EKS-BOT-00284

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-BOT-00284

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	392.3	1.4E-117	249	542	294

Status

Unreviewed

Ensembl Protein

ENSBTAP00000055112

UniProt Accession

G3MZV8;

Protein Name

Protein Synonyms/Alias

Gene Name

TGFBR2

Gene Synonyms/Alias

TGFBR2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000019832	ENSBTAP00000055112	ENSBTAT00000063984
ENSBTAG00000019832	ENSBTAP00000026423	ENSBTAT00000026423

Organism

Bos taurus

Functional Description

Protein Length

572

Protein Sequence
(FASTA)

MERKIQRTLQ PVFLAKLSWL RAIGRKHVPQ HPVPRAVNSD MMVTDHNGAI KLSQLCKFCD 60

VRSSTCDNQK SCWSNCSITA ICEKPEEVCV AVWRKNDENI TLETVCHDPK IAYHGFVLDD 120

AASSKCIMKE RKGSGETFFM CSCSSEECND HIIFSEEYTS SNPDLLLVIF QVTGVSLLPP 180

LGIAIAVIIT FYCYRIHRQQ KLSPAWDSGK PRKLMEFSEH LAIILEDDRS DISSTCANNI 240

NHNTELLPIE LDTLVGKGRF AEVYKAKLKQ NTSEQFETVA VKIFPYEEYA SWKTEKDIFS 300

DINLKHENIL QFLTAEERKT ELGKQYWLIT AFHAKGNLQE YLTRHVISWE DLRRLGGSLA 360

RGIAHLHSDH TLCGRPKMPI VHRDLKSSNI LVKGDLTCCL CDFGLSLRLD PTLSVDDLAN 420

SGQVGTARYM APEVLESRMN LENVESFKQT DVYSMALVLW EMTSRCNAVG EVKDYEPPFG 480

SKVREHPCVE SMKDNVLRDR GRPEIPSSWL NHQGIQTVCE TLAECWDHDP EARLTAQCVA 540

ERFSELEHLD RLSGRSSSEE KIPEDGSLNT TK 572

Nucleotide Sequence
(FASTA)

ATGGAACGCA AGATTCAGAG AACATTGCAG CCTGTATTTT TAGCTAAGCT GAGTTGGCTC 60

AGGGCAATAG GGAGAAAGCA CGTGCCGCAG CACCCAGTAC CACGTGCAGT TAACAGCGAT 120

ATGATGGTCA CTGACCACAA CGGCGCCATC AAGCTGTCGC AGCTGTGTAA GTTCTGCGAC 180

GTGCGGTCGT CCACCTGTGA CAACCAGAAG TCCTGCTGGA GCAACTGCAG CATCACGGCC 240

ATCTGCGAGA AGCCGGAGGA GGTCTGCGTG GCTGTCTGGA GGAAGAATGA TGAGAACATC 300

ACGCTGGAGA CAGTCTGCCA TGACCCCAAG ATTGCCTACC ATGGATTTGT CCTGGACGAT 360

GCTGCTTCTT CAAAGTGTAT CATGAAGGAA AGAAAGGGGT CCGGAGAGAC TTTCTTCATG 420

TGCTCCTGCA GCTCCGAAGA ATGCAATGAC CACATTATCT TCTCCGAAGA GTACACCAGC 480

AGTAACCCCG ACTTGCTGCT GGTTATCTTC CAAGTGACAG GCGTCAGCCT CCTGCCACCG 540

CTGGGCATCG CCATCGCAGT CATCATCACT TTCTACTGCT ACCGCATCCA CCGGCAGCAG 600

AAGCTGAGCC CAGCCTGGGA CTCGGGCAAG CCGCGCAAGC TGATGGAGTT CAGTGAGCAC 660

CTGGCCATCA TCCTGGAGGA CGACCGCTCC GACATCAGCT CCACCTGCGC CAACAACATC 720

AACCACAACA CGGAGCTGCT GCCCATCGAG CTGGACACCC TGGTGGGCAA GGGGCGCTTC 780

GCCGAGGTCT ACAAGGCCAA GCTGAAGCAG AACACGTCTG AGCAGTTCGA GACCGTGGCC 840

GTCAAGATCT TCCCCTACGA GGAGTATGCC TCCTGGAAGA CGGAGAAGGA CATCTTCTCG 900

GACATCAACC TCAAGCACGA GAACATCCTG CAGTTCCTGA CGGCCGAGGA GCGCAAGACG 960

GAGCTGGGCA AGCAGTACTG GCTCATCACT GCCTTCCACG CCAAGGGCAA CCTGCAGGAG 1020

TACCTGACGC GCCACGTCAT CAGCTGGGAG GACCTGCGCC GGCTGGGCGG CTCGCTGGCC 1080

CGCGGCATCG CGCACCTGCA CAGCGACCAC ACCCTGTGCG GCCGGCCCAA GATGCCCATC 1140

GTGCACAGGG ACCTCAAGAG CTCCAACATC CTGGTCAAGG GCGACCTCAC CTGCTGCCTC 1200

TGCGACTTCG GGCTCTCACT GCGGCTGGAC CCCACCCTGT CAGTGGATGA CCTGGCCAAC 1260

AGTGGGCAGG TGGGAACGGC GAGATACATG GCTCCAGAGG TCCTCGAGTC CAGGATGAAT 1320

CTGGAGAACG TGGAGTCCTT CAAGCAGACG GATGTCTACT CCATGGCCCT GGTGCTCTGG 1380

GAGATGACGT CTCGCTGCAA CGCAGTGGGA GAAGTGAAGG ACTATGAGCC TCCGTTCGGG 1440

TCTAAGGTGC GGGAGCATCC CTGTGTGGAA AGCATGAAGG ACAACGTGCT GAGAGATCGA 1500

GGCCGACCAG AGATTCCCAG CTCCTGGCTC AACCACCAGG GCATCCAGAC GGTGTGCGAG 1560

ACGCTGGCCG AATGCTGGGA CCATGACCCC GAGGCCCGGC TCACGGCGCA GTGCGTGGCC 1620

GAGCGCTTCA GCGAGCTGGA GCACCTGGAC AGGCTCTCCG GGAGGAGCAG CTCGGAGGAG 1680

AAGATCCCCG AAGATGGCTC CCTCAACACT ACCAAATAG 1719

Domain Profile

S: 1     lklleligkGrygeVwkaklrg......eevAvKifstedeaswkrEkeiyqtvllrhen  54

         ++l +l+gkGr++eV+kakl++      e+vAvKif++e+ aswk+Ek+i++ ++l+hen

Q: 249   IELDTLVGKGRFAEVYKAKLKQntseqfETVAVKIFPYEEYASWKTEKDIFSDINLKHEN  308

         678899***************99999999*******************************

S: 55    ilqfiaadkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHe  114

         ilqf++a+++++++ ++++l+t++h kg+L++yL+r+++++e+l rl  sla+G+ahLH+

Q: 309   ILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRRLGGSLARGIAHLHS  368

         ************************************************************

S: 115   eivgtkgkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtk  174

         + ++ +g+ K+ i+HRDlks Nilvk dltcc++D+GL+l+l+ + ++ dla++ qvGt

Q: 369   D-HTLCGRPKMPIVHRDLKSSNILVKGDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTA  427

         *.7888******************************************************

S: 175   RYmaPEvleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsd  234

         RYmaPEvle+++nl+++e+fk++DvYs++LvlWE++sRc++  +ev++y++pf ++v+++

Q: 428   RYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNA-VGEVKDYEPPFGSKVREH  486

         *****************************************.999***************

S: 235   PsleemkevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkr  290

         P++e+mk+ v++++ rP+ip++w +++ +++++++l ecWd+dpeaRlta++v++r

Q: 487   PCVESMKDNVLRDRGRPEIPSSWLNHQGIQTVCETLAECWDHDPEARLTAQCVAER  542

         *****************************************************987

Domain Sequence
(FASTA)

IELDTLVGKG RFAEVYKAKL KQNTSEQFET VAVKIFPYEE YASWKTEKDI FSDINLKHEN 60

ILQFLTAEER KTELGKQYWL ITAFHAKGNL QEYLTRHVIS WEDLRRLGGS LARGIAHLHS 120

DHTLCGRPKM PIVHRDLKSS NILVKGDLTC CLCDFGLSLR LDPTLSVDDL ANSGQVGTAR 180

YMAPEVLESR MNLENVESFK QTDVYSMALV LWEMTSRCNA VGEVKDYEPP FGSKVREHPC 240

VESMKDNVLR DRGRPEIPSS WLNHQGIQTV CETLAECWDH DPEARLTAQC VAER 294

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005901	; C:caveola
GO:0009897	; C:external side of plasma membrane
GO:0016021	; C:integral to membrane
GO:0043235	; C:receptor complex
GO:0005524	; F:ATP binding
GO:0005539	; F:glycosaminoglycan binding
GO:0046872	; F:metal ion binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005026	; F:transforming growth factor beta receptor activity, type II
GO:0032147	; P:activation of protein kinase activity
GO:0006915	; P:apoptotic process
GO:0007420	; P:brain development
GO:0060434	; P:bronchus morphogenesis
GO:0051216	; P:cartilage development
GO:0048701	; P:embryonic cranial skeleton morphogenesis
GO:0035162	; P:embryonic hemopoiesis
GO:0007369	; P:gastrulation
GO:0007507	; P:heart development
GO:0001701	; P:in utero embryonic development
GO:0002088	; P:lens development in camera-type eye
GO:0060463	; P:lung lobe morphogenesis
GO:0060443	; P:mammary gland morphogenesis
GO:0043011	; P:myeloid dendritic cell differentiation
GO:0060021	; P:palate development
GO:0060389	; P:pathway-restricted SMAD protein phosphorylation
GO:0001569	; P:patterning of blood vessels
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0018107	; P:peptidyl-threonine phosphorylation
GO:0002663	; P:positive regulation of B cell tolerance induction
GO:0010634	; P:positive regulation of epithelial cell migration
GO:0002053	; P:positive regulation of mesenchymal cell proliferation
GO:0051138	; P:positive regulation of NK T cell differentiation
GO:2000379	; P:positive regulation of reactive oxygen species metabolic process
GO:0002666	; P:positive regulation of T cell tolerance induction
GO:0002651	; P:positive regulation of tolerance induction to self antigen
GO:0070723	; P:response to cholesterol
GO:0042493	; P:response to drug
GO:0023014	; P:signal transduction by phosphorylation
GO:0007224	; P:smoothened signaling pathway
GO:0060440	; P:trachea formation
GO:0007179	; P:transforming growth factor beta receptor signaling pathway
GO:0001570	; P:vasculogenesis

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR017194	; Transform_growth_fac-b_typ-2.
IPR015013	; Transforming_GF_b_rcpt_2_ecto.

Pfam

PF08917	; ecTbetaR2; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013