHWLKHPGL AQLCVTIEEC WDHDAEARLS AGCVEERVSL 480

IRRSVNGTTS DCLVSLVTSV TNVDLPPKES SI 512

Nucleotide Sequence
(FASTA)

ATGACGGCGC CCTGGGCGGC CCTCGCCCTC CTCTGGGGAT CGCTGTGCGC CGGTTCGGGG 60

CGCGGGGAGG CCGAGACACG GGAGTGCATC TACTACAACG CCAACTGGGA GCTGGAGCGC 120

ACCAACCAGA GCGGCCTGGA GCGCTGCGAG GGCGAGCGGG ACAAGCGGCT GCACTGCTAC 180

GCCTCCTGGC GCAACAGCTC GGGCACCATC GAGCTCGTCA AGAAAGGCTG CTGGCTGGAC 240

GACTTCAACT GCTACGACAG GCAGGAGTGC GTGGCCACCG AGGAGAACCC CCAGGTGTAC 300

TTCTGCTGCT GCGAAGGCAA CTTCTGCAAC GAGCGCTTCA CCCACCTGCC CGAGGCGGGC 360

GGCCCAGAAG TCACGTACGA GCCACCCCCG ACAGCCCCCA CCCTGCTCAC TGTGCTGGCC 420

TACTCGCTGC TGCCCGTCGG GGGCCTCTCC CTCATCGCCC TGCTGGCCTT CTGGATGTAC 480

CGACATCGCA AGCCCCCCTA CGGCCACGTG GACATCCACG AGGACCCTGG ACCTCCACCC 540

CCGTCCCCTC TGGTGGGCCT GAAGCCTCTG CAACTGCTGG AGATCAAGGC TCGGGGGCGC 600

TTTGGTTGTG TCTGGAAGGC GCAGCTCATG AACGACTTCG TGGCTGTCAA GATCTTCCCA 660

CTCCAGGACA AGCAGTCGTG GCAGAGTGAG CGGGAGATCT TCAGCACGCC TGGCATGAAG 720

CACGAGAACC TGCTGCAGTT CATTGCCGCT GAGAAGCGAG GCTCCAGCCT GGAGGCAGAG 780

CTGTGGCTCA TCACGGCCTT CCACGACAAG GGCTCCCTCA CGGATTACCT CAAGGGGAAC 840

ATCATCACAT GGAACGAACT GTGTCACGTG GCAGAGACGA TGTCTAGAGG CCTCTCATAC 900

CTACACGAGG ATGTGCCCTG GTGCCGGGGC GAGGGCCACA AGCCATCTAT TGCCCACAGG 960

GACTTTAAGA GCAAGAATGT ATTGCTGAAG AGTGACCTCA CTGCTGTGCT GGCTGACTTT 1020

GGCCTGGCTG TTCGGTTTGA GCCAGGGAAA CCTCCGGGGG ACACTCACGG GCAGGTGGGC 1080

ACGCGGCGGT ACATGGCCCC CGAGGTGCTC GAGGGAGCCA TCAACTTCCA GAGAGACGCC 1140

TTTCTGCGCA TCGACATGTA CGCCATGGGG CTGGTGCTGT GGGAGCTCGT GTCCCGCTGC 1200

AAAGCTGCCG ATGGACCTGT GGATGAGTAC ATGCTGCCTT TTGAGGAGGA GATCGGCCAG 1260

CACCCGTCAC TGGAGGAGCT GCAGGAGGTG GTGGTGCACA AGAAGATGCG GCCCGCCATC 1320

AAGGATCACT GGCTGAAACA CCCGGGCCTG GCCCAGCTCT GCGTGACCAT CGAGGAGTGC 1380

TGGGACCACG ATGCAGAGGC TCGCCTGTCT GCGGGCTGTG TGGAGGAGCG AGTGTCCCTG 1440

ATCCGGAGGT CGGTCAACGG CACTACCTCG GACTGTCTTG TCTCCCTGGT GACCTCCGTC 1500

ACCAATGTGG ACCTGCCCCC GAAGGAGTCG AGCATCTAA 1539

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         l+lle+ ++Gr+g+Vwka+l+++ vAvKif+ +d++sw++E+ei++t+ ++hen+lqfia

Q: 190   LQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPGMKHENLLQFIA  249

         6899********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         a+k+ ++++ el+l+t++h+kgsL+dyLk ++++++el+++a+++++Gl++LHe++++++

Q: 250   AEKRGSSLEAELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSYLHEDVPWCR  309

         ************************************************************

S: 121   g.kkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaP  179

         g  +Kp+iaHRD+kskN+l+k+dlt+++aD+GLa+++e  k   d  ++ qvGt+RYmaP

Q: 310   GeGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGD--THGQVGTRRYMAP  367

         *99***************************************888..79***********

S: 180   EvleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPslee  239

         Evle+a+n+++ +af r+D+Y++gLvlWE++sRc+++d+ v+ey+lpfee++g++Pslee

Q: 368   EVLEGAINFQR-DAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHPSLEE  426

         **********9.9***********************************************

S: 240   mkevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkr  290

         ++evvv+kk+rP i+++w k++ l++l+ ++eecWd+d+eaRl+a +v++r

Q: 427   LQEVVVHKKMRPAIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEER  477

         ************************************************998

Domain Sequence
(FASTA)

LQLLEIKARG RFGCVWKAQL MNDFVAVKIF PLQDKQSWQS EREIFSTPGM KHENLLQFIA 60

AEKRGSSLEA ELWLITAFHD KGSLTDYLKG NIITWNELCH VAETMSRGLS YLHEDVPWCR 120

GEGHKPSIAH RDFKSKNVLL KSDLTAVLAD FGLAVRFEPG KPPGDTHGQV GTRRYMAPEV 180

LEGAINFQRD AFLRIDMYAM GLVLWELVSR CKAADGPVDE YMLPFEEEIG QHPSLEELQE 240

VVVHKKMRPA IKDHWLKHPG LAQLCVTIEE CWDHDAEARL SAGCVEER 288

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0009986	; C:cell surface
GO:0005737	; C:cytoplasm
GO:0016020	; C:membrane
GO:0017002	; F:activin-activated receptor activity
GO:0005524	; F:ATP binding
GO:0004712	; F:protein serine/threonine/tyrosine kinase activity
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0032147	; P:activation of protein kinase activity
GO:0009952	; P:anterior/posterior pattern specification
GO:0060840	; P:artery development
GO:0001974	; P:blood vessel remodeling
GO:0030509	; P:BMP signaling pathway
GO:0007368	; P:determination of left/right symmetry
GO:0048617	; P:embryonic foregut morphogenesis
GO:0001702	; P:gastrulation with mouth forming second
GO:0007507	; P:heart development
GO:0030073	; P:insulin secretion
GO:0001822	; P:kidney development
GO:0030324	; P:lung development
GO:0001946	; P:lymphangiogenesis
GO:0060836	; P:lymphatic endothelial cell differentiation
GO:0007498	; P:mesoderm development
GO:0042475	; P:odontogenesis of dentin-containing tooth
GO:0035265	; P:organ growth
GO:0060021	; P:palate development
GO:0031016	; P:pancreas development
GO:0032927	; P:positive regulation of activin receptor signaling pathway
GO:0030501	; P:positive regulation of bone mineralization
GO:0045669	; P:positive regulation of osteoblast differentiation
GO:0009791	; P:post-embryonic development
GO:0009749	; P:response to glucose stimulus
GO:0061298	; P:retina vasculature development in camera-type eye
GO:0023014	; P:signal transduction by phosphorylation
GO:0048705	; P:skeletal system morphogenesis
GO:0060841	; P:venous blood vessel development

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR015768	; Activin_II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013