EKS-BOT-00119

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-BOT-00119

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/NAK	359.3	1.3E-107	41	313	273

Status

Unreviewed

Ensembl Protein

ENSBTAP00000025537

UniProt Accession

F1MIB2;

Protein Name

Protein Synonyms/Alias

Gene Name

GAK

Gene Synonyms/Alias

GAK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000019188	ENSBTAP00000025537	ENSBTAT00000025537

Organism

Bos taurus

Functional Description

Protein Length

1268

Protein Sequence
(FASTA)

MSLLQSALDF LAGPGSLGGA AGRDQTDFVG QTVEMGELRL RVRRVLAEGG FAFVYEAQDL 60

GSGREYALKR LLSNEEEKNR AIIQEVCFMK KLSGHPNIVQ FCSAASIGKE ESDTGQAEFL 120

LLMELCRGQL VEFLKKVESK GPLSCDTVLK IFYQTCRAVQ HMHRQKPPII HRDLKVENLL 180

LSNQGTIKLC DFGSATTISH YPDYSWSAQR RALVEEEITR NTTPMYRTPE IVDLYSNFPI 240

GEKQDIWALG CILYLLCFGQ HPFEDGAKLR IVNGKYAIPA DDTRYSVFHS LIRSMLKVNP 300

EERLSVTELV NQLQEIAAAR NVNPKSPITE LLEQNGGYGH AAPPGSTGSS LVVTEYEQPY 360

GGFLDILRGG TERLFTNIKD TSSKVIQSVA NYAKGDLDIS YITSRIAVMS FPAEGVESAI 420

KNNIEDVRLF LDSKHPGRYA VYNLSPRTYR PSKFHNRVSD CGWVARRAPS LRSLYSLCRN 480

MHAWLRRDPG NVCVVHCMDG RAVSAVAVCS FLCFCRLFST AEAAVYMFSM KRCPPGIWPS 540

HKRYIEYMCD MVAEEPVTPH SKPILVKAVV MTPVPLFSKQ RSGCRPFCEV YVGDERVTTT 600

SQEYDKMRDF KIEDGKAVIP LGITVQGDVL IIIYHARSTL GGRLQAKMAS MKMFQIQFHT 660

GFVPRNAATV KFAKYDLDAC DIQEKYPDLF QVSLEVEVEP RDRPGHEAPP WEGAGMRGLN 720

PKILFSSREE QQDVLSKFGK PELPRQPGST AQYDAEAGPA DAEPPESDSP HSSVDADHFL 780

HTLDWREDRD SSVGPEGHLA EEGPSAVAED GCVSEPSDEE APTPSAESGD TGDEDVPAPA 840

APQDDSVDLL GLHAEAGPVP APQAPGGPPS NADLLGCLLG APGPAPEGAV GGLLDGDAAL 900

LFSSPAPAPC TQTTAPAADP FGPLLLPPDV DTPPSSQPDL FGEFLNSDAP AAQPAPFPST 960

HSAPPPACST DFLHLGDLPA EPSKMTASAS HPDLLGAWDA WAEAPAPALA ADGTFFSPGD 1020

QPAPSGLPAG QTKSQSQDPF ADLGDLSAGL QGSPAAAAPG GFGPKAAPPP KASSSWQTSR 1080

PPAQGTPWPP QAKPPPKASV PPRPNYTSSF SVIGSREERG VRAPSFGPKP RVSENDFEDL 1140

LSNQGFSSRA DRKGPRTIAE MRRQDQARDL DPLKLKLLEW TEGKERNIRA LLSTLHTALW 1200

DGESRWTPVG MADLVTPAQV KKHYRRAVLV VHPDKARGQP YEQYARMIFM ELNDAWAEFE 1260

SQGSRPLF 1268

Nucleotide Sequence
(FASTA)

ATGTCGCTGC TGCAGTCCGC GCTCGACTTC CTGGCGGGCC CGGGCTCCCT GGGGGGCGCG 60

GCCGGCCGCG ACCAGACGGA CTTCGTGGGG CAGACGGTGG AGATGGGCGA GCTGCGGCTG 120

CGGGTGCGCC GGGTCCTGGC TGAAGGAGGG TTTGCATTTG TGTATGAAGC TCAAGATCTG 180

GGAAGTGGCA GAGAGTATGC ATTGAAGAGA CTGCTGTCCA ACGAAGAGGA GAAGAACAGA 240

GCCATCATTC AGGAAGTGTG TTTCATGAAA AAACTTTCAG GCCACCCAAA CATTGTCCAG 300

TTTTGTTCTG CAGCATCGAT AGGAAAAGAG GAGTCGGACA CTGGGCAGGC GGAGTTCCTG 360

CTGCTCATGG AGCTCTGCAG AGGGCAGCTG GTGGAATTTT TAAAAAAAGT TGAATCGAAA 420

GGTCCGCTCT CGTGCGACAC CGTCCTGAAG ATCTTCTACC AGACGTGCCG GGCGGTGCAG 480

CACATGCACA GACAGAAGCC GCCCATCATC CACAGGGACC TCAAGGTTGA AAACTTACTG 540

CTTAGTAACC AGGGGACCAT CAAGCTGTGC GACTTCGGCA GTGCCACGAC CATCTCACAC 600

TACCCAGACT ACAGCTGGAG CGCCCAGCGC CGGGCCCTGG TGGAGGAGGA GATCACCAGG 660

AACACGACCC CCATGTACAG GACGCCGGAA ATTGTGGACT TGTACTCAAA CTTTCCGATT 720

GGCGAGAAGC AGGACATCTG GGCCCTGGGC TGCATCCTGT ACCTGCTCTG CTTCGGGCAG 780

CACCCCTTTG AGGACGGAGC GAAGCTTCGC ATCGTCAACG GGAAGTACGC AATCCCTGCC 840

GACGACACGC GGTACTCCGT GTTCCACAGC CTCATCCGTT CCATGCTCAA GGTCAACCCG 900

GAGGAGCGGC TGTCCGTCAC CGAGCTGGTC AACCAGCTCC AGGAGATCGC GGCCGCCCGC 960

AACGTGAACC CCAAGTCACC CATCACTGAG CTCCTGGAGC AGAATGGAGG CTATGGGCAC 1020

GCGGCCCCTC CCGGCTCCAC GGGCAGCAGT CTGGTGGTCA CTGAGTACGA GCAGCCCTAT 1080

GGCGGGTTCC TGGACATTCT GCGTGGGGGC ACCGAGCGCC TCTTCACCAA CATCAAGGAC 1140

ACCTCCTCCA AAGTCATCCA GTCCGTTGCC AACTATGCGA AGGGAGATCT GGATATTTCT 1200

TACATCACGT CTAGAATCGC AGTCATGTCG TTCCCGGCGG AGGGCGTGGA GTCGGCCATC 1260

AAGAACAACA TTGAGGATGT ACGGCTGTTC CTGGACTCGA AGCACCCGGG CCGCTACGCC 1320

GTCTACAACC TGTCCCCGCG GACCTACCGG CCCTCGAAGT TCCACAACCG GGTCTCCGAC 1380

TGCGGCTGGG TGGCCCGGCG GGCCCCGAGC CTCCGCAGCC TGTACAGCCT CTGCAGGAAC 1440

ATGCACGCCT GGCTGCGCCG CGACCCTGGC AACGTCTGCG TGGTGCACTG CATGGACGGG 1500

AGGGCGGTGT CGGCCGTGGC CGTGTGCTCC TTCTTGTGCT TCTGCCGGCT CTTCAGCACC 1560

GCGGAGGCCG CTGTGTACAT GTTCAGCATG AAGCGGTGCC CACCGGGCAT CTGGCCATCC 1620

CACAAGAGGT ACATTGAGTA CATGTGTGAC ATGGTGGCCG AGGAGCCCGT CACGCCCCAC 1680

AGCAAGCCCA TCCTGGTGAA GGCCGTGGTC ATGACGCCTG TGCCGCTCTT CAGCAAGCAG 1740

AGGAGCGGCT GCAGGCCCTT CTGCGAGGTC TACGTGGGGG ATGAGCGCGT GACCACCACG 1800

TCCCAGGAAT ACGACAAGAT GAGAGACTTT AAAATTGAGG ATGGCAAAGC GGTCATTCCC 1860

CTGGGCATAA CAGTCCAGGG GGACGTGCTC ATCATCATCT ATCATGCGAG GTCCACCCTG 1920

GGAGGAAGGC TGCAGGCCAA GATGGCGTCC ATGAAGATGT TTCAGATCCA GTTTCACACA 1980

GGGTTCGTGC CTCGGAACGC AGCTACTGTG AAGTTTGCCA AGTATGATCT GGATGCTTGC 2040

GACATCCAGG AGAAGTACCC CGACTTGTTC CAAGTGAGCC TGGAGGTGGA GGTGGAGCCC 2100

AGAGACAGGC CCGGCCACGA GGCCCCGCCC TGGGAGGGTG CAGGCATGCG AGGGCTGAAC 2160

CCCAAGATCC TCTTCTCCAG CCGGGAGGAG CAGCAAGATG TCCTGTCCAA GTTTGGGAAG 2220

CCAGAGCTCC CCAGGCAGCC TGGGTCCACC GCACAGTACG ACGCCGAGGC CGGGCCCGCG 2280

GATGCCGAGC CCCCCGAGTC AGACTCGCCG CACAGCAGCG TGGATGCTGA CCACTTCCTG 2340

CACACGCTGG ACTGGCGGGA GGATCGGGAC TCCAGTGTGG GCCCGGAGGG TCACCTGGCC 2400

GAGGAGGGTC CCTCTGCTGT GGCCGAGGAC GGCTGTGTGA GTGAGCCATC GGACGAGGAA 2460

GCCCCGACAC CCTCTGCGGA GAGCGGGGAC ACAGGCGATG AGGACGTGCC CGCCCCCGCC 2520

GCCCCGCAGG ACGACAGCGT GGACCTTCTG GGGCTGCACG CGGAGGCGGG GCCTGTGCCC 2580

GCCCCCCAGG CCCCCGGCGG CCCCCCCAGC AATGCAGACC TGCTCGGCTG CCTGCTCGGG 2640

GCCCCGGGCC CCGCTCCGGA GGGTGCTGTG GGGGGCCTGC TCGACGGGGA TGCGGCCCTG 2700

CTCTTCAGCA GCCCAGCCCC CGCGCCTTGC ACCCAGACAA CTGCCCCGGC CGCTGACCCG 2760

TTCGGCCCGC TCCTGCTGCC GCCCGACGTG GACACCCCTC CTAGCTCGCA GCCTGACCTC 2820

TTCGGGGAAT TCCTCAACTC AGACGCCCCG GCCGCCCAGC CCGCGCCCTT CCCCTCCACC 2880

CACAGCGCTC CGCCGCCAGC CTGCAGCACC GACTTCCTGC ATCTTGGGGA CCTGCCCGCC 2940

GAGCCCAGCA AGATGACAGC CTCTGCCAGC CACCCCGACC TGCTGGGAGC CTGGGATGCC 3000

TGGGCTGAGG CGCCGGCCCC CGCGCTGGCT GCAGACGGCA CCTTCTTCTC TCCTGGAGAC 3060

CAGCCAGCCC CTTCTGGCCT TCCGGCTGGC CAGACCAAGT CTCAGAGCCA GGACCCGTTT 3120

GCAGACCTTG GCGACCTCAG TGCCGGCCTC CAAGGCTCGC CTGCCGCAGC TGCTCCTGGG 3180

GGCTTTGGTC CCAAAGCAGC GCCCCCTCCC AAGGCCAGCA GCTCCTGGCA GACGAGTCGG 3240

CCCCCAGCCC AGGGCACCCC GTGGCCCCCC CAGGCCAAGC CGCCCCCCAA AGCCAGTGTA 3300

CCGCCAAGGC CTAACTACAC CTCCAGCTTC AGTGTGATCG GTAGCCGGGA GGAGCGGGGG 3360

GTCCGCGCCC CCAGCTTTGG TCCAAAGCCG AGGGTGTCAG AAAACGACTT TGAAGACCTG 3420

CTCTCCAACC AGGGCTTCTC CTCGCGGGCT GACAGGAAGG GGCCGCGGAC CATCGCTGAG 3480

ATGAGGAGGC AGGACCAGGC CCGGGACTTG GATCCGCTGA AGCTGAAGCT TCTGGAGTGG 3540

ACGGAGGGCA AGGAGAGGAA CATCCGCGCC CTGCTGTCCA CGCTGCACAC GGCGCTGTGG 3600

GACGGCGAGA GCCGCTGGAC GCCGGTGGGC ATGGCCGACC TGGTGACGCC CGCACAAGTG 3660

AAGAAGCACT ACCGCCGTGC CGTGCTGGTG GTCCACCCCG ACAAGGCCCG GGGGCAGCCC 3720

TACGAGCAGT ATGCCCGGAT GATCTTCATG GAGCTCAACG ATGCGTGGGC TGAGTTTGAG 3780

AGCCAGGGCT CCCGGCCACT CTTCTGA 3807

Domain Profile

S: 2     riekvlaeGGfalvylaedastgekyalKrilvneeedleeikrEieimkklsghknivk  61

         r+++vlaeGGfa+vy a+d+ +g++yalKr+l+neee++++i++E+++mkklsgh+niv+

Q: 41    RVRRVLAEGGFAFVYEAQDLGSGREYALKRLLSNEEEKNRAIIQEVCFMKKLSGHPNIVQ  100

         89**********************************************************

S: 62    lv..dssvkeekdngskevlllleyckkgslvdllnkrlekgelseaeilkilldvtrav  119

         ++  +s  kee+d+g++e+lll+e+c+ g+lv++l+k ++kg ls++++lki+++++rav

Q: 101   FCsaASIGKEESDTGQAEFLLLMELCR-GQLVEFLKKVESKGPLSCDTVLKIFYQTCRAV  159

         **877888999***************9.8*******************************

S: 120   aalHalsvpliHRDlkveNillsdegelvlcDlGSattaileve...skqelsalqeeie  176

         +++H++++p+iHRDlkveN+lls++g+++lcD+GSatt+++ ++   s+q+++ ++eei+

Q: 160   QHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDyswSAQRRALVEEEIT  219

         *******************************************999999***********

S: 177   knttlsyrsPElidlysnlvideksDiWaLGcllYklcffesPfeesvklailngkysiP  236

         +ntt++yr+PE++dlysn++i+ek+DiWaLGc+lY lcf+++Pfe+++kl+i+ngky iP

Q: 220   RNTTPMYRTPEIVDLYSNFPIGEKQDIWALGCILYLLCFGQHPFEDGAKLRIVNGKYAIP  279

         ************************************************************

S: 237   ensryseklkslikkmlevdpeeRptiaqvlell  270

          +++ ++ ++sli++ml+v+peeR+++++++++l

Q: 280   ADDTRYSVFHSLIRSMLKVNPEERLSVTELVNQL  313

         ******************************9986

Domain Sequence
(FASTA)

RVRRVLAEGG FAFVYEAQDL GSGREYALKR LLSNEEEKNR AIIQEVCFMK KLSGHPNIVQ 60

FCSAASIGKE ESDTGQAEFL LLMELCRGQL VEFLKKVESK GPLSCDTVLK IFYQTCRAVQ 120

HMHRQKPPII HRDLKVENLL LSNQGTIKLC DFGSATTISH YPDYSWSAQR RALVEEEITR 180

NTTPMYRTPE IVDLYSNFPI GEKQDIWALG CILYLLCFGQ HPFEDGAKLR IVNGKYAIPA 240

DDTRYSVFHS LIRSMLKVNP EERLSVTELV NQL 273

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005794	; C:Golgi apparatus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR008973	; C2_Ca/lipid-bd_dom_CaLB.
IPR001623	; DnaJ_N.
IPR011009	; Kinase-like_dom.
IPR014019	; Phosphatase_tensin-typ.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR014020	; Tensin_phosphatase_C2-dom.

Pfam

PF00226	; DnaJ; 1.
PF00069	; Pkinase; 1.
PF10409	; PTEN_C2; 1.

SMARTs

SM00271

; DnaJ; 1.

Prosites

PS51182	; C2_TENSIN; 1.
PS50076	; DNAJ_2; 1.
PS51181	; PPASE_TENSIN; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013