EKS-BOT-00108

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-BOT-00108

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Tec	488.9	2.8E-147	402	652	251

Status

Unreviewed

Ensembl Protein

ENSBTAP00000030121

UniProt Accession

Q3ZC95;

Protein Name

Protein Synonyms/Alias

Bruton agammaglobulinemia tyrosine kinase;

Gene Name

BTK

Gene Synonyms/Alias

BTK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000019250	ENSBTAP00000030121	ENSBTAT00000030136

Organism

Bos taurus

Functional Description

Protein Length

659

Protein Sequence
(FASTA)

MATVILESIF LKRSQQKKKT SPLNFKKRLF LLTVQKLSYY EYDFERGRRG SKKGSIDVEK 60

ITCVETVVPE KNPPPERQIP RRGEESSETE QISIIERFPY PFQVVYDEGP LYVFSPTEEL 120

RKRWIHQLKN VIRYNSDLVQ KYHPCFWIDG QYLCCSQTAK NAMGCQILEN RNGSLKPGSS 180

HRKTKKPLPP TPEEDQILKK PLPPEPTAAP VSTSELKKVV ALYDYMPMNA NDLQLHKGNE 240

YFILEESNLP WWRARDKNGQ EGYIPSNYVT EAEDSIEMYE WYSKHMTRSQ AEQLLKQEGK 300

EGGFIVRDSS KAGKYTVSVF AKSTGEPQGV IRHYVVCSTP QSQYYLAEKH LFSTIPELIN 360

YHQHNSAGLI SRLKYPVSQQ NKNAPSTAGL GYGSWEIDPK DLTFLKELGT GQFGVVKYGK 420

WRGQYDVAIK MIKEGSMSED EFIEEAKVMM NLSHEKLVQL YGVCTKQRPI FIITEYMANG 480

CLLNYLREMR HRFQTQQLLE MCKDVCEAME YLESKQFLHR DLAARNCLVN DQGVVKVSDF 540

GLSRYVLDDE YTSSVGSKFP VRWSPPEVLM YSKFSSKSDI WAFGVLMWEI YSLGKMPYER 600

FTNSETAEHI AQGLRLYRPH LASERVYAIM YSCWHEKADE RPTFKILLSN ILDVMDEES 659

Nucleotide Sequence
(FASTA)

ATGGCTACAG TGATACTGGA GAGCATCTTT CTGAAGCGAT CCCAGCAGAA AAAGAAAACA 60

TCACCTTTAA ATTTCAAGAA GCGCCTCTTT CTCTTAACCG TGCAAAAACT TTCCTACTAT 120

GAGTATGACT TTGAACGCGG GAGAAGAGGC AGTAAGAAGG GTTCAATAGA TGTTGAGAAG 180

ATCACCTGCG TTGAAACAGT GGTTCCTGAG AAAAATCCTC CCCCTGAAAG ACAGATTCCG 240

AGAAGGGGAG AAGAGTCCAG TGAAACTGAG CAGATCTCAA TTATTGAAAG GTTCCCTTAC 300

CCCTTCCAGG TTGTATATGA TGAAGGGCCT CTCTATGTCT TCTCCCCAAC CGAAGAACTA 360

AGGAAGCGTT GGATTCACCA GCTCAAAAAT GTAATCCGGT ACAACAGTGA TCTGGTACAG 420

AAATACCACC CTTGCTTCTG GATTGACGGG CAGTATCTCT GCTGCTCTCA GACAGCCAAA 480

AATGCTATGG GCTGCCAAAT TTTGGAGAAC AGAAATGGAA GCTTAAAACC TGGGAGTTCT 540

CACCGCAAGA CAAAAAAGCC TCTTCCTCCC ACACCTGAGG AGGACCAGAT CTTAAAAAAG 600

CCATTGCCCC CTGAGCCAAC AGCAGCACCT GTCTCGACAA GTGAGCTGAA AAAAGTTGTA 660

GCCCTTTATG ACTACATGCC AATGAATGCA AATGATCTAC AGCTGCATAA GGGCAATGAG 720

TATTTTATCC TGGAGGAGAG CAACTTACCC TGGTGGCGTG CCCGGGATAA AAATGGGCAG 780

GAAGGCTACA TCCCTAGTAA CTATGTAACT GAAGCAGAGG ACTCCATAGA AATGTATGAG 840

TGGTATTCCA AGCACATGAC TCGGAGTCAA GCTGAGCAAC TATTGAAGCA AGAGGGTAAA 900

GAAGGAGGCT TCATTGTTAG AGACTCCAGC AAAGCTGGAA AATATACCGT GTCTGTGTTT 960

GCGAAATCTA CAGGGGAACC TCAAGGGGTG ATACGCCACT ATGTCGTGTG TTCCACACCT 1020

CAGAGCCAGT ATTACCTGGC TGAGAAGCAC CTTTTCAGCA CTATCCCTGA GCTCATTAAC 1080

TACCATCAGC ATAACTCTGC TGGACTCATA TCTAGGCTCA AATATCCAGT GTCTCAACAA 1140

AACAAGAATG CACCTTCCAC TGCAGGCCTG GGATACGGAT CATGGGAAAT CGACCCAAAG 1200

GACTTGACCT TCTTGAAGGA GCTGGGGACT GGACAATTTG GAGTAGTGAA GTACGGGAAG 1260

TGGAGGGGCC AGTATGATGT GGCCATCAAG ATGATCAAAG AAGGCTCCAT GTCTGAGGAT 1320

GAGTTCATTG AAGAAGCCAA AGTCATGATG AATCTTTCCC ATGAGAAGCT GGTGCAGTTG 1380

TATGGCGTCT GCACGAAACA GCGCCCCATC TTCATCATCA CTGAGTACAT GGCCAATGGC 1440

TGCCTCCTGA ACTACCTGAG GGAGATGCGC CACCGCTTCC AGACTCAGCA GCTGCTGGAG 1500

ATGTGCAAGG ATGTCTGTGA AGCCATGGAA TACCTAGAGT CTAAGCAGTT CCTCCACCGA 1560

GACCTGGCAG CTCGAAACTG TTTGGTTAAT GATCAAGGAG TTGTTAAAGT ATCTGACTTT 1620

GGCCTGTCCA GGTATGTTCT GGATGATGAA TATACAAGCT CAGTAGGTTC CAAATTTCCT 1680

GTCCGGTGGT CTCCACCAGA AGTTCTTATG TACAGCAAGT TCAGCAGCAA ATCTGACATT 1740

TGGGCTTTTG GGGTGCTGAT GTGGGAAATT TACTCTCTGG GGAAGATGCC ATATGAGAGA 1800

TTTACTAACA GTGAAACAGC TGAACACATT GCCCAAGGCC TACGTCTCTA CAGGCCTCAT 1860

CTTGCTTCAG AGAGGGTATA TGCCATCATG TACAGCTGCT GGCATGAGAA AGCAGATGAA 1920

CGTCCCACTT TCAAAATTCT TCTGAGCAAC ATTCTAGATG TCATGGATGA AGAGTCCTGA 1980

Domain Profile

S: 1     ltllkelgsgqfgvvklgkwrakidvaikaikegamseedfieeakvmmklshpklvqly  60

         lt+lkelg+gqfgvvk+gkwr+++dvaik+ikeg+mse++fieeakvmm+lsh+klvqly

Q: 402   LTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLY  461

         79**********************************************************

S: 61    gvclkqkpiyivteylengcllnylrekkkklekelllemckdvcegmeylerksfihrd  120

         gvc+kq+pi+i+tey++ngcllnylre+++++++++llemckdvce+meyle+k+f+hrd

Q: 462   GVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRD  521

         ************************************************************

S: 121   laarnclvdeelvvkvsdfglaryvlddqyvssvgakfpvkwsppevlsyskyssksdvw  180

         laarnclv+++ vvkvsdfgl+ryvldd+y+ssvg+kfpv+wsppevl+ysk+ssksd+w

Q: 522   LAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIW  581

         ************************************************************

S: 181   afgvlmwevfsegklpyekksnsevvekvsrglrlyrpklaskkvyevmkscwkekpeer  240

         afgvlmwe++s+gk+pye+++nse++e++++glrlyrp+las++vy +m+scw+ek++er

Q: 582   AFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASERVYAIMYSCWHEKADER  641

         ************************************************************

S: 241   ptfkellsale  251

         ptfk lls++

Q: 642   PTFKILLSNIL  652

         ********996

Domain Sequence
(FASTA)

LTFLKELGTG QFGVVKYGKW RGQYDVAIKM IKEGSMSEDE FIEEAKVMMN LSHEKLVQLY 60

GVCTKQRPIF IITEYMANGC LLNYLREMRH RFQTQQLLEM CKDVCEAMEY LESKQFLHRD 120

LAARNCLVND QGVVKVSDFG LSRYVLDDEY TSSVGSKFPV RWSPPEVLMY SKFSSKSDIW 180

AFGVLMWEIY SLGKMPYERF TNSETAEHIA QGLRLYRPHL ASERVYAIMY SCWHEKADER 240

PTFKILLSNI L 251

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0031410	; C:cytoplasmic vesicle
GO:0005829	; C:cytosol
GO:0045121	; C:membrane raft
GO:0005634	; C:nucleus
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0005547	; F:phosphatidylinositol-3,4,5-trisphosphate binding
GO:0004713	; F:protein tyrosine kinase activity
GO:0048469	; P:cell maturation
GO:0007249	; P:I-kappaB kinase/NF-kappaB cascade
GO:0018108	; P:peptidyl-tyrosine phosphorylation

KEGG

bta:533459

;

InterPros

IPR011009	; Kinase-like_dom.
IPR011993	; PH_like_dom.
IPR001849	; Pleckstrin_homology.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR001562	; Znf_Btk_motif.

Pfam

PF00779	; BTK; 1.
PF00169	; PH; 1.
PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00107	; BTK; 1.
SM00233	; PH; 1.
SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.
PS51113	; ZF_BTK; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00402	; TECBTKDOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013