EKS-BOT-00404
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-BOT-00404
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR573.32.2E-172604937334
StatusUnreviewed
Ensembl ProteinENSBTAP00000024717
UniProt AccessionF1MRU0;
Protein Name
Protein Synonyms/Alias
Gene NameFLT3
Gene Synonyms/Alias FLT3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSBTAG00000018572ENSBTAP00000024717ENSBTAT00000024717
OrganismBos taurus
Functional Description
Protein Length987
Protein Sequence
(FASTA)
LPLFAFTVVF STMIFQTITN QDLPEIKCVL INHGNNDSSV RTSSSNPMAS ESREDLACAL 60
RPEGTETIYE AATVQVDVSA SITLQVLVSA PGNTSCLWVF KHRYLNCQPH LDLQNRGVFS 120
MVILKMTETQ AGEYRLLIQS AATNYTVLFT VSLRNTLLYT LRKPYFRKME NQDALVCISE 180
SVPEPTVEWV FCDSQSDSCK GESPAVVTKE ESVLHELFGT DIRCCARNEL GRECTKLFTI 240
DLNQTPQTTP PQLFLKVGEP LWIRCKAIHV NHGFGLSWEL ENKALEEGSY FEMSTYSTNR 300
TMIRILFAFV SSVGRNDTGY YTCSSSEHPS KSALVTILEK GFINVSKSNE DYEIDQYEEF 360
CFSVRFKAYP QIRCTWTFSR KSFPCEQSGL DDGYSISKFC NHKHQPGQYI FHAENDDAQF 420
TKEFTLNIRR KPQVLAEASA SQASCSSDGY PIPSWTWKKC SDKSPNCTEE ITEGIWNKKA 480
NRKVFGQWIS SSTLNMSEAV KGFLVKCCAY NALGTSCETI LLSSPGPFPS IQDNISFYAT 540
IGLCLPFIAV LTMLICHKYK KKQFRYESQL QMVQVTGSLD NEYLYIDFRE YEYDLKWEFP 600
RENLEFGKVL GSGAFGKVMN ATAYGISKTG VSIQVAVKML KEKADSSERE ALMSELKMMT 660
HLGSHENIVN LLGACTLSGP IYLIFEYCCY GDLLNYLRSK REKFHRTWTE IFKEHNFSFY 720
PTFQSHPNSS MPGSREVQIH PDSDPISGFN GNSFQSEDEI EYENQKRLEE EEDLNVLTFE 780
DLLCFAYQVA KGMEFLEFKS CLHRDLAARN VLVTHGKVAK IADFGLARDI MSDSNYVIRG 840
NARLPVKWMA PESLFEGIYT IKSDVWSYGI LLWEIFSLGV NPYPGIPADA NFYKLIQSGF 900
KMDQPFYATE EIYFIMQSCW AFDSRKRPSF PNLTSFLGCQ LADAEEAMYQ NMDGRVSERP 960
SVYQNRRPYS REVDLGLPSP QVHSEDS 987
Nucleotide Sequence
(FASTA)
CTGCCTTTGT TTGCTTTCAC AGTTGTTTTT TCCACAATGA TATTCCAGAC TATTACAAAT 60
CAAGATCTGC CTGAGATCAA GTGTGTTTTA ATCAACCATG GAAACAATGA TTCATCAGTG 120
AGGACATCAT CATCAAATCC CATGGCATCA GAATCCCGGG AAGACCTGGC ATGTGCATTG 180
AGGCCCGAGG GCACAGAGAC CATCTATGAA GCGGCCACGG TGCAGGTGGA CGTGTCTGCG 240
TCCATCACAC TGCAAGTACT GGTCTCCGCC CCAGGGAACA CTTCCTGTCT CTGGGTCTTT 300
AAACACAGAT ACCTAAACTG CCAGCCACAC TTGGATTTAC AAAACAGAGG AGTTTTTTCC 360
ATGGTCATTT TGAAAATGAC AGAAACCCAA GCTGGAGAAT ACCGACTTTT GATTCAGAGT 420
GCAGCTACCA ATTACACAGT ATTGTTTACA GTGAGTCTAA GAAATACACT GCTTTACACA 480
TTAAGAAAAC CTTACTTTAG AAAAATGGAA AATCAGGACG CCTTGGTCTG CATCTCAGAG 540
AGTGTTCCAG AACCGACGGT GGAATGGGTG TTCTGCGATT CACAGAGTGA CAGCTGTAAA 600
GGAGAGAGTC CAGCTGTTGT CACGAAGGAG GAGAGCGTCC TCCATGAGTT ATTTGGAACA 660
GATATCAGGT GCTGTGCAAG AAACGAGCTG GGCAGGGAAT GTACCAAGCT CTTCACTATA 720
GATCTAAACC AGACTCCTCA GACCACACCG CCACAATTAT TTCTTAAAGT AGGGGAACCC 780
TTATGGATAA GGTGCAAAGC CATTCACGTA AACCACGGAT TCGGGCTCAG CTGGGAATTA 840
GAGAATAAAG CACTGGAAGA GGGCAGCTAC TTTGAGATGA GTACCTATTC CACAAACAGA 900
ACTATGATAC GGATTCTGTT TGCTTTTGTA TCATCAGTGG GAAGAAACGA CACTGGCTAT 960
TACACTTGTT CCTCTTCAGA GCATCCCAGT AAATCAGCTT TGGTCACCAT CCTAGAAAAG 1020
GGATTTATAA ACGTTTCCAA ATCAAATGAA GATTATGAAA TTGACCAGTA TGAAGAATTT 1080
TGTTTTTCTG TCAGGTTTAA AGCATACCCA CAAATCAGAT GTACGTGGAC CTTCTCTCGA 1140
AAATCATTTC CTTGTGAGCA AAGTGGCCTG GATGATGGGT ACAGCATATC TAAGTTTTGC 1200
AACCATAAAC ACCAGCCAGG ACAGTATATC TTCCATGCAG AAAATGATGA CGCCCAGTTC 1260
ACAAAAGAGT TCACACTGAA TATAAGAAGG AAACCTCAAG TGCTGGCTGA GGCATCTGCA 1320
AGTCAGGCTT CTTGCTCCTC TGATGGGTAC CCTATACCAT CTTGGACCTG GAAGAAGTGC 1380
TCAGACAAGT CCCCCAACTG CACAGAAGAA ATCACAGAAG GAATTTGGAA TAAAAAGGCC 1440
AACAGGAAAG TGTTTGGACA GTGGATATCG AGCAGCACGC TGAACATGAG TGAGGCTGTC 1500
AAAGGGTTCC TGGTGAAGTG TTGTGCCTAT AACGCCCTCG GCACGTCCTG TGAGACAATC 1560
CTTCTGAGCT CACCAGGGCC CTTCCCTTCC ATCCAGGACA ACATCTCATT CTATGCGACA 1620
ATTGGCCTCT GTCTTCCCTT CATTGCCGTT TTAACCATGC TGATTTGTCA CAAGTACAAA 1680
AAGAAGCAAT TTCGTTACGA AAGCCAGCTG CAGATGGTGC AGGTGACCGG CTCTCTGGAT 1740
AACGAGTACT TGTACATTGA CTTCAGAGAA TATGAGTATG ATCTCAAATG GGAGTTTCCA 1800
AGAGAAAACT TAGAATTTGG GAAGGTCCTG GGGTCGGGTG CTTTTGGAAA AGTGATGAAT 1860
GCGACCGCCT ACGGAATTAG TAAGACAGGG GTCTCCATCC AGGTTGCAGT CAAGATGCTG 1920
AAAGAAAAAG CAGACAGCTC GGAGAGAGAG GCTCTCATGT CTGAACTCAA AATGATGACC 1980
CACCTGGGCA GCCACGAGAA TATTGTGAAT CTCCTGGGGG CGTGCACCCT GTCAGGACCA 2040
ATTTACTTGA TTTTTGAATA CTGTTGCTAC GGCGACCTTC TCAACTATCT AAGAAGTAAA 2100
AGAGAAAAAT TTCACAGGAC GTGGACGGAG ATTTTCAAGG AACATAATTT CAGTTTTTAT 2160
CCCACTTTCC AATCACACCC TAATTCCAGT ATGCCAGGTT CAAGAGAAGT TCAAATACAC 2220
CCGGACTCAG ATCCTATCTC AGGGTTCAAT GGGAATTCAT TTCAGTCTGA AGATGAAATT 2280
GAATACGAAA ACCAAAAAAG GCTGGAGGAA GAAGAAGACC TGAATGTACT GACCTTTGAA 2340
GATCTCCTTT GCTTTGCATA TCAAGTGGCC AAAGGAATGG AATTTCTGGA ATTTAAGTCG 2400
TGTCTTCACA GAGACCTGGC AGCCAGGAAT GTCCTGGTGA CCCACGGGAA AGTGGCGAAG 2460
ATCGCTGATT TTGGGCTGGC TCGGGATATT ATGAGTGATT CCAACTACGT CATCAGGGGA 2520
AATGCCCGTC TGCCTGTGAA GTGGATGGCC CCTGAAAGCT TGTTTGAGGG CATCTACACA 2580
ATTAAAAGCG ATGTCTGGTC GTATGGAATA TTACTCTGGG AAATATTCTC GCTTGGTGTC 2640
AATCCTTACC CTGGGATTCC CGCTGATGCT AACTTCTACA AACTCATCCA GAGTGGGTTC 2700
AAGATGGACC AGCCATTTTA TGCCACGGAA GAAATATACT TTATAATGCA ATCCTGCTGG 2760
GCTTTTGACT CCAGGAAACG ACCATCCTTC CCTAACCTGA CTTCATTTTT AGGGTGTCAG 2820
CTGGCAGATG CAGAAGAAGC GATGTATCAG AACATGGATG GCCGTGTTTC AGAGCGTCCT 2880
TCTGTTTACC AAAACAGGCG ACCTTACAGC AGAGAGGTGG ACTTGGGGCT ACCCTCTCCT 2940
CAGGTTCACA GTGAAGATTC CTAG 2964
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         le+GkvlGsGafGkv++atayG+sk++++++vavkmlk++a+sse+ealmselk+++hlG
Q: 604   LEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTHLG  663
         79**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +henivnllGact +Gpiy+i+eyccyGdllnylr+kre+f+++++e++ke++++++ + 
Q: 664   SHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPT-  722
         *********************************************************99.
S: 121   lladkslrsksslssesseeyvdlkkdvsdvssskadklasekkksalerevkaaleeed  180
               ++s+ ++s+++s+e v++++d++ +s ++ ++++se++ +++++++   +eeed
Q: 723   ------FQSHPNSSMPGSRE-VQIHPDSDPISGFNGNSFQSEDEIEYENQKRL--EEEED  773
         ......9*************.**************************999877..78999
S: 181   sevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGkvvkicdfGlardimkd  240
          +vl++edll+f+yqvakGmefl++k+c+hrdlaarnvl+t+Gkv+ki+dfGlardim+d
Q: 774   LNVLTFEDLLCFAYQVAKGMEFLEFKSCLHRDLAARNVLVTHGKVAKIADFGLARDIMSD  833
         ************************************************************
S: 241   snyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifslGstpypgllvdskfy  300
         snyv++Gnarlpvkwmapes+f+++yt+ksdvwsyGillweifslG++pypg++ d++fy
Q: 834   SNYVIRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPADANFY  893
         ************************************************************
S: 301   klikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvell  344
         kli++G++m+qp+yateeiy imq+cw+++++krpsf +l+++l
Q: 894   KLIQSGFKMDQPFYATEEIYFIMQSCWAFDSRKRPSFPNLTSFL  937
         ****************************************9986
Domain Sequence
(FASTA)
LEFGKVLGSG AFGKVMNATA YGISKTGVSI QVAVKMLKEK ADSSEREALM SELKMMTHLG 60
SHENIVNLLG ACTLSGPIYL IFEYCCYGDL LNYLRSKREK FHRTWTEIFK EHNFSFYPTF 120
QSHPNSSMPG SREVQIHPDS DPISGFNGNS FQSEDEIEYE NQKRLEEEED LNVLTFEDLL 180
CFAYQVAKGM EFLEFKSCLH RDLAARNVLV THGKVAKIAD FGLARDIMSD SNYVIRGNAR 240
LPVKWMAPES LFEGIYTIKS DVWSYGILLW EIFSLGVNPY PGIPADANFY KLIQSGFKMD 300
QPFYATEEIY FIMQSCWAFD SRKRPSFPNL TSFL 334
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00375
EKS-ANC-00393
EKS-CAJ-00408
EKS-CAF-00404
EKS-CAP-00433
EKS-DAR-00790
EKS-EQC-00396
EKS-FEC-00388
EKS-GAG-00343
EKS-GOG-00396
EKS-HOS-00410
EKS-ICT-00383
EKS-LOA-00413
EKS-MAM-00403
EKS-MEG-00337
EKS-MOD-00392
EKS-MUM-00436
EKS-MUP-00397
EKS-MYL-00399
EKS-NOL-00369
EKS-OCP-00084
EKS-ORA-00348
EKS-ORC-00379
EKS-OTG-00406
EKS-PAT-00382
EKS-PES-00360
EKS-POA-00395
EKS-SAH-00374
EKS-SUS-00354
EKS-TAG-00475
EKS-TAR-00506
EKS-TUT-00119
EKS-XET-00516
Gene Ontology
GO:0009986; C:cell surface
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0002318; P:myeloid progenitor cell differentiation
GO:0045578; P:negative regulation of B cell differentiation
GO:0008285; P:negative regulation of cell proliferation
GO:0002328; P:pro-B cell differentiation
GO:0002572; P:pro-T cell differentiation
GO:0046777; P:protein autophosphorylation
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR003599; Ig_sub.
IPR013151; Immunoglobulin.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR001824; Tyr_kinase_rcpt_3_CS.
Pfam
PF00047; ig; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 1.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
Created Date20-Feb-2013