EKS-BOT-00282

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-BOT-00282

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	419.6	6.7E-126	192	478	287

Status

Reviewed

Ensembl Protein

ENSBTAP00000024108

UniProt Accession

Q28043; A5D7L7;

Protein Name

Activin receptor type-2A

Protein Synonyms/Alias

Activin receptor type IIA; ACTR-IIA;

Gene Name

ACVR2A

Gene Synonyms/Alias

ACVR2A; ACTRII, ACVR2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000018114	ENSBTAP00000024108	ENSBTAT00000024108

Organism

Bos taurus

Functional Description

On ligand binding, forms a receptor complex consistingof two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A.

Protein Length

513

Protein Sequence
(FASTA)

MGAAAKLAFA VFLISCSSGA ILGRSETQEC IFYNANWERD RTNRTGVESC YGDKDKRRHC 60

FATWKNISGS IEIVKQGCWL DDINCYDRTD CIEKKDSPEV YFCCCEGNMC NERFSYFPEM 120

EVTQPTSNPV TPKPPYYNIL LYSLVPLMLI AGIVICAFWV YRHHKMAYPP VLVPTQDPGP 180

PPPSPLLGLK PLQLLEVKAR GRFGCVWKAQ LLNEYVAVKI FPIQDKQSWQ NEYEVYSLPG 240

MKHENILQFI GAEKRGTSVD VDLWLITAFH EKGSLSDFLK ANVVSWNELC HIAETMARGL 300

AYLHEDIPGL KDGHKPAISH RDIKSKNVLL KNNLTACIAD FGLALKFEAG KSAGDTHGQV 360

GTRRYMAPEV LEGAINFQRD AFLRIDMYAM GLVLWELASR CTAADGPVDE YMLPFEEEIG 420

QHPSLEDMQE VVVHKKKRPV LRDYWQKHAG MAMLCETIEE CWDHDAEARL SAGCVGERIT 480

QMQRLTNIIT TEDIVTVVTM VTNVDFPPKE SSL 513

Nucleotide Sequence
(FASTA)

ATGGGAGCTG CTGCAAAGTT GGCGTTTGCC GTCTTTCTTA TCTCTTGTTC TTCAGGTGCT 60

ATACTTGGTA GATCAGAAAC TCAGGAGTGT ATTTTCTATA ATGCTAATTG GGAAAGAGAT 120

AGAACGAATC GCACTGGTGT TGAATCCTGT TACGGTGACA AAGATAAACG GCGGCATTGT 180

TTTGCTACAT GGAAGAATAT TTCTGGTTCC ATTGAAATAG TGAAGCAAGG TTGTTGGCTG 240

GATGATATCA ACTGCTATGA CAGGACTGAT TGTATAGAAA AAAAAGATAG CCCTGAAGTA 300

TATTTTTGTT GCTGTGAGGG CAATATGTGT AACGAAAGGT TTTCTTATTT TCCGGAGATG 360

GAGGTCACAC AGCCTACGTC GAATCCAGTA ACTCCTAAGC CTCCCTATTA CAACATCTTG 420

CTCTATTCTT TGGTGCCACT TATGTTAATT GCGGGGATTG TCATTTGTGC ATTTTGGGTG 480

TACAGACATC ATAAGATGGC TTACCCTCCT GTGCTCGTTC CAACTCAAGA CCCAGGACCA 540

CCCCCACCTT CTCCATTACT AGGTTTGAAG CCATTACAGT TACTAGAAGT GAAAGCAAGA 600

GGAAGATTTG GTTGTGTGTG GAAAGCCCAG TTACTCAATG AATATGTGGC TGTGAAAATA 660

TTTCCAATAC AGGATAAACA GTCATGGCAG AATGAATATG AAGTCTATAG TTTGCCTGGA 720

ATGAAGCATG AGAACATACT GCAGTTCATT GGTGCAGAGA AACGAGGCAC CAGTGTTGAT 780

GTGGATCTTT GGCTAATCAC AGCATTTCAT GAAAAGGGTT CACTATCAGA CTTTCTTAAG 840

GCTAATGTGG TCTCTTGGAA TGAATTGTGT CATATTGCAG AAACCATGGC TAGAGGATTG 900

GCATATTTAC ATGAGGATAT ACCTGGCCTA AAAGATGGCC ACAAACCCGC CATATCTCAC 960

AGGGACATCA AAAGTAAAAA TGTGCTGTTG AAAAACAATC TGACAGCCTG CATTGCTGAC 1020

TTTGGGTTGG CGTTAAAGTT TGAGGCTGGC AAGTCTGCAG GTGATACTCA TGGACAGGTG 1080

GGTACCCGAA GGTATATGGC TCCAGAGGTG TTAGAGGGTG CTATCAACTT CCAAAGGGAT 1140

GCATTTTTGA GGATAGATAT GTACGCCATG GGATTAGTCC TGTGGGAACT GGCTTCTCGC 1200

TGTACTGCTG CAGATGGACC TGTAGATGAA TACATGCTGC CATTTGAGGA AGAAATTGGC 1260

CAGCATCCCT CTCTTGAAGA CATGCAGGAA GTTGTTGTGC ATAAAAAAAA GAGGCCTGTT 1320

TTAAGAGATT ATTGGCAGAA ACATGCTGGA ATGGCAATGC TCTGTGAAAC GATAGAAGAA 1380

TGTTGGGATC ACGATGCAGA AGCCAGGTTA TCAGCTGGAT GTGTAGGTGA AAGAATTACT 1440

CAGATGCAAA GACTAACAAA TATCATTACC ACAGAGGACA TTGTAACAGT GGTCACGATG 1500

GTGACAAATG TTGACTTTCC TCCCAAAGAA TCTAGTCTAT GA 1542

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         l+lle+ ++Gr+g+Vwka+l +e+vAvKif+ +d++sw++E e+y+++ ++henilqfi+

Q: 192   LQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFIG  251

         6899********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         a+k+ +++ ++l+l+t++hekgsLsd+Lk+++++++el+++a+++a+Gla+LHe+i+g k

Q: 252   AEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLK  311

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         + +Kpai+HRD+kskN+l+k++lt+ciaD+GLalk+e+ k++ d  ++ qvGt+RYmaPE

Q: 312   DGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGD--THGQVGTRRYMAPE  369

         *****************************************888..79************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vle+a+n+++ +af r+D+Y++gLvlWE+asRc+++d+ v+ey+lpfee++g++Psle+m

Q: 370   VLEGAINFQR-DAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDM  428

         *********9.9************************************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkr  290

         +evvv+kk+rP +++ w+k++ +++l++++eecWd+d+eaRl+a +v +r

Q: 429   QEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGER  478

         ***********************************************987

Domain Sequence
(FASTA)

LQLLEVKARG RFGCVWKAQL LNEYVAVKIF PIQDKQSWQN EYEVYSLPGM KHENILQFIG 60

AEKRGTSVDV DLWLITAFHE KGSLSDFLKA NVVSWNELCH IAETMARGLA YLHEDIPGLK 120

DGHKPAISHR DIKSKNVLLK NNLTACIADF GLALKFEAGK SAGDTHGQVG TRRYMAPEVL 180

EGAINFQRDA FLRIDMYAMG LVLWELASRC TAADGPVDEY MLPFEEEIGQ HPSLEDMQEV 240

VVHKKKRPVL RDYWQKHAGM AMLCETIEEC WDHDAEARLS AGCVGER 287

Keyword

ATP-binding; Complete proteome; Disulfide bond; Glycoprotein; Kinase; Magnesium; Manganese; Membrane; Metal-binding; Nucleotide-binding; Receptor; Reference proteome; Serine/threonine-protein kinase; Signal; Transferase; Transmembrane; Transmembrane helix.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0009986	; C:cell surface
GO:0005737	; C:cytoplasm
GO:0034673	; C:inhibin-betaglycan-ActRII complex
GO:0016021	; C:integral to membrane
GO:0017002	; F:activin-activated receptor activity
GO:0005524	; F:ATP binding
GO:0015026	; F:coreceptor activity
GO:0046872	; F:metal ion binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0009952	; P:anterior/posterior pattern specification
GO:0030509	; P:BMP signaling pathway
GO:0007368	; P:determination of left/right symmetry
GO:0048706	; P:embryonic skeletal system development
GO:0001702	; P:gastrulation with mouth forming second
GO:0007498	; P:mesoderm development
GO:0043084	; P:penile erection
GO:0032927	; P:positive regulation of activin receptor signaling pathway
GO:0030501	; P:positive regulation of bone mineralization
GO:0045648	; P:positive regulation of erythrocyte differentiation
GO:0045669	; P:positive regulation of osteoblast differentiation
GO:0010862	; P:positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0030510	; P:regulation of BMP signaling pathway
GO:0050999	; P:regulation of nitric-oxide synthase activity
GO:0060011	; P:Sertoli cell proliferation
GO:0023014	; P:signal transduction by phosphorylation
GO:0042713	; P:sperm ejaculation
GO:0007283	; P:spermatogenesis

KEGG

bta:281598

;

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR015768	; Activin_II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; FALSE_NEG.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013