EKS-BOT-00389

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-BOT-00389

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	360.8	5.6E-108	652	905	254

Status

Unreviewed

Ensembl Protein

ENSBTAP00000026456

UniProt Accession

F1N3W6;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K15

Gene Synonyms/Alias

MAP3K15;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000019855	ENSBTAP00000026456	ENSBTAT00000026456

Organism

Bos taurus

Functional Description

Protein Length

1314

Protein Sequence
(FASTA)

MESGGGATPA GAVGAAAEPP QCQLPPVGEG VAGPPGPPEP EGSAEGAGVG GEGGGAGGPR 60

RALRAVYVRS ESPQGGPEAG ARQCLLRACE AEGAHLTSVS FGELDFGETA VLDTFYDADV 120

AVVDMSDVSR QPSLFYHLGV RESFDMANNV ILYHDTDADT ALSLKDMVTQ KNTASSGNYY 180

FIPYIVTPCA DYFCCESDAQ RRASEYMQPN WDTLLGPLCV PLVDRFTSLL KDIHVTSCAY 240

YKETLLNDIR RAREKYQGDE LAKELARIKL RMDNTEVLTS DIIINLLLSY RDIQDYDAMV 300

KLVETLEMLP TCDLADQHNI KFHYAFALNR RNSAGDREKA LQVMLQVLQS CDHPAPDMFC 360

LCGRIYKDVF LDSDCKDDAS RDSAIEWYRK GFALQPSLYS GINLAVLLIV AGQQFETSME 420

LRKIGVRLNS LLGRKGSLEK MNSYWDVGQF FSVSMLASDV GKAVQAAERL FRLKPPVWYL 480

RSLVQNLLLI QRFKKPLIEH SPRQERLNFW LDIIFEATNE VTNGLRFPVL VIEPTKVYQP 540

SYVSINSEAE ERTVSLWHVS PTEMKQIHEW NFTASSIRGI SISKFDERCC FLYVHDNSDD 600

FQIYFSTENQ CSRFCSLVKE MIANGMGSTV ELEGETDGDT LEYEYDHDEK GERVVLGKGT 660

YGVVYAGRDL SNQVRIAIKE IPERDSRYSQ PLHEEIALHK YLKHRNIVQY LGSVSEDGYI 720

KIFMEQVPGG SLSALLRSKW GPMKEPTIRF YTKQILEGLK YLHENQIVHR DIKGDNVLVN 780

TYSGVVKISD FGTSKRLAGV NPCTETFAGT LQYMAPEIID QGPRGYGAPA DIWSLGCTII 840

EMATSKPPFH ELGEPQAVMF KVGMFKIHPE IPETLSAEAR ACLLSCFEPD PHKRVTAAGL 900

LQEGFFRQMH KGKKNRIAFK PAEGPRGAVL TLPPSGELPG SSSSEHGSVS PDSDAQPDPF 960

FEKSRLPVQR LSHLLSVPDE SSALEDRSAA SSPEDRDPGL FLLRKDSERR AILYKILWEE 1020

QNQVASNLQE CVAQSSEELH LSVGHIKQII AILRDFIRCP EHRVMASTIS KLKVDLDFDS 1080

SSINQIHLVL FGFQDAVNKI LRNHLIRPHW MFAMDNIIRR AVQAAVTILI PELQAHFEPA 1140

SETEGVEKDT DEMEEDYPPA DLPASEAQEA SPQQHLSFQL SKLRQETSRL LEHLVQKEIE 1200

YQNLLRHILE QKTQELYHLR LQFTSNENSV SPPGSQEQRT DKELVDWLQL QGADTRTIEK 1260

ILEEGYTLSD ILNDITKEDL RYLRLRGGLL CRLWTAVSQY RRRAQGAPAT QDEA 1314

Nucleotide Sequence
(FASTA)

ATGGAGAGCG GCGGCGGGGC GACCCCGGCG GGGGCGGTCG GGGCGGCAGC CGAGCCCCCC 60

CAGTGCCAGC TGCCGCCGGT GGGCGAGGGC GTGGCGGGGC CGCCGGGCCC GCCGGAGCCC 120

GAGGGGTCGG CCGAGGGCGC GGGGGTCGGA GGCGAGGGCG GGGGCGCGGG TGGGCCGCGG 180

CGGGCGCTGC GGGCAGTATA CGTGCGCAGC GAGAGCCCCC AGGGCGGCCC CGAGGCGGGG 240

GCGCGCCAGT GCCTGCTGCG GGCCTGCGAG GCTGAGGGCG CCCACCTCAC CTCTGTATCC 300

TTCGGGGAGC TCGACTTCGG GGAGACGGCC GTGCTAGACA CCTTCTACGA CGCAGATGTT 360

GCTGTGGTGG ACATGAGCGA TGTCTCCAGA CAGCCTTCAC TCTTCTACCA TCTTGGAGTC 420

CGTGAAAGCT TCGACATGGC CAATAACGTG ATCCTGTACC ATGACACCGA TGCTGACACT 480

GCTCTTTCTT TGAAGGATAT GGTAACTCAA AAAAACACAG CATCCAGTGG AAATTATTAC 540

TTCATCCCAT ATATCGTGAC ACCATGTGCT GATTATTTTT GCTGTGAGAG TGATGCCCAG 600

CGGCGTGCCT CGGAGTACAT GCAGCCCAAC TGGGACACCC TCCTCGGTCC ACTGTGTGTG 660

CCTCTGGTGG ACAGGTTTAC TAGCCTCCTC AAGGACATCC ATGTGACCTC ATGTGCTTAT 720

TACAAAGAAA CCTTGTTAAA TGACATCCGG AGAGCCAGAG AGAAATACCA GGGTGATGAA 780

CTGGCCAAGG AGCTGGCTCG GATCAAACTC CGCATGGATA ACACTGAGGT TCTGACCTCA 840

GACATCATCA TTAATTTACT GCTGTCCTAT CGCGATATCC AGGACTATGA TGCAATGGTG 900

AAGCTGGTAG AAACACTGGA GATGCTGCCT ACATGTGATT TGGCTGACCA GCATAACATT 960

AAATTCCACT ATGCGTTTGC ACTGAATAGG AGAAACAGCG CAGGTGATCG TGAGAAGGCC 1020

CTGCAGGTCA TGCTCCAGGT TCTGCAGAGC TGTGACCACC CGGCCCCTGA CATGTTCTGC 1080

CTCTGTGGGA GGATCTACAA GGACGTCTTC TTAGATTCAG ACTGCAAAGA TGATGCCAGC 1140

AGAGACAGCG CCATTGAATG GTATCGCAAA GGGTTTGCGC TCCAGCCATC TCTCTATTCA 1200

GGAATCAACC TTGCGGTATT GCTGATAGTT GCTGGACAAC AATTTGAAAC TTCCATGGAA 1260

CTGAGGAAAA TAGGTGTCCG GCTGAACAGT TTGTTGGGAA GAAAAGGGAG CTTGGAGAAA 1320

ATGAACAGCT ACTGGGATGT AGGTCAGTTC TTCAGTGTCA GCATGTTGGC CAGTGATGTG 1380

GGGAAGGCTG TCCAGGCAGC AGAGAGGTTG TTCAGACTGA AACCTCCCGT CTGGTACCTG 1440

CGGTCATTAG TTCAGAACTT GTTGTTAATT CAGCGTTTCA AGAAACCCCT TATTGAACAT 1500

TCACCCAGGC AAGAACGGCT GAACTTCTGG CTAGATATAA TTTTTGAGGC AACAAATGAA 1560

GTTACTAATG GACTCAGATT TCCAGTGCTG GTGATAGAAC CAACCAAAGT CTACCAGCCT 1620

TCTTATGTCT CCATAAACAG CGAAGCTGAG GAGAGGACCG TTTCTCTGTG GCATGTCTCA 1680

CCCACGGAAA TGAAACAAAT TCATGAATGG AATTTTACAG CCTCTTCCAT TAGAGGAATA 1740

AGCATATCCA AGTTCGACGA ACGGTGTTGT TTTCTTTACG TCCATGATAA TTCTGATGAC 1800

TTTCAAATCT ACTTTTCCAC TGAAAACCAG TGCAGTAGGT TTTGCTCTTT GGTCAAAGAG 1860

ATGATAGCCA ATGGAATGGG CAGCACAGTG GAGCTGGAGG GAGAGACTGA TGGGGATACC 1920

TTAGAGTATG AGTACGACCA TGATGAGAAA GGTGAGAGAG TGGTGCTCGG GAAGGGCACG 1980

TATGGAGTCG TGTACGCTGG CAGAGATCTG AGCAATCAAG TGCGAATAGC CATCAAAGAA 2040

ATTCCAGAGA GAGACAGCAG GTACTCCCAG CCTCTGCACG AGGAGATCGC CCTGCACAAG 2100

TACCTCAAGC ACCGCAACAT TGTTCAATAC CTAGGCTCCG TGTCCGAGGA CGGCTACATC 2160

AAGATATTTA TGGAGCAGGT GCCTGGGGGA AGCCTTTCAG CTCTTCTGCG ATCAAAGTGG 2220

GGGCCAATGA AGGAGCCCAC CATCAGATTC TACACCAAGC AGATCCTGGA AGGCCTCAAA 2280

TACCTGCACG AAAACCAGAT TGTGCACAGA GACATCAAGG GTGATAACGT TCTGGTGAAC 2340

ACCTATAGTG GAGTGGTGAA GATCTCCGAT TTTGGCACCT CGAAACGTCT TGCAGGAGTG 2400

AATCCGTGTA CGGAGACTTT TGCTGGCACG CTGCAGTACA TGGCACCTGA GATTATCGAT 2460

CAAGGCCCTC GTGGGTATGG CGCCCCGGCT GATATCTGGT CCCTGGGCTG CACCATCATT 2520

GAGATGGCCA CCAGCAAGCC TCCATTCCAT GAGCTCGGTG AACCACAGGC AGTGATGTTC 2580

AAGGTGGGGA TGTTCAAGAT CCACCCAGAG ATTCCAGAAA CCCTCTCAGC TGAAGCCAGA 2640

GCCTGCCTTT TATCCTGTTT TGAGCCTGAC CCCCACAAAC GTGTCACCGC CGCGGGCCTG 2700

CTCCAAGAGG GCTTCTTCAG GCAGATGCAC AAGGGCAAGA AGAACCGGAT TGCTTTCAAG 2760

CCGGCAGAGG GTCCCCGGGG TGCCGTGCTG ACCCTGCCCC CGTCCGGAGA GCTGCCGGGC 2820

AGCAGCAGCA GCGAGCATGG CTCCGTCTCC CCGGACTCCG ACGCCCAGCC CGACCCATTC 2880

TTCGAGAAGT CCCGGCTGCC GGTGCAGCGG CTCAGCCACC TGCTCAGTGT TCCCGATGAG 2940

AGTTCGGCCT TGGAGGACCG GAGTGCAGCC TCGTCCCCTG AAGACAGGGA CCCGGGCCTT 3000

TTCCTGCTGC GAAAGGACAG TGAGCGCCGT GCCATCCTTT ACAAAATCCT CTGGGAGGAG 3060

CAGAATCAGG TGGCTTCCAA CCTGCAGGAG TGCGTGGCCC AGAGTTCAGA AGAGTTGCAT 3120

CTCTCGGTCG GCCACATCAA GCAAATCATT GCGATCCTTA GAGACTTCAT CCGCTGCCCA 3180

GAGCACAGGG TGATGGCATC CACAATATCA AAGCTCAAGG TGGACCTGGA CTTTGACAGC 3240

TCATCCATCA ATCAGATTCA CCTGGTACTG TTTGGATTTC AGGATGCTGT AAATAAAATC 3300

TTGAGGAACC ACTTAATTAG GCCCCACTGG ATGTTTGCAA TGGACAACAT CATCCGACGA 3360

GCAGTGCAGG CTGCGGTCAC CATCCTCATC CCAGAGCTCC AAGCCCACTT TGAGCCCGCC 3420

TCAGAGACTG AAGGTGTGGA AAAGGACACA GATGAGATGG AAGAGGACTA TCCCCCCGCA 3480

GACCTGCCTG CAAGCGAGGC ACAGGAGGCC TCACCCCAGC AGCACCTGAG CTTTCAGCTG 3540

AGCAAGCTGA GGCAGGAGAC CAGCAGACTT TTGGAACACC TGGTTCAAAA AGAAATAGAG 3600

TACCAGAATC TTCTACGGCA CATCCTAGAA CAGAAAACTC AAGAATTATA CCACCTTCGG 3660

TTACAATTCA CCTCCAATGA GAACTCAGTA TCCCCTCCTG GGTCTCAGGA GCAGCGAACA 3720

GATAAAGAGC TTGTCGATTG GTTGCAACTG CAAGGAGCGG ATACGAGAAC AATTGAAAAG 3780

ATTCTTGAAG AGGGTTACAC ACTGTCTGAT ATTCTTAATG ATATCACTAA GGAAGACCTA 3840

AGGTACCTTA GACTACGCGG TGGTCTTCTC TGCAGGCTCT GGACTGCAGT CTCCCAGTAC 3900

AGAAGACGGG CTCAGGGGGC GCCAGCAACC CAAGATGAGG CTTAA 3945

Domain Profile

S: 3     krevigkGsfgsvyaaldvdtgellavKeveikpekksekkevkalkeEikllkelkHen  62

         +r v+gkG++g vya++d++++ ++a+Ke+   pe++s+  ++++l+eEi+l+k lkH+n

Q: 652   ERVVLGKGTYGVVYAGRDLSNQVRIAIKEI---PERDSR--YSQPLHEEIALHKYLKHRN  706

         6889**************************...888775..9******************

S: 63    ivkyyGveveeeelkiflEyvegGslsslle.kygkleesvikkytkqileglayLHekk  121

         iv+y+G+ +e++++kif+E+v+gGsls+ll+ k+g+++e +i++ytkqilegl+yLHe++

Q: 707   IVQYLGSVSEDGYIKIFMEQVPGGSLSALLRsKWGPMKEPTIRFYTKQILEGLKYLHENQ  766

         *******************************9****************************

S: 122   ivHRDiKgaNillds.sgvvklsDFGaskrlaelntkaaelesltGtlaymaPEvikkke  180

         ivHRDiKg+N+l+++ sgvvk+sDFG+skrla +n++   +e+++Gtl+ymaPE+i+++

Q: 767   IVHRDIKGDNVLVNTySGVVKISDFGTSKRLAGVNPC---TETFAGTLQYMAPEIIDQGP  823

         *************************************...8*******************

S: 181   kgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakktkPeipeklseegkdfl  240

         +gyg+ aDiWslgc++iem+t+k+Pf+el+e++a+mfkvg+ k++Peipe+ls+e+++ l

Q: 824   RGYGAPADIWSLGCTIIEMATSKPPFHELGEPQAVMFKVGMFKIHPEIPETLSAEARACL  883

         ************************************************************

S: 241   ekcleldpkkrpsaeeLLkhef  262

          +c+e dp+kr++a+ LL++ f

Q: 884   LSCFEPDPHKRVTAAGLLQEGF  905

         *******************988

Domain Sequence
(FASTA)

ERVVLGKGTY GVVYAGRDLS NQVRIAIKEI PERDSRYSQP LHEEIALHKY LKHRNIVQYL 60

GSVSEDGYIK IFMEQVPGGS LSALLRSKWG PMKEPTIRFY TKQILEGLKY LHENQIVHRD 120

IKGDNVLVNT YSGVVKISDF GTSKRLAGVN PCTETFAGTL QYMAPEIIDQ GPRGYGAPAD 180

IWSLGCTIIE MATSKPPFHE LGEPQAVMFK VGMFKIHPEI PETLSAEARA CLLSCFEPDP 240

HKRVTAAGLL QEGF 254

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR025136	; DUF4071.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR013761	; SAM/pointed.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF13281	; DUF4071; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013