EKS-BOT-00470

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-BOT-00470

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	362.2	1.9E-108	15	305	291

Status

Unreviewed

Ensembl Protein

ENSBTAP00000026467

UniProt Accession

F1N3N6;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK15

Gene Synonyms/Alias

MAPK15;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSBTAG00000019864	ENSBTAP00000026467	ENSBTAT00000026467

Organism

Bos taurus

Functional Description

Protein Length

536

Protein Sequence
(FASTA)

MCTAEVDRHV AQRYLLKRRL GKGAYGIVWK AVDRRTGEVV AIKKIFDAFK DKTDAQRTFR 60

EITLLQEFGD HPNIVRLLDV IPAENDRDIY LVFESMDTDL NAVICKGTLL KDTHKRYIFY 120

QLLRATKFIH SGRVIHRDQK PSNVLLDASC LVKLCDFGLA RPLSGLPEVP EGHALTEYVA 180

TRWYRAPEVL LSSSWYTPGV DMWSLGCILG EMLRGRPLFP GTSTLHQLEL ILEAIPPPSK 240

EDLLALGSGC NISVLQHLGS RPRQTLDALL PPDTPPDALD LLSRLLVFAP HKRLSAAQAL 300

QHPYVQRFHC PAREWTLGGD VRLPVQEGAQ LSAAEYRRRL HQMILERRGH GRLSKETGLG 360

GGPPTPEPEA QLPSGSPALN SGRRPRNNPG LGPVHDALGG AQDPPRQNSA PLHQPPPPGG 420

PGREAGPGGA TSSSWVKPGV REAAPSLTSQ AAAQVAVRAL IRSDRNPGRG ENAPGAPRVP 480

PRSPGAARPG RRMFGASATQ GAQGAARATL GGYSQAYGTV CLSALGCLPL LPGPRA 536

Nucleotide Sequence
(FASTA)

ATGTGCACCG CCGAGGTGGA CCGTCACGTC GCCCAGCGAT ACCTGCTCAA GCGGCGGCTC 60

GGGAAGGGGG CCTATGGCAT CGTGTGGAAG GCGGTGGATC GGAGGACTGG CGAGGTCGTG 120

GCCATCAAGA AAATCTTTGA TGCCTTCAAG GATAAGACAG ATGCCCAGAG GACGTTCCGG 180

GAAATCACGC TTCTCCAGGA ATTTGGGGAC CATCCCAACA TCGTCCGCCT CCTGGATGTG 240

ATCCCGGCAG AGAACGACAG GGACATTTAC CTGGTGTTTG AGTCTATGGA TACCGACCTG 300

AATGCTGTCA TCTGCAAGGG CACGCTGCTA AAGGACACCC ACAAACGCTA CATCTTCTAC 360

CAGCTGCTGC GGGCCACCAA GTTCATTCAC TCAGGGCGGG TCATCCACCG GGACCAGAAG 420

CCATCCAATG TTCTCCTGGA TGCCAGCTGT TTGGTGAAGC TCTGTGACTT TGGCCTGGCT 480

CGCCCCCTCA GTGGCCTCCC TGAGGTCCCC GAGGGGCATG CCCTGACGGA GTATGTGGCC 540

ACGAGATGGT ACCGGGCTCC AGAGGTGTTG CTGTCTTCCA GCTGGTACAC CCCTGGGGTG 600

GACATGTGGA GTCTGGGCTG CATTCTGGGG GAGATGCTGC GGGGGCGGCC CTTGTTCCCT 660

GGCACGTCCA CCCTCCACCA GCTGGAGCTC ATCCTGGAGG CCATCCCGCC ACCATCCAAG 720

GAGGACCTCC TGGCGCTCGG CTCTGGCTGC AACATCTCAG TTCTGCAGCA CCTGGGGTCC 780

CGGCCCAGGC AGACGCTAGA TGCCCTCCTG CCCCCCGACA CCCCTCCAGA TGCCCTGGAC 840

CTCCTCTCGA GACTCCTGGT GTTTGCCCCG CACAAGCGGC TCAGCGCAGC CCAGGCCCTG 900

CAGCACCCCT ACGTGCAGAG GTTCCACTGC CCGGCCCGTG AGTGGACACT GGGGGGGGAC 960

GTGCGGCTCC CGGTGCAGGA AGGAGCCCAG CTCTCAGCCG CCGAGTATCG CCGCCGCCTC 1020

CATCAGATGA TCTTGGAGCG CAGGGGCCAC GGCCGCCTCT CGAAGGAGAC GGGCCTGGGG 1080

GGCGGCCCCC CGACCCCCGA GCCGGAGGCC CAGCTGCCCT CGGGCTCGCC CGCGTTGAAC 1140

TCCGGACGCC GGCCTCGGAA TAACCCCGGC CTCGGCCCCG TGCACGACGC CCTCGGCGGA 1200

GCCCAGGACC CTCCCAGGCA GAACTCAGCC CCCCTGCACC AGCCTCCGCC CCCAGGAGGT 1260

CCTGGGAGAG AGGCGGGGCC CGGCGGGGCG ACGTCATCCT CGTGGGTGAA GCCCGGCGTG 1320

AGGGAGGCGG CGCCCTCCTT GACCTCGCAG GCCGCCGCCC AGGTGGCCGT CCGGGCACTG 1380

ATCAGGAGTG ACCGGAACCC GGGCCGCGGT GAGAACGCGC CCGGCGCGCC ACGGGTTCCT 1440

CCTCGATCTC CCGGGGCGGC CCGGCCCGGT CGGAGGATGT TCGGGGCCTC GGCCACACAG 1500

GGGGCCCAGG GAGCCGCGCG GGCCACGCTG GGGGGCTACT CCCAAGCCTA CGGGACCGTC 1560

TGCCTCTCGG CGCTGGGCTG CCTGCCCCTC CTCCCGGGAC CTCGCGCCTG A 1611

Domain Profile

S: 2     eslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkel.kheNi  60

           +++lg+Gayg+v++avd+rt+e vaikk++++f+++t+a+rt+RE++ll+e+ +h+Ni

Q: 15    LLKRRLGKGAYGIVWKAVDRRTGEVVAIKKIFDAFKDKTDAQRTFREITLLQEFgDHPNI  74

         56789*******************************************************

S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksq.klsdehiklllyqilrglkylH  119

         ++lldv+ +e+     +d+Ylv+e m+tdL++vi +   l+d+h ++++yq+lr++k++H

Q: 75    VRLLDVIPAEN----DRDIYLVFESMDTDLNAVICKGtLLKDTHKRYIFYQLLRATKFIH  130

         *******8888....9******************999799********************

S: 120   sanviHrDlKPsNllvnedcelkildFGlarsadkekekk....lteyvatrwYraPeil  175

         s +viHrD+KPsN+l+++ c +k++dFGlar  +   e      lteyvatrwYraPe+l

Q: 131   SGRVIHRDQKPSNVLLDASCLVKLCDFGLARPLSGLPEVPeghaLTEYVATRWYRAPEVL  190

         *******************************9665544434556****************

S: 176   lslkeytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkiesee  235

         ls++ yt  vD+Ws+GCIl+E+l+g+plfpg+++++qle+ile ++ ps+e+l ++ s +

Q: 191   LSSSWYTPGVDMWSLGCILGEMLRGRPLFPGTSTLHQLELILEAIPPPSKEDLLALGSGC  250

         ************************************************************

S: 236   arnyikslpkkkkkdfeelfpk.aseealdLleklLvldpdkRisveeaLehpYl  289

           +++++l +++++++++l+p  + ++aldLl++lLv++p+kR+s+++aL+hpY+

Q: 251   NISVLQHLGSRPRQTLDALLPPdTPPDALDLLSRLLVFAPHKRLSAAQALQHPYV  305

         *******************9874789****************************7

Domain Sequence
(FASTA)

LLKRRLGKGA YGIVWKAVDR RTGEVVAIKK IFDAFKDKTD AQRTFREITL LQEFGDHPNI 60

VRLLDVIPAE NDRDIYLVFE SMDTDLNAVI CKGTLLKDTH KRYIFYQLLR ATKFIHSGRV 120

IHRDQKPSNV LLDASCLVKL CDFGLARPLS GLPEVPEGHA LTEYVATRWY RAPEVLLSSS 180

WYTPGVDMWS LGCILGEMLR GRPLFPGTST LHQLELILEA IPPPSKEDLL ALGSGCNISV 240

LQHLGSRPRQ TLDALLPPDT PPDALDLLSR LLVFAPHKRL SAAQALQHPY V 291

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0046777	; P:protein autophosphorylation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013