EPS-BOT-00030

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-BOT-00030

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	167.9	3.8E-49	315	500	186

Status

Reviewed

Ensembl Protein

ENSBTAP00000026003

UniProt Accession

P79126; Q3ZBB4;

Protein Name

Protein phosphatase 1G

Protein Synonyms/Alias

Magnesium-dependent calcium inhibitable phosphatase; MCPP; Protein phosphatase 1B; Protein phosphatase 2C isoform gamma; PP2C-gamma; Protein phosphatase magnesium-dependent 1 gamma;

Gene Name

PPM1G

Gene Synonyms/Alias

PPM1G; PPM1C;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000019522	ENSBTAP00000026003	ENSBTAT00000026003

Organism

Bos taurus

Functional Description

Protein Length

543

Protein Sequence
(FASTA)

MGAYLSQPNT VKCSGDGVGA SRLPLPYGFS AMQGWRVSME DAHNCIPELD SETAMFSVYD 60

GHGGEEVALY CAKYLPDIIK DQKAYKEGKL QKALEDAFLA IDAKLTTEEV IKELAQIAGR 120

PTEDEDEKEK VADEDDVDNE EAALLHEEAT MTIEELLTRY GQNCHKGAPH SKSGAGTGEE 180

PGSQGLNGEA GPEDPSRETS AEENGPTAKA HTGLSSNSEC GTEAGQGGEP GTPTGEAGPS 240

CSSASDKLPR VAKSKFFEDS EDESDEAEEE EEDSEECSEE EDGYSSEEAE NEEDEDDTEE 300

AEEDDEEEEM MVPGMEGKEE PGSDSGTTAV VALIRGKQLI VANAGDSRCV VSEAGKALDM 360

SYDHKPEDEV ELARIKNAGG KVTMDGRVNG GLNLSRAIGD HFYKRNKNLP PEEQMISALP 420

DIKVLTLTDD HEFMVIACDG IWNVMSSQEV IDFIQSKISQ RDENGELRLL SSIVEELLDQ 480

CLAPDTSGDG TGCDNMTCII ICFKPRNTAA PQPESGKRKL EEVLSTEGAE ENGNSDKKKA 540

KRD 543

Nucleotide Sequence
(FASTA)

ATGGGTGCCT ACCTCTCTCA GCCCAACACG GTGAAGTGCT CTGGAGACGG GGTCGGCGCT 60

TCGCGCCTGC CGCTGCCCTA CGGCTTCTCC GCCATGCAAG GCTGGCGCGT CTCCATGGAG 120

GATGCTCACA ACTGTATTCC TGAGCTGGAC AGTGAGACAG CCATGTTTTC TGTCTATGAT 180

GGACATGGAG GGGAGGAAGT TGCCTTGTAC TGTGCCAAAT ATCTTCCTGA TATCATCAAA 240

GATCAGAAGG CCTACAAAGA AGGCAAGCTA CAGAAGGCTT TGGAAGATGC CTTCTTGGCT 300

ATTGATGCCA AGCTAACCAC TGAGGAAGTC ATTAAGGAGC TGGCACAGAT TGCAGGGCGA 360

CCCACTGAAG ACGAGGATGA AAAAGAAAAA GTTGCTGATG AAGATGATGT GGACAATGAG 420

GAGGCTGCAC TGCTGCATGA AGAGGCTACC ATGACTATTG AAGAGCTGCT GACACGCTAC 480

GGGCAGAACT GTCACAAGGG TGCTCCCCAC AGCAAATCTG GAGCTGGGAC AGGCGAGGAA 540

CCAGGGTCCC AGGGCCTCAA TGGGGAGGCA GGACCTGAGG ACCCATCTAG GGAAACTTCT 600

GCAGAGGAAA ATGGCCCCAC AGCCAAGGCT CACACAGGCC TTTCCTCCAA CTCGGAATGT 660

GGGACTGAGG CAGGCCAAGG TGGGGAGCCT GGCACTCCCA CTGGTGAGGC TGGGCCTTCC 720

TGCTCTTCAG CCTCCGACAA GCTGCCTCGA GTTGCTAAGT CCAAGTTCTT TGAGGACAGT 780

GAGGATGAGT CAGATGAGGC GGAGGAGGAA GAGGAAGACA GCGAGGAATG CAGTGAGGAA 840

GAAGATGGCT ACAGCAGTGA AGAGGCAGAG AATGAGGAAG ACGAGGATGA CACTGAGGAG 900

GCTGAAGAGG ATGATGAAGA AGAAGAGATG ATGGTGCCTG GGATGGAAGG CAAAGAGGAG 960

CCTGGCTCTG ACAGTGGTAC AACAGCAGTG GTGGCTCTGA TACGAGGGAA GCAGTTGATT 1020

GTAGCCAATG CAGGAGACTC CCGCTGTGTG GTGTCTGAGG CCGGCAAAGC TTTAGACATG 1080

TCCTATGACC ACAAACCGGA GGATGAAGTG GAGCTAGCAC GCATCAAGAA TGCTGGGGGC 1140

AAGGTTACCA TGGATGGGCG AGTCAACGGT GGCCTCAACC TCTCCAGAGC CATTGGAGAC 1200

CACTTTTACA AGAGAAACAA GAACTTGCCA CCAGAGGAAC AGATGATTTC GGCCCTTCCT 1260

GACATCAAGG TGCTGACTCT CACAGATGAT CATGAGTTTA TGGTCATTGC CTGTGATGGC 1320

ATATGGAATG TGATGAGCAG CCAGGAAGTT ATAGACTTTA TTCAATCGAA GATCAGCCAG 1380

CGCGATGAAA ATGGGGAGCT TCGGTTACTG TCATCCATTG TGGAAGAGCT GCTGGATCAA 1440

TGCCTGGCAC CAGACACTTC TGGGGACGGT ACAGGGTGTG ACAACATGAC CTGCATCATC 1500

ATTTGCTTCA AGCCCCGAAA TACAGCAGCG CCTCAGCCAG AGAGTGGCAA GCGGAAACTG 1560

GAGGAGGTGC TGTCTACCGA GGGGGCTGAA GAAAATGGCA ACAGTGACAA GAAGAAGGCC 1620

AAGCGGGACT AG 1632

Domain Profile

S: 93    leeksldidksGstavvalikdsklyvanvGdSravLcrngkavelssdHkpsredEleR  152

         +e k++  + sG+tavvali++++l+van+GdSr+v +  gka+ +s dHkp+ e El+R

Q: 315   MEGKEEPGSDSGTTAVVALIRGKQLIVANAGDSRCVVSEAGKALDMSYDHKPEDEVELAR  374

         3444444556**************************************************

S: 153   ieeaggsvilkdgaRvlGvLavsRalGdlylk.........pyvtpePevtshrltsede  203

         i++agg+v+ +   Rv+G L++sRa+Gd ++k         +++++ P++ + +lt ++e

Q: 375   IKNAGGKVTMDG--RVNGGLNLSRAIGDHFYKrnknlppeeQMISALPDIKVLTLTDDHE  432

         ***********9..**********************************************

S: 204   fliLasDGlwdvvsneeavslvrdvle......kkeaeqeaakkLvklalargsk.....  252

         f+++a+DG+w+v+s++e+++++++ ++      + + ++++ ++L++++la  ++

Q: 433   FMVIACDGIWNVMSSQEVIDFIQSKISqrdengELRLLSSIVEELLDQCLAPDTSgdgtg  492

         ************************999887766666778899999999999999877777

S: 253   .dnvsaiv  259

          dn++ i+

Q: 493   cDNMTCII  500

77777766

Domain Sequence
(FASTA)

MEGKEEPGSD SGTTAVVALI RGKQLIVANA GDSRCVVSEA GKALDMSYDH KPEDEVELAR 60

IKNAGGKVTM DGRVNGGLNL SRAIGDHFYK RNKNLPPEEQ MISALPDIKV LTLTDDHEFM 120

VIACDGIWNV MSSQEVIDFI QSKISQRDEN GELRLLSSIV EELLDQCLAP DTSGDGTGCD 180

NMTCII 186

Keyword

Acetylation; Complete proteome; Cytoplasm; Hydrolase; Magnesium; Manganese; Metal-binding; Phosphoprotein; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0046872	; F:metal ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0007050	; P:cell cycle arrest
GO:0035970	; P:peptidyl-threonine dephosphorylation

KEGG

bta:286880

;

InterPros

IPR001932	; PP2C-like.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481

; PP2C; 2.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013