EPS-BOT-00157

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-BOT-00157

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PSP-Other/RPAP2	N/A	N/A	N/A	N/A	N/A

Status

Reviewed

Ensembl Protein

ENSBTAP00000041791

UniProt Accession

F6RRD7; A4FV88;

Protein Name

Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

Protein Synonyms/Alias

RNA polymerase II-associated protein 2;

Gene Name

RPAP2

Gene Synonyms/Alias

RPAP2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000018739	ENSBTAP00000041791	ENSBTAT00000044283

Organism

Bos taurus

Functional Description

Protein phosphatase that displays CTD phosphataseactivity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes (By similarity).

Protein Length

608

Protein Sequence
(FASTA)

MADWVGPCSA GRKARRSRAS RDVAGTKQTS ALNQEDASQR KAELEAAVRK KIEFERKALH 60

IVEQLLEENI SEEFLRECGK FITPAHYSDV VDERSIIKLC GYPLCQNKLG IVPKQKYKIS 120

TKTNKVYDIT ERKCFCSNFC YKASKFFEAQ IPKSPVWIRE EERHPDFQLL QDGQSGPSGE 180

EIQLCSKAIK TSDIDSPGHF EKHYESSSSS SHSDSSSDNE QDFVSSILPG NRPNATRPQL 240

HEKSIMKKKA GQKVNSQHES KEQTVVDVIE QLGNCRLDNQ EKATACELPL QNVNTQISSN 300

SSLQKKLEAS EISDIKYSSS KVTLVGISKK SAEHFKRKFA KSNQVSGSAS SSLQVCPEIA 360

KANLLKALKE TLIEWKTEET LRFLYGQNYA SVCLKSSSTP LVKEEELDED DMNSDPDSHS 420

PALQELNSLD ESLPFRASDT AIKPLPSYEN LKKETETLNL RIREFYRGRY VLNEETTKSQ 480

DSEEHDPTFP LIDSSSQNQI RKRIVLEKLN KVLPGLLGPL QITLGDIYTQ LKNLVHTFRL 540

TNRNIIHKPA EWTLIALVLL SILTSTLGIQ KLSQENVMFT QFMTTLLEEL HLKNEDLESL 600

TIIFRTSC 608

Nucleotide Sequence
(FASTA)

ATGGCTGACT GGGTCGGACC GTGCTCTGCG GGCCGCAAAG CCCGGCGTTC CCGCGCCTCC 60

CGAGATGTCG CAGGTACTAA GCAGACAAGT GCCTTGAACC AAGAAGATGC TTCTCAAAGG 120

AAAGCAGAAC TAGAAGCAGC TGTGAGAAAG AAGATTGAGT TTGAGAGAAA AGCTTTACAT 180

ATTGTGGAAC AGCTTTTAGA AGAGAATATT TCAGAAGAAT TCCTAAGGGA GTGTGGGAAG 240

TTCATCACAC CTGCTCACTA TAGTGATGTT GTGGATGAGC GTTCTATTAT CAAACTCTGT 300

GGCTATCCTT TATGTCAGAA CAAGCTAGGA ATTGTACCAA AACAGAAATA TAAAATTTCT 360

ACCAAAACTA ATAAAGTCTA TGATATTACT GAAAGAAAGT GTTTTTGCAG CAATTTTTGT 420

TATAAAGCAT CTAAGTTTTT TGAAGCACAA ATTCCTAAAA GTCCAGTGTG GATTCGCGAG 480

GAAGAAAGAC ATCCTGATTT TCAGCTGCTA CAGGATGGAC AAAGTGGTCC TTCTGGAGAA 540

GAAATACAGT TATGCAGCAA AGCCATTAAA ACATCAGATA TTGACAGTCC TGGCCATTTT 600

GAGAAGCATT ATGAATCTAG TTCTTCTAGC AGTCATAGTG ATAGTAGCAG TGATAATGAG 660

CAAGACTTTG TTTCCTCCAT TCTACCAGGA AACAGACCAA ATGCAACAAG GCCACAGCTG 720

CACGAAAAAA GCATAATGAA AAAGAAAGCT GGTCAAAAAG TTAACTCTCA GCATGAAAGC 780

AAAGAGCAAA CAGTAGTAGA TGTCATTGAG CAGTTAGGCA ATTGCAGATT AGATAATCAG 840

GAGAAAGCTA CTGCTTGTGA ACTTCCTTTA CAGAATGTAA ATACACAGAT TTCTTCAAAT 900

AGTTCTCTGC AAAAAAAATT AGAAGCTTCA GAAATTTCTG ATATTAAATA CAGTAGTTCA 960

AAAGTAACTC TTGTAGGCAT AAGTAAGAAA AGTGCTGAAC ATTTTAAGAG GAAATTTGCC 1020

AAATCAAACC AAGTTTCTGG GTCAGCTTCC AGTTCATTGC AGGTGTGCCC TGAAATTGCA 1080

AAGGCAAACT TACTTAAAGC CCTGAAAGAG ACTTTGATTG AGTGGAAGAC AGAAGAAACT 1140

TTGAGGTTTT TGTATGGCCA GAATTATGCA TCTGTATGTC TAAAATCCTC CTCAACCCCT 1200

CTGGTTAAAG AAGAAGAACT TGATGAAGAT GATATGAACT CTGATCCAGA TAGTCATTCC 1260

CCTGCCCTGC AGGAGTTGAA CAGCTTGGAT GAGTCTTTAC CATTTAGAGC CTCAGATACA 1320

GCCATTAAAC CACTGCCAAG TTATGAGAAC TTGAAAAAAG AAACTGAAAC ATTAAATTTA 1380

AGGATCAGGG AGTTTTATAG AGGACGATAT GTTTTGAATG AAGAAACCAC CAAATCACAA 1440

GACTCAGAAG AGCATGATCC CACCTTTCCA CTGATAGATT CAAGTTCTCA GAACCAGATC 1500

AGAAAACGCA TCGTACTTGA AAAATTGAAT AAAGTATTGC CTGGACTTTT GGGACCTCTT 1560

CAGATTACAT TAGGAGATAT TTACACACAA CTTAAAAATC TTGTCCATAC TTTCAGATTA 1620

ACAAATAGAA ATATTATACA TAAACCTGCA GAGTGGACCT TAATTGCTTT GGTGTTGCTG 1680

TCAATATTGA CCTCAACTCT TGGCATTCAG AAGCTTTCTC AGGAAAATGT GATGTTTACA 1740

CAGTTCATGA CCACCCTGCT TGAAGAATTG CATTTAAAAA ATGAAGACCT TGAAAGTTTA 1800

ACCATCATAT TTAGAACCAG CTGTTAA 1827

Domain Profile

N/A

Domain Sequence
(FASTA)

N/A

Keyword

Coiled coil; Complete proteome; Cytoplasm; Hydrolase; Metal-binding; Nucleus; Phosphoprotein; Protein phosphatase; Reference proteome; Transcription; Transcription regulation; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0016591	; C:DNA-directed RNA polymerase II, holoenzyme
GO:0008420	; F:CTD phosphatase activity
GO:0046872	; F:metal ion binding
GO:0070940	; P:dephosphorylation of RNA polymerase II C-terminal domain
GO:0009301	; P:snRNA transcription

KEGG

bta:529184

;

InterPros

IPR007308

; DUF408.

Pfam

PF04181

; RPAP2_Rtr1; 1.

SMARTs

Prosites

PS51479

; ZF_RTR1; 1.

Prints

Created Date

20-Feb-2013