EKS-BOT-00278

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-BOT-00278

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	452.9	4.6E-136	194	481	288

Status

Unreviewed

Ensembl Protein

ENSBTAP00000025753

UniProt Accession

F1MMW7;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR1C

Gene Synonyms/Alias

ACVR1C;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000019337	ENSBTAP00000025753	ENSBTAT00000025753

Organism

Bos taurus

Functional Description

Protein Length

492

Protein Sequence
(FASTA)

MKASVKFESE DARERDSTVR RYLGLKCVCL LCDSSNFTCQ TEGACWASVM LTNGKEQVIK 60

SCVSLPELNA QVFCHSSNNV TKTECCFTDF CNNITLHLPT ASPNAPKLGP MELTIVVTVP 120

VFLLSIASVL TVWACQGRQC TYRKKKRPNV EEPLSECNLV NAGKTLKDLI YDVTASGSGS 180

GLPLLVQRTI ARTIVLQEIV GKGRFGEVWH GRWCGEDVAV KIFSSRDERS WFREAEIYQT 240

VMLRHENILG FIAADNKDNG TWTQLWLVSE YHEQGSLYDY LNRNIVTVAG MIKLALSIAS 300

GLAHLHMEIV GTQGKPAIAH RDIKSKNILV KKCETCAIAD LGLAVKHDSI LNTIDIPQNP 360

KVGTKRYMAP EMLDDTINVN IFESFKRADI YSVGLVYWEI ARRCSVGGIV EEYQLPYYDM 420

VPSDPSVEEM RKVVCDQKFR PSIPNQWQSC EALRVMGRIM RECWYANGAA RLTALRIKKT 480

ISQLCVKEDC KA 492

Nucleotide Sequence
(FASTA)

ATGAAGGCCT CTGTCAAATT TGAATCAGAA GATGCTAGAG AGAGAGATTC TACTGTCAGA 60

AGATACCTAG GTTTGAAGTG TGTTTGTCTT TTGTGTGACT CTTCAAACTT TACCTGCCAA 120

ACAGAAGGAG CATGTTGGGC TTCTGTTATG TTAACCAATG GAAAGGAACA GGTGATCAAG 180

TCCTGTGTCT CTCTCCCAGA ATTAAATGCA CAAGTCTTCT GTCATAGTTC CAACAATGTT 240

ACCAAAACGG AATGCTGCTT CACAGATTTT TGCAACAACA TAACACTGCA CCTTCCAACA 300

GCATCACCAA ACGCCCCAAA GCTTGGACCC ATGGAGCTGA CCATTGTTGT CACCGTGCCA 360

GTTTTCCTCC TGTCCATAGC TTCAGTGCTG ACAGTATGGG CATGCCAAGG TCGACAGTGC 420

ACCTACAGAA AGAAAAAGAG ACCGAATGTG GAGGAGCCCC TCTCTGAATG CAATCTGGTA 480

AATGCTGGGA AAACTCTGAA AGATCTGATT TACGATGTGA CTGCCTCTGG ATCTGGCTCT 540

GGTCTGCCTC TGTTGGTTCA AAGAACAATT GCAAGGACGA TTGTACTTCA GGAAATAGTA 600

GGAAAAGGTA GATTTGGTGA GGTCTGGCAT GGAAGATGGT GTGGGGAAGA TGTGGCTGTG 660

AAAATATTCT CCTCCAGAGA TGAAAGATCG TGGTTTCGAG AGGCAGAAAT TTATCAGACT 720

GTTATGCTGA GACATGAAAA CATCCTTGGT TTCATTGCTG CTGATAACAA AGACAATGGA 780

ACCTGGACTC AGCTTTGGCT TGTCTCTGAA TATCATGAAC AGGGCTCCTT ATATGACTAT 840

TTGAATAGAA ACATAGTGAC CGTGGCTGGA ATGATCAAGC TGGCGCTATC AATAGCTAGC 900

GGTCTGGCCC ACCTTCATAT GGAGATTGTT GGTACACAAG GTAAACCTGC TATTGCTCAT 960

CGAGATATAA AATCAAAGAA TATCTTAGTG AAAAAATGTG AAACTTGTGC CATAGCAGAC 1020

TTAGGGTTGG CTGTGAAGCA TGATTCAATA CTGAACACTA TTGACATACC TCAGAACCCT 1080

AAAGTAGGAA CCAAAAGGTA TATGGCCCCT GAAATGCTTG ATGATACAAT AAATGTGAAT 1140

ATCTTCGAGT CCTTCAAACG AGCTGACATC TATTCTGTTG GTCTGGTTTA CTGGGAAATA 1200

GCCCGGAGGT GTTCAGTTGG AGGAATTGTT GAGGAGTACC AGTTGCCTTA TTATGACATG 1260

GTGCCTTCAG ATCCCTCGGT AGAAGAAATG AGGAAGGTTG TTTGTGACCA GAAGTTCCGA 1320

CCAAGTATTC CAAACCAATG GCAAAGCTGT GAAGCACTCC GAGTCATGGG GAGAATAATG 1380

CGTGAGTGTT GGTATGCCAA TGGGGCAGCA AGACTAACTG CTCTTCGGAT TAAGAAGACT 1440

ATATCTCAAC TTTGTGTCAA AGAAGACTGC AAAGCCTGA 1479

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         + l+e++gkGr+geVw++++ ge+vAvKifs++de+sw+rE+eiyqtv+lrhenil+fia

Q: 194   IVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIA  253

         5789********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k+++++t+l+lv+eyhe+gsL+dyL+r++++v  +++lals+asGlahLH+eivgt+

Q: 254   ADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMIKLALSIASGLAHLHMEIVGTQ  313

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  KpaiaHRD+kskNilvkk +tc+iaDlGLa+k+++  +++d+ +n +vGtkRYmaPE

Q: 314   G--KPAIAHRDIKSKNILVKKCETCAIADLGLAVKHDSILNTIDIPQNPKVGTKRYMAPE  371

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         +l++++n++ fe+fkraD+Ys+gLv+WE+a+Rc+  +++veey+lp++++v+sdPs+eem

Q: 372   MLDDTINVNIFESFKRADIYSVGLVYWEIARRCSV-GGIVEEYQLPYYDMVPSDPSVEEM  430

         **********************************9.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         ++vv+++k rP+ip++w+++eal+++ ++++ecW+a+++aRltalr+kk++

Q: 431   RKVVCDQKFRPSIPNQWQSCEALRVMGRIMRECWYANGAARLTALRIKKTI  481

         ************************************************986

Domain Sequence
(FASTA)

IVLQEIVGKG RFGEVWHGRW CGEDVAVKIF SSRDERSWFR EAEIYQTVML RHENILGFIA 60

ADNKDNGTWT QLWLVSEYHE QGSLYDYLNR NIVTVAGMIK LALSIASGLA HLHMEIVGTQ 120

GKPAIAHRDI KSKNILVKKC ETCAIADLGL AVKHDSILNT IDIPQNPKVG TKRYMAPEML 180

DDTINVNIFE SFKRADIYSV GLVYWEIARR CSVGGIVEEY QLPYYDMVPS DPSVEEMRKV 240

VCDQKFRPSI PNQWQSCEAL RVMGRIMREC WYANGAARLT ALRIKKTI 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0048179	; C:activin receptor complex
GO:0016361	; F:activin receptor activity, type I
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0030154	; P:cell differentiation
GO:0019915	; P:lipid storage
GO:0008285	; P:negative regulation of cell proliferation
GO:0046676	; P:negative regulation of insulin secretion
GO:0038092	; P:nodal signaling pathway
GO:0043280	; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0002021	; P:response to dietary excess
GO:0009749	; P:response to glucose stimulus
GO:0032868	; P:response to insulin stimulus

KEGG

InterPros

IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013